Association of Blood MCP-1 Levels with Risk of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Plan
2.2. Recognizing of Articles
2.3. Suitability Criteria
2.4. Data Collection
2.5. Quality Assessment
2.6. Statistical Analysis
3. Results
3.1. Study Selection
3.2. Characteristics
3.3. Pooled Analysis (Case vs. Control)
3.4. Pooled Analysis (Adults with Severe vs. Mild/Moderate OSA)
3.5. Subgroup Analysis
3.6. Meta-Regression
3.7. Sensitivity Analysis
3.8. Publication Bias
3.9. Trial Sequential Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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First Author, Publication Year | Country | Ethnicity | Cases | Controls | Sampling | Quality Score | ||||||
No. | Mean | No. | Mean | |||||||||
AHI, events/h | BMI, kg/m2 | Age, Years | AHI, events/h | BMI, kg/m2 | Age, Years | |||||||
Ohga, 2003 [21] | Japan | Asian | 20 | 38.9 | 29.4 | 47.8 | 10 | 3.1 | 28.4 | 48.9 | Serum | 9 |
Hai-rong, 2005 [25] | China | Asian | 35 | ≥5 | 29.24 | 50 | 25 | <5 | 28.04 | 50 | Serum | 8 |
Hayashi, 2006 [36] | Japan | Asian | 60 | 49.4 | 28.8 | 51.6 | 30 | 2.8 | 23.2 | 55 | Serum | 7 |
Kim, 2010 * [23] | Korea | Asian | 9 | 14.40 | 24.43 | 38 | 22 | 1.25 | 23.88 | 26 | Serum | 6 |
28 | 52.71 | 28.69 | 42 | |||||||||
Kong, 2017 ** [22] | China | Asian | 28 | ≥5 | 27.3 | 44.9 | 30 | <5 | 27.6 | 45.7 | Serum | 9 |
54 | ≥5 | 27.9 | 45.9 | |||||||||
Perrini, 2017 *** [24] | Italy | Caucasian | 16 | 42.5 | 38 | 46.3 | 15 | 4.6 | 41.1 | 43.7 | Serum | 8 |
15 | 27.3 | 38.7 | 46.1 | |||||||||
Wen, 2020 [37] | China | Asian | 155 | 28.53 | 23.59 | 52 | 52 | 3.00 | 27.21 | 49.67 | Plasma | 7 |
Silva, 2021 [26] | Brazil | Mixed | 188 | 26.97 | 25.1 | 47 | 520 | 4.8 | 28.7 | 45 | Plasma | 5 |
Variable, N | SMD | 95% CI | p-Value | I2, % | Pheterogeneity | |
Min | Max | |||||
Ethnicity | ||||||
Asian (8) | 1.10 | 0.69 | 1.52 | <0.00001 | 79 | <0.0001 |
Caucasian (2) | 0.03 | –0.47 | 0.54 | 0.89 | 0 | 0.98 |
Mixed (1) | –0.18 | –0.34 | –0.01 | 0.04 | - | - |
Sample size | ||||||
<100 (9) | 0.95 | 0.47 | 1.43 | <0.0001 | 81 | <0.00001 |
≥100 (2) | 0.24 | –0.59 | 1.07 | 0.58 | 95 | <0.00001 |
Sampling | ||||||
Serum (9) | 0.95 | 0.47 | 1.43 | <0.0001 | 81 | <0.00001 |
Plasma (4) | 0.24 | −0.59 | 1.07 | 0.58 | 95 | <0.00001 |
Variable | Point Estimate | Standard Error | Lower Limit | Upper Limit | Z-Value | p-Value |
Publication year | −0.06450 | 0.01084 | −0.08575 | −0.04325 | −5.94886 | <0.00001 |
Mean age of adults with OSA | −0.03085 | 0.02243 | −0.07481 | 0.01311 | −1.37525 | 0.16905 |
Mean age of controls | −0.03391 | 0.01188 | −0.05720 | −0.01063 | −2.85432 | 0.00431 |
Mean BMI of adults with OSA | 0.02835 | 0.01804 | −0.00701 | 0.06370 | 1.57128 | 0.00612 |
Mean BMI of controls | −0.07558 | 0.01744 | −0.10976 | −0.04139 | −4.33352 | 0.00001 |
Mean AHI of adults with OSA | 0.04198 | 0.00826 | 0.02579 | 0.05816 | 5.08275 | <0.00001 |
Sample size | −0.00165 | 0.00020 | −0.00204 | −0.00126 | −8.29125 | <0.00001 |
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Imani, M.M.; Sadeghi, M.; Mohammadi, M.; Brühl, A.B.; Sadeghi-Bahmani, D.; Brand, S. Association of Blood MCP-1 Levels with Risk of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis. Medicina 2022, 58, 1266. https://doi.org/10.3390/medicina58091266
Imani MM, Sadeghi M, Mohammadi M, Brühl AB, Sadeghi-Bahmani D, Brand S. Association of Blood MCP-1 Levels with Risk of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis. Medicina. 2022; 58(9):1266. https://doi.org/10.3390/medicina58091266
Chicago/Turabian StyleImani, Mohammad Moslem, Masoud Sadeghi, Mehdi Mohammadi, Annette Beatrix Brühl, Dena Sadeghi-Bahmani, and Serge Brand. 2022. "Association of Blood MCP-1 Levels with Risk of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis" Medicina 58, no. 9: 1266. https://doi.org/10.3390/medicina58091266