Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.3
3.8
Journals
Viruses
Special Issues
The Challenge of HIV Diversity
share announcement

The Challenge of HIV Diversity

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1431

Special Issue Editor

Dr. Brian T. Foley

E-Mail Website
Guest Editor
HIV Genetic Sequence and Immunology Databases, Theoretical Biology and Biophysics Group, Los Alamos National Lab, Los Alamos, NM, USA
Interests: HIV evolution; viral epidemiology; phylogenetic analyses; genetic recombination; viral taxonomy and nomenclature; HIV genotyping; HIV pathogenesis

Special Issue Information

Dear Colleagues,

Viruses invites the submission of original research and review articles to this Special Issue, covering challenges in HIV diversity. The articles can cover any level of diversity, from intrapatient immune evasion and development of drug resistance, to global challenges for vaccine design. Reports of research on HIV recombination at all levels, from intrapatient to inter-subtype, are encouraged. Although HIV-1 M-group viruses comprise the majority of global AIDS cases, submissions if research on other immunodeficiency viruses is also encouraged. Topics of interest can include challenges in methods (challenges of amplifying and sequencing viral genomes, for example) and computation (challenges with multiple sequence alignment, phylogenetic analyses, recombination detection, etc.). Analyses of trends in drug resistance, immune evasion or epidemiology are well suited for this Special Issue. Although submissions should focus on immunodeficiency viruses, comparisons or contrasts to other viruses can be illuminating and useful.

Dr. Brian T. Foley
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HIV diversity
  • immune evasion
  • drug resistance
  • vaccine design
  • HIV recombination
  • immunodeficiency viruses
  • epidemiology analysis

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

18 pages, 2568 KiB  
Article
Human Immunodeficiency Virus Type-1 Genetic Diversity and Drugs Resistance Mutations among People Living with HIV in Karachi, Pakistan
by Abdur Rashid, Li Kang, Feng Yi, Qingfei Chu, Sharaf Ali Shah, Syed Faisal Mahmood, Yimam Getaneh, Min Wei, Song Chang, Syed Hani Abidi and Yiming Shao
Viruses 2024, 16(6), 962; https://doi.org/10.3390/v16060962 - 14 Jun 2024
Viewed by 616
Abstract
The human immunodeficiency virus type-1 epidemic in Pakistan has significantly increased over the last two decades. In Karachi, Pakistan, there is a lack of updated information on the complexity of HIV-1 genetic diversity and the burden of drug resistance mutations (DRMs) that can [...] Read more.
The human immunodeficiency virus type-1 epidemic in Pakistan has significantly increased over the last two decades. In Karachi, Pakistan, there is a lack of updated information on the complexity of HIV-1 genetic diversity and the burden of drug resistance mutations (DRMs) that can contribute to ART failure and poor treatment outcomes. This study aimed to determine HIV-1 genetic diversity and identify drug-resistance mutations among people living with HIV in Karachi. A total of 364 HIV-positive individuals, with a median age of 36 years, were enrolled in the study. The HIV-1 partial pol gene was successfully sequenced from 268 individuals. The sequences were used to generate phylogenetic trees to determine clade diversity and also to assess the burden of DRMs. Based on the partial pol sequences, 13 distinct HIV-1 subtypes and recombinant forms were identified. Subtype A1 was the most common clade (40%), followed by CRF02_AG (33.2%). Acquired DRMs were found in 30.6% of the ART-experienced patients, of whom 70.7%, 20.7%, and 8.5% were associated with resistance to NNRTIs, NRTIs, and PIs, respectively. Transmitted DRMs were found in 5.6% of the ART-naïve patients, of whom 93% were associated with resistance against NNRTIs and 7% to PIs. The high prevalence of DRMs in ART-experienced patients poses significant challenges to the long-term benefits and sustainability of the ART program. This study emphasizes the importance of continuous HIV molecular epidemiology and drug resistance surveillance to support evidence-based HIV prevention, precise ART, and targeted AIDS care. Full article
(This article belongs to the Special Issue The Challenge of HIV Diversity)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop