HIV Assembly, Release and Maturation
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 1153
Special Issue Editor
Special Issue Information
Dear Colleagues,
The late stages of the HIV-1 replication cycle—assembly, release, and maturation—have previously defied detailed structural characterization due to the complexity of the multi-scale structural reorganizations involved. Recent progress in cryo-electron microscopy, structural biology, molecular biology, solid-state NMR, and the application of molecular modeling to large systems has now revealed the intricacies of the complex sequence of events that controls these stages. The domain rearrangements that drive global reorganization between the immature and mature states are now being understood at an atomistic level. The mechanisms that determine the selective packaging of genomic RNA into virions are now better understood, as is the importance of inositol hexakisphosphate (IP6) in the generation of both immature Gag and mature capsid lattices. The extent to which flexibility/dynamics play a regulatory role in the maturation process, and the concomitant reorganization of the envelope glycoproteins, is now better appreciated. Research papers exploring the implications of these findings to the replication cycle of HIV-1, drug design, and therapeutic interventions are invited to contribute to this Special Issue. Studies focusing on the virology, cell biology, and biochemistry of these stages are appropriate. Inter-disciplinary studies are also welcome.
Dr. Siddhartha Datta
Guest Editor
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Keywords
- HIV assembly and maturation
- capsid stability
- inositol hexakisphosphate (IP6)
- genome recognition
- endogenous reverse transcription
- reorganization
- maturation inhibitors
- flexibility and dynamics
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