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Search Results (1,127)

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26 pages, 1226 KB  
Article
A Generative AI–Based Technical Data Extraction Tool for IoT Application Systems
by Dezheng Kong, Nobuo Funabiki, Htoo Htoo Sandi Kyaw, I Nyoman Darma Kotama, Zihao Zhu and Alfiandi Aulia Rahmadani
Sensors 2026, 26(4), 1081; https://doi.org/10.3390/s26041081 (registering DOI) - 7 Feb 2026
Abstract
Nowadays, Internet of Things (IoT) application systems play an essential role in smart cities, industry, healthcare, agriculture, and smart homes. For non-expert users, designing and implementing IoT application systems remains challenging, especially when configuring sensors, edge devices, and server platforms. To support configuration [...] Read more.
Nowadays, Internet of Things (IoT) application systems play an essential role in smart cities, industry, healthcare, agriculture, and smart homes. For non-expert users, designing and implementing IoT application systems remains challenging, especially when configuring sensors, edge devices, and server platforms. To support configuration tasks of IoT application systems, we have developed an AI-based setup assistance tool. However, AI models still fail to reliably support newly released or previously unseen devices, sometimes producing incomplete or erroneous outputs that may lead to configuration failures. Incorporating their technical-document information into Retrieval-Augmented Generation (RAG) is an effective way to supplement AI knowledge and improve reliability. In this paper, we propose a generative AI-based technical data extraction tool to address the challenges. It extracts essential technical information using the schema-based extraction from given PDF or HTML datasheets and converts it into a structured format suitable for AI-supported configurations. A local vector database is used to enable semantic similarity retrieval and provide document-grounded evidence for RAG-based answering, ensuring consistent support for previously unseen IoT devices. For evaluations, we applied the proposal to several sensor and device datasheets and compared extracted specifications with ground-truth values to measure accuracy and completeness. Then, we compared end-to-end configuration QA reliability against a commercial baseline (ChatPDF) using the golden benchmark. The results show that the proposed tool reliably acquires key specifications and significantly improves end-to-end configuration QA reliability. Across 960 golden QA pairs, the proposed method improves Recall from 0.636 to 0.926 and Accuracy from 0.595 to 0.807 compared with ChatPDF. Full article
(This article belongs to the Collection Artificial Intelligence in Sensors Technology)
26 pages, 1691 KB  
Protocol
From Pilot to Practice: Developing a Family-Based Nutrition, Literacy, and Parenting Protocol for the Books & Cooks Education Intervention
by Miranda Badolato, David Diehl, Alicia Papanek, Jeneé Duncan, Karla Shelnutt and Anne Mathews
Future 2026, 4(1), 6; https://doi.org/10.3390/future4010006 - 6 Feb 2026
Abstract
Families with low income are faced with various intertwined public health issues, including low literacy levels and nutrition insecurity. Although numerous studies have detailed effective methodologies for delivering literacy or nutrition education in silos, there is no protocol for developing, implementing, and evaluating [...] Read more.
Families with low income are faced with various intertwined public health issues, including low literacy levels and nutrition insecurity. Although numerous studies have detailed effective methodologies for delivering literacy or nutrition education in silos, there is no protocol for developing, implementing, and evaluating a brief, interdisciplinary literacy and nutrition education program for parent–child dyads. Books & Cooks, a seven-week literacy and nutrition education program aimed at improving families’ literacy and nutrition capacities by providing parents with strategies to assist their child, facilitating interactive education lessons, and providing take-home reflection activities, was piloted during the 2023–2024 school year. Results informed the protocol for current and future cohorts in efforts to further enhance outcomes. Family literacy capacity is addressed using evidence-based, grade-appropriate literacy techniques and evaluated using validated and internally developed instruments. Family nutrition capacity is addressed through education and cooking lessons based on the 2020–2025 Dietary Guidelines and MyPlate and evaluated using validated instruments. Results will be analyzed by assessing change from baseline to post-program completion, addressing potential confounding factors, and utilizing randomization. By detailing the development, implementation, and evaluation of this study, we anticipate that this protocol will provide guidance for cross-functional collaborators who seek to address various public health concerns in at-risk populations. Full article
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26 pages, 2808 KB  
Article
An Automated ECG-PCG Coupling Analysis System with LLM-Assisted Semantic Reporting for Community and Home-Based Cardiac Monitoring
by Yi Tang, Fei Cong, Yi Li and Ping Shi
Algorithms 2026, 19(2), 117; https://doi.org/10.3390/a19020117 - 2 Feb 2026
Viewed by 127
Abstract
Objective: Cardiac monitoring in community and home environments requires automated operation, cross-state robustness, and interpretable feedback under resource-constrained and uncontrolled conditions. Unlike accuracy-driven ECG–PCG studies focusing on diagnostic performance, this work emphasizes systematic modeling of cardiac electromechanical coupling for long-term monitoring and engineering [...] Read more.
