Viral Resistance in HCV Infection
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 25606
Special Issue Editors
Interests: clinical virology; HIV infection; antiviral drugs and strategies; HIV-HBV-HCV drug-resistance; viral pathogenesis; viral tropism; viral evolution and dynamics; genotypic (by Sanger and NGS sequencing); structural and functional analysis of viral proteins
Interests: clinical virology; molecular epidemiology and resistance of HIV and hepatitis; sexually transmitted infections; Mycoplasma genitalium epidemiologya, pathogenesis and resistance to antibiotics; microbiome and metagenome analysis; infectious and non infectious diseases
Special Issue Information
Dear Colleagues,
The introduction of new multi-genotypic direct-acting antivirals (DAA) in clinical practice has revolutionized HCV treatment, permitting the achievement of >95% rates of sustained virological response in many patients. However, virological failures can occur particularly if the treatments are sub-optimal and/or with too short a duration. Failure is often associated with the development of resistance. The wide genetic variability in terms of different genotypes and subtypes, together with the natural presence and/or easy development of resistance during treatment, are intrinsic characteristics of HCV that may affect the treatment outcome and the chances of achieving a virological cure.
This issue will explore, in detail, aspects of HCV variability and resistance to new interferon-free DAA regimens.
Dr. Francesca Ceccherini-Silberstein
Dr. Federico Garcia
Guest Editors
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Keywords
- hepatitis C virus
- resistance associated substitutions
- direct acting antivirals
- treatment
- natural resistance
- genotype
- unusual subtypes
- failure
- rescue therapy
- reinfection
- coinfection
- compartmentalization
- epidemiology
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