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14 pages, 1338 KB  
Article
Impact of Trapping Programs for Ips typographus (Linnaeus) (Curculionidae: Scolytinae) on Predators, Parasitoids, and Other Non-Target Insects
by Matteo Bracalini, Andrea Martini, Lorenzo Tagliaferri and Tiziana Panzavolta
Forests 2025, 16(10), 1510; https://doi.org/10.3390/f16101510 - 24 Sep 2025
Viewed by 32
Abstract
The European spruce bark beetle, Ips typographus (Linnaeus, 1758), poses a significant threat to Picea abies (Linnaeus) Karsten, 1881 forests, with outbreaks often exacerbated by abiotic disturbances like the 2018 Vaia windstorm in the Italian Alps. Pheromone-baited traps are widely used for control, [...] Read more.
The European spruce bark beetle, Ips typographus (Linnaeus, 1758), poses a significant threat to Picea abies (Linnaeus) Karsten, 1881 forests, with outbreaks often exacerbated by abiotic disturbances like the 2018 Vaia windstorm in the Italian Alps. Pheromone-baited traps are widely used for control, yet their overall efficacy and potential side effects, particularly the incidental capture of non-target insects, remain debated. This study aimed to comprehensively assess the presence and composition of non-target insects in I. typographus pheromone traps, used for both mass-trapping and monitoring, in the affected Alpine regions. We took into account single monitoring traps (dry collection) and three-trap cross configurations for mass-trapping (with preservative liquid), collecting and morphologically identifying insect by-catch. Our results revealed a non-target proportion (excluding bark beetles) significantly higher in mass-trapping (4.15%) compared to monitoring (1.00%), with approximately half being natural enemies of bark beetles. Crucially, we report that bark beetle parasitoids were repeatedly caught, with Tomicobia seitneri (Ruschka, 1924) (the third most abundant non-target species) particularly well represented, and Ropalophorus clavicornis (Wesmaël, 1835) also detected, which is noteworthy given its ecological role despite its lower numbers. Our findings underscore the significant, previously underreported, capture of beneficial parasitoids and highlight the need for careful consideration of non-target catches in I. typographus pest management strategies. Full article
(This article belongs to the Section Forest Biodiversity)
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14 pages, 276 KB  
Article
Isolation and Characterization Through Whole-Genome Sequencing of STEC Strains from Free-Ranging Red Deer
by Stefania Lauzi, Rosangela Tozzoli, Paola Chiani, Matteo Nava, Arnold Knijn, Valeria Michelacci, Stefano Giacomelli, Gaia Scavia, Stefano Morabito and Camilla Luzzago
Vet. Sci. 2025, 12(10), 929; https://doi.org/10.3390/vetsci12100929 - 24 Sep 2025
Viewed by 110
Abstract
Whole-genome sequence (WGS) analysis was used in this study to characterize Shiga toxin-producing Escherichia coli (STEC) isolates in free-ranging red deer from the central Italian Alps. Fecal samples from 92 hunted red deer collected between September and December 2022 were analyzed for the [...] Read more.
Whole-genome sequence (WGS) analysis was used in this study to characterize Shiga toxin-producing Escherichia coli (STEC) isolates in free-ranging red deer from the central Italian Alps. Fecal samples from 92 hunted red deer collected between September and December 2022 were analyzed for the presence of STEC. Single E. coli colonies positive by PCR for stx genes were analyzed by WGS. STEC were isolated from eleven (12%) samples, showing eight stx2b, one stx2a, two stx1c, and one stx1a subtypes. Different serotypes and sequence types were identified (n = 8 each). Three isolates of O27:H30 serotype and ST753 showed no correlation in the cgMLST analysis (AD range 44–98). All strains harbored additional virulence factors. The only isolate harboring stx2a also possessed the eae gene and belonged to serotype O26:H11. Some isolates displayed shuffled virulence features of more than one E. coli pathotype. The high genetic diversity of strains circulating in the red deer population living in the central Italian Alps, including the STEC O26:H11 strain associated with STEC from severe disease in humans, confirms red deer as STEC reservoirs and highlights the need for monitoring the presence of these pathogens in wild ruminants. Full article
15 pages, 1674 KB  
Article
Characterization of Litter and Topsoil Under Different Vegetation Cover by Using a Chemometric Approach
by Fulvia Tambone, Anna Masseroli, Paolo Beccarelli, Luca Breno, Marco Zuccolo, Gigliola Borgonovo, Stefania Mazzini, Alex Golinelli and Barbara Scaglia
Forests 2025, 16(8), 1349; https://doi.org/10.3390/f16081349 - 19 Aug 2025
Viewed by 561
Abstract
Leaf litter conservation practices in forests can contribute to increasing CO2 storage in natural soils as organic matter; however, this process depends on the type of vegetation cover. This study, using different approaches, aimed to assess this process starting from the characteristics [...] Read more.