Objective: Cardiac monitoring in community and home environments requires automated operation, cross-state robustness, and interpretable feedback under resource-constrained and uncontrolled conditions. Unlike accuracy-driven ECG–PCG studies focusing on diagnostic performance, this work emphasizes systematic modeling of cardiac electromechanical coupling for long-term monitoring and engineering feasibility validation. Methods: An automated ECG–PCG coupling analysis and semantic reporting framework is proposed, covering signal preprocessing, event detection and calibration, multimodal coupling feature construction, and rule-constrained LLM-assisted interpretation. Electrical events from ECG are used as global temporal references, while multi-stage consistency correction mechanisms are introduced to enhance the stability of mechanical event localization under noise and motion interference. A structured electromechanical feature set is constructed to support fully automated processing. Results: Experimental results demonstrate that the proposed system maintains coherent event sequences and stable coupling parameter extraction across resting, movement, and emotional stress conditions. The incorporated LLM module integrates precomputed multimodal metrics under strict constraints, improving report readability and consistency without performing autonomous medical interpretation. Conclusions: This study demonstrates the methodological feasibility of an ECG–PCG coupling analysis framework for long-term cardiac state monitoring in low-resource environments. By integrating end-to-end automation, electromechanical coupling features, and constrained semantic reporting, the proposed system provides an engineering-oriented reference for continuous cardiac monitoring in community and home settings rather than a clinical diagnostic solution. Full article
(This article belongs to the Special Issue Machine Learning in Medical Signal and Image Processing (4th Edition))
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32 pages, 2836 KB  
Article
Towards Trustworthy AI Agents in Geriatric Medicine: A Secure and Assistive Architectural Blueprint
by Elena-Anca Paraschiv, Adrian Victor Vevera, Carmen Elena Cîrnu, Lidia Băjenaru, Andreea Dinu and Gabriel Ioan Prada
Future Internet 2026, 18(2), 75; https://doi.org/10.3390/fi18020075 - 1 Feb 2026
Viewed by 350
Abstract
As artificial intelligence (AI) continues to expand across clinical environments, healthcare is transitioning from static decision-support tools to dynamic, autonomous agents capable of reasoning, coordination, and continuous interaction. In the context of geriatric medicine, a field characterized by multimorbidity, cognitive decline, and the [...] Read more.
As artificial intelligence (AI) continues to expand across clinical environments, healthcare is transitioning from static decision-support tools to dynamic, autonomous agents capable of reasoning, coordination, and continuous interaction. In the context of geriatric medicine, a field characterized by multimorbidity, cognitive decline, and the need for long-term personalized care, this evolution opens new frontiers for delivering adaptive, assistive, and trustworthy digital support. However, the autonomy and interconnectivity of these systems introduce heightened cybersecurity and ethical challenges. This paper presents a Secure Agentic AI Architecture (SAAA) tailored to the unique demands of geriatric healthcare. The architecture is designed around seven layers, grouped into five functional domains (cognitive, coordination, security, oversight, governance) to ensure modularity, interoperability, explainability, and robust protection of sensitive health data. A review of current AI agent implementations highlights limitations in security, transparency, and regulatory alignment, especially in multi-agent clinical settings. The proposed framework is illustrated through a practical use case involving home-based care for elderly patients with chronic conditions, where AI agents manage medication adherence, monitor vital signs, and support clinician communication. The architecture’s flexibility is further demonstrated through its application in perioperative care coordination, underscoring its potential across diverse clinical domains. By embedding trust, accountability, and security into the design of agentic systems, this approach aims to advance the safe and ethical integration of AI into aging-focused healthcare environments. Full article
(This article belongs to the Special Issue Intelligent Agents and Their Application)
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26 pages, 331 KB  
Article
Individuals’ Climate Change and Course of Energy Transition Process Efforts for Local Communities in Rural Poland
by Magdalena Kowalska, Ewa Chomać-Pierzecka, Małgorzata Bogusz, Adam Dąbrowski and Izabella Kęsy
Energies 2026, 19(2), 534; https://doi.org/10.3390/en19020534 - 21 Jan 2026
Viewed by 204
Abstract
It is imperative to continuously monitor public awareness, attitudes, and environmental actions to adjust policy to promote and support transition processes given the ongoing phenomenon of climate change. Insights into poorly investigated domains, such as rural areas, are particularly valuable in this context. [...] Read more.
