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Clinical Advances in Pain Management
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Clinical Advances in Pain Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Anesthesiology".

Deadline for manuscript submissions: 29 August 2025 | Viewed by 406

Special Issue Editors

Dr. Jamal Hasoon

E-Mail Website
Guest Editor
McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA
Interests: peripheral nerve stimulation; spinal cord stimulation; interventional pain procedures; prescription patterns in pain medicine; practice patterns in pain medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Omar Viswanath

E-Mail Website
Guest Editor
Department of Anesthesiology, Creighton University School of Medicine, Phoenix, AZ, USA
Interests: pain management; acute pain; chronic pain; neuralgia; anesthesiology

Special Issue Information

Dear Colleagues,

Chronic pain remains a global health challenge, affecting millions and significantly impacting quality of life. The field of pain management has seen remarkable advancements in recent years, driven by innovative interventional procedures, emerging pharmacological therapies, and a deeper understanding of the complex mechanisms underlying pain. This Special Issue, Clinical Advances in Pain Management, aims to showcase cutting-edge research and clinical strategies that are shaping the future of pain care.

This Special Issue covers a broad spectrum of cutting-edge topics in pain management. Among them are innovative minimally invasive therapies for conditions like spinal stenosis, advancements in neuromodulation techniques such as spinal cord and peripheral nerve stimulation, and significant breakthroughs in regenerative medicine approaches. This Special Issue also explores the use of ultrasound-guided regional blocks for acute and chronic pain, highlighting their efficacy and growing role in clinical practice. Additionally, it emphasizes evidence-based strategies for pharmacological management, focusing on optimizing opioid use.

With contributions from leading experts in pain medicine, this Special Issue seeks to provide clinicians, researchers, and healthcare professionals with actionable insights and practical updates to enhance patient care. By bridging the gap between research and clinical practice, this compilation emphasizes innovation, safety, and patient-centered approaches to tackling acute and chronic pain.

We invite you to explore these transformative advancements that continue to redefine pain management and improve patient outcomes.

Dr. Jamal Hasoon
Dr. Omar Viswanath
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • postoperative pain
  • acute pain
  • chronic pain
  • nociceptive
  • analgesia
  • analgesics
  • interventional pain procedures

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

13 pages, 870 KiB  
Article
Retrospective Analysis of Cement Extravasation Rates in Vertebroplasty, Kyphoplasty, and Bone Tumor Radiofrequency Ablation
by Soun Sheen, Prit Hasan, Xiaowen Sun, Jian Wang, Claudio Tatsui, Kent Nouri and Saba Javed
J. Clin. Med. 2025, 14(9), 2908; https://doi.org/10.3390/jcm14092908 - 23 Apr 2025
Abstract
Background: Percutaneous vertebral augmentation techniques, including vertebroplasty, kyphoplasty, and bone tumor radiofrequency ablation (BT-RFA), are commonly used to treat painful vertebral compression fractures (VCFs). While generally safe and effective, they carry risks, including cement extravasation, which can lead to pulmonary embolism or spinal [...] Read more.
Background: Percutaneous vertebral augmentation techniques, including vertebroplasty, kyphoplasty, and bone tumor radiofrequency ablation (BT-RFA), are commonly used to treat painful vertebral compression fractures (VCFs). While generally safe and effective, they carry risks, including cement extravasation, which can lead to pulmonary embolism or spinal cord compression. This study aims to compare the rate of cement extravasation across different vertebral augmentation techniques and identify potential risk factors. Methods: A retrospective cohort study was conducted at a comprehensive cancer center on 1002 procedure encounters in 888 patients who underwent vertebral augmentation for painful VCFs. Data were collected on patient demographics, fracture pathology, procedure type, imaging guidance, and pain scores. Intraoperative and postoperative imaging were manually reviewed to assess cement extravasation. Statistical analyses were performed using pairwise comparisons with Tukey’s Honest Significant Difference adjustment to compare cement extravasation rates across the procedure groups and generalized linear mixed models to assess the association between the cement extravasation with other variables. Results: Cement extravasation occurred in 573 (57.2%) encounters. Kyphoplasty had the lowest rate of cement extravasation (46.2%) with significantly lower odds compared to vertebroplasty (OR: 0.42, 95% CI: 0.30–0.58; p < 0.0001) and BT-RFA (OR: 0.57, 95% CI: 0.42–0.77; p = 0.0009). Pathologic fractures and multilevel augmentations were linked to a 64% (p = 0.001) and 63% (p = 0.0003) increased odds of cement extravasation, respectively. Male sex and older age were protective factors. Conclusions: Cement extravasation is a common but largely asymptomatic complication of percutaneous vertebral augmentation. It is crucial to consider patient-specific risk factors when selecting an augmentation technique to optimize outcomes. Kyphoplasty may be the optimal choice for patients at increased risk of cement extravasation. Full article
(This article belongs to the Special Issue Clinical Advances in Pain Management)
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13 pages, 933 KiB  
Article
Trends in Celecoxib Prescribing: A Single Institution 16-Month Review
by Ivo H. Cerda, Helen Jung, Maria C. Guerrero, Rodrigo Diez Tafur, Robert Jason Yong, Christopher L. Robinson and Jamal J. Hasoon
J. Clin. Med. 2025, 14(8), 2823; https://doi.org/10.3390/jcm14082823 - 19 Apr 2025
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Abstract
Background/Objectives: Celecoxib, a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID), is widely prescribed for pain management due to its efficacy and improved gastrointestinal safety profile compared to traditional NSAIDs. Understanding prescription trends and their comparison to other NSAIDs provides valuable insight into prescribing behaviors [...] Read more.
Background/Objectives: Celecoxib, a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID), is widely prescribed for pain management due to its efficacy and improved gastrointestinal safety profile compared to traditional NSAIDs. Understanding prescription trends and their comparison to other NSAIDs provides valuable insight into prescribing behaviors in clinical settings. Methods: This retrospective study analyzed celecoxib prescriptions written by three pain management physicians in a single institution over a 16-month period from 1 January 2023 to 30 April 2024. Prescription data were collected and grouped into four 4-month intervals to assess temporal trends. Additionally, we compared celecoxib prescriptions to other commonly prescribed NSAIDs, including ibuprofen, meloxicam, naproxen, and diclofenac. Results: A total of 143 celecoxib prescriptions were identified during the study period, with a steady increase observed across consecutive intervals: 8 prescriptions from January–April 2023, 22 from May–August 2023, 46 from September–December 2023, and 67 from January–April 2024. In comparison, a total of 165 prescriptions were written for other NSAIDs over the same period, with 26 prescriptions from January–April 2023, 41 from May–August 2023, 45 from September–December 2023, and 53 from January–April 2024. While prescriptions for both celecoxib and other NSAIDs increased over time, the rate of celecoxib prescriptions showed a steeper rise. Conclusions: The findings demonstrate a notable increase in celecoxib prescriptions in this pain management clinic, outpacing the growth of other NSAIDs. This trend may reflect increasing provider preference for COX-2 selective inhibitors due to their favorable safety profile and efficacy. Further research is warranted to explore the underlying factors driving these prescribing patterns. Full article
(This article belongs to the Special Issue Clinical Advances in Pain Management)
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