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Most Cited

  • Feature Paper
  • Review
  • Open Access
54 Citations
13,081 Views
31 Pages

Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION): A Comprehensive Overview

  • Maria Letizia Salvetat,
  • Francesco Pellegrini,
  • Leopoldo Spadea,
  • Carlo Salati and
  • Marco Zeppieri

9 November 2023

Non-arteritic anterior ischemic optic neuropathy (NA-AION) represents one of the most important causes of blindness or severely impaired vision in middle-aged and elderly people. Unilateral optic disc edema and abrupt, painless vision loss are its de...

  • Review
  • Open Access
29 Citations
15,243 Views
22 Pages

Toxic External Exposure Leading to Ocular Surface Injury

  • Steven H. Rauchman,
  • Brandon Locke,
  • Jacqueline Albert,
  • Joshua De Leon,
  • Morgan R. Peltier and
  • Allison B. Reiss

3 April 2023

The surface of the eye is directly exposed to the external environment, protected only by a thin tear film, and may therefore be damaged by contact with ambient particulate matter, liquids, aerosols, or vapors. In the workplace or home, the eye is su...

  • Review
  • Open Access
16 Citations
3,979 Views
12 Pages

Corneal Nerve Assessment by Aesthesiometry: History, Advancements, and Future Directions

  • Jordan R. Crabtree,
  • Shadia Tannir,
  • Khoa Tran,
  • Charline S. Boente,
  • Asim Ali and
  • Gregory H. Borschel

12 May 2024

The measurement of corneal sensation allows clinicians to assess the status of corneal innervation and serves as a crucial indicator of corneal disease and eye health. Many devices are available to assess corneal sensation, including the Cochet&ndash...

  • Article
  • Open Access
15 Citations
3,226 Views
18 Pages

12 March 2023

Various diffractive, refractive and holographic optical elements, such as diffraction gratings; microlens raster; phase plates; multi-order diffractive optical elements; adaptive mirrors; diffractive and refractive axicons; holographic multiplexes an...

  • Article
  • Open Access
15 Citations
3,381 Views
12 Pages

3 April 2023

Natural environment experiences in virtual reality (VR) can be a feasible option for people unable to connect with real nature. Existing research mostly focuses on health and emotional advantages of the “virtual nature” therapy, but studi...

  • Article
  • Open Access
15 Citations
4,893 Views
25 Pages

23 August 2024

Computer vision is a powerful tool in medical image analysis, supporting the early detection and classification of eye diseases. Diabetic retinopathy (DR), a severe eye disease secondary to diabetes, accompanies several early signs of eye-threatening...

  • Review
  • Open Access
14 Citations
7,599 Views
14 Pages

Transepithelial Photorefractive Keratectomy—Review

  • Christopher Way,
  • Mohamed Gamal Elghobaier and
  • Mayank A. Nanavaty

21 March 2024

The type and nature of refractive surgery procedures has greatly increased over the past few decades, allowing for almost all patient populations to be treated to extremely high satisfaction. Conventional photorefractive keratectomy involves the remo...

  • Review
  • Open Access
14 Citations
6,565 Views
27 Pages

20 October 2023

This article reviews historically significant phenomenological studies of visual mental imagery (VMI), starting with Fechner in 1860 and continuing to the present. This synthesis of diverse VMI phenomenological studies in healthy adults serves as a u...

  • Case Report
  • Open Access
13 Citations
5,740 Views
12 Pages

Amblyopia Treatment through Immersive Virtual Reality: A Preliminary Experience in Anisometropic Children

  • Ainhoa Molina-Martín,
  • Luis Leal-Vega,
  • Dolores de Fez,
  • Elena Martínez-Plaza,
  • María Begoña Coco-Martín and
  • David P. Piñero

19 May 2023

The use of digital devices provides a wide range of possibilities for measuring and improving visual function, including concepts such as perceptual learning and dichoptic therapy. Different technologies can be used to apply these concepts, including...

  • Review
  • Open Access
13 Citations
4,432 Views
14 Pages

Ocular Biomechanics and Glaucoma

  • Rodrigo Brazuna,
  • Ruiz S. Alonso,
  • Marcella Q. Salomão,
  • Bruno F. Fernandes and
  • Renato Ambrósio

23 April 2023

Biomechanics is a branch of biophysics that deals with mechanics applied to biology. Corneal biomechanics have an important role in managing patients with glaucoma. While evidence suggests that patients with thin and stiffer corneas have a higher ris...

  • Review
  • Open Access
11 Citations
5,702 Views
26 Pages

13 March 2023

Corneal dystrophies are a group of non-inflammatory inherited disorders of the cornea. This review considers treatment options for epithelial-stromal and stromal corneal dystrophies: namely Reis–Bücklers, Thiel–Behnke, lattice, Avell...

  • Protocol
  • Open Access
11 Citations
5,264 Views
20 Pages

Automated Analysis Pipeline for Extracting Saccade, Pupil, and Blink Parameters Using Video-Based Eye Tracking

  • Brian C. Coe,
  • Jeff Huang,
  • Donald C. Brien,
  • Brian J. White,
  • Rachel Yep and
  • Douglas P. Munoz

18 March 2024

The tremendous increase in the use of video-based eye tracking has made it possible to collect eye tracking data from thousands of participants. The traditional procedures for the manual detection and classification of saccades and for trial categori...

  • Review
  • Open Access
10 Citations
4,658 Views
14 Pages

7 March 2023

High-order aberrations (HOAs) are optical defects that degrade the image quality. They change with factors such as pupil diameter, age, and accommodation. The changes in optical aberrations during accommodation are mainly due to lens shape and positi...

  • Article
  • Open Access
10 Citations
5,281 Views
13 Pages

The Influence of Tear Film Quality on Visual Function

  • Snježana Kaštelan,
  • Ksenija Gabrić,
  • Maša Mikuličić,
  • Danijela Mrazovac Zimak,
  • Mirela Karabatić and
  • Antonela Gverović Antunica

26 February 2024

Background: The prevalence of dry eye disease (DED) is increasing globally, resulting in a variety of eye symptoms characterized by discomfort and visual disturbances. The accurate diagnosis of the disease is often challenging and complex, requiring...

  • Review
  • Open Access
9 Citations
4,976 Views
13 Pages

Circulating Biomarkers to Predict Diabetic Retinopathy in Patients with Diabetic Kidney Disease

  • Jonny,
  • Laurencia Violetta,
  • Arief S. Kartasasmita,
  • Rudi Supriyadi and
  • Coriejati Rita

9 April 2023

The purpose of this review is to outline the currently available circulating biomarkers to predict diabetic retinopathy (DR) in patients with diabetic kidney disease (DKD). Studies have extensively reported the association between DR and DKD, suggest...

  • Article
  • Open Access
9 Citations
2,516 Views
10 Pages

19 May 2023

Objectives: To analyze the outcomes and complications of Descemet‘s membrane endothelial keratoplasty (DMEK) performed without prophylactic peripheral iridotomy (PI). Methods: Design: Retrospective study. Setting: Institutional, tertiary care e...

  • Article
  • Open Access
8 Citations
4,584 Views
11 Pages

Measuring the Pupillary Light Reflex Using Portable Instruments in Applied Settings

  • Nicola S. Gray,
  • Menna Price,
  • Jennifer Pink,
  • Chris O’Connor,
  • Ana Antunes and
  • Robert J. Snowden

1 October 2024

The early components of the pupillary light reflex (PLR) are governed by the parasympathetic nervous system. The use of cheap, portable pupillometry devices may allow for the testing of parasympathetic-system health in field settings. We examined the...

  • Review
  • Open Access
8 Citations
6,015 Views
22 Pages

Paracentral Acute Middle Maculopathy (PAMM) in Ocular Vascular Diseases—What We Know and Future Perspectives

  • Daniele Fumi,
  • Francesco Ruggeri,
  • Davide Fasciolo,
  • Elettra Antonello,
  • Giammarco Burtini and
  • Solmaz Abdolrahimzadeh

3 March 2025

Paracentral acute middle maculopathy (PAMM) is a macular condition primarily detected using optical coherence tomography (OCT) imaging. It presents as hyperreflective bands within the inner nuclear layer (INL) of the retina, often leading to localize...

  • Review
  • Open Access
8 Citations
3,733 Views
15 Pages

2 March 2023

Decisions are often made under uncertainty. The most that one can do is use prior knowledge (e.g., base rates, prior probabilities, etc.) and make the most probable choice given the information we have. Unfortunately, most people struggle with Bayesi...

  • Review
  • Open Access
8 Citations
4,565 Views
11 Pages

Combined Branch Retinal Artery and Central Retinal Vein Occlusion: A Systematic Review

  • Antonio Pinna,
  • Angelo Zinellu,
  • Rita Serra,
  • Giacomo Boscia,
  • Lorenza Ronchi and
  • Stefano Dore

28 July 2023

We performed a systematic review and analyzed the current available data on branch retinal artery occlusion (BRAO) with simultaneous central retinal vein obstruction (CRVO), a rarely described occurrence. MEDLINE/PubMed and ISI Web of Sciences search...

  • Technical Note
  • Open Access
7 Citations
4,293 Views
14 Pages

3 July 2024

Myopic traction maculopathy (MTM) affects 20% of eyes with pathologic myopia (PM). The MTM Staging System (MSS), published in 2020, describes the nomenclature of MTM as well as a proposal of pathogenesis, natural evolution, and prognosis. A study of...

  • Article
  • Open Access
7 Citations
5,046 Views
19 Pages

An Insight into Knowledge, Perspective, and Practices of Indian Optometrists towards Childhood Myopia

  • Archana Naik,
  • Siddharth K. Karthikeyan,
  • Jivitha Jyothi Ramesh,
  • Shwetha Bhaskar,
  • Chinnappa A. Ganapathi and
  • Sayantan Biswas

16 April 2024

The current understanding of clinical approaches and barriers in managing childhood myopia among Indian optometrists is limited. This research underscores the necessity and relevance of evidence-based practice guidelines by exploring their knowledge,...

  • Systematic Review
  • Open Access
7 Citations
4,972 Views
11 Pages

15 November 2023

Mirror visual feedback (MVF), a noninvasive treatment method, is attracting attention as a possibility to promote the recovery of upper limb function in stroke patients. However, the cognitive effects of this therapy have received limited attention i...

  • Article
  • Open Access
7 Citations
4,473 Views
12 Pages

Treatment of Rapid Progression of Myopia: Topical Atropine 0.05% and MF60 Contact Lenses

  • Nir Erdinest,
  • Maya Atar-Vardi,
  • Naomi London,
  • David Landau,
  • David Smadja,
  • Eran Pras,
  • Itay Lavy and
  • Yair Morad

19 January 2024

This retrospective study evaluates the effectiveness of combining 0.05% atropine with MF60 contact lenses in managing rapid myopia progression in children over one year. The study involved three groups: the treatment group (TG) with 15 children (53%...

  • Review
  • Open Access
7 Citations
5,095 Views
21 Pages

Modifiable Lifestyle Risk Factors and Strategies for Slowing the Progression of Age-Related Macular Degeneration

  • Khushi Saigal,
  • Joshua E. Salama,
  • Alfredo A. Pardo,
  • Sebastian E. Lopez and
  • Ninel Z. Gregori

23 February 2025

Age-related macular degeneration (AMD) is a multifactorial disorder influenced by genetic, lifestyle, nutritional, and systemic health factors that contribute to increased oxidative stress and chronic inflammation in the retina. This article reviews...

  • Systematic Review
  • Open Access
7 Citations
4,423 Views
15 Pages

27 February 2023

Refractive errors (myopia and hyperopia) are the most common visual disorders and are severe risk factors for secondary ocular pathologies. The development of refractive errors has been shown to be associated with changes in ocular axial length, sugg...

  • Review
  • Open Access
7 Citations
4,517 Views
15 Pages

An Update on Multimodal Ophthalmological Imaging of Diffuse Choroidal Hemangioma in Sturge–Weber Syndrome

  • Chiara Ciancimino,
  • Mariachiara Di Pippo,
  • Daria Rullo,
  • Francesco Ruggeri,
  • Flaminia Grassi,
  • Gianluca Scuderi and
  • Solmaz Abdolrahimzadeh

6 October 2023

Sturge–Weber syndrome (SWS) is characterized by facial port-wine stains, leptomeningeal hemangiomas, and prominent ocular manifestations such as glaucoma and diffuse choroidal hemangiomas (DCHs). Imaging modalities are critical for diagnosing a...

  • Brief Report
  • Open Access
7 Citations
4,122 Views
9 Pages

Automated pupil light reflex (PLR) is a valid indicator of dysfunctional autonomic brain function following traumatic brain injury. PLR’s use in identifying disturbed autonomic brain function following repeated head impacts without outwardly vi...

  • Review
  • Open Access
6 Citations
4,522 Views
23 Pages

Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

  • Georgios Tsokolas,
  • Charalambos Tossounis,
  • Straton Tyradellis,
  • Lorenzo Motta,
  • Georgios D. Panos and
  • Theo Empeslidis

5 March 2024

Aim: Angioid streaks (ASs) are a rare retinal condition and compromise visual acuity when complicated with choroidal neovascularization (CNV). They represent crack-like dehiscences at the level of the Bruch’s membrane. This objective narrative...

  • Article
  • Open Access
6 Citations
2,382 Views
17 Pages

20 March 2025

Visual conditions significantly influence fear of movement (FOM), which is a condition that impairs postural control and quality of life (QOL). This study examined how visual conditions influence sway velocity during repeated one-leg standing tasks a...

  • Article
  • Open Access
6 Citations
3,188 Views
9 Pages

The Ellipsoid Zone Is a Structural Biomarker for Visual Outcomes in Diabetic Macular Edema and Macular Hole Management

  • Shivani Chaturvedi,
  • Amisha Paul,
  • Samya Singh,
  • Levent Akduman and
  • Sandeep Saxena

13 January 2025

Objectives: The goal was to study the ellipsoid zone (EZ) as a structural biomarker for final visual outcomes after pharmacological intervention in center-involving diabetic macular edema (DME) and surgical intervention for full-thickness macular hol...

  • Article
  • Open Access
6 Citations
4,138 Views
34 Pages

The Lifetime Expenditure in People with Keratoconus in Saudi Arabia

  • Saleha Al-Atawi,
  • Ali Alghamdi and
  • Khaled Alzahrani

3 August 2023

Aim: This study measured and evaluated the socioeconomic burden of people living with keratoconus in Saudi Arabia. Methods: This study employed a cross-sectional design, a Keratoconus Economic Burden Questionnaire, and a convenient sample of 89 kerat...

  • Article
  • Open Access
6 Citations
3,580 Views
13 Pages

Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA

  • Joby Tsai,
  • Samuel Asanad,
  • Martha Whiting,
  • Xuemin Zhang,
  • Laurence Magder and
  • Osamah Saeedi

3 July 2023

Background: To investigate the repeatability in vessel caliber measurements by optical coherence tomography angiography (OCTA). Methods: In this prospective study, 28 patients (47 eyes) underwent sequential OCTA imaging of the optic nerve head and ma...

  • Article
  • Open Access
6 Citations
5,140 Views
15 Pages

3 April 2023

Introduction: Pro-inflammatory cytokines are important contributors to dry eye disease (DED). The cytokine interleukin (IL)-6 has become a therapeutic target in several DED drug studies. This randomized controlled trial aimed to determine the effecti...

  • Review
  • Open Access
5 Citations
5,868 Views
19 Pages

Visual Deficits and Diagnostic and Therapeutic Strategies for Neurofibromatosis Type 1: Bridging Science and Patient-Centered Care

  • Kiyoharu J. Miyagishima,
  • Fengyu Qiao,
  • Steven F. Stasheff and
  • Francisco M. Nadal-Nicolás

Neurofibromatosis type 1 (NF1) is an inherited autosomal dominant disorder primarily affecting children and adolescents characterized by multisystemic clinical manifestations. Mutations in neurofibromin, the protein encoded by the Nf1 tumor suppresso...

