Search Results (1,320)

Objectives: This prospective cohort study aimed to evaluate the accuracy and precision of static computer-guided, flapless implant surgery in partially edentulous patients, comparing the virtually planned and clinically achieved implant positions. Materials and Methods: From 2017 to 2022, 40 patients (20 males and 20 females) received a total of 129 implants across 59 partial rehabilitations, with 62 implants placed in the maxilla and 67 in the mandible. All interventions were performed by a single experienced operator using dental-supported stereolithographic guides and a flapless protocol. The discrepancy between planned and actual implant positions was measured using reverse engineering software, assessing linear deviations at the implant Platform (coronal) and apex, as well as angular deviations. Subgroup analyses were conducted based on the jaw (maxilla vs. mandible) and the type of surgical guide support (Kennedy classes I–IV). Results: The mean linear deviation was 1.16 ± 0.58 mm at the apex and 0.80 ± 0.41 mm at the implant Platform (coronal). The mean angular deviation was 3.23° ± 1.86°. Slightly higher deviations were observed in the mandible than in the maxilla. Group-wise analysis showed minor variations depending on the type of guide support. Conclusions: Static computer-guided surgery demonstrated measurable linear and angular deviations between planned and achieved implant positions. These discrepancies should be considered during treatment planning, especially in narrow ridges or Class I configurations. Full article

Background and Objectives: Vaginal vault prolapse is a known complication following anterior pelvic exenteration in women undergoing radical cystectomy. The aim of this study is to evaluate the feasibility, safety, and early outcomes of a novel anatomical approach for preventing vaginal vault prolapse after radical cystectomy. This study introduces a standardized laparoscopic technique that utilizes round ligament preservation and fixation to provide anatomical support to the vaginal apex. Materials and Methods: This study is a retrospective analysis of prospectively collected data from a single center, including thirteen female patients with uterus and adnexa in situ who underwent laparoscopic radical cystectomy with bilateral round ligament fixation to the vaginal cuff. The round ligaments were mobilized and sutured without tension. Vaginal closure was performed with barbed sutures. Results: No intraoperative complications occurred. At a median follow-up of 18.2 months, no cases of vaginal vault prolapse or dehiscence were observed. One patient experienced transient pelvic discomfort. Conclusions: This is the first report of a standardized mesh-free approach for vaginal apex support during laparoscopic anterior exenteration. The technique is feasible, safe, and may reduce postoperative prolapse risk. Full article

The Damietta–Port Said coast, Nile Delta, has experienced extreme morphological change over the past four decades due to sediment reduction due to Aswan High Dam and continued anthropogenic pressures. Using multi-temporal Landsat (1985–2025) and high-resolution RapidEye and PlanetScope imagery with 50 m-spaced transects, the study documents major shoreline shifts: the Damietta sand spit retreated by >1 km at its proximal apex while its distal tip advanced by ≈3.1 km southeastward under persistent longshore drift. Sectoral analyses reveal typical structure-induced patterns of updrift accretion (+180 to +210 m) and downdrift erosion (−50 to −330 m). To improve predictive capability beyond linear DSAS extrapolation, Nonlinear Autoregressive Exogenous (NARX) and Bidirectional Long Short-Term Memory (BiLSTM) neural networks were applied to forecast the 2050 shoreline. BiLSTM demonstrated superior stability, capturing nonlinear sediment transport patterns where NARX produced unstable over-predictions. Furthermore, coupled wave–flow modeling validates a sustainable management strategy employing successive short groins (45–50 m length, 150 m spacing). Simulations indicate that this configuration reduces longshore current velocities by 40–60% and suppresses rip-current eddies, offering a sediment-compatible alternative to conventional breakwaters and seawalls. This integrated remote sensing, hydrodynamic, and AI-based framework provides a robust scientific basis for adaptive, sediment-compatible shoreline management, supporting the long-term resilience of one of Egypt’s most vulnerable deltaic coasts under accelerating climatic and anthropogenic pressures. Full article

