Search Results (79,219)

This publication presents an improved manufacturing method for tetrahedral metal effect pigment particles that demonstrates reduced flowlines in injection-molded polymer components compared with conventional platelet-shaped pigment particles. The previously published cold forming process for tetrahedral particles, made entirely from aluminum, faced manufacturing challenges, resulting in a high reject rate due to particle adhesion to the micro-structured mold roller. In contrast, this study introduces a new manufacturing method for tetrahedral particles, now consisting of metallized UV-cured thermoset polymer. These particles, dispersed in amorphous matrix thermoplastics, have shown to maintain their shape during the injection molding process. The manufacturing technique for these novel particles is based on UV imprint lithography, omitting the reject rates compared with the previously presented cold rolling process of tetrahedral full aluminum particles. Thus, the novel manufacturing technique for tetrahedral pigment particles shows increased potential for automation through roll-to-roll manufacturing in the future. Full article

Autism spectrum disorder (ASD) and Fragile X syndrome (FXS) are neurodevelopmental disorders marked by deficits in communication and social interaction, often accompanied by anxiety, seizures, and intellectual disability. FXS, the most common monogenic cause of ASD, results from silencing of the FMR1 gene and consequent loss of FMRP, a regulator of synaptic protein synthesis. Disruptions in cyclic nucleotide (cAMP and cGMP) signaling underlie both ASD and FXS contributing to impaired neurodevelopment, synaptic plasticity, learning, and memory. Notably, reduced cAMP levels have been observed in platelets, lymphoblastoid cell lines and neural cells from FXS patients as well as Fmr1 KO and dfmr1 Drosophila models, linking FMRP deficiency to impaired cAMP regulation. Phosphodiesterase (PDE) inhibitors, which prevent the breakdown of cAMP and cGMP, have emerged as promising therapeutic candidates due to their ability to modulate neuronal signaling. Several PDE isoforms—including PDE2A, PDE4D, and PDE10A—have been implicated in ASD, and FXS, as they regulate pathways involved in synaptic plasticity, cognition, and social behavior. Preclinical and clinical studies show that PDE inhibition modulates neuroplasticity, neurogenesis, and neuroinflammation, thereby ameliorating autism-related behaviors. BPN14770 (a PDE4 inhibitor) has shown promising efficacy in FXS patients while cilostazol, pentoxifylline, resveratrol, and luteolin have showed improvements in children with ASD. However, challenges such as isoform-specific targeting, optimal therapeutic window, and timing of intervention remain. Collectively, these findings highlight PDE inhibition as a novel therapeutic avenue with the potential to restore cognitive and socio-behavioral functions in ASD and FXS, for which effective targeted treatments remain unavailable. Full article

The ongoing energy transition and decarbonization efforts have prompted the development of Hybrid Renewable Energy Systems (HRES) capable of integrating multiple generation and storage technologies to enhance energy autonomy. Among the available options, hydrogen has emerged as a versatile energy carrier, yet most studies have focused either on stationary applications or on mobility, seldom addressing their integration withing a single framework. In particular, the potential of Metal Hydride (MH) tanks remains largely underexplored in the context of sector coupling, where the same storage unit can simultaneously sustain household demand and provide in-house refueling for light-duty fuel-cell vehicles. This study presents the design and analysis of a residential-scale HRES that combines photovoltaic generation, a PEM electrolyzer, a lithium-ion battery and MH storage intended for direct integration with a fuel-cell electric microcar. A fully dynamic numerical model was developed to evaluate system interactions and quantify the conditions under which low-pressure MH tanks can be effectively integrated into HRES, with particular attention to thermal management and seasonal variability. Two simulation campaigns were carried out to provide both component-level and system-level insights. The first focused on thermal management during hydrogen absorption in the MH tank, comparing passive and active cooling strategies. Forced convection reduced absorption time by 44% compared to natural convection, while avoiding the additional energy demand associated with thermostatic baths. The second campaign assessed seasonal operation: even under winter irradiance conditions, the system ensured continuous household supply and enabled full recharge of two MH tanks every six days, in line with the hydrogen requirements of the light vehicle daily commuting profile. Battery support further reduced grid reliance, achieving a Grid Dependency Factor as low as 28.8% and enhancing system autonomy during cold periods. Full article