It is imperative to continuously monitor public awareness, attitudes, and environmental actions to adjust policy to promote and support transition processes given the ongoing phenomenon of climate change. Insights into poorly investigated domains, such as rural areas, are particularly valuable in this context. Responding to this challenge, we aimed to diagnose the efforts in which individuals engage for the benefit of their local communities in rural areas of a selected region of Poland (Małopolskie Voivodeship) in the context of climate change and the energy transition. The study concerns a specific region, one with the most intensive deployment of climate and energy policy in Poland. It is also highly diversified in terms of the environment and population, from the densely urbanised Kraków Metropolitan Area to scattered rural areas where institutional resources are scarce. This diversity affects how local populations engage in climate and energy efforts. The study involves a literature review and an original 2024 survey among 300 people from five rural districts of Małopolskie Voivodeship selected to reflect the region’s diversity. The CAPI (Computer-Assisted Personal Interviewing) survey sample was built with chain referral. The in-depth analyses were performed in IBM SPSS, v.25. We employed statistical analyses, including one-way ANOVA to assess between-group variance, χ2 tests, Sidak tests, and Fisher’s tests. The results show that most respondents recognised an association between energy and climate, but the awareness is fragmented and varied. These conclusions call for amplifying environmental awareness, particularly regarding energy transition. We have also confirmed a significant spatial diversification of environmental attitudes and practices among the public regarding the energy transition. It has been confirmed by all indicators, from the state of the environment to the perceived agency to the structure of home heating systems. Additionally, the importance of local governments in pro-climate activities was indicated. This is particularly important in the context of the ‘Anti-smog resolution for Małopolska’, which has been in force in the Małopolska Province since 2019 and plays a leading role in climate policy in the region. What is particularly important is that the vast majority of respondents from all districts declared their support for these changes, for which local governments are responsible. Full article
(This article belongs to the Collection Energy Transition Towards Carbon Neutrality)
16 pages, 801 KB  
Article
Development of Deep Learning Models for AI-Enhanced Telemedicine in Nursing Home Care
by Nuria Luque-Reigal, Vanesa Cantón-Habas, Manuel Rich-Ruiz, Ginés Sabater-García, Álvaro Cosculluela-Fernández and José Luis Ávila-Jiménez
J. Clin. Med. 2026, 15(2), 828; https://doi.org/10.3390/jcm15020828 - 20 Jan 2026
Viewed by 210
Abstract
Background/Objectives: Acute health events in institutionalized older adults often lead to avoidable hospital referrals, requiring rapid, accurate remote decision-making. Telemedicine has become a key tool to improve assessment and care continuity in nursing homes. This study aimed to evaluate outcomes associated with telemedicine-supported [...] Read more.