A supplemental description of Lamproglena barbicola Fryer, 1961 is provided based on specimens collected from the gills of Labeobarbus altianalis (Boulenger, 1900) from the Nyando River, Lake Victoria Basin, Kenya, using an integrated approach of scanning electron microscopy (SEM) and molecular analysis (18S, 28S rDNA, and cox1 gene regions). Morphologically, the specimens conform to L. barbicola and closely resemble Lamproglena hoi Dippenaar, Luus-Powell & Roux, 2001; however, SEM revealed a previously undescribed feature on the uniramous antennule in L. barbicola, namely indistinctly three-segmented, tapering from a broad base to the apex, basal segment much longer than distal, comprising 14 setae of varying sizes, ventral laterally, absence of distinctive anterior fringe of setae on the antennule, as well as several characters that differentiate L. barbicola from L. hoi, including 5 setae at the basal endopod of leg one, five cuticular protuberances in the oral region, 19 setae on the basal antennular segment, and 10 setae on the distal segment, with 1 seta on each ramus. The phylogenetic analysis confirms L. barbicola as a sister taxon of L. hoi, supporting their close relationship. The genetic divergence presented as the uncorrected genetic p-distances between L. barbicola and L. hoi are 23.1% and 0.45% for cox1 and 28S rDNA regions, respectively, with observed nucleotide differences of 145 and 3 bp between the sequences, respectively. There was no interspecific variability detected in the 18S rDNA sequences. This study provides novel molecular sequences and the first high-resolution SEM images, which reveal additional taxonomic features for L. barbicola, establishing a robust reference for future identification. Full article

Emergences of periodical cicadas constitute intense, short-duration resource pulses that can produce significant functional and numerical responses among insectivorous species that prey on them. The response of coyotes, apex predators in Illinois USA, to an emergence of 13-year periodical cicadas was investigated in 1989. Coyotes are not strongly insectivorous. However, during a 4-week period coinciding with peak emergence, cicadas were present in 85.9% of coyote scats (n = 71 scats) and 49% of scats contained only cicadas. Compared to the same time period in 1986–88 (n = 276 scats), use of all other food items was significantly lower in 1989 as was dietary diversity and overlap. This alteration in coyote foraging patterns constituted a strong functional response to the cicada emergence. The high abundance of cicadas combined with their ease of capture and consumption resulted in cicadas being an energetically efficient item for coyotes to forage upon. It is unknown whether other aspects of coyote life history (e.g., space use, activity patterns) also were affected or whether reduced predation pressure resulted in any effects on populations of their usual prey species. Full article

Iron (Fe) is an essential micronutrient for plant development and productivity. Nevertheless, the role of gibberellins (GAs) in the control of iron homeostasis is less studied compared to other growth regulators. We found that GAs modulate iron homeostasis in maize by inducing deficiency-like responses independent of rhizosphere iron availability. Plant phenotyping demonstrated that exogenous GA₃ application under iron-sufficient conditions phenocopied iron deprivation, while inhibiting GA biosynthesis with mepiquat chloride prevented the development of typical symptoms of Fe deficiency (–Fe). Gibberellins positively control strategy II Fe uptake genes, albeit indirectly, as opposed to the direct negative transcriptional regulation of phytosiderophore biosynthesis. Additionally, gibberellins disrupt iron partitioning by suppressing root-to-shoot Fe translocation, causing iron overaccumulation in roots of GA₃ treated plants. A functional ferrous iron uptake pathway was identified and was found to operate in conjunction with the strategy II uptake pathway via the differentially regulated Zea mays Iron-Regulated Transporter (IRT) paralogs ZmIRT1 and ZmIRT2. Root responses are spatially organized: gene expression in the lateral root sector reflects the shoot iron status, while transcriptional responses in the root apex correlate with local Fe demands. This study demonstrates that maize leverages a hybrid ferric/ferrous iron uptake strategy and establishes novel roles of GAs as pivotal regulators of iron homeostasis. Full article

The present work explores the effects of dental splints from a mechanical standpoint, aiming to provide a practical tool for the surgical decision-making process regarding splint cross-section dimensions. Our investigation centers on the anatomical structure of a pentamorphic dental arch encompassing central and lateral incisors and one canine on each side. Using parametric in silico models built up by means of an ad-hoc procedure, geometry, material properties, and boundary conditions are defined on a parametric anatomical model that can be tailored using RX-derived geometrical information. Two general cases have been considered, one with the splint and the other splintless, and a sensitivity analysis has been performed by varying the splint section height and thickness. The results show the diminishing mobility at the apex and basis of the diseased incisors, demonstrating the effectiveness of the periodontal treatment. Moreover, the stress due to physiological loads moves away from diseased teeth toward the healthy ones due to the splint effects, focusing on the splint–glue–canine contact zone and highlighting the crucial role played by the canine in fixing the entire dental structure. To establish a preliminary mechanical assessment of the dental structure’s safety and to confine its actual value within a mechanically reasonable range, a synthetic “traffic-light” indicator of stress-based failure risk is proposed. It is felt that the tool proposed in this study can help surgeons assess the pre-operative patient-specific mechanical effects of the splint treatment, driving the design and choice of periodontal splints. By linking splint geometry to mechanical safety via a stress-based indicator, the method supports the optimized design and selection of splints, improving treatment reliability while preserving comfort and clinical effectiveness. Full article

