59 Results Found

Ischemia/reperfusion injury (IRI) is a common damage due to the restoration of blood flow following an ischemic injury. Its pathogenesis is mainly linked to the production of reactive oxygen species (ROS), which sustain cell damage and promote cell d...

Pollen, the male gametophyte of seed plants, is extremely sensitive to UV light, which may prevent fertilization. As a result, strategies to improve plant resistance to solar ultraviolet (UV) radiation are required. The tardigrade damage suppressor p...

The genome sequencing of the tardigrade Ramazzottius varieornatus revealed a unique nucleosome-binding protein named damage suppressor (Dsup), which was discovered to be crucial for the extraordinary abilities of tardigrades in surviving extreme stre...

The Ramazzottius varieornatus tardigrade is an extremotolerant terrestrial invertebrate with a length of 0.1–1.0 mm. These small animals show an extraordinary tolerance to extreme conditions such as high pressure, irradiation, chemicals and dehydrati...

Tardigrades, also known as “water bears”, are microscopic invertebrates capable of surviving extreme conditions, including extreme temperatures, intense radiation, and the vacuum of space. Recent studies have unveiled a novel nucleosome-b...

Genomic DNA stores all genetic information and is indispensable for maintenance of normal cellular activity and propagation. Radiation causes severe DNA lesions, including double-strand breaks, and leads to genome instability and even lethality. Rega...

Microalgae-mediated nanoparticle (NP) biosynthesis is a promising green synthesis method that overcomes the challenges of conventional synthesis methods. The novel Desmochloris edaphica strain CCAP 6006/5 was isolated, purified, and characterized mor...

The existence of fractures has a significant influence on the mechanical properties of a rock mass. The sensitivity of the rock mass’s mechanical properties to the fracture’s geometric parameters is conducive to improving the measurement...

The flat-joint model, which constructs round particles as polygons, can suppress rotation after breakage between particles and simulate more larger compression and tension ratios than the linear parallel-bond model. The flat-joint contact model was c...

To study the surrounding rock stability of the excavated geologically weak section of the #2 diversion tunnel in the Xulong Hydropower Station, a quasi-3D numerical model was built using the Realistic Failure Process Analysis (RFPA^3D) system to simul...

Rainfall infiltration is the primary factor that induces landslides. In this paper, discrete element software (PFC^3D) was used to establish a novel rainfall infiltration model, which integrates water transfer, intensity decay and seepage force into t...

The surface deformation caused by underground mining seriously affects the normal life and personal safety of local residents and also causes unfavorable factors for the safe and efficient exploitation of underground resources. While the study of sur...

This research aims to investigate the impact of high-pressure water jet cutting parameters on pressure alleviation around the coal slot. A numerical model of high-pressure water jet cutting coal was developed using FLAC^3D software, allowing for a det...

Pancreatic ductal adenocarcinoma (PDAC) can originate from acinar-to-ductal metaplasia (ADM). Pancreatic acini harboring oncogenic Kras mutations are transdifferentiated to a duct-like phenotype that further progresses to become pancreatic intraepith...

Slit2 expression is downregulated in various cancers, including lung cancer. We identified two Slit2 splicing variants at exon15—Slit2-WT and Slit2-ΔE15. In the RT-PCR analyses, the Slit2-WT isoform was predominantly expressed in all the...

The subsea tunnel of Qingdao metro line 1 has been excavated using the drill and blast method. Blasting vibration during tunneling may cause larger water inflow and even severe security risks and considerable economic losses. However, the prediction...

The analysis of crosscut stability is an indispensable task in underground mining activities. Crosscut instabilities usually cause geological disasters and delay of the project. On site, mining engineers analyze and predict the crosscut condition by...

Rice is an important food crop extensively cultivated worldwide, and rice’s grain yield should be improved to meet future food demand. Grain number per panicle is the main trait that determines the grain yield in rice, and other panicle-related...

In recent years, researchers have been making a persistent effort to discover innovative and appropriate oxide materials that can be exploited in optoelectronics devices. The primary objective of this research is to study the effect of Na/Mg co-dopin...

Colchicum luteum L. is an economically important and endangered medicinal plant of the Kashmir Himalaya. The corm extract is used for the treatment of rheumatism, gout, Behcet’s syndrome, and Alzheimer disease. It is also used extensively in pl...

A comparison of d² law and penetration length of biofuels with Jet–A through the incorporation of fuel properties and actual combustor inlet data at various flight trajectories is presented. This study aims to identify fuel properties and flight oper...

Deformation failure and support methods of roadways have always been critical issues in mining production and safety, especially for roadways buried in complex engineering geological conditions. To resolve these support issues of kilometer-depth road...

Pancreatic ductal adenocarcinoma (PDAC) is well known for its high death rate due to prompt cancer metastasis caused by cancer cell migration and invasion within the early stages of its development. Here, we reveal a new function of cytokine CCL15, n...

The stability of the embankment’s slopes is a critical aspect of geotechnical engineering and it is essential to guarantee the effectiveness of the factor of safety to prevent any potential failures in the slope both during and post-constructio...