Leaf litter conservation practices in forests can contribute to increasing CO2 storage in natural soils as organic matter; however, this process depends on the type of vegetation cover. This study, using different approaches, aimed to assess this process starting from the characteristics of three different types of litters and topsoil (0–5 cm depth) originating from chestnut, beech, and pine in various forest locations within the territory of Edolo (Camonica Valley, Central Italian Alps). Both labile (DOM) and recalcitrant (ROM) organic matter fractions were considered. Microbial degradation activity was strongly influenced by DOM (DOM vs. Respiration mg CO2 g−1 dry matter: r = 0.96), and NMR spectroscopy showed that aromatic C and polymethylene C in long-chain aliphatic structures (e.g., lipids, cutin) became more evident from litters to topsoils due to a concentration effect. Finally, chemometric elaboration of quantitative and qualitative data identified two principal component (PC) profiles, explaining 88% of the total variance, in which litter and the topsoil samples were spatially separated, indicating that significant changes occurred during the decomposition process. An Evolution Index (EI) calculated highlighted greater changes for chestnut (0.90) followed by pine (0.60) and beech (0.48), in agreement with chemical (degradation rates of 14.21%, 49.11%, and 48% for beech, chestnut, and pine litter, respectively) and spectroscopic data. Beech litter appears to be more efficient at conserving organic carbon. These findings underscore the importance of understanding litter characteristics for forest management, suggesting which species are most effective in promoting soil carbon storage. Full article
(This article belongs to the Section Forest Soil)
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20 pages, 3576 KB  
Review
An Overview of Upland Peatlands’ Vegetation of Apennines, Sicily, and Sardinia (Italy)
by Enrico Bajona, Emilio Di Gristina and Giuseppe Venturella
Plants 2025, 14(13), 1931; https://doi.org/10.3390/plants14131931 - 23 Jun 2025
Viewed by 749
Abstract
Upland mires in Italy, excluding the Alps, have a fragmentary distribution, and most of them persist in climatically optimal mountain refugia. Based on the literature data, we assessed that the state of knowledge of Italian upland mires distributed in the Apennines, Sicily, and [...] Read more.
Upland mires in Italy, excluding the Alps, have a fragmentary distribution, and most of them persist in climatically optimal mountain refugia. Based on the literature data, we assessed that the state of knowledge of Italian upland mires distributed in the Apennines, Sicily, and Sardinia is outdated. We analyzed 54 publications, and 220 peatland sites were found. Only a few publications were published in the last ten years, and most of the peat bogs described in the past have not been resurveyed. The largest number of sites is concentrated in the Tuscan-Emilian Apennines (60), followed by Sicily (51 sites) and Calabria (42). The vegetation belongs to 38 phytosociological associations, 19 sub-associations and variants, and 54 communities of 6 different classes; the most represented class is Scheuchzerio palustris-Caricetea fuscae. The most widespread disturbances are uncontrolled grazing by domestic livestock and wild fauna, groundwater extraction, and road construction. New investigations are urgently needed to update the state of Italian upland mires knowledge, which is the basis for all conservation strategies prescribed by national, European, and international policies. Full article
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25 pages, 3465 KB  
Article
Recovery of Soil-Based Ecosystem Services in Abandoned Ski Resorts: The Valcanale Case Study (Bergamo, Italian Alps)
by Cristian Arosio, Luca Giupponi, Annamaria Giorgi, Alessio Cislaghi and Michele Eugenio D’Amico
Sustainability 2025, 17(12), 5418; https://doi.org/10.3390/su17125418 - 12 Jun 2025
Viewed by 898
Abstract
Climate change and declining economic revenues are driving the closure of many ski resorts in mountainous regions worldwide, particularly at lower elevations, where winter snow cover is becoming increasingly sporadic. This abandonment is impacting wide areas of the Alps, previously managed to reduce [...] Read more.