Lane detection is one of the key technologies for local map construction, and it is also a challenging task in intelligent driving, where various computer vision-based methods have been applied to address this issue. However, these methods often suffer from redundancy issues due to the sparse and narrow structure of the lane lines, and full generalization to lane detection needs more effort. To solve these problems, we propose a stepwise positive guidance strategy that utilizes the visually presented lane structure characteristics, which are inspired by the reference points in the DETR-Family methods. This strategy guides the network detection from the reference points to the reference lanes, improving the accuracy of the detection process. Moreover, we propose a new multi-scale feature fusion strategy that directly performs feature fusion on high-quality proposals. This approach differs from traditional object detection models using the Feature Pyramid Network (FPN). It fully uses the sparsity of lanes and reduces the network’s redundant computation. We proposed ProposalLaneNet, which takes full advantage of the lanes’ structure and sparse distribution characteristics. Significant improvements in speed and accuracy have been achieved by our method, enabling it to reach the state-of-the-art performance on the popular datasets CULane and TuSimple. Our method can be used as a new detection paradigm for lane detection. Full article

Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma (NHL) worldwide. Currently, approximately sixty percent of patients are cured with R-CHOP as frontline treatment, while the remaining patients experience primary refractory or relapsed (R/R) disease. Recently, the introduction of Pola-R-CHP as front-line therapy has represented a major advance in the management of DLBCL, resulting in improved outcomes. Prognosis of R/R DLBCL patients is poor, particularly for those eligible neither for chimeric antigen receptor (CAR) T-cell therapy nor autologous stem cell transplantation (ASCT), representing a significant unmet clinical need. The advent of bispecific monoclonal antibodies (BsAbs), such as bispecific T-cell engagers (BiTEs), dual affinity retargeting (DART) molecules and IgG-like bispecific antibodies, offers a novel promising therapeutic approach in the treatment of DLBCL, both as frontline treatment and in the R/R setting. BsAbs simultaneously engage two different antigens, a tumor-associated antigen and an immune cell antigen, redirecting T-cells against malignant cells and enhancing the immune response. Most BsAbs developed for the treatment of NHLs engage T-cells via CD3 and malignant B-cells via CD20, a surface antigen expressed on most lymphomatous cells. Engagement of malignant B-cells by BsAbs activates T-cells, leading to the release of multiple cytokines and potentially to two characteristic adverse events: cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). The most extensively studied BsAbs, in both the frontline and relapsed/refractory (R/R) settings, include epcoritamab, glofitamab, mosunetuzumab, and odronextamab. Epcoritamab and glofitamab have received FDA and EMA approval for R/R DLBCL after two or more systemic line of therapies. EMA has also approved glofitamab in combination with gemcitabine and oxaliplatin (GemOx) for patients with R/R DLBCL ineligible for ASCT, whereas this indication has not been approved by FDA. Odronextamab is approved by EMA for R/R DLBCL and FL in patients who have received at least two prior lines of therapy, but it has not been approved by FDA. Mosunetuzumab is approved by both agencies—but only for R/R follicular lymphoma (FL). BsAbs represent a breakthrough therapy in the treatment of DLBCL, especially in R/R diseases. The purpose of this article is to review the landscape of BsAbs in DLBCL. Full article

This narrative review addresses ongoing controversies and advancements concerning ultrasound-guided peripheral intravenous (IV) catheter insertion, and the impact of ultrasound guidance on success rate, procedural time, patient and staff experience, complications and costs, as well as requirements for its use. Growing evidence suggests that ultrasound-guided insertion of peripheral IV catheter represents a superior technique across various patient populations, particularly those presenting with difficult IV access (DIVA). Key findings highlight significant improvements in first-attempt success rates, reduction of procedural complications, and enhanced patient comfort. Ultrasound-guided insertion is also associated with an increase in catheter dwell time, a reduction in repeat procedures and in central line placements, leading to improved resource utilization and the potential for substantial long-term cost-effectiveness, despite the cost of initial investment and training. However, obtaining these improvements involves a critical importance for standardized training, adherence to rigorous aseptic techniques, and generalization of the transformative impact of ongoing technological advancements in ultrasound devices. The collective body of evidence supports the widespread adoption of ultrasound-guided peripheral IV cannulation as an evidence-based best practice in modern healthcare. Full article

