Variable Surface Glycoprotein from Trypanosoma brucei Undergoes Cleavage by Matrix Metalloproteinases: An in silico Approach
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
HAT | Human African Trypanosomiasis |
VSG | Variable surface protein |
MSP | Major surface protein |
PLC | Phospholipase C |
MMPs | Matrix metalloproteinases |
References
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VSG Domain A (NCBI CDD * Accession: cl03014) | Number of MMP Cleavage Sites | MMP Cleavage Site Consensus Sequences Portion (WebLogo) | |
---|---|---|---|
Tbb (85 sequences) | MMP2 | 309 | |
MMP3 | 372 | ||
MMP9 | 1673 | ||
Tbr (5 sequences) | MMP2 | 17 | |
MMP3 | 21 | ||
MMP9 | 98 | ||
Tbg (22 sequences) | MMP2 | 58 | |
MMP3 | 62 | ||
MMP9 | 333 |
VSG Domain B (NCBI CDD Accession: cl26244) | Number of MMP Cleavage Sites | MMP Cleavage Site Consensus Sequences (WebLogo) | |
---|---|---|---|
Tbb (151 sequences) | MMP2 | 454 | |
MMP3 | 593 | ||
MMP9 | 2983 | ||
Tbr (10 sequences) | MMP2 | 17 | |
MMP3 | 21 | ||
MMP9 | 98 | ||
Tbg (49 sequences) | MMP2 | 145 | |
MMP3 | 176 | ||
MMP9 | 949 |
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Moreno, C.J.G.; Torres, T.; Silva, M.S. Variable Surface Glycoprotein from Trypanosoma brucei Undergoes Cleavage by Matrix Metalloproteinases: An in silico Approach. Pathogens 2019, 8, 178. https://doi.org/10.3390/pathogens8040178
Moreno CJG, Torres T, Silva MS. Variable Surface Glycoprotein from Trypanosoma brucei Undergoes Cleavage by Matrix Metalloproteinases: An in silico Approach. Pathogens. 2019; 8(4):178. https://doi.org/10.3390/pathogens8040178
Chicago/Turabian StyleMoreno, Cláudia Jassica Gonçalves, Taffarel Torres, and Marcelo Sousa Silva. 2019. "Variable Surface Glycoprotein from Trypanosoma brucei Undergoes Cleavage by Matrix Metalloproteinases: An in silico Approach" Pathogens 8, no. 4: 178. https://doi.org/10.3390/pathogens8040178