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47 Results Found

  • Article
  • Open Access
3 Citations
3,182 Views
16 Pages

And Yet It Moves: Clinical Outcomes and Motion Management in Stereotactic Body Radiation Therapy (SBRT) of Centrally Located Non-Small Cell Lung Cancer (NSCLC): Shedding Light on the Internal Organ at Risk Volume (IRV) Concept

  • Felix-Nikolai Oschinka Jegor Habermann,
  • Daniela Schmitt,
  • Thomas Failing,
  • David Alexander Ziegler,
  • Jann Fischer,
  • Laura Anna Fischer,
  • Manuel Guhlich,
  • Stephanie Bendrich,
  • Olga Knaus and
  • Leif Hendrik Dröge
  • + 7 authors

4 January 2024

The internal organ at risk volume (IRV) concept might improve toxicity profiles in stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC). We studied (1) clinical aspects in central vs. peripheral tumors, (2) the IRV concep...

  • Article
  • Open Access
23 Citations
4,847 Views
30 Pages

IRv2-Net: A Deep Learning Framework for Enhanced Polyp Segmentation Performance Integrating InceptionResNetV2 and UNet Architecture with Test Time Augmentation Techniques

  • Md. Faysal Ahamed,
  • Md. Khalid Syfullah,
  • Ovi Sarkar,
  • Md. Tohidul Islam,
  • Md. Nahiduzzaman,
  • Md. Rabiul Islam,
  • Amith Khandakar,
  • Mohamed Arselene Ayari and
  • Muhammad E. H. Chowdhury

7 September 2023

Colorectal polyps in the colon or rectum are precancerous growths that can lead to a more severe disease called colorectal cancer. Accurate segmentation of polyps using medical imaging data is essential for effective diagnosis. However, manual segmen...

  • Article
  • Open Access
10 Citations
5,243 Views
20 Pages

Rockfall Hazard Assessment in Volcanic Regions Based on ISVS and IRVS Geomechanical Indices

  • Luis I. González de Vallejo,
  • Luis E. Hernández-Gutiérrez,
  • Ana Miranda and
  • Mercedes Ferrer

In volcanic regions, rockfalls represent a major hazard strongly conditioned by the geomechanical behaviour of volcanic materials, the geomorphological characteristics of the relief and the climatic conditions. Volcanic rocks possess very different p...

  • Article
  • Open Access
1 Citations
3,809 Views
19 Pages

Multiple hazards, which threaten people’s lives and property, are the main concern for engineers in preventing dangers to buildings. In particular, densely populated areas, such as capital cities and tall buildings, are exposed to higher risks...

  • Article
  • Open Access
4,761 Views
18 Pages

13 January 2023

The development of the concept of mental discipline can be understood from three clues, as a puritanical phenomenon, as a phenomenon rooted in the classics, and, on the other hand, as one rooted in faculty psychology. The aim of this research is to e...

  • Article
  • Open Access
1,930 Views
15 Pages

Experimental Study on IRV Ramming Artificial Model Ice

  • Chunyu Guo,
  • Chengsen Zhang,
  • Chunhui Wang and
  • Chao Wang

20 October 2023

When the icebreaker sails in the polar region, it adopts continuous and ramming icebreaking operations. When the ice condition exceeds the design working condition, it uses the ramming icebreaking method to advance. The nonlinear icebreaking process...

  • Article
  • Open Access
3 Citations
3,654 Views
13 Pages

Carbon Quantum Dots’ Synthesis with a Strong Chemical Claw for Five Transition Metal Sensing in the Irving–Williams Series

  • Anastasia Yakusheva,
  • Anastasia Sayapina,
  • Lev Luchnikov,
  • Dmitry Arkhipov,
  • Gopalu Karunakaran and
  • Denis Kuznetsov

27 February 2022

Carbon quantum dots (CQDs) are an excellent eco-friendly fluorescence material, ideal for various ecological testing systems. Herein, we establish uniform microwave synthesis of the group of carbon quantum dots with specific functionalization of ethy...

  • Article
  • Open Access
4 Citations
2,116 Views
15 Pages

A Phase 1/2 Randomized Study to Evaluate the Safety, Tolerability, and Immunogenicity of Nucleoside-Modified Messenger RNA Influenza Vaccines in Healthy Adults

  • Angela Branche,
  • Mark J. Mulligan,
  • Alok Maniar,
  • Orlando Puente,
  • Islamiat Oladipupo,
  • Graham Crowther,
  • Agnieszka M. Zareba,
  • Zhuobiao Yi,
  • Ingrid Scully and
  • Kelly Lindert
  • + 6 authors

3 April 2025

Background/Objectives: Circulating influenza strains antigenically differing from vaccine antigens increase disease burden by decreasing vaccine efficacy. Nucleoside-modified mRNA (modRNA) influenza vaccines may facilitate rapid production allowing l...

