Search Results (16,644)

Osseointegration is the direct contact between living bone and a dental implant, with supporting evidence confirming the direct connection between bone and titanium, found using an electron microscope. However, the fundamental mechanisms and interconnections between the bone and titanium are not clearly understood. At present, osteoimmunology explores the interaction between bone and immune cells not only in the medical field but also in dentistry. Immunology in bone cell formation has long been a research topic; however, interest in these effects has recently surged. Through subsequent studies, osteoimmune reaction occurs in response to dental implant insertion into the bone and this mechanism portrays more accurate tissue response compared to the traditional term osseointegration. Additionally, osseointegration is a foreign body defense mechanism to protect the implant when bone forms at the contact surface between the dental implant and the alveolar bone. The term “osteoimmunology” refers to the relationship between the immune system and bone tissues. Understanding osteoimmunologic concepts may enable the development of immunomodulatory strategies to improve, maintain, and ultimately restore osseointegration. In order for biocompatible materials such as dental implants to settle and be maintained in the body, it is necessary to understand the complex interrelationships of the bone immune environment, which will enable the development of biomaterials that are more favorable to osteoimmune environments. Therefore, this review presents previous insights into cellular and molecular interactions between bone and the immune system, specifies the roles of T-regulatory cells (Tregs) and macrophages, and demonstrates their potential for translational applications worldwide. Full article

Background: Topical application within peri-implant pockets ensures high drug concentrations at the infection site while minimizing systemic exposure. However, the comparative effectiveness of non-surgical causal therapy alone versus its combination with doxycycline remains unclear. This retrospective observational clinical study aimed to evaluate the impact of adjunctive doxycycline on peri-implant parameters, considering smoking, systemic conditions, and implant–prosthetic rehabilitation (single implant, implant-supported bridge, or full-arch). Methods: Patients were retrospectively assigned to a control group (CG), receiving non-surgical causal therapy alone, or a test group (TG), which is also treated with topical doxycycline. Peri-implant parameters, including Peri-implant Probing Depht (PPD), Bleeding on Probing (BoP), Plaque Index (PI), and suppuration, were assessed at baseline (T0) and follow-up (T1). Multivariate logistic regression and stratified subgroup analyses were conducted to adjust for confounders such as smoking, systemic conditions, and implant–prosthetic rehabilitation types. Results: Two hundred nine patients were included in the study, of whom 97 were in the CG and 112 were in the TG. At T1, the TG exhibited a statistically significant reduction in PPD, BoP, PI, and suppuration compared to the CG (p < 0.05). Conclusions: The adjunctive use of topical doxycycline significantly enhances clinical outcomes in non-surgical peri-implantitis treatment. Further longitudinal studies are needed to confirm these findings and assess long-term stability. Full article

The rapid development of wearable electronics requires multifunctional, transient electronic devices to reduce the ecological footprint and ensure data security. Unfortunately, existing transient electronic materials need to be degraded in chemical solvents or body fluids. Here, we report green luminescent, water-soluble, and biocompatible piezoelectric nanofibers developed by electrospinning green carbon quantum dots (G-CQDs), mulberry silk fibroin (SF), and polyvinyl alcohol (PVA). The introduction of G-CQDs significantly enhances the piezoelectric output of silk fibroin-based fiber materials. Meanwhile, the silk fibroin-based hybrid fibers maintain the photoluminescent response of G-CQDs without sacrificing valuable biocompatibility. Notably, the piezoelectric output of a G-CQD/PVA/SF fiber-based nanogenerator is more than three times higher than that of a PVA/SF fiber-based nanogenerator. This is one of the highest levels of state-of-the-art piezoelectric devices based on biological organic materials. As a proof of concept, in the actual scenario of a rope skipping exercise, the G-CQD/PVA/SF fiber-based nanogenerator is further employed as a self-powered wearable sensor for real-time sensing of athletic motions. It demonstrates high portability, good flexibility, and stable piezoresponse for smart sports applications. This class of water-disposable, piezo/photoactive biological materials could be compelling building blocks for applications in a new generation of versatile, transient, wearable/implantable devices. Full article