Background: We describe the post-mortem analysis of a CARD11 variant allele, p.Ser995Leu, identified in fraternal twins who died in early infancy with no identifiable cause of death. CARD11 variants through varied inheritance models can alter immune function through loss- or gain-of-function mechanisms, involving distinct protein domains; yet the significance of GUK domain variants remains poorly characterized. Twin autopsies showed non-specific findings, such as pulmonary macrophage accumulation and splenic white pulp expansion, but without infection or structural abnormalities. Methods: Whole-exome sequencing, performed as part of molecular autopsies, identified the shared CARD11 p.Ser995Leu variant, previously classified as a variant of uncertain significance (VUS). We assessed evolutionary conservation across CARD family proteins and species and predicted functional impact using in silico tools, which estimate the likelihood that a variant is deleterious. AlphaFold-based structural modeling emphasized qualitative biophysical assessment. Using epidemiological data, population allele frequency, and Bayesian ACMG variant classification, we assessed competing hypotheses under an autosomal dominant model. Results: The p.Ser995Leu substitution affects a conserved, surface-exposed β-sheet within the GUK domain. While CADD scores exceeded 20, other predictive algorithms offered only partial support of pathogenicity. Structural modeling suggested a potential GUK domain destabilization. Integrating genetic, pathologic, immunologic, and probabilistic modeling, we propose a biologically plausible model in which the variant, like other GUK variants, may alter NF-κB or other signaling pathways and is likely pathogenic. Conclusions: While the CARD11 p.Ser995Leu variant’s contribution to disease is uncertain without functional validation or parental testing, and phenotypic findings are non-specific, the presence of an ultra-rare GUK domain variant in both twins, combined with in silico and statistical modeling, supports its interpretation as likely pathogenic or high risk. The results highlight the challenges of data-limited post-mortem variant interpretation. Full article

This study introduces an innovative sensor architecture predicated on surface plasmon polaritons (SPPs), comprising a metal–insulator–metal (MIM) waveguide in conjunction with a cat-faced circular split resonator (TCRSW). The efficacy of the proposed nanosensor was meticulously evaluated utilizing the finite element method (FEM). It was determined that the TCRSW configuration significantly impacts the sensor’s performance. By means of a comprehensive optimization of the structural parameters, the sensor attained an apex sensitivity of 3380 nm/RIU and a figure of merit (FOM) of 56.33 in its optimal configuration. Furthermore, the study comprehensively evaluated the sensor’s applicability for temperature sensing, demonstrating a measured temperature sensitivity of 1.673 nm/°C. Meanwhile, the application of the proposed structure in biosensing was comprehensively evaluated. When employed as a concentration sensor for detecting sodium and potassium ion solutions, the maximum achievable sensitivities reached 0.49 mg·d/L and 0.6375 mg·d/L, respectively, which highlights its significant potential not only for high-precision temperature monitoring but also for sensitive and reliable biosensing applications. Additionally, the proposed nanosensor holds considerable promise for applications in other nanophotonic fields. Full article