  • Article
  • Open Access
9 Citations
4,063 Views
12 Pages

Pyrazinoic Acid Inhibits the Bifunctional Enzyme (Rv2783) in Mycobacterium tuberculosis by Competing with tmRNA

  • Lei He,
  • Peng Cui,
  • Wanliang Shi,
  • Qiong Li,
  • Wenhong Zhang,
  • Min Li and
  • Ying Zhang

12 November 2019

Pyrazinamide (PZA) is a key drug for tuberculosis treatment. The active form of PZA, pyrazinoic acid (POA), appears to inhibit multiple targets in M. tuberculosis. Recently, the bifunctional enzyme Rv2783 was reported as a new target of POA. However,...

  • Communication
  • Open Access
3 Citations
2,197 Views
11 Pages

The Role of Rv1476 in Regulating Stress Response and Intracellular Survival of Mycobacterium tuberculosis

  • Aikebaier Reheman,
  • Yifan Wang,
  • Huaiyuan Cai,
  • Pingyang Wei,
  • Gang Cao and
  • Xi Chen

16 February 2024

The virulence of Mycobacterium tuberculosis (M. tuberculosis) is related to many factors, including intracellular survival, cell wall permeability, and cell envelope proteins. However, the biological function of the M. tuberculosis membrane protein R...

  • Review
  • Open Access
2 Citations
5,631 Views
31 Pages

Insulin-regulated glucose uptake is a central mechanism in maintaining systemic glucose homeostasis, primarily occurring in skeletal muscle and adipose tissue. This process relies on the insulin-stimulated translocation of the glucose transporter, GL...

  • Article
  • Open Access
164 Citations
11,364 Views
15 Pages

The current genome editing system Clustered Regularly Interspaced Short Palindromic Repeats Cas9 (CRISPR/Cas9) has already confirmed its proficiency, adaptability, and simplicity in several plant-based applications. Together with the availability of...

  • Article
  • Open Access
3 Citations
1,142 Views
21 Pages

2 January 2025

Drought presents significant challenges in arid regions, influencing local climate and environmental dynamics. While the large-scale climatic phenomena in Xinjiang, northwest China, are well-documented, the finer-scale climatic variability in subregi...

  • Article
  • Open Access
2,316 Views
22 Pages

A High-Throughput and Robust Relative Potency Assay Measuring Human Cytomegalovirus Infection in Epithelial Cells for Vaccine Development

  • Nicole M. Smiddy,
  • Nisarg Patel,
  • Matthew C. Troutman,
  • Kristine M. Kearns,
  • Zachary P. Davis,
  • Christopher S. Adams,
  • Carl Hofmann,
  • Donald J. Warakomski,
  • Harrison Davis and
  • John W. Loughney
  • + 3 authors

10 June 2025

Background/Objectives: A preventative vaccine against human cytomegalovirus (HCMV) infection and disease remains an unmet medical need. Several attenuated virus and antigen-based HCMV vaccine candidates have been proposed; however, development challe...

  • Systematic Review
  • Open Access
1,536 Views
14 Pages

Cardiorespiratory Effects of Inverse Ratio Ventilation in Obese Patients During Laparoscopic Surgery: A Systematic Review and Meta-Analysis

  • Michele Carron,
  • Enrico Tamburini,
  • Alessandra Maggiolo,
  • Federico Linassi,
  • Nicolò Sella and
  • Paolo Navalesi

18 March 2025

Background/Objectives: Managing ventilatory strategies in patients with obesity under general anesthesia presents significant challenges due to obesity-related pathophysiological changes. Inverse ratio ventilation (IRV) has emerged as a potential str...

  • Article
  • Open Access
1 Citations
2,943 Views
10 Pages

Objective: Analysis and presentation of the capabilities of the new ultrasound technique —the index of volume remodeling (IRV), which allows comprehensive assessing of pathological remodeling of the heart as an integrated functional anatomical...

  • Article
  • Open Access
13 Citations
3,859 Views
24 Pages

23 March 2022

The mechanism of convection initiation (CI) over Ili River Valley (IRV) in Xinjiang, Northwest China, was investigated based on both weather stations and radar observations and Weather Research and Forecasting (WRF) model simulation. Observations sho...

