Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.3
3.8
Journals
Viruses
Special Issues
New Insights into Silkworm Viral Disease Research
share announcement

New Insights into Silkworm Viral Disease Research

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Insect Viruses".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 3999

Special Issue Editors

Prof. Dr. Xijie Guo

E-Mail Website
Guest Editor
1. School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, China
2. Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang, China
Interests: Bombyx mori Cypovirus (BmCPV); Bombyx mori nucleopolyhedrosis virus (BmNPV); viral infection; virus–host interactions; viral non-coding RNA; control strategies of silkworm viral diseases
Prof. Dr. Chengliang Gong

E-Mail Website
Guest Editor
Pre-Clinical Medical and Biological Science College, Agricultural Biotechnology and Ecological Research Institute, Soochow University, Suzhou, China
Interests: virus receptor; cell entry mechanism; virus molecular biology; pathogenesis and immunity; silkworm resistance to virus disease
Prof. Dr. Liang Jiang

E-Mail Website
Guest Editor
1. State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China
2. Biological Science Research Center, Southwest University, Chongqing, China
Interests: silkworm immunity and antivirus; biological breeding based on gene editing and transgene

Special Issue Information

Dear Colleagues,

Silkworm (Bombyx mori) is an important economic insect producing fantastic proteinous silk fiber. However, the silkworm always suffers from infection with viruses, causing serious losses to sericulture production. Several viruses of the different genus have been identified to be infectious to the silkworm. Exploring the mechanism of viral infection and virus–host interaction in the silkworm is an ongoing endeavour and commitment for both the scientific community and the sericulture.

In recent decades, the research on silkworm viruses has been greatly advanced, including viral structure, viral genomes, viral infection, viral non-coding RNAs, virus–silkworm interaction, antiviral immunity and control strategies of silkworm viral diseases. At the same time, the Bombyx mori nucleopolyhedrosis virus has been studied and engineered as a baculovirus expression vector and successfully used to express medically important proteins.

The aim of this Special Issue of Viruses is to compile the newest contributions in the research field of silkworm viral diseases, especially encouraging new insights and research on unresolved issues, such as structural biology, viral replication, virus–host interaction, pathogenesis, and immunity. The development of the control strategies for silkworm viral diseases is also a selection of the topics that can be of relevance to sericulture production.

Prof. Dr. Xijie Guo
Prof. Dr. Chengliang Gong
Prof. Dr. Liang Jiang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • viral molecular biology
  • viral infection
  • virus–host interaction
  • pathogenesis and immunity
  • virological diagnosis
  • antiviral strategies
  • recombinant viruses

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 1847 KiB  
Article
Deacetylation of ACO2 Is Essential for Inhibiting Bombyx mori Nucleopolyhedrovirus Propagation
by Miao Hu, Yi You, Yao Li, Shiyi Ma, Jiaqi Li, Meng Miao, Yanping Quan and Wei Yu
Viruses 2023, 15(10), 2084; https://doi.org/10.3390/v15102084 - 12 Oct 2023
Cited by 1 | Viewed by 1117
Abstract
Bombyx mori nucleopolyhedrovirus (BmNPV) is a specific pathogen of Bombyx mori that can significantly impede agricultural development. Accumulating evidence indicates that the viral proliferation in the host requires an ample supply of energy. However, the correlative reports of baculovirus are deficient, especially on [...] Read more.
Bombyx mori nucleopolyhedrovirus (BmNPV) is a specific pathogen of Bombyx mori that can significantly impede agricultural development. Accumulating evidence indicates that the viral proliferation in the host requires an ample supply of energy. However, the correlative reports of baculovirus are deficient, especially on the acetylation modification of tricarboxylic acid cycle (TCA cycle) metabolic enzymes. Our recent quantitative analysis of protein acetylome revealed that mitochondrial aconitase (ACO2) could be modified by (de)acetylation at lysine 56 (K56) during the BmNPV infection; however, the underlying mechanism is yet unknown. In order to understand this regulatory mechanism, the modification site K56 was mutated to arginine (Lys56Arg; K56R) to mimic deacetylated lysine. The results showed that mimic deacetylated mitochondrial ACO2 restricted enzymatic activity. Although the ATP production was enhanced after viral infection, K56 deacetylation of ACO2 suppressed BmN cellular ATP levels and mitochondrial membrane potential by affecting citrate synthase and isocitrate dehydrogenase activities compared with wild-type ACO2. Furthermore, the deacetylation of exogenous ACO2 lowered BmNPV replication and generation of progeny viruses. In summary, our study on ACO2 revealed the potential mechanism underlying WT ACO2 promotes the proliferation of BmNPV and K56 deacetylation of ACO2 eliminates this promotional effect, which might provide novel insights for developing antiviral strategies. Full article
(This article belongs to the Special Issue New Insights into Silkworm Viral Disease Research)
►▼ Show Figures

Figure 1

30 pages, 6816 KiB  
Article
Identification and Profiling of a Novel Bombyx mori latent virus Variant Acutely Infecting Helicoverpa armigera and Trichoplusia ni
by Thomas-Wolf Verdonckt, Anton Bilsen, Filip Van Nieuwerburgh, Loes De Troij, Dulce Santos and Jozef Vanden Broeck
Viruses 2023, 15(5), 1183; https://doi.org/10.3390/v15051183 - 17 May 2023
Cited by 1 | Viewed by 1811
Abstract
Insect cell expression systems are increasingly being used in the medical industry to develop vaccines against diseases such as COVID-19. However, viral infections are common in these systems, making it necessary to thoroughly characterize the viruses present. One such virus is Bombyx mori latent [...] Read more.
Insect cell expression systems are increasingly being used in the medical industry to develop vaccines against diseases such as COVID-19. However, viral infections are common in these systems, making it necessary to thoroughly characterize the viruses present. One such virus is Bombyx mori latent virus (BmLV), which is known to be specific to Bombyx mori and to have low pathogenicity. However, there has been little research on the tropism and virulence of BmLV. In this study, we examined the genomic diversity of BmLV and identified a variant that persistently infects Trichoplusia ni-derived High Five cells. We also assessed the pathogenicity of this variant and its effects on host responses using both in vivo and in vitro systems. Our results showed that this BmLV variant causes acute infections with strong cytopathic effects in both systems. Furthermore, we characterized the RNAi-based immune response in the T. ni cell line and in Helicoverpa armigera animals by assessing the regulation of RNAi-related genes and profiling the generated viral small RNAs. Overall, our findings shed light on the prevalence and infectious properties of BmLV. We also discuss the potential impact of virus genomic diversity on experimental outcomes, which can help interpret past and future research results. Full article
(This article belongs to the Special Issue New Insights into Silkworm Viral Disease Research)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop