New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering
Abstract
:1. Introduction
2. Polysaccharide-Based Hydrogels
2.1. Cross-Linking Density
2.2. Swelling Behavior
2.3. Thixotropy
Hydrogel | State | G' (Pa) | G" (Pa) | ||
---|---|---|---|---|---|
Carboxymethylcellulose | Native | 550 | ±30 | 25 | ±1 |
Squeezed | 240 | ±20 | 20 | ±2 | |
Hyaluronic acid | Native | 970 | ±25 | 65 | ±10 |
Squeezed | 340 | ±20 | 45 | ±5 | |
Chitosan | Native | 4350 | ±650 | 165 | ±45 |
Squeezed | 3460 | ±150 | 230 | ±15 |
3. Medical Applications of Injectable Polysaccharide Hydrogels
- regenerative medicine;
- local therapy through drug delivery.
3.1. Minimally Invasive Surgery for Regenerative Medicine
3.2. Interpenetrating Hydrogels as Three-Dimensional Cell Scaffolds
3.3. Drug Delivery for Local Therapy
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Camponeschi, F.; Atrei, A.; Rocchigiani, G.; Mencuccini, L.; Uva, M.; Barbucci, R. New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering. Gels 2015, 1, 3-23. https://doi.org/10.3390/gels1010003
Camponeschi F, Atrei A, Rocchigiani G, Mencuccini L, Uva M, Barbucci R. New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering. Gels. 2015; 1(1):3-23. https://doi.org/10.3390/gels1010003
Chicago/Turabian StyleCamponeschi, Francesca, Andrea Atrei, Giulia Rocchigiani, Lorenzo Mencuccini, Marianna Uva, and Rolando Barbucci. 2015. "New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering" Gels 1, no. 1: 3-23. https://doi.org/10.3390/gels1010003