Background/Objectives:Accurate implant impressions are critical for capturing the three-dimensional (3D) spatial positioning of implants. Digital workflows using intraoral scanners (IOSs) and scan bodies offer distinct advantages over conventional elastomeric techniques. However, the geometry of scan bodies may influence the precision and trueness of IOS-acquired data, and optimal design parameters remain undefined. This systematic review aims to evaluate the effects of scan body geometry on the trueness of digital implant impressions captured using IOSs. Methods: A systematic search was conducted across PubMed, Scopus, EMBASE, Web of Science, the Cochrane Library, and Google Scholar up to 25 February 2025. Eligible studies assessed the impact of scan body geometry on the accuracy of implant-level impressions acquired with IOSs. Study quality was assessed using the Quality Assessment Tool for In Vitro Studies of Dental Materials (QUIN). Results: Twenty-eight studies were included, of which twenty-six were in vitro. The included studies, published between 2020 and 2025, demonstrated that variations in macro- and micro-geometries influenced both linear and angular trueness. Cylindrical designs with optimal dimensions generally outperformed cuboidal or spherical forms. Structural modifications, such as rigid bar extensions and surface facets, often improved scan accuracy. Some hybrid or modified designs performed comparably to conventional scan bodies. According to QUIN, 27 studies were moderate quality and one had high quality. Conclusions: Scan body geometry affected the accuracy of intraoral implant digital impressions. Designs featuring rigid extensions or simplified geometries improve trueness and precision. Further standardized clinical studies are needed to define optimal design features and validate current in vitro findings. Full article

Purpose: To evaluate the clinical and histological outcomes of patients that receive implant-supported crowns after vacuum plasma surface treatment (VPST) of biomaterials used in socket preservation (SP) and guided bone regeneration (GBR). Materials and methods: This study was designed as a case series. Patients in need of tooth extraction and socket preservation or guided bone regeneration were enrolled. The socket preservation technique was performed after tooth extraction using a heterologous collagen bone graft and a collagen xenomatrix, both activated with vacuum plasma. Meanwhile, a two-stage horizontal ridge augmentation was performed using a customized titanium mesh and a mix of autologous (untreated) and heterologous (treated) bone grafts, along with a treated collagen membrane. ACTILINK Reborn with Universal Vortex Holder (Plasmapp Co., Ltd., Daejeon, Republic of Korea) was used to treat all biomaterials. The outcome measures were implant and prosthesis failures, complications, and histological examination. Soft and hard tissue samples were collected at the time of implant placement only in patients treated with SP. Results: A total of six patients were treated—three with socket preservation and delayed implant placement, and three with staged GBR. No implant or prosthesis failed. One customized titanium mesh broke after plasma treatment, requiring replacement with a pericardium membrane. No other complications occurred. Histological analysis at three months post-surgery revealed well-vascularized newly formed bone at different stages of maturation with integrated bone graft particles, while the soft tissue appeared to be physiologically structured. Conclusion: VPST may enhance the hydrophilicity of biomaterials, supporting favorable healing outcomes in SP and GBR. Further randomized controlled trials with appropriate sample size calculations are needed to confirm these preliminary results. Full article

Background/Objectives: Congenital rubella syndrome (CRS) is an infection caused by rubella virus transmitted to the fetus during pregnancy, which can cause congenital hearing loss. Cochlear implant can be an effective therapy in patients with severe to profound bilateral hearing loss. The aim of this study was to evaluate the benefits of cochlear implantation in patients with profound hearing loss caused by congenital rubella syndrome. Methods: In total, 38 patients with profound hearing loss caused by intrauterine rubella virus infection were considered for cochlear implantation. Patients ranged in age from 8 to 72 years on the day of surgery, with a mean age of 27 years and median of 25 years (SD = 13.2). Preoperatively, all patients underwent pure-tone audiometry, and free-field speech audiometry was conducted in a quiet environment with the patient wearing a fitted hearing aid. Postoperatively, patients underwent pure-tone audiometry to assess residual hearing, and free-field speech audiometry was conducted when the patients had an active implant. Results: The average preoperative hearing threshold (averaged across the seven frequencies from 0.125 to 8 kHz) was 99.2 dB HL (SD = 6.79), while the average postoperative hearing threshold was 103.4 dB HL (SD = 5.74). Twelve months after the operation, patients achieved a WRS in quiet scores ranging from 10% to 90%, with an average of 59.1% and median of 70% (SD = 25.8). Conclusions: Rubella during pregnancy can lead to severe congenital defects, with sensorineural hearing loss being the most common. Cochlear implants appear to be an effective treatment for profound hearing loss caused by congenital rubella syndrome. Full article