  • Article
  • Open Access
9 Citations
2,370 Views
14 Pages

8 July 2020

Because the penetration level of renewable energy sources has increased rapidly in recent years, uncertainty in power system operation is gradually increasing. As an efficient tool for power system analysis under uncertainty, probabilistic power flow...

  • Article
  • Open Access
6 Citations
4,336 Views
20 Pages

WHIRL Study: Workplace Health Interprofessional Learning in the Construction Industry

  • Holly Blake,
  • Sarah Somerset,
  • Katharine Whittingham,
  • Matthew Middleton,
  • Mehmet Yildirim and
  • Catrin Evans

Interprofessional learning (IPL) is essential to prepare healthcare trainees as the future public health workforce. WHIRL (Workplace Health InteRprofessional Learning) was an innovative IPL intervention that engaged volunteer healthcare trainees (n =...

  • Article
  • Open Access
5 Citations
2,672 Views
15 Pages

Allelic Diversification of the Wx and ALK Loci in Indica Restorer Lines and Their Utilisation in Hybrid Rice Breeding in China over the Last 50 Years

  • Li-Xu Pan,
  • Zhi-Zhong Sun,
  • Chang-Quan Zhang,
  • Bu Li,
  • Qing-Qing Yang,
  • Fei Chen,
  • Xiao-Lei Fan,
  • Dong-Sheng Zhao,
  • Qi-Ming Lv and
  • Qiao-Quan Liu
  • + 1 author

Hybrid rice technology has been used for more than 50 years, and eating and cooking quality (ECQ) has been a major focus throughout this period. Waxy (Wx) and alkaline denaturation (ALK) genes have received attention owing to their pivotal roles in d...

  • Article
  • Open Access
10 Citations
2,308 Views
21 Pages

The Infrared Radiation Characteristics of Sandstone Fracture Seepage under Coupled Stress-Hydro Effect

  • Ruoyu Cui,
  • Kewang Cao,
  • Xinci Li,
  • Rana Muhammad Asad Khan,
  • Naseer Muhammad Khan,
  • Wei Liu,
  • Qiangqiang Gao,
  • Fagang Wang,
  • Yuanzhong Yang and
  • Saad S. Alarifi
  • + 1 author

8 December 2022

Effective monitoring of rock fracture and seepage is an important information means to ensure the safety of geotechnical engineering. Therefore, sandstone samples were subject to uniaxial compression under different hydraulic conditions in the presen...

  • Article
  • Open Access
58 Citations
9,811 Views
25 Pages

Automotive Lightweight Design: Simulation Modeling of Mass-Related Consumption for Electric Vehicles

  • Francesco Del Pero,
  • Lorenzo Berzi,
  • Andrea Antonacci and
  • Massimo Delogu

3 September 2020

A thorough assessment of Life-Cycle effects involved by vehicle lightweighting needs a rigorous evaluation of mass-induced consumption, on which energy and sustainability benefits during use stage directly depend. The paper proposes an analytical cal...

  • Article
  • Open Access
172 Views
20 Pages

Clinical Behavior of Aggressive Variants of Papillary Thyroid Carcinoma: A Retrospective Case–Control Study

  • Jovan Ilic,
  • Nikola Slijepcevic,
  • Katarina Tausanovic,
  • Bozidar Odalovic,
  • Goran Zoric,
  • Marija Milinkovic,
  • Branislav Rovcanin,
  • Milan Jovanovic,
  • Matija Buzejic and
  • Vladan Zivaljevic
  • + 5 authors

22 January 2026

Background/Objectives: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. The classic variant (cPTC) is characterized by indolent behavior and excellent prognosis. However, rare subtypes of PTC most often exhibit adverse clini...

  • Article
  • Open Access
17 Citations
3,950 Views
20 Pages

14 April 2020

The National Aeronautics and Space Administration (NASA) Cyclone Global Navigation Satellite System (CYGNSS) mission was launched in December 2016. CYGNSS provides ocean surface wind speed retrieval along specular reflection tracks at an interval res...

  • Article
  • Open Access
1,274 Views
14 Pages

The complexes of Ephedrine with Nickel, Zinc and Cadmium ions have been investigated spectrophotometricalfy using the method of corresponding solutions [I-3] and pH-metrically using Irving and Rossoti technique [4] Two compositions were observed spec...

  • Article
  • Open Access
1 Citations
1,264 Views
20 Pages

7 August 2025

The inability of existing super-resolution methods to jointly model short-range and long-range spatial dependencies in remote sensing imagery limits reconstruction efficacy. To address this, we propose LSTMConvSR, a novel framework inspired by top-do...

