Virus Infections and Host Metabolism 2026

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".

Deadline for manuscript submissions: 15 May 2026 | Viewed by 1941

Special Issue Editors


E-Mail Website
Guest Editor
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore
Interests: systems biology; host-virus interactions; immunometabolism
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore
Interests: host-virus interactions; functional genomics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Singapore-MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group, Campus for Research Excellence and Technological Enterprise, Singapore 138602, Singapore
Interests: metabolomics; lipidomics; mass spectrometry; viral pathogenesis

Special Issue Information

Dear Colleagues,

Viruses have evolved mechanisms to target the host cell metabolism and to channel host metabolic resources and energy towards viral production and propagation. On the other hand, the hosts have also developed a repertoire of strategies to counteract and resist these metabolic changes induced by virus infections. However, the complex interplay between virus and host metabolic changes has only recently begun to be understood.

This Special Issue will highlight the host–virus metabolic interactions that promote viral infection and disease pathogenesis. We are also interested in submissions exploring how host variations can affect host metabolic responses to viruses. A better understanding of these virus–host metabolic interactions provides insights into the vulnerabilities in virus infection, thereby facilitating antiviral therapeutic development, to reduce the global burden of viral diseases.

Dr. Kuan Rong Chan
Dr. Yaw Shin Ooi
Dr. Liang Cui
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • host–virus interactions
  • host response to viruses
  • immunometabolism
  • viral pathogenesis
  • metabolic reprogramming
  • metabolome
  • metabolism
  • lipidomics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

20 pages, 2565 KB  
Article
Host Cell Central Carbon Metabolism and Cellular NAD+ Pool Regulate Efficient Replication of Vesicular Stomatitis Virus
by Kush K. Pandey, Bikash R. Sahoo, D. S. McVey and Asit K. Pattnaik
Viruses 2026, 18(3), 326; https://doi.org/10.3390/v18030326 - 6 Mar 2026
Viewed by 903
Abstract
Vesicular stomatitis virus (VSV) is a promising oncolytic virus whose replication efficiency and tumor selectivity are strongly influenced by host cell metabolism. Cancer cells, including glioblastoma, exhibit profound rewiring of central carbon metabolism to sustain proliferation, redox balance, and biosynthetic demand, yet how [...] Read more.
Vesicular stomatitis virus (VSV) is a promising oncolytic virus whose replication efficiency and tumor selectivity are strongly influenced by host cell metabolism. Cancer cells, including glioblastoma, exhibit profound rewiring of central carbon metabolism to sustain proliferation, redox balance, and biosynthetic demand, yet how these metabolic states regulate VSV replication remains incompletely defined. Here, we investigated the dependency of VSV replication on glycolysis, the pentose phosphate pathway (PPP), and glutamine metabolism in A172 human glioblastoma cells. Pharmacologic inhibition of glycolysis using 2-DG strongly suppressed VSV replication in a dose-dependent manner, highlighting a robust requirement for glycolytic flux and downstream intermediates. While inhibiting the PPP with 6-AN, a nicotinamide adenine dinucleotide (NAD) analog, markedly impaired viral replication, D-ribose was unable to rescue the inhibition, indicating that nucleotide precursor limitation alone was insufficient to explain this effect. Interestingly, depletion of glucose 6-phosphate dehydrogenase (G6PD), a key enzyme in the PPP, resulted in significant enhancement of VSV replication. Restoration of viral replication by NAD+ precursors in the presence of 6-AN or suppression of replication by the NAMPT inhibitor FK866 suggested NAD+ availability as a critical determinant of VSV replication. Additionally, blockade of glutaminase activity with BPTES reduced viral replication, underscoring the importance of anaplerotic pathways in glioblastoma cells. Collectively, these findings demonstrate that VSV replication is tightly coupled to metabolic programs, particularly those governing energy production and NAD(P)H balance. This work provides a metabolic framework for optimizing oncolytic VSV therapies and suggests that metabolic interventions in cancer treatment may influence oncolytic virus efficacy. Full article
(This article belongs to the Special Issue Virus Infections and Host Metabolism 2026)
Show Figures

Figure 1

Back to TopTop