This study introduces a novel and versatile application of neural networks (NNs) to enhance two distinct aspects of Wireless Power Transfer (WPT) systems. First, a compact NN architecture is presented for accurate distance estimation and automated impedance matching in a WPT system. Trained on either impedance measurements or scattering parameters acquired from the transmitter side, this NN effectively predicts the inter-coil distance and identifies optimal capacitance values for maximizing power transfer. Validation using both simulated and experimental data demonstrates consistently low prediction error rates. Second, a separate NN is employed to predict the optimal transmission frequency for minimizing the phase angle between voltage and current, thereby maximizing the power factor. This NN, validated on experimental data spanning various load conditions and inter-coil distances, achieves performance comparable to traditional PI control, but with significantly faster prediction speeds. This speed advantage is crucial for real-time applications and directly contributes to improved power efficiency. The results presented in this study, including the high accuracy of distance and capacitance prediction and the rapid determination of optimal frequencies for power factor maximization, showcase the significant potential of NNs for optimizing WPT systems. These findings open the way for more efficient, adaptable, and intelligent wireless energy transfer solutions, with potential applications ranging from dynamic charging of electric vehicles to real-time optimization of implantable medical devices. Full article

Background: Prior studies suggest that patients’ body composition changes following transjugular intrahepatic portosystemic shunt (TIPS) implantation, potentially influencing complications and survival. Method: A prototype artificial intelligence (AI)-based, automated computed tomography (CT) body composition analysis tool was used to assess body composition imaging parameters in pre- and postinterventional scans of TIPS patients: visceral (VAT) and subcutaneous adipose tissue (SAT) areas, psoas muscle area (PMA), and total abdominal muscle area (TAMA). Sarcopenia was defined as a lumbar skeletal muscle index (LSMI) ≤ 38.5 cm²/m² in women and ≤52.4 cm²/m² in men. We analyzed longitudinal changes in body composition and investigated the impact of sarcopenia at TIPS implantation on the risk of TIPS thrombosis, hepatic encephalopathy, complications, and death using Cox regression models. Results: No clear trend emerged regarding changes in body composition parameters during postinterventional follow-up. Sarcopenia at TIPS implantation increased the instantaneous risk of postinterventional complications (hazard ratio (HR) 1.67; 95% confidence interval (CI) 0.95–2.93), development of hepatic encephalopathy (HR 1.65; 0.81–3.33), as well as the risk of dying within one year (HR 1.39; 0.66–2.92). Conclusions: CT body composition analysis may help in identifying high-risk patients undergoing TIPS implantation. Sarcopenia was associated with increased mortality and a higher incidence of postinterventional complications, particularly hepatic encephalopathy. Full article

Three-dimensional (3D) printing has gained substantial interest among scientists and surgeons over the past decade due to its broad potential in medical applications. Its clinical utility has been increasingly recognized, demonstrating promising outcomes for patient care. Currently, 3D printing technology enables surgeons to enhance operative precision by facilitating the creation of patient-specific anatomical models, customized implants, biological tissues, and even surgical instruments. This personalization contributes to improved surgical outcomes, reduced operative times, and shorter postoperative recovery periods. Furthermore, 3D printing significantly aids in the customization of prostheses to conform closely to individual anatomical structures. Beyond therapeutic applications, 3D printing serves as a valuable educational tool in medical training. It enhances case-specific visualization, elucidates fracture mechanisms, and provides tangible models for simulation-based practice. Although the use of 3D printing might be seen as useful mostly in orthopedics, it has expanded into multiple medical specialties, including plastic surgery, dentistry, and emergency medicine. Presently, 3D-printed constructs are routinely employed for preoperative planning, prosthetic development, fracture management, and the fabrication of patient-specific surgical tools. Futuristically, the integration of 3D printing into clinical practice is expected to play a pivotal role in the advancement of personalized medicine, offering substantial benefits for both healthcare providers and patients. Full article