  • Article
  • Open Access
7 Citations
2,029 Views
14 Pages

7 October 2022

In the process of uniaxial loading of rocks, the original temperature information of infrared radiation is easily submerged in the noise signal, which leads to distortion of the obtained infrared radiation response information. In this paper, we prop...

  • Review
  • Open Access
27 Citations
9,230 Views
32 Pages

Schistosome Vaccine Adjuvants in Preclinical and Clinical Research

  • Rachel Stephenson,
  • Hong You,
  • Donald P. McManus and
  • Istvan Toth

2 September 2014

There is currently no vaccine available for human use for any parasitic infections, including the helminth disease, schistosomiasis. Despite many researchers working towards this goal, one of the focuses has been on identifying new antigenic targets....

  • Article
  • Open Access
1 Citations
3,395 Views
14 Pages

23 March 2022

Tropical cyclone (TC) intensity observations considerably improve forecast models. They are particularly used to continuously measure TC intensity for landfalling cyclones to improve their forecast. For example, TC Irving, which operated in the Gulf...

  • Article
  • Open Access
22 Citations
4,171 Views
20 Pages

Shear-Thinning in Oligomer Melts—Molecular Origins and Applications

  • Ranajay Datta,
  • Leonid Yelash,
  • Friederike Schmid,
  • Florian Kummer,
  • Martin Oberlack,
  • Mária Lukáčová-Medvid’ová and
  • Peter Virnau

20 August 2021

We investigate the molecular origin of shear-thinning in melts of flexible, semiflexible and rigid oligomers with coarse-grained simulations of a sheared melt. Entanglements, alignment, stretching and tumbling modes or suppression of the latter all c...

  • Article
  • Open Access
36 Citations
12,401 Views
10 Pages

26 January 2011

Logarithms of stability constants, log K1 and log β2, of the first transition series metal mono- and bis-complexes with any of four aliphatic amino acids (glycine, alanine, valine and leucine) decrease monotonously with third order valence connectivi...

  • Article
  • Open Access
41 Citations
6,080 Views
22 Pages

Colon Tissues Classification and Localization in Whole Slide Images Using Deep Learning

  • Pushpanjali Gupta,
  • Yenlin Huang,
  • Prasan Kumar Sahoo,
  • Jeng-Fu You,
  • Sum-Fu Chiang,
  • Djeane Debora Onthoni,
  • Yih-Jong Chern,
  • Kuo-Yu Chao,
  • Jy-Ming Chiang and
  • Wen-Sy Tsai
  • + 1 author

Colorectal cancer is one of the leading causes of cancer-related death worldwide. The early diagnosis of colon cancer not only reduces mortality but also reduces the burden related to the treatment strategies such as chemotherapy and/or radiotherapy....

  • Article
  • Open Access
25 Citations
7,295 Views
19 Pages

Genome-Scale Metabolic Model of the Human Pathogen Candida albicans: A Promising Platform for Drug Target Prediction

  • Romeu Viana,
  • Oscar Dias,
  • Davide Lagoa,
  • Mónica Galocha,
  • Isabel Rocha and
  • Miguel Cacho Teixeira

11 September 2020

Candida albicans is one of the most impactful fungal pathogens and the most common cause of invasive candidiasis, which is associated with very high mortality rates. With the rise in the frequency of multidrug-resistant clinical isolates, the identif...

  • Article
  • Open Access
10 Citations
4,627 Views
14 Pages

13 December 2022

Prussian blue analogs (PBAs) have been reported as promising ammonia (NH3) adsorbents with a high capacity compared to activated carbon, zeolite, and ion exchange resins. The adsorbed NH3 was desorbed by heating and washing with water or acid. Recent...

  • Article
  • Open Access
11 Citations
4,533 Views
18 Pages

Clinical and Therapeutic Evaluation of the Ten Most Prevalent CRB1 Mutations

  • Bruna Lopes da Costa,
  • Masha Kolesnikova,
  • Sarah R. Levi,
  • Thiago Cabral,
  • Stephen H. Tsang,
  • Irene H. Maumenee and
  • Peter M. J. Quinn

Mutations in the Crumbs homolog 1 (CRB1) gene lead to severe inherited retinal dystrophies (IRDs), accounting for nearly 80,000 cases worldwide. To date, there is no therapeutic option for patients suffering from CRB1-IRDs. Therefore, it is of great...