Background/Objectives: Acute health events in institutionalized older adults often lead to avoidable hospital referrals, requiring rapid, accurate remote decision-making. Telemedicine has become a key tool to improve assessment and care continuity in nursing homes. This study aimed to evaluate outcomes associated with telemedicine-supported management of acute events in residential care facilities for older adults and to develop a deep learning model to classify episodes and predict hospital referrals. Methods: A quasi-experimental study analyzed 5202 acute events managed via a 24/7 telemedicine system in Vitalia nursing homes (January–October 2024). The dataset included demographics, comorbidities, vital signs, event characteristics, and outcomes. Data preprocessing involved imputation, normalization, encoding, and dimensionality reduction via Truncated SVD (200 components). Given the imbalance in referral outcomes (~10%), several resampling techniques (SMOTE, SMOTEENN, SMOTETomek) were applied. A deep feedforward neural network (256–128–64 units with Batch Normalization, LeakyReLU, Dropout, AdamW) was trained using stratified splits (70/10/20) and optimized via cross-validation. Results: Telemedicine enabled the resolution of approximately 90% of acute events within the residential setting, reducing reliance on emergency services. The deep learning model outperformed traditional algorithms, achieving its best performance with SMOTEENN preprocessing (AUC = 0.91, accuracy = 0.88). The proposed model achieved higher overall performance than baseline classifiers, providing a more balanced precision–specificity trade-off for hospital referral prediction, with an F1-score of 0.63. Conclusions: Telemedicine-enabled acute care, strengthened by a robust deep learning classifier, offers a reliable strategy to enhance triage accuracy, reduce unnecessary transfers, and optimize clinical decision-making in nursing homes. These findings support the integration of AI-assisted telemedicine systems into long-term care workflows. Full article
(This article belongs to the Section Geriatric Medicine)
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24 pages, 2343 KB  
Article
Design and Implementation of a Low-Water-Consumption Robotic System for Cleaning Residential Balcony Glass Walls
by Maria-Alexandra Mielcioiu, Petruţa Petcu, Dumitru Nedelcu, Augustin Semenescu, Narcisa Valter and Ana-Maria Nicolau
Appl. Sci. 2026, 16(2), 945; https://doi.org/10.3390/app16020945 - 16 Jan 2026
Viewed by 155
Abstract
Manual window cleaning in high-rise urban buildings is labor-intensive, risky, and resource-inefficient. This study addresses these challenges by investigating a resource-aware mechatronic architecture through the design, development, and experimental validation of a modular Automated Window Cleaning System (AWCS). Unlike conventional open-loop solutions, the [...] Read more.
Manual window cleaning in high-rise urban buildings is labor-intensive, risky, and resource-inefficient. This study addresses these challenges by investigating a resource-aware mechatronic architecture through the design, development, and experimental validation of a modular Automated Window Cleaning System (AWCS). Unlike conventional open-loop solutions, the AWCS integrates mechanical scrubbing with a closed-loop fluid management system, featuring precise dispensing and vacuum-assisted recovery. The system is governed by a deterministic finite state machine implemented on an ESP32 microcontroller, enabling low-latency IoT connectivity and autonomous operation. Two implementation variants—integrated and retrofit—were validated to ensure structural adaptability. Experimental results across 30 cycles demonstrate a cleaning efficiency of ~2 min/m2, a water consumption of <150 mL/m2 (representing a >95% reduction compared to manual methods), and an optical cleaning efficacy of 96.9% ± 1.4%. Safety protocols were substantiated through a calculated mechanical safety factor of 6.12 for retrofit applications. This research establishes the AWCS as a sustainable, safe, and scalable solution for autonomous building maintenance, contributing to the advancement of resource-circular domestic robotics and smart home automation. Full article
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13 pages, 950 KB  
Article
Sensory Reinforcement Feedback Using Movement-Controlled Smartphone App Facilitates Movement in Infants with Neurodevelopmental Disorders: A Pilot Study
by Anina Ritterband-Rosenbaum, Jens Bo Nielsen and Mikkel Damgaard Justiniano
Sensors 2026, 26(2), 554; https://doi.org/10.3390/s26020554 - 14 Jan 2026
Viewed by 227
Abstract
New wearable technology opens new possibilities for low-cost, easily accessible home-based interventions as a supplement to typical clinical rehabilitation therapy. In this pilot study, we tested a new interactive adjustable Feedback training system on 14 infants at high risk of cerebral palsy between [...] Read more.