This study examines the deployment of a Common Data Environment (CDE) during the extension of a major North American metro line—an infrastructure project marked by complex stakeholder dynamics and fragmented digital practices. Employing a four-phase action research approach (diagnosis, planning, implementation, evaluation), the research identifies inefficiencies in existing document management through contract reviews, field observations, and stakeholder interviews. In response, three standardized processes were introduced to streamline document workflows within the Autodesk Construction Cloud (ACC). These processes enabled partial automation of data handling, reduced reliance on manual inputs, and improved the consistency of information exchanges. While constrained by limited governance and executive engagement, the initiative demonstrates the potential of CDEs to support digital integration and automation in construction. Findings highlight the need for early planning, field-level support, and a strategic framework to ensure sustainable adoption. The results contribute practical insights for leveraging CDEs to enhance automation in large-scale infrastructure projects. Full article

This paper examines the advances and challenges of Bus Rapid Transit (BRT) systems in Brazil, considering their potential in promoting sustainable urban mobility. Rapid urbanization and the predominance of private motorized transport have intensified the need for efficient, accessible, and environmentally sound collective transport solutions. BRT has emerged as a cost-effective alternative to rail systems, combining high capacity, lower implementation costs, and operational flexibility. The study focuses on three Brazilian cities (Rio de Janeiro, Belo Horizonte, and Fortaleza) selected for their regional diversity and distinct BRT models. Using the Delphi method, the analysis was structured around three dimensions: road infrastructure, transport planning and networks, and system operation and performance. Results indicate significant progress in terms of exclusive corridors, integration terminals, express services, and the adoption of Intelligent Transport Systems. However, structural gaps persist, particularly regarding incomplete infrastructure, weak integration between trunk and feeder lines, limited monitoring of feeder services, and insufficient adaptation of networks to urban dynamics. The findings highlight that the effectiveness of Brazilian BRT systems depends on strengthening feeder lines, improving physical and fare integration, and expanding sustainable infrastructure. Full article

The BRI1-EMS suppressor/Brassinazole-resistant (BES/BZR) transcription factors (TFs) act as regulators of the Brassinosteroid (BR) signaling pathway and play key roles in modulating plant growth, development, and abiotic stress tolerance. However, the function of BES/BZR TFs remains unknown in warm-season turfgrass species. In this study, ZjBZR2, a BES/BZR TF in Zoysia japonica was identified and shared the closest evolutionary relationship with OsBZR2 from Oryza sativa. ZjBZR2 was a nuclear-localized protein and had transcriptional activation activity. ZjBZR2 was predominantly expressed in roots, stems, and lamina joints, and could be significantly induced by BR treatment and osmotic stresses including PEG and salinity. ZjBZR2-overexpressing rice lines increased leaf angle compared with wild-type plants. Furthermore, overexpression of ZjBZR2 enhanced osmotic stress (PEG and salt) tolerance which is associated with the upregulation of stress-responsive and ROS-scavenging genes. These findings provide the first functional characterization of ZjBZR2 in rice and offer excellent genetic resources for the improvement of turfgrass cultivars. Full article

