Rational Design of Cyclic Antimicrobial Peptides Based on BPC194 and BPC198
Abstract
:1. Introduction
2. Results and Discussion
2.1. Structural Factors Governing the Activity of Cyclic Peptides BPC194 and BPC198
2.2. Stable Secondary Structure of BPC194 and BPC198
2.3. Design and Synthesis of BPC194 and BPC198 Analogues
2.4. Antibacterial Activity of the Designed Cyclic Decapeptides
3. Materials and Methods
3.1. Chemicals and Instruments
3.2. Synthesis of the Cyclic Peptides
3.3. Bacterial Strains and Growth Conditions
3.4. Antibacterial Activity
3.5. Molecular Dynamics Simulations
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Sample Availability: Not available. |
Code | MIC Intervals (μM) | ||
---|---|---|---|
Pss a | Xav a | Ea a | |
BPC194 | 3.1-6.2 | 3.1–6.2 | 6.2–12.5 |
BPC198 | 3.1–6.2 | 3.1–6.2 | 12.5–25 |
BPC480 | 12.5–25 | 12.5–25 | >50 |
BPC482 | 6.2–12.5 | 6.2–12.5 | >50 |
BPC484 | 12.5–25 | 25–50 | >50 |
BPC486 | 12.5–25 | >50 | >50 |
BPC488 | 6.2–12.5 | 6.2–12.5 | >50 |
BPC490 | 3.1–6.2 | 3.1–6.2 | 12.5–25 |
BPC492 | 12.5–25 | 12.5–25 | >50 |
BPC494 | 6.2–12.5 | 6.2–12.5 | >50 |
BPC496 | 6.2–12.5 | 6.2–12.5 | >50 |
BPC914 | 12.5–25 | 12.5–25 | >50 |
BPC916 | 6.2–12.5 | 12.5–25 | >50 |
BPC918 | 3.1–6.2 | 1.6–3.1 | 12.5–25 |
BPC920 | 12.5–25 | 25–50 | >50 |
BPC922 | 12.5–25 | 12.5–25 | >50 |
BPC924 | 3.1–6.2 | 1.6–3.1 | 12.5–25 |
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Cirac, A.D.; Torné, M.; Badosa, E.; Montesinos, E.; Salvador, P.; Feliu, L.; Planas, M. Rational Design of Cyclic Antimicrobial Peptides Based on BPC194 and BPC198. Molecules 2017, 22, 1054. https://doi.org/10.3390/molecules22071054
Cirac AD, Torné M, Badosa E, Montesinos E, Salvador P, Feliu L, Planas M. Rational Design of Cyclic Antimicrobial Peptides Based on BPC194 and BPC198. Molecules. 2017; 22(7):1054. https://doi.org/10.3390/molecules22071054
Chicago/Turabian StyleCirac, Anna D., Maria Torné, Esther Badosa, Emilio Montesinos, Pedro Salvador, Lidia Feliu, and Marta Planas. 2017. "Rational Design of Cyclic Antimicrobial Peptides Based on BPC194 and BPC198" Molecules 22, no. 7: 1054. https://doi.org/10.3390/molecules22071054