Viral Myocarditis: Diagnosis and Treatment

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: closed (1 February 2024) | Viewed by 2058

Special Issue Editor


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Guest Editor
Jiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soo-chow University, Suzhou 215123, China
Interests: mechanisms of immune recognition; cellular and molecular defense mechanisms in infectious diseases; cellular and molecular basis for autoimmune diseases; design and application of novel vaccines

Special Issue Information

Dear Colleagues,

Due to increasingly intensive studies on coxsackievirus group B type 3 (CVB3), viral myocarditis, an inflammatory disease of the myocardium, is now recognized as the major cause of sudden cardiac death in young adults and identified as the primary cause of dilated cardiomyopathy.

To better diagnose and treat viral myocarditis, it is vital to conduct mechanistic studies addressing the antiviral immune responses that could provide clues for identifying novel tools, biomarkers, and therapeutic targets. While endomyocardial biopsy is still the gold standard for diagnosis, comprehensive criteria have been established by integrating imaging and multi-omics data for the evaluation of cardiac function, symptoms, laboratory findings, and the identification of viruses, contributing to non-invasive precision diagnosis. Meanwhile, aside from supportive care and complementary therapeutics, such as corticosteroids and heart medications, Traditional Chinese medicine has shown promise as an alternative therapy for viral myocarditis. Additionally, multiple vaccines and therapeutic antibodies have been developed for the condition.

This Special Issue aims to provide up-to-date mechanistic studies and reviews addressing the disease pathogenesis, diagnostic criteria, and translational therapeutic explorations of viral myocarditis. By shedding new light on the disease, we hope to advance the diagnosis and treatment of viral myocarditis.

Prof. Dr. Sidong Xiong
Guest Editor

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Published Papers (1 paper)

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Perspective
Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal
by Francesco Samarelli, Giovanni Graziano, Nicola Gambacorta, Elisabetta Anna Graps, Francesco Leonetti, Orazio Nicolotti and Cosimo Damiano Altomare
Viruses 2024, 16(3), 450; https://doi.org/10.3390/v16030450 - 14 Mar 2024
Cited by 1 | Viewed by 1844
Abstract
People affected by COVID-19 are exposed to, among others, abnormal clotting and endothelial dysfunction, which may result in deep vein thrombosis, cerebrovascular disorders, and ischemic and non-ischemic heart diseases, to mention a few. Treatments for COVID-19 include antiplatelet (e.g., aspirin, clopidogrel) and anticoagulant [...] Read more.
People affected by COVID-19 are exposed to, among others, abnormal clotting and endothelial dysfunction, which may result in deep vein thrombosis, cerebrovascular disorders, and ischemic and non-ischemic heart diseases, to mention a few. Treatments for COVID-19 include antiplatelet (e.g., aspirin, clopidogrel) and anticoagulant agents, but their impact on morbidity and mortality has not been proven. In addition, due to viremia-associated interconnected prothrombotic and proinflammatory events, anti-inflammatory drugs have also been investigated for their ability to mitigate against immune dysregulation due to the cytokine storm. By retrieving patent literature published in the last two years, small molecules patented for long-COVID-related blood clotting and hematological complications are herein examined, along with supporting evidence from preclinical and clinical studies. An overview of the main features and therapeutic potentials of small molecules is provided for the thromboxane receptor antagonist ramatroban, the pan-caspase inhibitor emricasan, and the sodium–hydrogen antiporter 1 (NHE-1) inhibitor rimeporide, as well as natural polyphenolic compounds. Full article
(This article belongs to the Special Issue Viral Myocarditis: Diagnosis and Treatment)
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