The Immune Response to Influenza Virus Infection
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: closed (1 October 2022) | Viewed by 1570
Special Issue Editor
Interests: SARS-CoV-2; virus
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Influenza viruses are one of the most notorious human viruses. There are two main types of human flu viruses: A and B. A and B flu viruses routinely spread in people and are responsible for seasonal flu epidemics each year. They are contagious and pathogenic and are responsible for severe respiratory infection in humans and animals worldwide. Upon influenza A or B infection, the infected human immune system defense is able to combat the infection and usually clear the virus in a few days. The innate immune response of the infected host comprises physical barriers, primarily mucus, collectins, phagocytic cells, cytokines, interferons (IFNs), and IFN-stimulated genes as the first line of defense against the viral attack. Later, adaptive immunity kicks in with B cells and T cells, which are antigen-specific memory cells that capture and neutralize the invading pathogen. The humoral immune response functions using hemagglutinin-specific circulating antibodies that efficiently neutralize the influenza virus. These antibodies also bind to the surface of infected cells and induce antibody-dependent cell-mediated cytotoxicity or complement activation. Although neutralizing antibodies are quite effective against the virus, cellular immunity also plays a crucial role in this fight against viral influenza infections. Interestingly, influenza viruses have developed multiple strategies to escape all these host immune surveillance and defense systems and continue their successful replication. We dedicate this Special Issue of Viruses to discussing how the innate immune system and specialized molecules from the immune cell repertoire participate in creating a cumulative antiviral defense response against influenza viruses. Additionally, we will focus on novel strategies that these viruses use to antagonize these immune responses to complete their viral replication cycle and cause successful infection. This Special Issue invites original, high-quality research articles, as well as new perspectives or reviews on this subject.
Prof. Dr. Sunil Lal
Guest Editor
Manuscript Submission Information
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