Influenza and Other Respiratory Viruses: Prevention, Diagnosis, Treatment: 2nd Edition

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 547

Special Issue Editor

Department of Basic and Clinical Sciences, Albany College of Pharmacy and Health Sciences, 106 New Scotland Avenue, Albany, NY 12208, USA
Interests: RNA viruses; influenza; vaccine development; antiviral development; viral immunology; viral pathogenesis; molecular virology; virus–host interaction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Viral respiratory infections are the most common diseases in humans, contributing to substantial morbidity, mortality, and economic losses annually worldwide. As the world continues to deal with COVID-19, upsurges in infections caused by other respiratory viruses, such as influenza, respiratory syncytial virus, parainfluenza, metapneumovirus, bocaviruses, and non-rhinovirus enteroviruses, have burdened healthcare systems in several countries. Because of their transmissibility, advances in the diagnosis and surveillance of these respiratory viruses are critically needed to guide the use of available therapeutics, the allocation of hospital as well as community resources, and the targeting of vaccination in addition to behavioral change campaigns by public health officials to mitigate their spread. Furthermore, since many of these respiratory viruses have limited therapeutic options and lack effective vaccines, there is an urgent need for further research into the biology of these viruses to help guide the development of effective strategies for the treatment and prevention of infection.

This Special Issue of Viruses seeks to attract original research and review articles focused on (1) advances and innovations in the development of highly sensitive diagnostic tests for the early detection of human respiratory virus infections; (2) timely findings on the epidemiology and transmission of human respiratory viruses; (3) the development and clinical trials of new vaccines, antivirals, and immunotherapeutics for influenza, RSV, coronaviruses, and other clinically relevant human respiratory viruses; (4) studies detailing the effectiveness and/or immunogenicity of existing vaccines; and (5) mitigation measures or strategies to reduce viral transmission/community spread, disease incidence in at-risk populations, and cross-species transmission.

Dr. Eric Yager
Guest Editor

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Keywords

  • influenza
  • adenovirus
  • coronoavirus
  • respiratory syncytial virus
  • rhinovirus
  • respiratory virus
  • antiviral strategies
  • epidemiology
  • diagnosis
  • treatment
  • vaccination
  • surveillance
  • vaccine development

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Published Papers (1 paper)

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Research

13 pages, 5104 KiB  
Article
Structure and Antigenicity of the Porcine Astrovirus 4 Capsid Spike
by Danielle J. Haley, Sarah Lanning, Kyle E. Henricson, Andre A. Mardirossian, Iyan Cirillo, Michael C. Rahe and Rebecca M. DuBois
Viruses 2024, 16(10), 1596; https://doi.org/10.3390/v16101596 - 11 Oct 2024
Viewed by 416
Abstract
Porcine astrovirus 4 (PoAstV4) has been recently associated with respiratory disease in pigs. In order to understand the scope of PoAstV4 infections and to support the development of a vaccine to combat PoAstV4 disease in pigs, we designed and produced a recombinant PoAstV4 [...] Read more.
Porcine astrovirus 4 (PoAstV4) has been recently associated with respiratory disease in pigs. In order to understand the scope of PoAstV4 infections and to support the development of a vaccine to combat PoAstV4 disease in pigs, we designed and produced a recombinant PoAstV4 capsid spike protein for use as an antigen in serological assays and for potential future use as a vaccine antigen. Structural prediction of the full-length PoAstV4 capsid protein guided the design of the recombinant PoAstV4 capsid spike domain expression plasmid. The recombinant PoAstV4 capsid spike was expressed in Escherichia coli, purified by affinity and size-exclusion chromatography, and its crystal structure was determined at 1.85 Å resolution, enabling structural comparisons to other animal and human astrovirus capsid spike structures. The recombinant PoAstV4 capsid spike protein was also used as an antigen for the successful development of a serological assay to detect PoAstV4 antibodies, demonstrating that the recombinant PoAstV4 capsid spike retains antigenic epitopes found on the native PoAstV4 capsid. These studies lay a foundation for seroprevalence studies and the development of a PoAstV4 vaccine for swine. Full article
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