  • Article
  • Open Access
5 Citations
3,745 Views
15 Pages

20 February 2025

Chronic low back pain (LBP) impairs balance control due to deficits in sensory integration, yet limited research examines postural sway under varying visual conditions. This study assessed the effects of visual input on postural stability using the n...

  • Case Report
  • Open Access
5 Citations
2,952 Views
8 Pages

27 April 2023

Several studies have reported motor deficiencies in children with dyslexia, in line with the cerebellar deficit theory. In the present study, we explored whether tests used by physiotherapists during clinical evaluation were able to report motor defi...

  • Article
  • Open Access
5 Citations
4,425 Views
13 Pages

21 March 2023

Pseudomonas aeruginosa is the most common causative agent associated with microbial keratitis. During contact lens wear, pathogens may be introduced into the ocular environment, which might cause adverse events. Lehfilcon A is a recently developed co...

  • Article
  • Open Access
5 Citations
2,481 Views
17 Pages

22 August 2023

The visual inspection of scenes is disrupted when participants are forced to begin inspection away from the centre of an image. The present study explored the effect of the starting point on the visual inspection of paintings. Eye movements were reco...

  • Article
  • Open Access
5 Citations
2,733 Views
11 Pages

Dexamethasone Modulates the Dynamics of Wnt Signaling in Human Trabecular Meshwork Cells

  • Chi Zhang,
  • Elizabeth Tannous,
  • Alseena Thomas,
  • Natalia Jung,
  • Edmond Ma and
  • Jie J. Zheng

25 May 2023

Trabecular meshwork (TM) tissue is highly specialized, and its structural integrity is crucial for maintaining homeostatic intraocular pressure (IOP). The administration of glucocorticoids, such as dexamethasone (DEX), can perturb the TM structure an...

  • Review
  • Open Access
5 Citations
3,023 Views
37 Pages

Clinical Applications of Artificial Intelligence in Corneal Diseases

  • Omar Nusair,
  • Hassan Asadigandomani,
  • Hossein Farrokhpour,
  • Fatemeh Moosaie,
  • Zahra Bibak-Bejandi,
  • Alireza Razavi,
  • Kimia Daneshvar and
  • Mohammad Soleimani

18 August 2025

We evaluated the clinical applications of artificial intelligence models in diagnosing corneal diseases, highlighting their performance metrics and clinical potential. A systematic search was conducted for several disease categories: keratoconus (KC)...

  • Article
  • Open Access
4 Citations
2,630 Views
14 Pages

19 March 2024

While our direct observations of the features or behaviours of the stimuli around us tell us much about them (e.g., should they be feared?), the origin of much of our knowledge is often untethered from directly observable properties (e.g., through wh...

  • Article
  • Open Access
4 Citations
2,025 Views
11 Pages

11 April 2025

This study assesses the accuracy and consistency of a commercially available large language model (LLM) in extracting and interpreting sensitivity and reliability data from entire visual field (VF) test reports for the evaluation of glaucomatous defe...

  • Review
  • Open Access
4 Citations
5,235 Views
19 Pages

Emerging Treatments for Persistent Corneal Epithelial Defects

  • Jeonghyun (Esther) Kwon,
  • Christie Kang,
  • Amirhossein Moghtader,
  • Sumaiya Shahjahan,
  • Zahra Bibak Bejandi,
  • Ahmad Alzein and
  • Ali R. Djalilian

1 April 2025

Persistent corneal epithelial defects (PCEDs) are a challenging ocular condition characterized by the failure of complete corneal epithelial healing after an insult or injury, even after 14 days of standard care. There is a lack of therapeutics that...

  • Article
  • Open Access
4 Citations
4,288 Views
11 Pages

Kinematic Assessment of Fine Motor Skills in Children: Comparison of a Kinematic Approach and a Standardized Test

  • Ewa Niechwiej-Szwedo,
  • Taylor A. Brin,
  • Benjamin Thompson and
  • Lisa W. T. Christian

17 February 2024

Deficits in fine motor skills have been reported in some children with neurodevelopmental disorders such as amblyopia or strabismus. Therefore, monitoring the development of motor skills and any potential improvement due to therapy is an important cl...

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Vision - ISSN 2411-5150