JC Polyomavirus
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 543
Special Issue Editors
2. Inserm UMR 1291, CNRS UMR5051, Université Toulouse III, Toulouse, France.
Interests: quasi-enveloped viruses; epidemiology; pathogenesis
Special Issues, Collections and Topics in MDPI journals
Interests: JC polyomavirus
Special Issue Information
Dear Colleagues,
We are delighted to invite you to contribute to a Special Issue dedicated to JC polyomavirus (JCPyV).
JCPyV, a small, nonenveloped, circular double-stranded DNA virus, was the first of two human polyomaviruses to be isolated in 1971 and was associated with progressive multifocal leukoencephalopathy (PML). PML is a rare, debilitating, and often fatal disease of the central nervous system (CNS) caused by JCPyV, historically described in patients with hematologic malignancies. In the 1980s, the HIV pandemic resulted in a dramatic increase in PML incidence, which significantly decreased with the use of combined antiretroviral therapy. More recently, the wider use of immunomodulatory therapies for chronic inflammatory diseases, organ and stem cell transplantation, has led to iatrogenic PML. To date, no antiviral therapies are available for JCPyV infection.
PML is associated with neurotropic variants harboring rearrangements in the JCPyV genomic regulatory non-coding control region (NCCR), which regulates viral transcription and replication. The mechanisms and the site of emergence of such neurotropic variants are still poorly understood. The absence of robust cell culture systems and animal models and the rarity of the disease allowing studies in large cohorts hampered, at least in part, the understanding of the pathophysiology.
This Special Issue of Viruses focuses on our current knowledge of JC polyomavirus and the direction of future research. We hope to assemble an up-to-date collection of research papers and reviews on JCPyV, its pathophysiology, molecular biology, virus–host interactions, epidemiology, and antiviral development.
We look forward to receiving your contributions.
Dr. Sébastien Lhomme
Dr. Anne-Sophie L’Honneur
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- JC polyomavirus
- progressive multifocal leukoencephalopathy (PML)
- neurotropic variants
- viral genomic rearrangements
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