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Microorganisms
Volume 12
Issue 3
10.3390/microorganisms12030441
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Article

Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains against Oral Pathogens

by
Diletta F. Squarzanti
1,*,
Federica Dell’Atti
2,
Alessandro C. Scalia
3,
Ziba Najmi
3,
Andrea Cochis
3 and
Patrizia Malfa
1
1
Synbalance Srl, 21040 Origgio, VA, Italy
2
Immunomics Laboratory, Department of Health Sciences, Center for Translational Research on Autoimmune and Allergic Diseases (CAAD), University of Eastern Piedmont, 28100 Novara, NO, Italy
3
Biomedical Materials Laboratory, Department of Health Sciences, Center for Translational Research on Autoimmune and Allergic Diseases (CAAD), University of Eastern Piedmont, 28100 Novara, NO, Italy
*
Author to whom correspondence should be addressed.
Microorganisms 2024, 12(3), 441; https://doi.org/10.3390/microorganisms12030441
Submission received: 25 January 2024 / Revised: 19 February 2024 / Accepted: 20 February 2024 / Published: 21 February 2024
(This article belongs to the Section Medical Microbiology)
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Abstract

The microbiota in the oral cavity has a strict connection to its host. Its imbalance may determine oral diseases and can also have an impact on the systemic health. Probiotic strains may help in the restoration of a balanced condition. For this purpose, we screened the antibacterial and antiadhesive activities of many viable probiotic strains (Lactobacillus acidophilus PBS066, Lactobacillus crispatus LCR030, Lactobacillus gasseri LG050, Lactiplantibacillus plantarum PBS067, Limosilactobacillus reuteri PBS072, Lacticaseibacillus rhamnosus LRH020, Bifidobacterium animalis subsp. lactis BL050, Lacticaseibacillus paracasei LPC 1101, L. paracasei LPC 1082, and L. paracasei LPC 1114) against two main oral pathogens, Streptococcus mutans and Aggregatibacter actinomycetemcomitans, involved in dental caries and periodontal disease development and progression. Considering both the agar overlay preventive and treatment models, seven probiotics determined greater inhibition zones against the tested pathogens. This behavior was further analyzed by the plate count method and scanning electron microscope imaging. L. plantarum PBS067, L. rhamnosus LRH020, L. paracasei LPC 1101, L. paracasei LPC 1082, and L. paracasei LPC 1114 prevent the growth and adhesion of oral pathogens in a strain-specific manner (p < 0.0001). These probiotics might be considered as an alternative effective adjuvant to improve oral and systemic well-being for future personalized treatments.
Keywords: probiotics; oral; pathogens; infection; host interaction; microbiota; dysbiosis probiotics; oral; pathogens; infection; host interaction; microbiota; dysbiosis

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MDPI and ACS Style

Squarzanti, D.F.; Dell’Atti, F.; Scalia, A.C.; Najmi, Z.; Cochis, A.; Malfa, P. Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains against Oral Pathogens. Microorganisms 2024, 12, 441. https://doi.org/10.3390/microorganisms12030441

AMA Style

Squarzanti DF, Dell’Atti F, Scalia AC, Najmi Z, Cochis A, Malfa P. Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains against Oral Pathogens. Microorganisms. 2024; 12(3):441. https://doi.org/10.3390/microorganisms12030441

Chicago/Turabian Style

Squarzanti, Diletta F., Federica Dell’Atti, Alessandro C. Scalia, Ziba Najmi, Andrea Cochis, and Patrizia Malfa. 2024. "Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains against Oral Pathogens" Microorganisms 12, no. 3: 441. https://doi.org/10.3390/microorganisms12030441

APA Style

Squarzanti, D. F., Dell’Atti, F., Scalia, A. C., Najmi, Z., Cochis, A., & Malfa, P. (2024). Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains against Oral Pathogens. Microorganisms, 12(3), 441. https://doi.org/10.3390/microorganisms12030441

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