Background: Orbital dermoid cysts are common benign lesions; however, deep-seated or recurrent lesions near the orbital apex pose major surgical challenges due to their proximity to critical neurovascular structures. Lateral orbitotomy remains the reference approach, but accurate osteotomies and stable reconstruction can be difficult to achieve using conventional techniques. This study reports our initial experience using a fully digital, hospital-based point-of-care (POC) workflow to enhance precision and safety in complex orbital dermoid cyst surgery. Methods: We present a case series of three patients with orbital dermoid cysts treated at a tertiary center (2024–2025) using a comprehensive digital workflow. Preoperative assessment included CT and/or MRI followed by virtual surgical planning (VSP) with orbit–tumor segmentation and 3D modeling. Cutting guides and patient-specific implants (PSIs) were manufactured in-house under a certified hospital-based POC protocol. Surgical strategies were tailored to each lesion and included piezoelectric osteotomy, intraoperative navigation, intraoperative CT, and structured-light scanning when indicated. Results: Complete en bloc resection was achieved in all cases without capsular rupture or optic nerve injury. Intraoperative CT confirmed complete lesion removal and accurate PSI positioning and fitting. Structured-light scanning enabled radiation-free postoperative monitoring when used. All patients preserved full ocular motility, visual acuity, and facial symmetry, with no complications or recurrences during follow-up. Conclusions: The integration of VSP, in-house POC manufacturing, and image-guided surgery within a lateral orbitotomy approach provides a reproducible and fully integrated workflow. This strategy appears to improve surgical precision and safety while supporting optimal long-term functional and aesthetic outcomes in challenging orbital dermoid cyst cases. Full article

The Apex-Shifted Hyperbolic Radon Transform (ASHRT) is a variant of the Radon Transform. In the field of seismic exploration, it can be applied to simultaneous source separation, diffraction- and reflection-wave separation, seismic data reconstruction, among other purposes. This paper primarily investigates the application of ASHRT in the separation of diffraction and reflection waves. Detailed exploration of complex structures using diffraction wave imaging has become a new trend, thereby necessitating the separation of diffraction wave fields. The conventional ASHRT based on the Stolt operator, due to its weak sparsity, increasingly struggles to meet current separation requirements. Compared to conventional ASHRT, the Stolt-based ASHRT enables fast, efficient computation; however, the Stolt operator exhibits relatively weaker sparseness and fidelity. To address this issue, replacing the Stolt operator with the PS operator for performing ASHRT allows the transform to achieve both high sparseness and high fidelity simultaneously. In this study, synthetic data were used to investigate the advantages of the PS operator over the Stolt operator. Furthermore, both operators were applied to separate diffraction and reflection waves in marine seismic data and land seismic data, respectively. The research demonstrates that, in the separation of diffraction and reflection waves using the ASHRT method, the PS operator provides significant advantages over the Stolt operator in terms of both sparseness and fidelity. Full article

Background/Objectives: This study evaluates the penetration of a calcium silicate-based sealer (BC Universal) into dentinal tubules after different final irrigation protocols. Methods: Eighty-four single-rooted extracted teeth were instrumented with ProTaper Gold to size F4 and assigned to four groups (n = 21) according to the final irrigation protocol as follows: conventional needle irrigation (CNI), sonic agitation with EndoActivator (EA), ultrasonic activation (UA), and XP-Endo Finisher (XPF). A total of 20 canals from each group were filled with BC Universal sealer mixed with fluorescein and the single-cone obturation technique. The remaining specimen in each group served as a negative control to assess potential imaging bias. Specimens were sectioned 3 mm from the apex and analyzed under confocal laser scanning microscopy. Sealer penetration was assessed by penetration area (PA), maximum depth (MaxD), mean depth (MeanD), and percentage of canal perimeter infiltrated (P). Data were analyzed using Kruskal–Wallis or ANOVA tests (α = 0.05). Results: All activation/agitation techniques showed significantly higher penetration than CNI across all variables (p < 0.001). No significant differences were found among EA, PUI, and XPF for PA, MaxD, and MeanD. However, XPF exhibited the highest perimeter infiltration, which was significantly greater than EA and UA (p < 0.001). Conclusions: Irrigant activation significantly enhanced dentinal tubule penetration of BC Universal sealer compared to CNI. XPF provided superior P, suggesting superior circumferential distribution. These findings suggest a more effective cleaning of the root canal in the apical third achieved by the tested irrigant activation/agitation techniques, which may improve the sealing potential of BC Universal sealer. Full article