Underground stope stability has important implications for the safety and efficiency of metal mining, especially when there are subsidence zones above. To analyze the stope stability around the subsidence area of the Hongling ore body, this paper inn...

Pre-existing cracks significantly influence the macro-mechanical properties of rock. The macro-mechanical properties and crack propagation process of brittle materials with a 3D internal crack were investigated with PFC^3D simulation in this paper. To...

In order to consider the effect of fabric anisotropy in the analysis of geotechnical boundary value problems, this study proposes a modified model based on a fabric-based modified Cam-clay model, which can account for the anisotropic response of soil...

The vibration waves generated by pressure fluctuations can substantially impair and jeopardize the structural integrity of roadway anchorage within adjacent rock formations, thereby presenting a significant risk to the safety and operational efficien...

Fault fracture zones, characterized by high weathering, low strength, and a high degree of fragmentation, are common adverse geological phenomena encountered in tunneling projects. This paper performed a series of large-scale triaxial compression tes...

Group 11 metals form with pyrazolate ligand complexes with a general formula of [MPz]_n. The value of “n” varies depending on the type of substituent in the ligand and the metal atom. Copper(I) and silver(I) ions mainly form cyclic di-, tr...

This study investigates the micro-mechanical behavior of mortar under uniaxial compression using a three-phase model in PFC^3D. By simulating mortar as a composite of cement, sand, and the interfacial transition zone (ITZ), the research examines the i...

To investigate the mechanical response characteristics of damming rockfill materials under different confining pressure conditions, this study integrates laboratory triaxial compression tests and PFC^2D numerical simulations to systematically analyze...

To explore the effect of hob temperature on the rock-breaking characteristics of full-section tunnel boring machines (TBMs) in sandstone strata, high-temperature furnace heating experiments of sandstone and physical and mechanical experiments at room...

The development of effective inhibitors targeting the Kirsten rat sarcoma viral proto-oncogene (KRAS^G12D) mutation, a prevalent oncogenic driver in cancer, represents a significant unmet need in precision medicine. In this study, an integrated comput...

The study presents a novel meshed horizontal–vertical (H–V) geogrid, offering promising advancements in geotechnical structure performance. The study pioneers a modeling approach for H–V geogrid foundation bearing capacity with disc...

Due to the thin bedrock, typical geological characteristics, and the high-intensity underground mining in western China, the water and sand inrush pour into the panels through the broken rock fragmentations in the caving zone, which could result in s...

The availability of accurate models capturing the realistic behaviour of complex systems is critical for the safe operation and optimal management of nuclear installations. However, the dynamic nature of such systems and the resulting dense network o...

The construction of tunnels excavated by the conventional method in densely populated urban environments requires an adequate characterization of the loads acting on the primary lining during the excavation process, to ensure that the ground is defor...

Horizontal well cavern completion and stress release is considered a potential technique for efficient development of coalbed methane in tectonically deformed coal (TDC). Pulsating loading and unloading is a key technique for the controlled expansion...

The mechanical properties of rock can be weakened under the influence of high temperatures. To describe the mechanical behavior of rock under the action of high temperature more accurately, based on the Zienkiewicz–Pande yield criterion, the da...

Internal erosion involves migration and loss of soil particles due to seepage. The process of fluid–solid interaction is a complex multiphase, coupled nonlinear dynamic problem. In this study, we used Particle Flow Code (PFC^3D, three-dimensiona...

Data-driven intelligent transportation systems (D²ITSs) have drawn significant attention lately. This work investigates a novel multi-agent-based data-driven distributed adaptive cooperative control (MA-DD-DACC) method for multi-direction queuing str...

The distribution of in situ stress fields in reservoirs is critical for the accurate exploration and efficient exploitation of hydrocarbon resources, especially in deep, fault-developed strata where tectonic activities significantly complicate stress...

The instability of mine roadways is significantly influenced by the coupled effects of groundwater seepage and non-uniform loading. These interactions often induce localized plastic deformation and progressive failure, particularly in the roof and si...

Cyclical footage, a fundamental parameter in tunnel construction, has received limited attention despite its critical role in ensuring excavation stability and safety. To investigate the underlying mechanisms by which different cyclical footage value...

This study investigated the freeze–thaw resistance of ordinary and nano-TiO₂-modified concrete (NTC) based on mass loss, ultrasonic velocity, compressive strength, and fracture toughness. The compressive behavior and internal damage evolution w...

Fujian Tulou, a UNESCO World Heritage Site, is highly vulnerable to environmental and anthropogenic stresses, with its earthen walls prone to surface cracking that threatens both structural stability and cultural value. Traditional manual inspection...

In order to investigate the compression damage characteristics of the “interface section coal pillar–backfill body (ICPF)” composite structure formed after coal pillar excavation and gangue material backfill in the key technologies...

The shear and particle crushing characteristics of the failure plane (or shear surface) in catastrophic mass movements are examined with a ring shear apparatus, which is generally employed owing to its suitability for large deformations. Based on res...

In recent decades, many studies on the treatment and prevention of pancreatic cancer have been conducted. However, pancreatic cancer remains incurable, with a high mortality rate. Although mouse models have been widely used for preclinical pancreatic...