(1) Background: With the increasing incidence of cancer, the need for handling cytotoxic drugs has also grown. However, manipulating these drugs exposes healthcare professionals to significant risks, including occupational exposure to hazardous chemicals. Therefore, it is important to adopt protective measures, including personal protective equipment (PPE) and correct ergonomic practices, to ensure safe drug preparation and minimize health risks for the operators. However, while chemical exposure and PPE have been extensively addressed in the literature, the combined impact of ergonomic practices and protective measures remains insufficiently emphasized, representing a critical gap this review aims to address. Accordingly, the objective of this literature review was to analyze the ergonomic and individual protection practices during the handling of cytostatic drugs and all the implications that bad ergonomic practices and/or poor individual protection have on the operator’s health; (2) Methods: In order to perform this integrative review, a structured literature search was conducted using online databases (Web of Science^®, Google Scholar^®, and PubMed^®) from January 2005 to June 2025. (3) Results: A total of 19 articles were analyzed, with 17 focusing on PPE and 17 on ergonomics. The findings emphasize that PPE, such as gloves, masks, gowns, sleeves and safety glasses, plays a critical role in the safe handling of cytotoxic drugs, particularly when combined with other safety measures. Additionally, maintaining correct ergonomic posture is important in preventing musculoskeletal disorders; (4) Conclusions: This review emphasizes the significance of integrating appropriate PPE use with sound ergonomic procedures. Although PPE is still the secondary line of defense against occupational exposure, ergonomic issues must also be addressed to avoid chronic musculoskeletal problems. Continuous training, rigorous attention to safety procedures, and ergonomic enhancements should be prioritized by healthcare facilities as a key element of occupational safety programs to reduce the short-term and long-term health hazards for personnel handling dangerous drugs. Full article

Background: Unintended adolescent pregnancy and sexually transmitted infections (STIs) remain pressing public health concerns in Northeastern Thailand. Although school-based sexuality education is widespread, risk behaviors persist, underscoring the need for innovative approaches. This study evaluated the SESS (System–Empowerment–Support–Social Network) model, a multi-component framework designed to strengthen adolescent sexual health. Methods: A quasi-experimental, two-school study was conducted among 240 students aged 15–19 years in Nakhon Ratchasima Province. One school (n = 120) implemented a 16-week SESS program, while a comparison school (n = 120) continued with the standard curriculum. The SESS model combined system coordination, empowerment workshops, peer and institutional support, and digital platforms (Facebook, LINE). Data were collected with validated questionnaires and analyzed using ANCOVA, adjusting for baseline values. Exploratory analyses reported mean differences with 95% confidence intervals (CIs). Results: Groups were comparable at baseline. Post-intervention, the intervention school showed higher perception scores (mean difference = +13.0; 95% CI: 10.5–17.0) and preventive practice scores (mean difference = +14.0; 95% CI: 10.1–17.9). Attitudes showed minimal change. No pregnancies or self-reported STI cases were documented among intervention participants during the follow-up period. Conclusions: In this two-school quasi-experimental evaluation, the SESS model was associated with improvements in perceptions and practices, though attitudinal changes were limited. Findings suggest the feasibility of integrating empowerment, social support, and digital engagement into school-based programs while highlighting the need for multi-school trials to establish effectiveness. Full article

Glioblastoma multiforme (GBM) is an aggressive brain cancer characterized by highly invasive growth driven by glial-mesenchymal transition (GMT). Given the urgent need for effective therapies targeting this process, we aimed to discover potential GMT inhibitors using transcriptomic-based repurposing applied to both approved and experimental drugs. Deep bioinformatic analysis of transcriptomic data from GBM patient tumors and GBM cell lines with mesenchymal phenotype using gene set variation analysis (GSVA), weighted gene co-expression network analysis (WGCNA), reconstruction of GMT-related gene association networks, gene set enrichment analysis (GSEA), and the search for correlation with transcriptomic profiles of known GMT markers, revealed a novel 31-gene GMT signature applicable as relevant input data for the connectivity map-based drug repurposing study. Using this gene signature, a number of small-molecule compounds were predicted as potent anti-GMT agents. Further ranking according to their blood–brain barrier permeability, as well as structural and transcriptomic similarities to known anti-GBM drugs, revealed SP600125, vemurafenib, FG-7142, dibenzoylmethane, and phensuximide as the most promising for GMT inhibition. In vitro validation showed that SP600125, which is most closely associated with GMT-related hub genes, effectively inhibited TGF-β1- and chemical hypoxia-induced GMT in U87 GBM cells by reducing morphological changes, migration, vasculogenic mimicry, and mesenchymal marker expression. These results clearly demonstrate the applicability of connectivity mapping as a powerful tool to accelerate the discovery of effective GMT-targeting therapies for GBM and significantly expand our understanding of the antitumor potential of SP600125. Full article