Background/Objective: Maxillary canine impaction is a frequent orthodontic challenge. Three-dimensional CBCT assessment allows precise evaluation of periradicular bone density, which may play a role in eruption failure. This study aimed to compare bone density (HU) around impacted canines with that of the contralateral erupted tooth and to assess correlations with age and sex. Methods: A total of 26 patients (10 males, 16 females; 13–19 years) with unilateral maxillary canine impaction were examined. Pre-treatment CBCT scans acquired were analyzed. Bone density was measured in HU at three root levels (cervical, middle, apical) and in four regions (buccal, palatal, mesial, distal). Statistical analyses included Student’s t-tests, linear regression, and correlation coefficients, with significance set at p < 0.05. Results: Tooth 2.3 was the most frequently impacted (61.5%), with a slight predominance of palatal impactions (53.8%). Bone density was significantly higher around impacted canines than around the contralateral erupted teeth in all regions and levels (p = 0.000), with values increasing from the cervical portion toward the apex. In impacted canines, bone density increased significantly with age, whereas no meaningful differences were found between males and females. Conclusions: Higher bone density surrounding impacted canines supports its potential role in eruption failure. The age-related increase highlights the clinical importance of early diagnosis and timely orthodontic–surgical intervention. Full article

Background: Adult patients with a thin buccal cortical plate and fragile periodontal phenotype are at high risk of dehiscence, fenestration and recession during transverse orthodontic expansion. Conventional mechanics often create a cervical compression-dominant environment that exceeds the adaptive capacity of the periodontal ligament (PDL)–bone complex. Objectives: This study proposes an integrative mechanobiological model in which a skeletal-anchorage-assisted loading protocol (Bone Protection System, BPS) transforms expansion into a tension-dominant regime that favours buccal phenotype preservation. Methods: Patient-specific finite element models were used to compare conventional expansion with a BPS-modified force system. Regional PDL stress patterns and crown/apex displacement vectors were analysed to distinguish tipping-dominant from translation-dominated mechanics. A pilot CBCT proof-of-concept (n = 1 thin-phenotype adult) with voxel-based registration quantified changes in maxillary and mandibular alveolar ridge width and buccal cortical plate thickness before and after BPS-assisted expansion. The mechanical findings were integrated with current evidence on compression- versus tension-driven inflammatory and osteogenic pathways in the PDL and cortical bone. Results: FEM demonstrated that conventional expansion concentrates high cervical compressive stress along the buccal PDL and cortical surface, accompanied by bending-like crown–root divergence. In contrast, the BPS protocol redirected forces to create a buccal tensile-favourable region and a more parallel crown–apex displacement pattern, indicative of translation-dominated movement. In the proof-of-concept (n = 1) CBCT case, BPS-assisted expansion was associated with preservation or increase of buccal ridge dimensions without radiographic signs of cortical breakdown. Conclusions: A tension-dominant orthodontic loading environment generated by a skeletal-anchorage-assisted force system may support buccal cortical preservation and vestibular phenotype reinforcement in thin-phenotype patients. The proposed mechanobiological model links these imaging and FEM findings to known molecular pathways of inflammation, angiogenesis and osteogenesis. It suggests a functional biomaterial-based strategy for widening the biological envelope of safe tooth movement. Full article

Background/Objectives: Precise implant positioning is critical for successful prosthetic rehabilitation, particularly in completely edentulous patients where anatomical landmarks are lost. The aim of this study was to assess the accuracy of implant placement in the edentulous maxilla and mandible using computer-assisted planning and a bone-supported stackable surgical guide protocol. Methods: This retrospective clinical study included 15 completely edentulous patients who received a total of 60 implants. A dual-scan protocol was utilized for planning. The surgical protocol involved a base guide fixed to the bone with pins, serving as a rigid foundation for stackable components used for osteotomy and implant insertion. Postoperative CBCT scans were superimposed onto the preoperative plan to calculate angular deviations, 3D linear deviations at the implant neck and apex, and depth deviations. Results: The analysis demonstrated high accuracy with a mean angular deviation of 1.25° ± 0.80°. The mean 3D linear deviation was 0.96 ± 0.57 mm at the implant neck and 1.07 ± 0.56 mm at the apex. Depth deviation showed a mean discrepancy of 0.37 ± 0.58 mm. All measured parameters were statistically significantly lower (p < 0.05) than the pre-established clinical safety thresholds. Conclusions: Within the limitations of this study, the bone-supported stackable surgical guide protocol proved to be a highly accurate method for full-arch rehabilitation. By eliminating mucosal resilience and ensuring rigid fixation, this approach enables predictable implant placement and facilitates the passive fit of screw-retained bar-supported prostheses, representing a reliable alternative to dynamic navigation in daily clinical practice. Full article