  • Article
  • Open Access
2,059 Views
23 Pages

A Virome Scanning of Saffron (Crocus sativus L.) at the National Scale in Iran Using High-Throughput Sequencing Technologies

  • Hajar Valouzi,
  • Akbar Dizadji,
  • Alireza Golnaraghi,
  • Seyed Alireza Salami,
  • Nuria Fontdevila Pareta,
  • Serkan Önder,
  • Ilhem Selmi,
  • Johan Rollin,
  • Chadi Berhal and
  • Sébastien Massart
  • + 6 authors

4 August 2025

Saffron (Crocus sativus L.) is a vegetatively propagated crop of high economic and cultural value, potentially affected by viral infections that may impact its productivity. Despite Iran’s dominance in global saffron production, knowledge of it...

  • Article
  • Open Access
3 Citations
4,379 Views
17 Pages

30 November 2022

The COVID-19 pandemic has altered all aspects of human life since its breakout in March 2020 in the USA and around the world. There has been a tremendous increase in the use of plastic products as most of the PPE (masks, gloves, and other medical equ...

  • Article
  • Open Access
3 Citations
1,955 Views
26 Pages

26 April 2024

This study aims to characterize graphene epoxy nanocomposite properties using multiscale modeling. Molecular dynamics was used to study the nanocomposite at the nanoscale and finite element analysis at the macroscale to complete the multiscale modeli...

  • Article
  • Open Access
12 Citations
5,739 Views
12 Pages

Head-Mounted Display for Clinical Evaluation of Neck Movement Validation with Meta Quest 2

  • Manuel Trinidad-Fernández,
  • Benoît Bossavit,
  • Javier Salgado-Fernández,
  • Susana Abbate-Chica,
  • Antonio J. Fernández-Leiva and
  • Antonio I. Cuesta-Vargas

13 March 2023

Neck disorders have a significant impact on people because of their high incidence. The head-mounted display (HMD) systems, such as Meta Quest 2, grant access to immersive virtual reality (iRV) experiences. This study aims to validate the Meta Quest...

  • Article
  • Open Access
5 Citations
1,878 Views
18 Pages

22 September 2022

There are a huge number of harmonics in the railway power supply system. Accurately estimating the harmonic impedance of the system is the key to evaluating the harmonic emission level of the power supply system. A harmonic impedance estimation metho...

  • Brief Report
  • Open Access
6 Citations
2,912 Views
7 Pages

(1) Objective: There are limited data regarding community-acquired pneumonia (CAP) admissions patterns in US hospitals. Current expert CAP guidelines advocate for outpatient treatment or an abbreviated hospital stay for CAP patients in pneumonia seve...

  • Article
  • Open Access
1 Citations
981 Views
13 Pages

Divergent Manifestations in Biallelic Versus Monoallelic Variants of RP1-, BEST1-, and PROM1-Associated Retinal Disorders

  • Maximilian D. Kong,
  • Jedrzej Golebka,
  • Vanessa R. Anderson,
  • Caroline Bao,
  • Johnathan A. Bailey,
  • Abdhel Exinor,
  • Aykut Demirkol and
  • Stephen H. Tsang

To compare the clinical characteristics of inherited retinal diseases (IRDs) caused by biallelic versus monoallelic variants in the RP1, BEST1, and PROM1 genes. A total of 52 patients (26 female) with genetically confirmed IRDs were retrospectively s...

  • Article
  • Open Access
3 Citations
3,594 Views
10 Pages

COVID-19 on Chest CT: Translating Known Microscopic Findings to Imaging Observations

  • Belinda Dsouza,
  • Kathleen M. Capaccione,
  • Aron Soleiman,
  • Jay Leb and
  • Mary Salvatore

8 June 2022

Purpose: To describe the imaging findings of COVID-19 and correlate them with their known pathology observations. Methods: This is an IRB-approved retrospective study performed at Columbia University Irving Medical Center (IRB # AAAS9652) that includ...

  • Article
  • Open Access
1 Citations
1,421 Views
13 Pages

Does Pelleted Starter Feed Restriction and Provision of Total Mixed Ration Ad Libitum during Weaning Influence the Behavior of Dairy Calves?

  • Anna Antonella Spina,
  • Marina Tortadès,
  • Domenico Britti,
  • Raffaella Grande and
  • Valeria Maria Morittu

24 September 2024

Currently, in dairy farming, there is growing concern for the welfare of calves during the critical period between the separation from their dams and weaning. During weaning, rationed feeding is a practice used to improve feed efficiency and control...