The aim of this study was to evaluate the effect of suture material made of polyester (PET), polypropylene (PP), and polytetrafluoroethylene (PTFE) on the calcification of a bovine pericardium (BP) consisting of collagen biopolymer preserved with an epoxy compound. Non-porous film made of the synthetic reinforced polymer REPEREN^® was chosen as a control material. Samples of the material (sutured or non-sutured with each of the three types of surgical sutures) were implanted subcutaneously in 45 young rats for 30, 60, and 90 days. The calcium content of the explants was quantified using atomic absorption spectrometry, a histological examination was performed using hematoxylin and eosin and von Kossa staining, and the structure of the calcium phosphate deposits was studied using scanning electron microscopy (SEM) and energy dispersive spectrometry (EDS) with color field mapping. The results demonstrated the absence of calcification in the non-sutured BP and in all the REPEREN^® groups. In the sutured BP samples, a dynamic increase in the Ca content and the Ca/P ratio to 1.67–1.7 (crystalline hydroxyapatite) was observed by the 90th day. The minimum Ca content among the sutured BP groups was detected in samples where the PET thread was used. The cellular reaction to BP was significantly more pronounced than the reaction to REPEREN^® throughout the entire observation period; collagen homogenization was noted near the sutures. It can be concluded that all the studied suture materials provoke BP calcification. PET has the minimal negative effect. Full article

Biomaterials and biomedical devices interact with the human body at different levels. At one end of the spectrum, medical devices in contact with tissue pose risks depending on whether they are deployed on the skin or implanted. On the other hand, food packaging and associated material technologies must also be biocompatible to prevent the transfer of harmful molecules and contamination of food, which could impact human health. These seemingly unlinked domains converge into a shared need for the elaboration of new laboratory evaluation protocols that consider recent advances in biomaterials and biodevices, coupled with increasing legal restrictions on the use of animal models. Here, we aim to select and prescribe physiologically relevant microenvironment conditions for biocompatibility testing of novel biomaterials and biodevices. Our discussion spans (1) the development of testing protocols according to material classes, (2) current legislation and standards, and (3) the preparation of biomimetic setups that replicate the microenvironment, with a focus on the multidisciplinary dimension of such studies. Testing spans several characterization domains, beginning with chemical properties, followed by mechanical integrity and, finally, biological response. Biomimetic testing conditions typically include temperature fluctuations, humidity, mechanical stress and loading, exposure to body fluids, and interaction with multifaceted biological systems. Full article

Background and Objectives: This study aimed to evaluate marginal bone level (MBL) changes in implant-supported rehabilitation based on patient demographics, implant location, transmucosal abutment height, and crown emergence profile. Materials and Methods: A total of 50 patients (28 females and 22 males), with 111 implant–abutment (IA) sets, were analyzed. The mean age was 65.2 ± 10.9 years (range: 33–81). Implants were placed in the maxilla (68.5%) and mandible (31.5%), with an average evaluation period of 12.7 ± 4.1 months. MBL changes at mesial (MBLm) and distal (MBLd) sites were recorded and analyzed based on sex, age, implant location, abutment transmucosal height, and crown emergence profile. Statistical comparisons were performed using Bonferroni’s multiple comparison test and one-way ANOVA with Tukey’s post hoc test. Results: MBL changes did not show significant differences based on sex (p > 0.05) or age group (p > 0.05). However, maxillary implants exhibited greater bone loss than mandibular implants, though this difference was not statistically significant. Transmucosal abutment height (TMh) significantly influenced MBL, with taller abutments (TMh3: −1.07 ± 0.93 mm) showing less bone loss than shorter abutments (TMh1: −2.11 ± 1.82 mm) (p < 0.05). Crown emergence profile also affected MBL, particularly in the distal emergence profile, where design 1 exhibited the least bone loss compared to designs 2 and 3 (p = 0.0176). Conclusions: The study findings suggest that transmucosal abutment height and crown emergence profile significantly influence peri-implant bone stability. Transmucosal abutment height (> 2.5 mm) was associated with reduced bone loss. Further research is recommended to evaluate the long-term effects on peri-implant bone maintenance. Full article