Climate change and declining economic revenues are driving the closure of many ski resorts in mountainous regions worldwide, particularly at lower elevations, where winter snow cover is becoming increasingly sporadic. This abandonment is impacting wide areas of the Alps, previously managed to reduce erosion and to control trees/shrubs encroachment. As result, natural rewilding processes may lead either to the environmental degradation or to the restoration of pre-disturbance conditions, each with different implications for sustainability. Our aim was to assess the rewilding state and the drivers of sustainability at an abandoned ski resort in the Italian Alps (Valcanale, Bergamo), where the ecosystem has been evolving under minimal human pressure since the ski facilities were decommissioned in 1993. The assessment focused on pedological/vegetational perspectives, with particular attention to soil-based ecosystem services (SBESs). The results show that the interventions made during ski run construction significantly influenced the recovery of SBESs (and thus their long-term sustainability). Areas with minimal disturbance (e.g., forest vegetation removal without soil movement) now support SBESs at levels comparable to nearby undisturbed areas. Conversely, ski runs that underwent slope reshaping/grading support poorly developed soils and significant sheet/gully erosion, rendering them hazardous for pedestrians. Nevertheless, plant biodiversity has benefited in some cases, as many rare/endemic protected species colonize stony/eroded ski runs soils, extending their distribution beyond their original habitat. Full article
(This article belongs to the Section Soil Conservation and Sustainability)
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13 pages, 5283 KB  
Article
Assessing the Conservation Priority of Alpine Carabid Beetle Communities by Mapping the Index of Natural Value (INV) in Natura 2000 Habitats in the Brenta Dolomites (Italian Alps)
by Emiliano Peretti, Marco Armanini, Roberta Chirichella, Andrea Mustoni and Mauro Gobbi
Insects 2025, 16(6), 602; https://doi.org/10.3390/insects16060602 - 7 Jun 2025
Viewed by 878
Abstract
The Dolomites (European Alps) are a UNESCO World Heritage Site known to harbor distinctive communities of carabid beetles adapted to high-altitude environments, whose composition is shaped mainly by landform and habitat type. We aimed to assess the conservation priority of carabid beetle communities [...] Read more.
The Dolomites (European Alps) are a UNESCO World Heritage Site known to harbor distinctive communities of carabid beetles adapted to high-altitude environments, whose composition is shaped mainly by landform and habitat type. We aimed to assess the conservation priority of carabid beetle communities in the Brenta mountain group (Italy). We used the Index of Natural Value (INV), based on the relative frequencies and abundances of highly specialized Alpine species, as a proxy of the sensitivity to disturbance, and, thus, to the vulnerability of the carabid beetle communities to extinction. We used information on Natura 2000 habitat cover to produce a map for identifying areas of the Brenta Dolomites inhabited by the carabid beetle communities most relevant for conservation. We also report on the main differences in terms of species composition between the investigated communities. We found a positive correlation between vulnerability and altitude. Specifically, the most vulnerable communities were recorded in high-altitude habitat types (limestone cliffs and pavements, calcareous and calcschist screes, and alpine calcareous grasslands). Alkaline fens resulted in having the least vulnerable community, while those in all other habitats (bush and forests) were found to have intermediate levels of vulnerability. Full article
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34 pages, 18742 KB  
Article
New Insights into Graphite Deposits in Chisone and Germanasca Valleys (Dora-Maira Massif, Western Italian Alps): Scientific Advances and Applied Perspectives
by Licia Santoro, Viviane Bertone, Simona Ferrando and Chiara Groppo
Minerals 2025, 15(5), 455; https://doi.org/10.3390/min15050455 - 27 Apr 2025
Cited by 1 | Viewed by 901
Abstract
Graphite is a critical raw material due to its pivotal role in the green transition; hence, there is a renewed interest in its exploration across Europe. The Chisone and Germanasca Valleys (Piemonte, IT) were home to significant graphite exploitation until the 20th century, [...] Read more.