New wearable technology opens new possibilities for low-cost, easily accessible home-based interventions as a supplement to typical clinical rehabilitation therapy. In this pilot study, we tested a new interactive adjustable Feedback training system on 14 infants at high risk of cerebral palsy between 2 and 12 months of age to facilitate increased movements. The system consists of four wireless motion sensors placed on the infant’s limbs. Inertial sensors track the infant’s movements which control auditory and visual stimuli that act as motivational feedback. A 15 min usage of the Feedback training system four days a week for approximately six months was aimed for. None of the participants reached the recommended amount of intervention, due to time limitations. Seven of the twelve participating infants (58%) achieved at least 50% of the recommended training amount. Parents found the Feedback training system easy to use with minimal need for technical assistance. Preliminary data suggest that infants engaged more actively during training sessions where their movements actively controlled the presentation of the stimuli. The Feedback training system is promising as a user-friendly add-on to the playful and interactive stimulation of motor and cognitive development in infants with neurodevelopmental disorders. Full article
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32 pages, 946 KB  
Review
Paper-Based Microfluidic Chips for At-Home Point-of-Care Nucleic Acid Testing: Applications and Challenges
by Hao Liu, Yuhan Jia, Yitong Jiang, You Nie and Rongzhang Hao
Diagnostics 2026, 16(2), 251; https://doi.org/10.3390/diagnostics16020251 - 13 Jan 2026
Viewed by 447
Abstract
Along with the growing demands for personalized medicine and public health surveillance, diagnostic technologies capable of rapid and accurate pathogen nucleic acid testing in home settings are becoming increasingly crucial. Paper-based microfluidic chips (μPADs) have emerged as a potential core platform for enabling [...] Read more.
Along with the growing demands for personalized medicine and public health surveillance, diagnostic technologies capable of rapid and accurate pathogen nucleic acid testing in home settings are becoming increasingly crucial. Paper-based microfluidic chips (μPADs) have emerged as a potential core platform for enabling molecular testing at home, owing to their advantages of low cost, portability, and independence from complex instrumentation. However, significant challenges remain in the current μPADs systems regarding nucleic acid extraction efficiency, isothermal amplification stability, and signal readout standardization, which hinder their practical and large-scale application. This review systematically summarizes recent research progress in μPADs for home-based nucleic acid testing from four key aspects: extraction–amplification–detection system integration, with a particular focus on the synergistic effects and development trends of critical technologies such as material engineering, fluid control, signal transduction, and intelligent readout. We further analyze typical application cases of this technology in the rapid screening of infectious disease. Promising optimization pathways are proposed, focusing on standardized manufacturing, cold-chain-independent storage, and AI-assisted result interpretation, aiming to provide a feasible framework and forward-looking perspectives for constructing home-based molecular diagnostic systems. Full article
(This article belongs to the Special Issue Point-of-Care Testing (POCT) for Infectious Diseases)
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18 pages, 3673 KB  
Article
Design and Preliminary Evaluation of an Electrically Actuated Exoskeleton Glove for Hand Rehabilitation in Early-Stage Osteoarthritis
by Dana Fraij, Dima Abdul-Ghani, Batoul Dakroub and Hussein A. Abdullah
Actuators 2026, 15(1), 42; https://doi.org/10.3390/act15010042 - 7 Jan 2026
Viewed by 368
Abstract
Osteoarthritis (OA) is a progressive musculoskeletal disorder that affects not only older adults but also younger populations, often leading to chronic pain, joint stiffness, functional impairment, and a decline in quality of life. Non-invasive physical rehabilitation plays a critical role in slowing disease [...] Read more.