Background and Clinical Significance: Non-prosthetic peri-implant fractures (NPPIFs) are rare injuries occurring around internal fixation devices, and are distinct from periprosthetic fractures. While most studies focus on the femur, humeral NPPIFs remain poorly documented. This case illustrates a complex humeral NPPIF and highlights key surgical considerations. Case Presentation: A 62-year-old woman presented with a spiral humeral shaft fracture (AO 12B2) after a fall. Following closed reduction and antegrade intramedullary nailing, an intraoperative peri-implant fracture occurred at the distal interlocking screw. CT imaging revealed a complex fracture extending from the lateral condyle to the proximal humerus. Treatment included implant removal and open reduction with dual plate fixation—lateral distal and helically contoured proximal plates—plus cerclage bands and antibiotic-loaded beads. Recovery was uneventful, with a full range of motion achieved at six months. At one year, the DASH score and MEPS were 86 and 75, respectively. Conclusions: Humeral NPPIFs are challenging and require individualized, biomechanically sound strategies. This case reinforces the importance of intraoperative assessment and careful implant selection in humeral fracture management. Full article

Background: In this study, we aimed to investigate the association between a patient’s selection of implant treatment for a missing mandibular second molar and the magnitude of occlusal force, masticatory ability, mandibular morphology, and age before treatment intervention. Materials and Methods: We retrospectively assessed occlusal force, masticatory performance, and mandibular morphology in female patients who either selected or declined implant treatment for a missing unilateral mandibular second molar. Results: Thirty-three women (mean age of 56.1 ± 9.7 years) were divided into an implant treatment (IT) group and a no-treatment (NT) group. The IT group showed significantly higher occlusal force (p = 0.021 < 0.05), while masticatory performance and gonial angle demonstrated no significant difference. Conclusion: The IT group had significantly higher occlusal force, and age had no significant effect on it. Notably, masticatory performance in the IT group increased significantly with age (p = 0.047 < 0.05). Full article

Objectives: This study evaluated peripheral nerve stimulation (PNS) as a treatment for vertebra plana fractures, focusing on its impact on pain intensity, physical function, anxiety, depression, fatigue, social role participation, and pain interference. The goal was to assess whether PNS could serve as a minimally invasive alternative for managing pain in patients with severe vertebral fractures. Methods: Four patients with lumbar vertebra plana fractures received PNS implants for 60 days. Pain scores and PROMIS-29 domains (physical function, anxiety, depression, fatigue, social participation, and pain interference) were assessed at 30, 60, 90, 180, and 365 days post-implantation. Data analysis included mean and standard deviation calculations. Results: PNS led to marked improvements in pain-related outcomes. The average pain intensity scores dropped from 8.5 at baseline to 4.25 at one year, and pain interference scores declined from 61.75 to 54.75. Physical function initially decreased but improved from 38.5 at three months to 46.75 at one year. Changes in depression, anxiety, fatigue, and social participation were minimal, reflecting their multifactorial nature and limited response to pain relief alone. Conclusions: This case series suggests that PNS may significantly reduce pain and pain interference while enhancing physical function in patients with vertebra plana fractures. Its sustained benefits highlight PNS as a promising minimally invasive treatment, especially for those ineligible for traditional procedures. However, the limited improvement in psychological and social domains underscores the need for comprehensive care strategies. Further research is warranted to explore the broader role of PNS in managing vertebral fracture pain. Full article