Graphite is a critical raw material due to its pivotal role in the green transition; hence, there is a renewed interest in its exploration across Europe. The Chisone and Germanasca Valleys (Piemonte, IT) were home to significant graphite exploitation until the 20th century, owing to the widespread presence of graphite ore bodies hosted in the metasedimentary succession of the Pinerolo Unit in the Dora-Maira Massif (Western Alps). This contribution presents a renewed study on the geology, mineralogy, petrography, and geochemistry of graphite ores and their host rocks, employing OM, SEM-EDS, and BSE, μRaman, and ICP-OES/MS and INAA analyses. Mineralization occurs in two metasedimentary successions: (i) the Bourcet-type succession (meta-conglomerates and meta-sandstones intercalated with meta-siltstones/metapelites) and (ii) the Pons-type succession (meta-siltstones/metapelites intercalated with minor meta-arenites). Graphite occurs as (i) high-purity, fine-grained crystals dispersed within or concentrated in layers along the regional schistosity, or (ii) low-purity, coarse-grained crystals within shear zones. Based on crystallinity, three types of graphite were distinguished: high (Type I), intermediate (Type II), and poor (Type III) crystalline graphite, likely formed under different genetic conditions. The comparison of these findings has implications for future exploration and provides new insights into the metallogeny and geological evolution of the area. Full article
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15 pages, 2913 KB  
Article
Extension of Cut-to-Length Logging Trails on Salvage Logging Operations: An Overview of the Northeastern Italian Alps
by Nicolò Di Marzio, Davide Imperiali, Luca Marchi and Stefano Grigolato
Forests 2025, 16(4), 673; https://doi.org/10.3390/f16040673 - 12 Apr 2025
Viewed by 673
Abstract
Climate change is increasing the frequency and severity of disturbances, calling for extensive salvage logging operations. This study examines fully mechanized cut-to-length operations in the northeastern Italian Alps as a response to windthrow and bark beetle outbreaks following Storm Vaia. Using high-resolution orthophotos, [...] Read more.
Climate change is increasing the frequency and severity of disturbances, calling for extensive salvage logging operations. This study examines fully mechanized cut-to-length operations in the northeastern Italian Alps as a response to windthrow and bark beetle outbreaks following Storm Vaia. Using high-resolution orthophotos, logging trail extent, density, and configuration were analyzed in relation to terrain and ecological sensitivity. A total of 29 forest sites, covering a worksite area of 1078 hectares, were analyzed, with a combined trail length exceeding 700 km. Results indicate an average logging trail density of 500 m/ha, and a machine-trafficked area percentage of 22%. Terrain analysis revealed that 68% of the worksite area was below a 30% slope, facilitating machinery operations, while 32% of the site required adaptive strategies for steeper terrain. Additionally, depth-to-water maps were implemented to assess sensitive zones according to different moisture conditions, revealing that one-fifth of the trafficked zones were at higher risk of soil disturbances due to potentially high moisture levels. This study provides critical baseline data on mechanized salvage logging effects at a large scale, offering insights for future data-driven decision making for efficient planning under sustainable forest management. Full article
(This article belongs to the Section Forest Operations and Engineering)
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30 pages, 17752 KB  
Article
From Alpine Catchment Classification to Debris Flow Monitoring
by Francesca Cantonati, Giulio Lissari, Federico Vagnon, Luca Paro, Andrea Magnani, Ivano Rossato, Giulio Donati Sarti, Christian Barresi and Davide Tiranti
GeoHazards 2025, 6(1), 15; https://doi.org/10.3390/geohazards6010015 - 15 Mar 2025
Viewed by 1575
Abstract
Debris flows are one of the most common and frequent natural hazards in mountainous environments. For this reason, there is a need to develop monitoring systems aimed at better understanding the initiation and propagation mechanisms of these phenomena to subsequently adopt the most [...] Read more.