This study explores the anticancer, antioxidant, and phytochemical activities of Laurus nobilis L. ethanolic leaf extract. The extract demonstrated selective cytotoxicity against four human cancer cell lines, showing strong cytotoxic effect against ovarian (ES2), head and neck (SAS), and colorectal (HT-29) cancer cells, with IC₅₀ values ranging from 3.8 ± 0.3 to 4.4 ± 0.6 µg/mL. Notably, it exhibited only moderate inhibition of the MDA-MB-231 breast cancer cell line (IC₅₀ = 18.5 ± 0.8 µg/mL), possibly reflecting intrinsic differences in cell line sensitivity. Importantly, the extract showed low toxicity toward normal human fibroblasts (HDF), with an IC₅₀ value exceeding 100 µg/mL, indicating a favorable selectivity profile. The flow cytometry analysis showed that the extract caused cell death and stopped the cell cycle in both SAS and ES2 cancer cell lines. In SAS cells, extract treatment significantly increased apoptotic cells (21.1% ± 0.3%) compared to the control (6.3% ± 0.4%), along with G2 phase accumulation, indicating G2 arrest. Similarly, in ES2 cells, apoptosis increased (16.2% ± 1.3% vs. control 8.1% ± 1.0%), and a significant cell accumulation in the S phase was observed, suggesting disruption of cell cycle progression. Antioxidant screenings showed impressive dose-dependent DPPH radical scavenging activity (25–2000 µg/mL), although less potent than ascorbic acid (2.6 µg/mL). UPLC-QTOF/MS phytochemical analysis revealed various phenolic constituents, such as flavonoids and phenolic acids, and an inferred association with the recorded bioactivities. This preliminary work indicates that L. nobilis extracts may act as natural anticancer and antioxidant agents; however, it was limited to in vitro testing with non-standardized samples, underscoring the need for further research to validate and extend these findings for future applications. Full article

The impact freezing of supercooled water droplets poses a significant threat to the safety of aircraft and power transmission equipment. In recent years, extensive research has been conducted using numerical methods to investigate this phenomenon. However, existing models often incorrectly predict premature freezing near the droplet–air contact line during the early stage of impact, thereby unreasonably suppressing the spreading process in these regions. To address this limitation, this study proposes a velocity-gate-based activation control strategy for the Darcy momentum source, enabling its dynamic adjustment during simulation. The methodology integrates the Volume of Fluid (VOF) model, the solidification model, and the dynamic contact angle (DCA) model with the proposed dynamic Darcy source, while accounting for the influence of supercooling on physical properties. The numerical simulations are performed using COMSOL Multiphysics 6.3 and validated against experimental spreading factor data. The results demonstrate that the proposed methodology effectively eliminates nonphysical freezing during the initial spreading stage, and the predicted spreading factors agree well with experiments, with a maximum relative deviation of up to 11.7% across all simulated cases. The proposed approach improves consistency with real-world behavior and enhances the reliability of existing numerical tools for aircraft icing prediction and anti-icing design. Full article

Sensors in power systems utilize the detection results of fault signals to guide subsequent fault handling procedures. However, the traditional phase-shift restart strategy exhibits limitations such as power interruptions, reactive power redundancy, and intersystem fault clearance failures when addressing faults in the hybrid AC/DC transmission system. To address these shortcomings, a power compensation-based fault ride-through (FRT) scheme and a protection-control cooperation FRT scheme are proposed, taking into account the operational characteristics of the symmetric monopole LCC-HVDC (SM-LCC-HVDC). The power compensation-based FRT scheme actively compensates for power, mitigating the impact of reactive power redundancy on the AC-side bus during faults. The protection-control cooperation FRT scheme is activated after sufficient AC components are detected on the DC side. It leverages the adjustability of the DC system to proactively activate protection for AC transmission lines. An electromagnetic transient simulation model of the hybrid AC/DC same-tower transmission system was developed in PSCAD/EMTDC. Simulation results validate the effectiveness and superiority of the proposed methods. Full article