Current Situation on Antiretroviral Therapy against HIV-1: Limitation and New Leads
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 10168
Special Issue Editor
Special Issue Information
Dear Colleague,
Antiretroviral therapy (ART) has dramatically reduced HIV-1-associated morbidity and mortality, and has transformed HIV-1 infection into a manageable chronic condition by suppressing viral replication. However, despite recent patient care improvements, ART still fails to cure HIV-1 infection, due to the inability to counteract the immune defects and metabolic disturbances associated with residual inflammation alongside viral persistence. Indeed, despite viral suppression, patients under ART display residual anatomic viral reservoirs that need to be targeted in the hope of curing HIV-1 infection. Life-long drug administration also results in multiple side-effects in patients, including lipodystrophy and insulin resistance.
Therefore, it is critical to obtain a clear and documented picture of all limitations that are associated with these current treatments, such as metabolic deregulations, molecule toxicity and reservoir persistence, in an attempt to develop new successful therapeutic strategies. Patient care improvements and the elimination of viral reservoirs can themselves be advanced as end goals to live with or to cure HIV-1 infection, respectively. In this Special Issue, we will focus on the existing antiviral therapy, metabolic and molecular deregulations associated with these medications, and novel viral and host cell targets that are considered to improve ART outcomes. We will also discuss the current situation in HIV-1 reservoirs and potential strategies which aim to purge these infected cells in treated patients.
Dr. Julien Van GrevenyngheGuest Editor
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Keywords
- ART (anti-retroviral therapy)
- HIV-1
- Metabolic perturbances
- Viral reservoirs
- Cure
- New drug discovery
- Residual inflammation
- Post-treatment controllers
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