Cellular Restriction Factors against Viral Infection
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".
Deadline for manuscript submissions: 30 October 2024 | Viewed by 7123
Special Issue Editor
Interests: cellular restriction factors; antiviral proteins; HIV; Ebola; SARS-CoV-2; innate immunity; retroviral integration; HERC5; ISG15; viral antagonists; virus–host interactions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cellular restriction factors are often upregulated by Type I interferons (IFNs) in an attempt by the host to rapidly and directly restrict viral replication and spread. The evolutionary origin of many restriction factors highlights their importance as a first line of defence against viruses. At the same time, the ability of viruses to counteract cellular restriction factors is critical for their survival and as we have observed recently, is an important characteristic of viruses of pandemic potential such as SARS-CoV-2. Thus, viral antagonists of host restriction factors show promise as potential targets for antiviral therapies.
In this Special Issue, we welcome submissions of original research, short communications and reviews which will contribute to an improved understanding of aspects related to the ‘protagonist–antagonistic’ relationship between viruses and host restriction factors.
Dr. Stephen Barr
Guest Editor
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Keywords
- cellular restriction factors
- antiviral proteins
- viral antagonists
- intrinsic immunity
- interferon response
- innate immunity
- evolution of restriction factors
- evolution of viral antagonists
- viral antagonists as druggable targets
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