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Viruses
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Pseudorabies Virus, Third Edition
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Pseudorabies Virus, Third Edition

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1334

Special Issue Editors

Dr. Yan-Dong Tang

E-Mail Website
Guest Editor
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, China
Interests: pseudorabies virus
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Xiangdong Li

E-Mail Website
Guest Editor
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
Interests: veterinary viruses; pathogenesis; vaccine and diagnostics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the success of the “Pseudorabies Virus” series (see history editions Pseudorabies Virus and Pseudorabies Virus, Volume II), we are editing a 2024 edition of this very popular topic and requesting new submissions.

Pseudorabies virus (PRV) is a herpesvirus of swine, a member of the Alphaherpesvirinae subfamily, and the etiological agent of Aujeszky’s disease. PRV is a pathogen of swine that results in devastating disease and economic losses worldwide. Recently, ever-more evidence from the outbreak of PRV variants has indicated that PRV could be transmitted cross-species and potentially infect humans. Therefore, studies focusing on PRV are urgent.

The aim of this Special Issue is to collect the newest contributions in the field of Pseudorabies virus research, providing new insights into and research on unresolved issues. Evolution, viral replication, virus–host interaction, pathogenesis, and immunity, gene therapy, viral oncotherapy, and novel antiviral strategies are just a selection of the topics relevant to this field, and papers on these subjects can be published in this Special Issue. All researchers working in the field are invited to contribute original research papers or propose reviews for inclusion in this Special Issue of Viruses (ISSN 1999-4915, https://www.mdpi.com/journal/viruses).

Dr. Yan-Dong Tang
Prof. Dr. Xiangdong Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pseudorabies virus
  • viral replication
  • virus–host interaction
  • pathogenesis and immunity
  • novel antiviral strategies

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Published Papers (2 papers)

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Research

15 pages, 5223 KiB  
Article
Enhanced Anti-Tumor Response Elicited by a Novel Oncolytic Pseudorabies Virus Engineered with a PD-L1 Inhibitor
by Guangtao Xiang, Mengdong Wang, Pu Wang, Rifei Li, Chao Gao, Yue Li, Xinxin Liang, Yun Liu, Aotian Xu and Jun Tang
Viruses 2024, 16(8), 1228; https://doi.org/10.3390/v16081228 - 31 Jul 2024
Viewed by 433
Abstract
Oncolytic viruses combined with immunotherapy offer significant potential in tumor therapy. In this study, we engineered a further attenuated pseudorabies virus (PRV) vaccine strain that incorporates a PD-L1 inhibitor and demonstrated its promise as an oncolytic virus in tumor therapy. We first showed [...] Read more.
Oncolytic viruses combined with immunotherapy offer significant potential in tumor therapy. In this study, we engineered a further attenuated pseudorabies virus (PRV) vaccine strain that incorporates a PD-L1 inhibitor and demonstrated its promise as an oncolytic virus in tumor therapy. We first showed that the naturally attenuated PRV vaccine strain Bartha can efficiently infect tumor cells from multiple species, including humans, mice, and dogs in vitro. We then evaluated the safety and anti-tumor efficacy of this vaccine strain and its different single-gene deletion mutants using the B16-F10 melanoma mouse model. The TK deletion strain emerged as the optimal vector, and we inserted a PD-L1 inhibitor (iPD-L1) into it using CRISPR/Cas9 technology. Compared with the control, the recombinant PRV (rPRV-iPD-L1) exhibited more dramatic anti-tumor effects in the B16-F10 melanoma mouse model. Our study suggests that PRV can be developed not only as an oncolytic virus but also a powerful vector for expressing foreign genes to modulate the tumor microenvironment. Full article
(This article belongs to the Special Issue Pseudorabies Virus, Third Edition)
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15 pages, 3444 KiB  
Article
Immune Responses Induced by a Recombinant Lactiplantibacillus plantarum Surface-Displaying the gD Protein of Pseudorabies Virus
by Assad Moon, Jingshan Huang, Xin Song, Tao Wang, Yanjin Wang, Yongfeng Li, Yuan Sun, Hongxia Wu and Huaji Qiu
Viruses 2024, 16(8), 1189; https://doi.org/10.3390/v16081189 - 24 Jul 2024
Viewed by 623
Abstract
Pseudorabies virus (PRV) is one of the herpes viruses that can infect a wide range of animals including pigs, cattle, sheep, mice, and wild animals. PRV is a neurotropic alphaherpesvirus capable of infecting a variety of mammals. There is a rising interest in [...] Read more.
Pseudorabies virus (PRV) is one of the herpes viruses that can infect a wide range of animals including pigs, cattle, sheep, mice, and wild animals. PRV is a neurotropic alphaherpesvirus capable of infecting a variety of mammals. There is a rising interest in the targeted application of probiotic bacteria to prevent viral diseases, including PRV. In this study, the surface expression of enhanced green fluorescent protein (EGFP) on recombinant Lactiplantibacillus plantarum NC8 (rNC8) through the LP3065 LPxTG motif of Lactobacillus plantarum WCFS1 was generated. The surface expression was observed through confocal microscopy. Dendritic cell targeting peptides (DCpep) were also fused with LPxTG that help to bind with mouse DCs. The PRV-gD was cloned in LP3065 LPxTG, resulting in the generation of rNC8-LP3065-gD. Inactivated rNC8-LP3065-gD was administered intravenously in mice on days 1 and 7 at a dose of 200 µL (109 CFU/mouse) for monitoring immunogenicity. Subsequently, a challenge dose of PRV TJ (104 TCID50) was administered intramuscularly at 14 days post-immunization. The survival rate of the immunized mice reached 80% (4/5) with no significant signs of illness. A significant rise in anti-gD antibodies was detected in the immunized mice by ELISA. Quantitative PCR (qPCR) results showed decreased viral loading in different body tissues. Flow cytometry of lymphocytes derived from mice spleen indicated an increase in CD3+CD4+ T cells, but CD3+CD8+ T cells were not detected. Moreover, it offers a model to delineate immune correlates with rNC8-induced immunity against swine viral diseases. Full article
(This article belongs to the Special Issue Pseudorabies Virus, Third Edition)
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