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Volume 13
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10.3390/nu13093171
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Article

A Randomised, Controlled Trial: Effect of a Multi-Strain Fermented Milk on the Gut Microbiota Recovery after Helicobacter pylori Therapy

by
Eric Guillemard
1,*,
Marion Poirel
1,
Florent Schäfer
1,
Laurent Quinquis
1,
Caroline Rossoni
1,
Christian Keicher
2,
Frank Wagner
2,
Hania Szajewska
3,
Frédéric Barbut
4,
Muriel Derrien
1,† and
Peter Malfertheiner
5,6,†
1
Danone Nutricia Research, Department of Innovation Science and Nutrition, 91767 Palaiseau, France
2
Charité Research Organisation GmbH, 10117 Berlin, Germany
3
Department of Paediatrics, Medical University of Warsaw, 02-091 Warszawa, Poland
4
INSERM S-1139, Université de Paris, 75006 Paris, France
5
Department of Gastroenterology, Hepatology and Infectious Diseases, Magdeburg Clinic, OVGU University, 39120 Magdeburg, Germany
6
Department of Internal Medicine II, LMU University Clinic, 81377 München, Germany
*
Author to whom correspondence should be addressed.
†
Co-last authors.
Nutrients 2021, 13(9), 3171; https://doi.org/10.3390/nu13093171
Submission received: 15 June 2021 / Revised: 27 August 2021 / Accepted: 7 September 2021 / Published: 11 September 2021
(This article belongs to the Section Prebiotics and Probiotics)
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Abstract

Helicobacter pylori (Hp) eradication therapy alters gut microbiota, provoking gastrointestinal (GI) symptoms that could be improved by probiotics. The study aim was to assess the effect in Hp patients of a Test fermented milk containing yogurt and Lacticaseibacillus (L. paracasei CNCM I-1518 and I-3689, L. rhamnosus CNCM I-3690) strains on antibiotic associated diarrhea (AAD) (primary aim), GI-symptoms, gut microbiota, and metabolites. A randomised, double-blind, controlled trial was performed on 136 adults under 14-day Hp treatment, receiving the Test or Control product for 28 days. AAD and GI-symptoms were reported and feces analysed for relative and quantitative gut microbiome composition, short chain fatty acids (SCFA), and calprotectin concentrations, and viability of ingested strains. No effect of Test product was observed on AAD or GI-symptoms. Hp treatment induced a significant alteration in bacterial and fungal composition, a decrease of bacterial count and alpha-diversity, an increase of Candida and calprotectin, and a decrease of SCFA concentrations. Following Hp treatment, in the Test as compared to Control group, intra-subject beta-diversity distance from baseline was lower (padj = 0.02), some Enterobacteriaceae, including Escherichia-Shigella (padj = 0.0082) and Klebsiella (padj = 0.013), were less abundant, and concentrations of major SCFA (p = 0.035) and valerate (p = 0.045) were higher. Viable Lacticaseibacillus strains were detected during product consumption in feces. Results suggest that, in patients under Hp treatment, the consumption of a multi-strain fermented milk can induce a modest but significant faster recovery of the microbiota composition (beta-diversity) and of SCFA production and limit the increase of potentially pathogenic bacteria.
Keywords: antibiotics; Helicobacter pylori; antibiotic associated diarrhea; gut microbiota; short chain fatty acids; recovery antibiotics; Helicobacter pylori; antibiotic associated diarrhea; gut microbiota; short chain fatty acids; recovery

Share and Cite

MDPI and ACS Style

Guillemard, E.; Poirel, M.; Schäfer, F.; Quinquis, L.; Rossoni, C.; Keicher, C.; Wagner, F.; Szajewska, H.; Barbut, F.; Derrien, M.; et al. A Randomised, Controlled Trial: Effect of a Multi-Strain Fermented Milk on the Gut Microbiota Recovery after Helicobacter pylori Therapy. Nutrients 2021, 13, 3171. https://doi.org/10.3390/nu13093171

AMA Style

Guillemard E, Poirel M, Schäfer F, Quinquis L, Rossoni C, Keicher C, Wagner F, Szajewska H, Barbut F, Derrien M, et al. A Randomised, Controlled Trial: Effect of a Multi-Strain Fermented Milk on the Gut Microbiota Recovery after Helicobacter pylori Therapy. Nutrients. 2021; 13(9):3171. https://doi.org/10.3390/nu13093171

Chicago/Turabian Style

Guillemard, Eric, Marion Poirel, Florent Schäfer, Laurent Quinquis, Caroline Rossoni, Christian Keicher, Frank Wagner, Hania Szajewska, Frédéric Barbut, Muriel Derrien, and et al. 2021. "A Randomised, Controlled Trial: Effect of a Multi-Strain Fermented Milk on the Gut Microbiota Recovery after Helicobacter pylori Therapy" Nutrients 13, no. 9: 3171. https://doi.org/10.3390/nu13093171

APA Style

Guillemard, E., Poirel, M., Schäfer, F., Quinquis, L., Rossoni, C., Keicher, C., Wagner, F., Szajewska, H., Barbut, F., Derrien, M., & Malfertheiner, P. (2021). A Randomised, Controlled Trial: Effect of a Multi-Strain Fermented Milk on the Gut Microbiota Recovery after Helicobacter pylori Therapy. Nutrients, 13(9), 3171. https://doi.org/10.3390/nu13093171

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