Potential Role of Colchicine in Combating COVID-19 Cytokine Storm and Its Ability to Inhibit Protease Enzyme of SARS-CoV-2 as Conferred by Molecular Docking Analysis
Abstract
:1. Introduction
2. Colchicine Mechanism of Action
3. Molecular Docking Analysis of Colchicine against RNA-dependent RNA Polymerase and Protease Enzymes of SARS-CoV-2
4. Colchicine Pharmacokinetics
4.1. Rationale for using Colchicine in Controlling ARDS and MOD
- Group 1:
- patient receiving maximum safety dose of colchicine alone.
- Group 2:
- patient receiving maximum safety dose of colchicine in addition to standard treatment (combination therapy).
- Group 3:
- patient receiving standard treatment alone (control group).
4.2. Potential Role of Colchicine in Suppressing Various Inflammatory Signaling Pathways and Their Associations with COVID-19
4.3. Colchicine Dosage, Timing, and Drug–Drug Interaction in COVID-19 Positive Patients
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Kamel, N.A.; Ismail, N.S.M.; Yahia, I.S.; Aboshanab, K.M. Potential Role of Colchicine in Combating COVID-19 Cytokine Storm and Its Ability to Inhibit Protease Enzyme of SARS-CoV-2 as Conferred by Molecular Docking Analysis. Medicina 2022, 58, 20. https://doi.org/10.3390/medicina58010020
Kamel NA, Ismail NSM, Yahia IS, Aboshanab KM. Potential Role of Colchicine in Combating COVID-19 Cytokine Storm and Its Ability to Inhibit Protease Enzyme of SARS-CoV-2 as Conferred by Molecular Docking Analysis. Medicina. 2022; 58(1):20. https://doi.org/10.3390/medicina58010020
Chicago/Turabian StyleKamel, Noha A., Nasser S. M. Ismail, Ibrahim S. Yahia, and Khaled M. Aboshanab. 2022. "Potential Role of Colchicine in Combating COVID-19 Cytokine Storm and Its Ability to Inhibit Protease Enzyme of SARS-CoV-2 as Conferred by Molecular Docking Analysis" Medicina 58, no. 1: 20. https://doi.org/10.3390/medicina58010020