Monoclonal Antibodies in Lymphoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1909

Special Issue Editor


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Guest Editor
U.O.C. di Ematologia, Azienda Ospedaliera Papardo, 98158 Messina, Italy
Interests: hematological diagnosis and treatment; lymphoma; clinical trials

Special Issue Information

Dear Colleagues,

The introduction of monoclonal antibodies (MoAbs) into clinical practice has significantly improved the prognosis of many hematological malignancies, representing  a milestone in the field of precision medicine.

Used in monotherapy or, more often, in combination with chemotherapy, MoAbs are currently essential in the treatment of lymphoid neoplasms.

MoAbs are able to target specific cancer antigens, using direct or indirect immunological killing to address cytotoxic agents to neoplastic cells, to recruit and activate immune effector cells, and to antagonize cell exhaustion.      

In this Special Issue, we would like to provide an overview of the biological basis and the current clinical use of MoAbs and of the optimal combination regimens and sequential schemes, with a look towards future therapeutic perspectives.

Dr. Donato Mannina
Guest Editor

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Keywords

  • monoclonal antibodies
  • immunotherapy
  • drug immunoconiugates
  • bispecific antibodies
  • checkpoints inhibitors
  • NHL
  • HL
  • CLL

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Published Papers (1 paper)

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Review

24 pages, 958 KiB  
Review
Bispecific Antibodies for Lymphoid Malignancy Treatment
by Matteo Bisio, Luca Legato, Filippo Fasano, Corrado Benevolo Savelli, Carola Boccomini, Maura Nicolosi, Elisa Santambrogio, Roberto Freilone, Mattia Novo and Barbara Botto
Cancers 2025, 17(1), 94; https://doi.org/10.3390/cancers17010094 - 31 Dec 2024
Viewed by 1419
Abstract
Backgroud: The introduction of highly active immunotherapies has changed the outcome of B-cell non-Hodgkin lymphomas (B-NHLs) in the last two decades. Since then, important progress has been shown using newer and more active immunotherapies, including chimeric antigen receptor T-cell therapy (CAR-T), conjugated monoclonal [...] Read more.
Backgroud: The introduction of highly active immunotherapies has changed the outcome of B-cell non-Hodgkin lymphomas (B-NHLs) in the last two decades. Since then, important progress has been shown using newer and more active immunotherapies, including chimeric antigen receptor T-cell therapy (CAR-T), conjugated monoclonal antibodies, and bispecific antobodies, which currently plays a significant role in the treatment of diffuse large B-cell (DLBCL), follicular (FL), and mantle cell (MCL) lymphoma. Purpose: In this review, we provide an updated overview of recently completed and ongoing BsAb trials in patients with relapsed/refractory(R/R) B-NHL and Hodgkin’s lymphoma, including single-agent results, emerging combinations, safety data, and novel constructs. Conclusions: Bispecific antibodies (BsAbs) are a novel class of “off-the-shelf” T-cell-redirecting drugs capable of targeting various cell-surface antigens. New antigen targets are currently under investigation, such as CD19 × CD3 and CD30 × CD3 or CD30 × CD16, in different settings. BsAbs are among the most promising therapeutic options for lymphoma today since they have demonstrated significant single-agent activity, along with a manageable toxicity profile, in patients with heavily pretreated B-NHL. Full article
(This article belongs to the Special Issue Monoclonal Antibodies in Lymphoma)
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