Debris flows are one of the most common and frequent natural hazards in mountainous environments. For this reason, there is a need to develop monitoring systems aimed at better understanding the initiation and propagation mechanisms of these phenomena to subsequently adopt the most reliable mitigation measures to safeguard anthropic assets and human lives exposed to the impact of debris flows in alluvial fan areas. However, the design of a responsive monitoring system cannot overlook the need for a thorough understanding of the catchment in which debris flows occur. This knowledge is essential for making optimized decisions regarding the type and number of sensors to include in the monitoring system and ensuring their accurate and efficient placement. In this paper, it is described how the preliminary characterization of an Alpine catchment and the geo-hydrological processes that have historically affected it—such as the lithological and geomechanical classification of the catchment’s bedrock, the identification and description of sediment source areas, the characterization of debris flow occurrence and quantification of the triggering causes—contribute to the optimal design of a monitoring system. Additionally, the data recorded from the sensors during a debris flow event in summer 2024 validate and confirm the results obtained from previous research. Full article
(This article belongs to the Special Issue Landslide Research: State of the Art and Innovations)
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13 pages, 1447 KB  
Review
Rice Fields and Aquatic Insect Biodiversity in Italy: State of Knowledge and Perspectives in the Context of Global Change
by Tiziano Bo, Anna Marino, Simone Guareschi, Alex Laini and Stefano Fenoglio
Water 2025, 17(6), 845; https://doi.org/10.3390/w17060845 - 15 Mar 2025
Viewed by 1509
Abstract
Rice fields are one of the most important and extensive agro-ecosystems in the world. Italy is a major non-Asian rice producer, with a significant proportion of its yield originating from a vast area within the Po Valley, a region nourished by the waters [...] Read more.
Rice fields are one of the most important and extensive agro-ecosystems in the world. Italy is a major non-Asian rice producer, with a significant proportion of its yield originating from a vast area within the Po Valley, a region nourished by the waters of the Alps. While the biodiversity of these rice fields has been extensively documented for certain faunal groups, such as birds, there remains a paucity of research on the biodiversity of aquatic insects. A further challenge is the limited dissemination of findings, which have been primarily published in “gray” literature (local journals, newsletters and similar). Moreover, rice fields are of particular significance in the field of invasion biology, given their role in the arrival and spread of alien species. While the efficacy of rice fields as a substitute for the now-disappeared lowland natural environments is well documented, it is equally evident that traditional rice-growing techniques can require an unsustainable use of water resources, which threatens the biodiversity of the surrounding lotic systems. Here, we summarize and review multiple sources of entomological information from Italian rice fields, analyzing both publications in ISI journals and papers published in local journals (gray literature). In the near future, strategies that reduce the demand for irrigation, promote the cultivation of drought-tolerant crops, and utilize precision farming techniques will be implemented. The challenge will be balancing the need to reduce water withdrawal from rivers with the maintenance of wetlands where possible to support this pivotal component of regional biodiversity. Full article
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20 pages, 2560 KB  
Article
Grazing Intensity Accelerates Surface Soil C and N Cycling in Alpine Pastures as Revealed by Soil Genes and δ15N Ratio
by Salvatore Raniolo, Luca Da Ros, Laura Maretto, Damiano Gianelle, Federica Camin, Luana Bontempo, Piergiorgio Stevanato, Enrico Sturaro, Andrea Squartini and Mirco Rodeghiero
Sustainability 2025, 17(5), 2165; https://doi.org/10.3390/su17052165 - 3 Mar 2025
Cited by 1 | Viewed by 839
Abstract
European grasslands are vital carbon (C) sinks, contributing to climate change mitigation. Grazing intensity significantly influences soil C and nitrogen (N) cycles through effects on soil conditions and microbial communities. While heavy grazing is linked to soil C loss and altered N processes, [...] Read more.
European grasslands are vital carbon (C) sinks, contributing to climate change mitigation. Grazing intensity significantly influences soil C and nitrogen (N) cycles through effects on soil conditions and microbial communities. While heavy grazing is linked to soil C loss and altered N processes, existing studies show conflicting outcomes. This study examines the impact of cattle grazing on soil C and N cycles in a historical alpine pasture in the eastern Italian Alps (1868 m a.s.l.). The following three grazing intensities were analyzed: heavy (8.19 LU ha−1), moderate (0.59 LU ha−1), and light (0.06 LU ha−1). Soil was sampled from two depth layers (0–5 cm, 5–10 cm) and analyzed for bulk density, C and N content, C/N ratio, exchangeable N, δ15N, and microbial genes targeting general abundance (16S), N fixation (nifH), nitrification (amoA), and denitrification (nirK, nosZ) using real-time PCR. The results revealed decreased C and N concentrations with increasing grazing intensity, exclusively in the 0–5 cm soil layer. Higher δ15N and enhanced nitrification and denitrification suggest a more open N cycle under heavy grazing. These findings highlight the potential of microbial gene markers and δ15N isotopic ratios to monitor N cycle dynamics in alpine pastures, informing sustainable grazing management. Full article
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9 pages, 752 KB  
Data Descriptor
Open Georeferenced Field Data on Forest Types and Species for Biodiversity Assessment and Remote Sensing Applications
by Patrizia Gasparini, Lucio Di Cosmo, Antonio Floris, Federica Murgia and Maria Rizzo
Data 2025, 10(3), 30; https://doi.org/10.3390/data10030030 - 21 Feb 2025
Viewed by 836
Abstract
Forest ecosystems are important for biodiversity conservation, climate regulation and climate change mitigation, soil and water protection, and the recreation and provision of raw materials. This paper presents a dataset on forest type and tree species composition for 934 georeferenced plots located in [...] Read more.