Osteoarthritis (OA) is a progressive musculoskeletal disorder that affects not only older adults but also younger populations, often leading to chronic pain, joint stiffness, functional impairment, and a decline in quality of life. Non-invasive physical rehabilitation plays a critical role in slowing disease progression, alleviating symptoms, and maintaining joint mobility. However, rehabilitation tools such as compression gloves and manual exercise aids are typically passive and provide minimal real-time feedback to patients or clinicians. Others, such as exoskeletons and soft-actuated devices, can be costly or complex to use. This study presents the design and development of an electrically actuated glove integrated with force and flex sensors, intended to assist individuals diagnosed with Stage 2 OA in performing guided finger exercises. The system integrates a digital front-end application that offers real-time feedback and data visualization, enabling more personalized and trackable therapy sessions for both patients and healthcare providers. Preliminary results from an initial human trial with healthy participants demonstrate that the glove enables naturalistic movement without imposing excessive restriction or augmentation of motion. These findings support the glove’s potential in preserving hand coordination and dexterity, key objectives in early-stage OA intervention, and suggest its suitability for integration into home-based or clinical rehabilitation protocols. Full article
(This article belongs to the Section Actuators for Robotics)
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24 pages, 1128 KB  
Article
The Role of Telemedicine Centers and Digital Health Applications in Home Care: Challenges and Opportunities for Family Caregivers
by Kevin-Justin Schwedler, Jan Ehlers, Thomas Ostermann and Gregor Hohenberg
Healthcare 2026, 14(1), 136; https://doi.org/10.3390/healthcare14010136 - 5 Jan 2026
Viewed by 440
Abstract
Background/Objectives: Home care plays a crucial role in contemporary healthcare systems, particularly in the long-term care of people with chronic and progressive illnesses. Family caregivers often experience substantial physical, emotional, and organizational burden. Telemedicine and digital health applications have the potential to support [...] Read more.
Background/Objectives: Home care plays a crucial role in contemporary healthcare systems, particularly in the long-term care of people with chronic and progressive illnesses. Family caregivers often experience substantial physical, emotional, and organizational burden. Telemedicine and digital health applications have the potential to support home care by improving health monitoring, communication, and care coordination. However, their use among family caregivers remains inconsistent, and little is known about how organizational support structures such as telemedicine centers influence acceptance and everyday use. This study aims to examine the benefits of telemedicine in home care and to evaluate the role of telemedicine centers as supportive infrastructures for family caregivers. Methods: A mixed-methods design was applied. Quantitative data were collected through an online survey of 58 family caregivers to assess the use of telemedicine and digital health applications, perceived benefits, barriers, and support needs. This was complemented by an in-depth qualitative case study exploring everyday caregiving experiences with telemedicine technologies and telemedicine center support. A systematic literature review informed the theoretical framework and the development of the empirical instruments. Results: Most respondents reported not using telemedicine or digital health applications in home care. Among users, telemedicine was associated with perceived improvements in quality of care, particularly through enhanced health monitoring, improved communication with healthcare professionals, and increased feelings of safety and control. Key barriers to adoption included technical complexity, data protection concerns, and limited digital literacy. Both quantitative findings and the qualitative case study highlighted the importance of structured support. Telemedicine centers were perceived as highly beneficial, providing technical assistance, training, coordination, and ongoing guidance that facilitated technology acceptance and sustained use. Conclusions: Telemedicine and digital health applications can meaningfully support home care and reduce caregiver burden when they are embedded in supportive socio-technical structures. Telemedicine centers can function as central points of contact that enhance usability, trust, and continuity of care. The findings suggest that successful implementation of telemedicine in home care requires not only technological solutions but also accessible organizational support and targeted training for family caregivers. Full article
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20 pages, 2067 KB  
Article
Modeling the Dynamics of Electric Field-Assisted Local Functionalization in Two-Dimensional Materials
by Fernando Borrás, Julio Ramiro-Bargueño, Óscar Casanova-Carvajal, Alicia de Andrés, Sergio J. Quesada and Ángel Luis Álvarez
Materials 2026, 19(1), 204; https://doi.org/10.3390/ma19010204 - 5 Jan 2026
Viewed by 363
Abstract
Electric field-assisted local functionalization of materials is a resist-free technique generally applied at the nanoscale, which has been understood within the paradigm of the water meniscus. Using a home-made prototype the authors applied this technique at scales compatible with the biosensor industry (tens [...] Read more.
