Promising New Treatments for Human Papillomavirus-Related Ano-Genital and the Cervico-Vaginal Diseases
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 1988
Special Issue Editors
Interests: virology; immunology; viral pathogenesis; human papillomavirus; genital warts; cervical intraepithelial neoplasia (CIN)
Interests: HPV pathogenesis; HPV preventive vaccine; L1-VLP vaccine; HPV therapeutic vaccine; PDT effect against HPV infection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human papillomaviruses are the reagent for the ano-genital warts and the precursor lesions of cervico-vaginal cancer, such as cervical or vaginal intraepithelial neoplasia (CIN, VaIN). Among more than 200 HPV genotypes, more than 50 HPV genotypes appear to cause ano-genital warts or cervical cancers and their precursor lesions. The E6 and E7 protein are the oncoproteins which are responsible for persistent infection, epithelial cell proliferation, and malignant progression. The most basic treatment for these lesions is surgical resection, but this may induce various complications after treatment. It is reported that the conization of the uterine cervix induces some adverse effects for future pregnancy and dysmenorrhea by shortening or narrowing the cervical canal after the procedure. Surgical scars might develop after the resection of ano-genital warts. Therefore, more preservative and effective methods are required for management of such lesions on the reproductive organ. Imiquimod is one of the best methods for ano-genital warts, but it cannot be used in mucosal areas such as the vagina or the uterine cervices. It is important to note that high-risk HPV types such as HPV16 or 18 are able to induce cancer through more than 10 years of persistent infection, and higher-grade lesions are more resistant to being cleared than lower-grade ones. However, even lower-grade lesions such as some condyloma acuminatum are difficult to clear in some immune-compromised hosts. Therefore, curability might depend on the immunological state of patients. Therefore, promising new therapy may be immune-therapies including therapeutic vaccine or immune-modifiers, photodynamic therapy, and the skin pealing method using tri-chloroacetic acid (TCA) or podophyllin.
Dr. Toshiyuki Sasagawa
Dr. Masaru Sakamoto
Guest Editors
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Keywords
- human papillomavirus
- anogenital warts
- cervical intraepithelial neoplasia (CIN)
- vaginal intraepithelial neoplasia (VaIN)
- anal or vulvar or penile intraepithelial neoplasia (AIN, VIN, PIN)
- immune evasion and persistent infection
- E6 and E7 proteins