Forest ecosystems are important for biodiversity conservation, climate regulation and climate change mitigation, soil and water protection, and the recreation and provision of raw materials. This paper presents a dataset on forest type and tree species composition for 934 georeferenced plots located in Italy. The forest type is classified in the field consistently with the Italian National Forest Inventory (NFI) based on the dominant tree species or species group. Tree species composition is provided by the percent crown cover of the main five species in the plot. Additional data on conifer and broadleaves pure/mixed condition, total tree and shrub cover, forest structure, sylvicultural system, development stage, and local land position are provided. The surveyed plots are distributed in the central–eastern Alps, in the central Apennines, and in the southern Apennines; they represent a wide range of species composition, ecological conditions, and silvicultural practices. Data were collected as part of a project aimed at developing a classification algorithm based on hyperspectral data. The dataset was made publicly available as it refers to forest types and species widespread in many countries of Central and Southern Europe and is potentially useful to other researchers for the study of forest biodiversity or for remote sensing applications. Full article
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17 pages, 10187 KB  
Article
A Proposal for the Sustainable Enhancement of the Cultural and Social Heritage of the Alps: The Project “La Montagna al Femminile”
by Monica Morazzoni, Valeria Pecorelli and Matteo Di Napoli
Sustainability 2025, 17(4), 1611; https://doi.org/10.3390/su17041611 - 15 Feb 2025
Viewed by 865
Abstract
The snow-based tourism, long a cornerstone of economic development for mountain destinations in the Italian Alps, is increasingly unsustainable. This study explores the potential of a cultural project dedicated to showcasing the representation of women in Alpine spaces as an alternative pull factor [...] Read more.
The snow-based tourism, long a cornerstone of economic development for mountain destinations in the Italian Alps, is increasingly unsustainable. This study explores the potential of a cultural project dedicated to showcasing the representation of women in Alpine spaces as an alternative pull factor to alpine tourism. The project aims to revitalise the cultural and social heritage of Alpine regions, offering them renewed appeal while promoting sustainable development practices. Aligned with the Declaration of Jena, the project also aims to foster cultural sustainability by amplifying the often-overlooked contributions of women across professional, cultural, artistic, and recreational spheres in the Alps. Full article
(This article belongs to the Special Issue Sustainable Heritage Tourism)
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21 pages, 7417 KB  
Article
Strategies for Glacier Retreat Communication with 3D Geovisualization and Open Data Sharing
by Federica Gaspari, Federico Barbieri, Rebecca Fascia, Francesco Ioli, Livio Pinto and Federica Migliaccio
ISPRS Int. J. Geo-Inf. 2025, 14(2), 75; https://doi.org/10.3390/ijgi14020075 - 10 Feb 2025
Cited by 3 | Viewed by 1269
Abstract
Images of melting ice have become powerful symbols of climate change, attracting both public attention and scientific interest. This research uses web technologies to document and communicate the ongoing retreat of the Belvedere Glacier in the Italian Alps. By combining historical and contemporary [...] Read more.