Electric field-assisted local functionalization of materials is a resist-free technique generally applied at the nanoscale, which has been understood within the paradigm of the water meniscus. Using a home-made prototype the authors applied this technique at scales compatible with the biosensor industry (tens of microns). However, interpreting these results requires a different paradigm. The expansion of the oxidized region over time in two-dimensional materials under a localized electric field is modeled from first physical principles. Boltzmann statistics is applied to the oxyanion incorporation at the perimeter of the oxidized zone, and a new general relation between oxide radius and time is formulated. It includes the reduction in the energy barrier due to the field effect and its dependence on the oxide radius. To gain insight into this dependence whatever the layers structure, 2D material involved, or electrical operating conditions, simple structures based on multilayer stacks representing the main constituents are proposed, where the Poisson equation is solved using finite element calculations. This enables to derive energy barriers for oxyanion incorporation at varying spot radii which are consistent with those resulting from fitting experimental data. The reasonable agreement obtained provides researchers with a new tool to predict the evolution of local functionalization of 2D layers as a function of the following fabrication parameters: time, applied voltage, and relative humidity, solely based on materials properties. Full article
(This article belongs to the Section Materials Simulation and Design)
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27 pages, 1217 KB  
Article
Immersive Virtual Reality for Stroke Rehabilitation: Linking Clinical and Digital Measures of Motor Recovery—A Pilot Study
by Livia-Alexandra Ion, Miruna Ioana Săndulescu, Claudia-Gabriela Potcovaru, Daniela Poenaru, Andrei Doru Comișel, Ștefan Ștefureac, Andrei Cristian Lambru, Alin Moldoveanu, Ana Magdalena Anghel and Delia Cinteză
Bioengineering 2026, 13(1), 59; https://doi.org/10.3390/bioengineering13010059 - 4 Jan 2026
Viewed by 589
Abstract
Background: Immersive virtual reality (VR) has emerged as a promising tool to enhance neuroplasticity, motivation, and engagement during post-stroke motor rehabilitation. However, evidence on its feasibility and data-driven integration into clinical practice remains limited. Objective: This pilot study aimed to evaluate the feasibility, [...] Read more.
Background: Immersive virtual reality (VR) has emerged as a promising tool to enhance neuroplasticity, motivation, and engagement during post-stroke motor rehabilitation. However, evidence on its feasibility and data-driven integration into clinical practice remains limited. Objective: This pilot study aimed to evaluate the feasibility, usability, and short-term motor outcomes of an immersive VR-assisted rehabilitation program using the Travee-VR system. Methods: Fourteen adults with post-stroke upper-limb paresis completed a 10-day hybrid rehabilitation program combining conventional therapy with immersive VR sessions. Feasibility and tolerability were assessed through adherence, adverse events, the System Usability Scale (SUS), and the Simulator Sickness Questionnaire (SSQ). Motor outcomes included active and passive range of motion (AROM, PROM) and a derived GAP index (PROM–AROM). Correlations between clinical changes and in-game performance metrics were explored to identify potential digital performance metrics of recovery. Results: All participants completed the program without adverse events. Usability was rated as high (mean SUS = 79 ± 11.3), and cybersickness remained mild (SSQ < 40). Significant improvements were observed in shoulder abduction (+7.3°, p < 0.01) and elbow flexion (+5.8°, p < 0.05), with moderate-to-large effect sizes. Performance gains in the Fire and Fruits games correlated with clinical improvement in shoulder AROM (ρ = 0.45, p = 0.041). Cluster analysis identified distinct responder profiles, reflecting individual variability in neuroplastic adaptation. Conclusions: The Travee-VR system proved feasible, well tolerated, and associated with measurable short-term improvements in upper-limb function. By linking clinical outcomes with real-time kinematic data, this study supports the role of immersive, feedback-driven VR as a catalyst for data-informed neuroplastic recovery. These results lay the groundwork for adaptive, clinic-to-home rehabilitation models integrating clinical and exploratory digital performance metrics. Full article
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13 pages, 1196 KB  
Article
Socially Assistive Robot Hyodol for Depressive Symptoms of Community-Dwelling Older Adults in Medically Underserved Areas: A Preliminary Study
by Han Wool Jung, Yujin Kim, Hyojung Kim, Min-kyeong Kim, Hyejung Lee, Jin Young Park, Woo Jung Kim and Jaesub Park
J. Clin. Med. 2026, 15(1), 217; https://doi.org/10.3390/jcm15010217 - 27 Dec 2025
Viewed by 411
Abstract
Background/Objectives: Socially assistive robots effectively support elderly care when they incorporate personalization, person-centered principles, rich interactions, and careful role setting with psychosocial alignment. Hyodol, a socially assistive robot designed for elderly people, embodies a grandchild’s persona, emulating the grandparent–grandchild relationship. Based [...] Read more.
