Search Results (28)

Standard numerical methods such as Runge–Kutta and Euler methods have been widely used to approximate solutions to nonlinear systems. These methods converge to the solution only for small step sizes; for larger time steps, they generally generate spurious or chaotic solutions. In this paper, we consider a malaria propagation model with control for which we construct a second-order nonstandard finite difference scheme that preserves the important mathematical properties of the continuous model, which are positivity, boundedness, and stability of solutions irrespective of the step size. Moreover, we show that the equilibrium points of the discrete model are the same as those of the continuous model. By applying the double mesh principle, we provide evidence that the second-order NSFD scheme approximates the true solution with small errors. Theoretical assertions and numerical results show the advantages of the developed second-order nonstandard finite difference method. Full article

The paper attempts to propose nonstandard finite difference theta schemes to analyze solutions of a competitive problem with toxicants. We have seen that the competitive system is elementary-stable, and the stability features of each equilibrium point of the derived model are the same as those of the continuous model for any value of step size. Therefore, we can say that nonstandard finite difference theta schemes exhibit symmetry at every stage where stability analyses of the mathematical model are performed. Full article

Tomato Yellow Leaf Curl Virus (TYLCV) has recently caused severe economic losses in global tomato production. According to the International Plant Protection Convention (IPPC), yield reductions of 50–60% have been reported in several regions, including the Caribbean, Central America, and South Asia, with losses in sensitive cultivars reaching up to 90–100%. In developing countries, TYLCV and mixed infections affect more than seven million hectares of tomato-growing land annually. In this study, we construct and analyze a nonlinear dynamic model describing the transmission of TYLCV, incorporating the Caputo fractional-order derivative operator. The existence and uniqueness of solutions to the proposed model are rigorously established. Equilibrium points are identified, and the Jacobian determinant approach is applied to compute the basic reproduction number, $R_0$. Suitable Lyapunov functions are formulated to analyze the global asymptotic stability of both the disease-free and endemic equilibria. The model is numerically solved using the Grünwald–Letnikov-based nonstandard finite difference method, and simulations assess how the memory index and preventive strategies influence disease propagation. The results reveal critical factors governing TYLCV transmission and suggest effective intervention measures to guide sustainable crop protection policies. Full article

According to the World Health Organization (WHO), globally, cervical cancer ranks as the fourth most common cancer in women, with around 660,000 new cases in 2022. In the same year, about 94 percent of the 350,000 deaths caused by cervical cancer occurred in low- and middle-income countries. This paper focuses on the dynamics of HPV by modeling the interactions between four compartments, as follows: S(t), the number of susceptible females; I(t), females infected with HPV; X(t), females infected with HPV but not yet affected by cervical cancer (CCE); and V(t), females infected with HPV and affected by CCE. A compartmental model is formulated to analyze the progression of HPV, ensuring all key mathematical properties, such as existence, uniqueness, positivity, and boundedness of the solution. The equilibria of the model, such as the HPV-free equilibrium and HPV-present equilibrium, are analyzed, and the basic reproduction number, $R_0$, is computed using the next-generation matrix method. Local and global stability of these equilibria are rigorously established to understand the conditions for disease eradication or persistence. Sensitivity analysis around the reproduction number is carried out using partial derivatives to identify critical parameters influencing $R_0$, which gives insights into effective intervention strategies. With appropriate positivity, boundedness, and numerical stability, a new stochastic non-standard finite difference (NSFD) scheme is developed for the proposed model. A comparison analysis of solutions shows that the NSFD scheme is the most consistent and reliable method for a stochastic fractional delay model. Graphical simulations are presented to provide visual insights into the development of the disease and lend the results to a more mature discourse. This research is crucial in highlighting the mathematical rigor and practical applicability of the proposed model, contributing to the understanding and control of HPV progression. Full article

Campylobacteriosis has been described as an ever-changing disease and health issue that is rather dangerous for different population groups all over the globe. The World Health Organization (WHO) reports that 33 million years of healthy living are lost annually, and nearly one in ten persons have foodborne illnesses, including Campylobacteriosis. This explains why there is a need to develop new policies and strategies in the management of diseases at the intergovernmental level. Within this framework, an advanced stochastic fractional delayed model for Campylobacteriosis includes new stochastic, memory, and time delay factors. This model adopts a numerical computational technique called the Grunwald–Letnikov-based Nonstandard Finite Difference (GL-NSFD) scheme, which yields an exponential fitted solution that is non-negative and uniformly bounded, which are essential characteristics when working with compartmental models in epidemic research. Two equilibrium states are identified: the first is an infectious Campylobacteriosis-free state, and the second is a Campylobacteriosis-present state. When stability analysis with the help of the basic reproduction number $R_0$ is performed, the stability of both equilibrium points depends on the $R_0$ value. This is in concordance with the actual epidemiological data and the research conducted by the WHO in recent years, with a focus on the tendency to increase the rate of infections and the necessity to intervene in time. The model goes further to analyze how a delay in response affects the band of Campylobacteriosis spread, and also agrees that a delay in response is a significant factor. The first simulations of the current state of the system suggest that certain conditions can be achieved, and the eradication of the disease is possible if specific precautions are taken. The outcomes also indicate that enhancing the levels of compliance with the WHO-endorsed SOPs by a significant margin can lower infection rates significantly, which can serve as a roadmap to respond to this public health threat. Unlike most analytical papers, this research contributes actual findings and provides useful recommendations for disease management approaches and policies. Full article

