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Review

Significance of Resveratrol in Clinical Management of Chronic Diseases

by
Awais Wahab
1,†,
Kuo Gao
1,†,
Caixia Jia
1,
Feilong Zhang
1,
Guihua Tian
1,2,
Ghulam Murtaza
1,3,4,* and
Jianxin Chen
1,*
1
School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
2
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
3
Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
4
Institute of Automation, Chinese Academy of Sciences, Beijing 100029, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2017, 22(8), 1329; https://doi.org/10.3390/molecules22081329
Submission received: 17 July 2017 / Revised: 4 August 2017 / Accepted: 9 August 2017 / Published: 18 August 2017
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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Abstract

Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their associated complications. The clinical outcomes are affected by many factors such as sample size. This article not only presents a comprehensive review of the current advances concerning the dose, the extent of absorption, interaction and toxicity of resveratrol in human studies, but also describes its therapeutic effects against several chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer and aging and the related diseases.
Keywords: pre-clinical studies; clinical studies; absorption; toxicity; diabetes mellitus; obesity; cardiovascular diseases; cancer; aging pre-clinical studies; clinical studies; absorption; toxicity; diabetes mellitus; obesity; cardiovascular diseases; cancer; aging

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MDPI and ACS Style

Wahab, A.; Gao, K.; Jia, C.; Zhang, F.; Tian, G.; Murtaza, G.; Chen, J. Significance of Resveratrol in Clinical Management of Chronic Diseases. Molecules 2017, 22, 1329. https://doi.org/10.3390/molecules22081329

AMA Style

Wahab A, Gao K, Jia C, Zhang F, Tian G, Murtaza G, Chen J. Significance of Resveratrol in Clinical Management of Chronic Diseases. Molecules. 2017; 22(8):1329. https://doi.org/10.3390/molecules22081329

Chicago/Turabian Style

Wahab, Awais, Kuo Gao, Caixia Jia, Feilong Zhang, Guihua Tian, Ghulam Murtaza, and Jianxin Chen. 2017. "Significance of Resveratrol in Clinical Management of Chronic Diseases" Molecules 22, no. 8: 1329. https://doi.org/10.3390/molecules22081329

APA Style

Wahab, A., Gao, K., Jia, C., Zhang, F., Tian, G., Murtaza, G., & Chen, J. (2017). Significance of Resveratrol in Clinical Management of Chronic Diseases. Molecules, 22(8), 1329. https://doi.org/10.3390/molecules22081329

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