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Review

Pregnancy-Associated Takotsubo Syndrome: A Narrative Review of the Literature

by
Panagiotis Iliakis
1,*,
Anna Pitsillidi
2,
Nikolaos Pyrpyris
1,
Christos Fragkoulis
1,
Ioannis Leontsinis
1,
Georgios Koutsopoulos
1,
Emmanouil Mantzouranis
1,
Stergios Soulaidopoulos
1,
Alexandros Kasiakogias
1,
Kyriakos Dimitriadis
1,
Günter Karl Noé
2 and
Konstantinos Tsioufis
1
1
First Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Hippokration General Hospital, 11527 Athens, Greece
2
Department of OB/GYN, Rheinland Klinikum Dormagen, Dr.-Geldmacher-Straße 20, 41540 Dormagen, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(7), 2356; https://doi.org/10.3390/jcm14072356
Submission received: 28 February 2025 / Revised: 15 March 2025 / Accepted: 26 March 2025 / Published: 29 March 2025
(This article belongs to the Special Issue Diagnosis and Management of Complications During Pregnancy)
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Abstract

Takotsubo syndrome (TTS) is a clinical syndrome defined most typically by transient systolic dysfunction and dilatation of the apex of the left ventricle or other regional areas in the documented absence of obstructive coronary artery disease. Although more commonly presented in postmenopausal women, there are reports in the literature of TTS during the peripartum and postpartum periods. Early TTS diagnosis in pregnancy is of great importance in improving both maternal and fetal mortality. Although TTS involves many pathogenetic pathways, the imbalance between declining estrogen and arising sympathetic nervous system tone plays an important role. This review aims to provide recent published evidence of TTS in pregnancy and delve into the epidemiology of TTS in pregnancy, the pathophysiological mechanisms involved, the prognosis of TTS for the mother and the fetus, and its therapeutic multi-disciplinary management.
Keywords: takotsubo syndrome; pregnancy; peripartum; coronary syndrome; peripartum cardiomyopathy takotsubo syndrome; pregnancy; peripartum; coronary syndrome; peripartum cardiomyopathy

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MDPI and ACS Style

Iliakis, P.; Pitsillidi, A.; Pyrpyris, N.; Fragkoulis, C.; Leontsinis, I.; Koutsopoulos, G.; Mantzouranis, E.; Soulaidopoulos, S.; Kasiakogias, A.; Dimitriadis, K.; et al. Pregnancy-Associated Takotsubo Syndrome: A Narrative Review of the Literature. J. Clin. Med. 2025, 14, 2356. https://doi.org/10.3390/jcm14072356

AMA Style

Iliakis P, Pitsillidi A, Pyrpyris N, Fragkoulis C, Leontsinis I, Koutsopoulos G, Mantzouranis E, Soulaidopoulos S, Kasiakogias A, Dimitriadis K, et al. Pregnancy-Associated Takotsubo Syndrome: A Narrative Review of the Literature. Journal of Clinical Medicine. 2025; 14(7):2356. https://doi.org/10.3390/jcm14072356

Chicago/Turabian Style

Iliakis, Panagiotis, Anna Pitsillidi, Nikolaos Pyrpyris, Christos Fragkoulis, Ioannis Leontsinis, Georgios Koutsopoulos, Emmanouil Mantzouranis, Stergios Soulaidopoulos, Alexandros Kasiakogias, Kyriakos Dimitriadis, and et al. 2025. "Pregnancy-Associated Takotsubo Syndrome: A Narrative Review of the Literature" Journal of Clinical Medicine 14, no. 7: 2356. https://doi.org/10.3390/jcm14072356

APA Style

Iliakis, P., Pitsillidi, A., Pyrpyris, N., Fragkoulis, C., Leontsinis, I., Koutsopoulos, G., Mantzouranis, E., Soulaidopoulos, S., Kasiakogias, A., Dimitriadis, K., Noé, G. K., & Tsioufis, K. (2025). Pregnancy-Associated Takotsubo Syndrome: A Narrative Review of the Literature. Journal of Clinical Medicine, 14(7), 2356. https://doi.org/10.3390/jcm14072356

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