Background/Objectives: Socially assistive robots effectively support elderly care when they incorporate personalization, person-centered principles, rich interactions, and careful role setting with psychosocial alignment. Hyodol, a socially assistive robot designed for elderly people, embodies a grandchild’s persona, emulating the grandparent–grandchild relationship. Based on the behavioral activation principles and a human-centered approach, this robot continuously supports users’ emotional well-being, health management, and daily routines. Methods: The current study evaluated Hyodol’s impact on depressive symptoms and other quality of life factors among older adults living in medically underserved areas. A total of 278 participants were assessed for depressive symptoms, loneliness, medication adherence, and user acceptance. Results: After six months of use, participants showed significant reductions in overall depressive symptoms, with a 45% decrease in the proportion of individuals at high risk of depression. Significant improvements were also observed in loneliness and medication adherence. Participants reported high levels of user acceptance and satisfaction, exceeding 70% of the total score. Participants who engaged more frequently in free chat with Hyodol showed greater improvements in depressive symptoms. Conclusions: These results highlight Hyodol’s potential as a promising tool for enhancing mental healthcare and overall well-being in this population. This at-home mental-healthcare framework can complement primary care and, if its effects are confirmed in controlled trials, could contribute to reducing healthcare burden and preventing the onset and escalation of depressive symptoms. Full article
(This article belongs to the Special Issue Innovations in the Treatment for Depression and Anxiety)
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13 pages, 257 KB  
Article
How Children with Kawasaki Disease Take Acetylsalicylic Acid Mini-Tablets at Home for the Prescribed Period
by Fuka Serizawa, Iori Taki, Taigi Yamazaki, Nao Tagawa, Chie Arai, Yuki Okada, Taro Kamiya, Takehiko Sambe, Akihiro Nakamura, Tsutomu Harada and Noriko Hida
J. Clin. Med. 2026, 15(1), 157; https://doi.org/10.3390/jcm15010157 - 25 Dec 2025
Viewed by 385
Abstract
Background/Objectives: Mini-tablets have gained popularity as a pediatric dosage form owing to their high acceptability. Since 2022, the Showa University Hospital has prescribed acetylsalicylic acid (ASA) mini-tablets to pediatric patients with Kawasaki disease (KD). In this study, we investigated the real-world, at-home [...] Read more.
Background/Objectives: Mini-tablets have gained popularity as a pediatric dosage form owing to their high acceptability. Since 2022, the Showa University Hospital has prescribed acetylsalicylic acid (ASA) mini-tablets to pediatric patients with Kawasaki disease (KD). In this study, we investigated the real-world, at-home administration status of ASA mini-tablets in pediatric patients with KD. Methods: This retrospective study included 14 pediatric patients with KD on ASA mini-tablet therapy between November 2022 and October 2024. Medication administration completeness, mood changes during administration, administration patterns, beverages consumed, and swallowing-related events were analyzed. Associations between changes in the administration pattern or beverage consumption and swallowing events or mood changes were evaluated. Serious adverse events and coronary artery aneurysms were assessed using medical records. Results: Patients were prescribed ASA mini-tablets for a mean duration of 60.9 days. No serious adverse events or coronary aneurysms were observed. Among the 679 medication records, 5 swallowing-related events were identified. No mood changes following administration were observed in >90% of cases. The mood worsened to “Bad” once, with no further deterioration. The “All at once” administration pattern occurred in 64% of occasions across 12 patients (age: 9–79 months). Patients aged <3 years used medication-assisted jelly, whereas older patients mostly used water. Conclusions: ASA mini-tablets can be safely administered at home with minimal swallowing problems. Patients completed full doses irrespective of tablet number, age, administration pattern, or beverage, supporting ASA mini-tablets as an acceptable dosage form option for ASA in KD. Full article
(This article belongs to the Topic Optimization of Drug Utilization and Medication Adherence)
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