Images of melting ice have become powerful symbols of climate change, attracting both public attention and scientific interest. This research uses web technologies to document and communicate the ongoing retreat of the Belvedere Glacier in the Italian Alps. By combining historical and contemporary 2D and 3D geospatial data, the paper presents a comprehensive digital platform that allows visualization of long-term changes of the Belvedere Glacier. To increase public understanding and engagement, we develop a user-friendly web platform that provides interactive tools for exploring glacier data. By fostering a deeper understanding of the complex processes involved in glacier retreat by different audiences (students, general public, and technical experts), this work aims to inspire further research and cooperation, also thanks to the reproducibility of the open-source code. Full article
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11 pages, 438 KB  
Article
Large Italian Multicenter Study on Prognostic Value of Baselines Variables in mCRPC Patients Treated with 223RaCl2: Ten Years of Clinical Experience
by Maria Silvia De Feo, Luca Filippi, Matteo Bauckneht, Elisa Lodi Rizzini, Cristina Ferrari, Valentina Lavelli, Andrea Marongiu, Gianmario Sambuceti, Claudia Battisti, Antonio Mura, Giuseppe Fornarini, Sara Elena Rebuzzi, Alessio Farcomeni, Alessandra Murabito, Susanna Nuvoli, Miriam Conte, Melissa Montebello, Renato Patrizio Costa, Arber Golemi, Manlio Mascia, Laura Travascio, Fabio Monari, Giuseppe Rubini, Angela Spanu, Giuseppe De Vincentis and Viviana Frantellizziadd Show full author list remove Hide full author list
Diagnostics 2025, 15(3), 339; https://doi.org/10.3390/diagnostics15030339 - 31 Jan 2025
Viewed by 1082
Abstract
Background/Objectives: The prognostic value of baseline clinical parameters in predicting the survival prolonging effect of Radium-223-dichloride (223RaCl2) for metastatic castration resistant prostate cancer (mCRPC) patients has been the object of intensive research and remains an open issue. This national [...] Read more.
Background/Objectives: The prognostic value of baseline clinical parameters in predicting the survival prolonging effect of Radium-223-dichloride (223RaCl2) for metastatic castration resistant prostate cancer (mCRPC) patients has been the object of intensive research and remains an open issue. This national multicenter study aimed to corroborate the evidence of ten years of clinical experience with 223RaCl2 by collecting data from eight Italian Nuclear Medicine Units. Methods: Data from 581 consecutive mCRPC patients treated with 223RaCl2 were retrospectively analyzed. Several baseline variables relevant to the overall survival (OS) analysis were considered, including age, previous radical prostatectomy/radiotherapy, number of previous treatment lines, prior chemotherapy, Gleason score, presence of lymphoadenopaties, number of bone metastases, concomitant use of bisphosphonates/Denosumab, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), as well as baseline values of hemoglobin (Hb), platelets, Total Alkaline Phosphatase (tALP), Lactate Dehydrogenase (LDH), and Prostate-Specific Antigen (PSA). Data were summarized using descriptive statistics, univariate analysis and multivariate analysis with the Cox model. Results: The median OS time was 14 months (95%CI 12–17 months). At univariate analysis age, the number of previous treatment lines, number of bone metastases, ECOG-PS, presence of lymphadenopathies at the time of enrollment, as well as baseline tALP, PSA, and Hb, were independently associated with OS. After multivariate analysis, the number of previous treatment lines (HR = 1.1670, CI = 1.0095–1.3491, p = 0.0368), the prior chemotherapy (HR = 0.6461, CI = 0.4372–0.9549, p = 0.0284), the presence of lymphadenopathies (HR = 1.5083, CI = 1.1210–2.0296, p = 0.0066), the number of bone metastases (HR = 0.6990, CI = 0.5416–0.9020, p = 0.0059), ECOG-PS (HR = 1.3551, CI = 1.1238–1.6339, p = 0.0015), and baseline values of tALP (HR = 1.0008, CI = 1.0003–1.0013, p = 0.0016) and PSA (HR = 1.0004, CI = 1.0002–1.0006, p = 0.0005) remained statistically significant. Conclusions: In the era of precision medicine and in the landscape of novel therapies for mCRPC, the prognostic stratification of patients undergoing 223RaCl2 has a fundamental role for clinical decision-making, ranging from treatment choice to optimal sequencing and potential associations. This large Italian multicenter study corroborated the prognostic value of several variables, emerging from ten years of clinical experience with 223RaCl2. Full article
(This article belongs to the Special Issue Diagnostic Imaging of Prostate Cancer)
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