The Hematopoietic Effect of Ninjinyoeito (TJ-108), a Traditional Japanese Herbal Medicine, in Pregnant Women Preparing for Autologous Blood Storage
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables | Group A | Group B | p Value |
---|---|---|---|
n = 38 | n = 27 | ||
Number or Median (Range) | Number or Median (Range) | ||
Age (year) | 35 (28–44) | 34 (24–44) | 0.310 |
Height (cm) | 160 (140–165) | 160 (151–169) | 0.329 |
Body weight before pregnancy (kg) | 52 (41–65) | 51 (44–87) | 0.669 |
BMI at before pregnancy (kg/m2) | 20.7 (16.4–27.8) | 20.4 (17.5–32.7) | 0.926 |
Body weight at birth (kg) | 61 (47–72) | 59 (50–89) | 0.680 |
BMI at birth (kg/m2) | 24 (21.0–28.5) | 24.2 (19.3–33.5) | 0.963 |
Gestational age (week) | 37.0 (34.4–37.3) | 37 (32.4–37.7) | 0.942 |
Primigravida (%) | 15 (39.5) | 15 (55.6) | 0.200 |
ART (%) | 6 (15.8) | 7 (25.9) | 0.314 |
Emergency cesarean delivery (%) | 7 (18.4) | 6 (22.2) | 0.706 |
Apgar score 1 min | 8 (1–9) | 8 (3–9) | 0.660 |
Apgar score 5 min | 9 (5–9) | 9 (6–9) | 0.225 |
Birth weight (g) | 2643 (1966–3440) | 2500 (1917–3035) | 0.250 |
Male (%) | 24 (63.2) | 11 (40.7) | 0.074 |
Female (%) | 14 (36.8) | 16 (59.3) | 0.074 |
Variables | Group A | Group B | p Value | |
---|---|---|---|---|
n = 38 | n = 27 | |||
Number or Median (Range) | Number or Median (Range) | |||
Total of autologous blood storage (mL) | 600 (300–1200) | 600 (300–1200) | 0.589 | |
Blood transfusion during cesarean section | Autologous transfusion (mL) | 300 (0–1200) | 300 (0–1200) | 0.336 |
Allogeneic transfusion (%) | 8 (21.1) | 8 (29.7) | 0.121 | |
RBC (unit) | 0 (0–10) | 0 (0–8) | 0.729 | |
FFP (unit) | 0 (0–10) | 0 (0–6) | 0.779 | |
PC (unit) | 0 (0–10) | 0 (0–0) | 0.919 | |
Infusion (mL) | 1950 (850–4300) | 1450 (700–3400) | 0.186 | |
Blood loss (mL) | 1835 (340–7500) | 1760 (895–5500) | 0.863 | |
Urine output (mL) | 110 (0–550) | 80 (0–500) | 0.105 | |
Operation time (min) | 65 (39–148) | 68 (41–104) | 0.739 |
Group A | Group B | p Value | |
---|---|---|---|
38 Storage (n = 38) | 27 Storage (n = 27) | ||
Median (Range) | Median (Range) | ||
Cancellation rate of next storage (%) | 17 (44.7) | 3 (11.1) | 0.004 * |
Hb level before storage (g/dL) | 10.5 (10.0–12.6) | 10.8 (10.2–12.1) | 0.070 |
Hb level after 7 days of storage (g/dL) | 10.0 (8.3–11.6) | 10.6 (9.5–12.3) | 0.001 ** |
Amount of change in Hb (g/dL) | −0.6 (−2.1–0.4) | −0.2 (−1.5–0.6) | 0.012 * |
Ht level before storage (%) | 31.9 (29.6–39.5) | 32.3 (29.8–36.3) | 0.394 |
Ht level after 7 days of storage (%) | 30.5 (27.7–36.5) | 32.1 (28.4–36.4) | 0.015 * |
Amount of change in Ht (%) | −1.8 (−5.8–1.9) | −0.7 (−2.5–1.2) | 0.015 * |
RBC level before storage (×104/μL) | 356 (296–433) | 354 (318–430) | 0.730 |
RBC level after 7 days of storage (×104/μL) | 333 (270–396) | 349 (299–398) | 0.125 |
Amount of change in RBC (×104/μL) | −24 (−69–12) | −11.5 (−45–12) | 0.003 ** |
Group A | Group B | p Value | |
---|---|---|---|
55 Storage (n = 38) | 38 Storage (n = 27) | ||
Median (Range) | Median (Range) | ||
Cancel rate of next storage (%) | 6 (10.9) | 1 (2.7) | 0.137 |
Hb level before storage (g/dL) | 10.6 (10.0–11.8) | 10.5 (10.0–12.3) | 0.769 |
Hb level after 7 days of storage (g/dL) | 10.7 (9.1–11.8) | 10.5 (9.9–11.5) | 1.000 |
Amount of change in Hb (g/dL) | −0.1 (−1.0–1.1) | 0.0 (−1.4–0.6) | 0.692 |
Ht level before storage (%) | 32.2 (29.0–37.2) | 31.8 (28.9–36.4) | 0.367 |
Ht level after 7 days of storage (%) | 32.2 (28.8–37.2) | 31.7 (28.6–34.1) | 0.259 |
Amount of change in Ht (%) | 0.2 (−3.4–3.2) | −0.1 (−3.1–2.7) | 0.629 |
RBC level before storage (×104/μL) | 343 (305–404) | 337 (298–398) | 0.205 |
RBC level after 7 days of storage (×104/μL) | 344 (292–392) | 332 (297–384) | 0.082 |
Amount of change in RBC (×104/μL) | −4 (−36–24) | −8 (−34–18) | 0.841 |
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Fukuda, E.; Misugi, T.; Kitada, K.; Fudaba, M.; Kurihara, Y.; Tahara, M.; Hamuro, A.; Nakano, A.; Koyama, M.; Tachibana, D. The Hematopoietic Effect of Ninjinyoeito (TJ-108), a Traditional Japanese Herbal Medicine, in Pregnant Women Preparing for Autologous Blood Storage. Medicina 2022, 58, 1083. https://doi.org/10.3390/medicina58081083
Fukuda E, Misugi T, Kitada K, Fudaba M, Kurihara Y, Tahara M, Hamuro A, Nakano A, Koyama M, Tachibana D. The Hematopoietic Effect of Ninjinyoeito (TJ-108), a Traditional Japanese Herbal Medicine, in Pregnant Women Preparing for Autologous Blood Storage. Medicina. 2022; 58(8):1083. https://doi.org/10.3390/medicina58081083
Chicago/Turabian StyleFukuda, Eriko, Takuya Misugi, Kohei Kitada, Megumi Fudaba, Yasushi Kurihara, Mie Tahara, Akihiro Hamuro, Akemi Nakano, Masayasu Koyama, and Daisuke Tachibana. 2022. "The Hematopoietic Effect of Ninjinyoeito (TJ-108), a Traditional Japanese Herbal Medicine, in Pregnant Women Preparing for Autologous Blood Storage" Medicina 58, no. 8: 1083. https://doi.org/10.3390/medicina58081083