This paper introduces a stable non-standard finite difference (NSFD) method to solve time-fractional singularly perturbed convection–diffusion problems. The fractional derivative in time is defined in the Caputo sense. The proposed method shows high efficiency when applied using a uniform mesh and can be easily extended to a Shishkin mesh in the spatial domain. We discuss error estimates to demonstrate the convergence of the numerical scheme. Additionally, various numerical examples are presented to illustrate the behavior of the solution for different values of the perturbation parameter $ϵ$ and the order of the fractional derivative. Full article

Cassava is the sixth most important food crop worldwide and the third most important source of calories in the tropics. More than 800 million people depend on this plant’s tubers and sometimes leaves. To protect cassava crops and the livelihoods depending on them, we developed a stochastic fractional delayed model based on stochastic fractional delay differential equations (SFDDEs) to analyze the dynamics of cassava mosaic disease, focusing on two equilibrium states, the state of being absent from cassava mosaic disease and the state of being present with cassava mosaic disease. The basic reproduction number and sensitivity of parameters were estimated to characterize the level beyond which cassava mosaic disease prevails or declines in the plants. We analyzed the stability locally and globally to determine the environment that would ensure extinction and its persistence. To support the theoretical analysis, as well as the reliable results of the model, the present study used a nonstandard finite difference (NSFD) method. This numerical method not only improves the model’s accuracy but also guarantees that cassava mosaic probabilities are positive and bounded, which is essential for the accurate modeling of the cassava mosaic processes. The NSFD method was applied in all the scenarios, and it was determined that it yields adequate performance in modeling cassava mosaic disease. The ideas of the model are crucial for exploring key variables, which affect the scale of cassava mosaic and the moments of intervention. The present work is useful for discerning the mechanism of cassava mosaic disease as it presents a solid mathematical model capable of determining the stage of cassava mosaic disease. Full article

Nonstandard finite-difference (NSFD) methods, pioneered by R. E. Mickens, offer accurate and efficient solutions to various differential equation models in science and engineering. NSFD methods avoid numerical instabilities for large time steps, while numerically preserving important properties of exact solutions. However, most NSFD methods are only first-order accurate. This paper introduces two new classes of explicit second-order modified NSFD methods for solving n-dimensional autonomous dynamical systems. These explicit methods extend previous work by incorporating novel denominator functions to ensure both elementary stability and second-order accuracy. This paper also provides a detailed mathematical analysis and validates the methods through numerical simulations on various biological systems. Full article

The therapeutic potential of delta9-tetrahydrocannabinol (THC), a primary cannabinoid in the cannabis plant, has led to its development into oral medical products for treating various conditions. However, THC, being a psychoactive substance, can lead to addiction if taken in inappropriate amounts. Thus, studying the pharmacokinetics of THC is crucial for understanding how the drug behaves in the body after administration. This study aims to develop a multi-compartmental model to investigate the pharmacokinetics of medical THC and its metabolites after oral administration. Using the law of mass action, the model was converted into ordinary differential equations (ODEs) to describe the rate of concentration changes of THC and its metabolites in each compartment. The nonstandard finite difference (NSFD) method was then applied to construct numerical solution schemes, which were implemented in MATLAB along with estimated pharmacokinetic rate constants. The results demonstrate that the simulation curves depicting the plasma concentration–time profiles of THC and 11-hydroxy-THC (THC-OH) closely resemble actual data samples, indicating the model’s accuracy. Moreover, the model predicts the pharmacokinetics of THC and its metabolites in various tissues. Consequently, this model serves as a valuable tool for enhancing our understanding of the pharmacokinetics of THC and its metabolites, guiding dosage adjustments, and determining administration durations for oral medical THC. Full article

A nonlinear mathematical model of COVID-19 containing asymptomatic as well as symptomatic classes of infected individuals is considered and examined in the current paper. The largest eigenvalue of the next-generation matrix known as the reproductive number is obtained for the model, and serves as an epidemic indicator. To better understand the dynamic behavior of the continuous model, the unconditionally stable nonstandard finite difference (NSFD) scheme is constructed. The aim of developing the NSFD scheme for differential equations is its dynamic reliability, which means discretizing the continuous model that retains important dynamic properties such as positivity of solutions and its convergence to equilibria of the continuous model for all finite step sizes. The Schur–Cohn criterion is used to address the local stability of disease-free and endemic equilibria for the NSFD scheme; however, global stability is determined by using Lyapunov function theory. We perform numerical simulations using various values of some key parameters to see more characteristics of the state variables and to support our theoretical findings. The numerical simulations confirm that the discrete NSFD scheme maintains all the dynamic features of the continuous model. Full article

The main aim of this contribution is to construct a numerical scheme for solving stochastic time-dependent partial differential equations (PDEs). This has the advantage of solving problems with positive solutions. The scheme provides conditions for obtaining positive solutions, which the existing Euler–Maruyama method cannot do. In addition, it is more accurate than the existing stochastic non-standard finite difference (NSFD) method. Theoretically, the suggested scheme is more accurate than the current NSFD method, and its stability and consistency analysis are also shown. The scheme is applied to the linear scalar stochastic time-dependent parabolic equation and the nonlinear auto-catalytic Brusselator model. The deficiency of the NSFD in terms of accuracy is also shown by providing different graphs. Many observable occurrences in the physical world can be traced back to certain chemical concentrations. Examining and understanding the inter-diffusion between chemical concentrations is important, especially when they coincide. The Brusselator model is the gold standard for describing the relationship between chemical concentrations and other variables in chemical systems. A computational code for the proposed model scheme may be made available to readers upon request for convenience. Full article

This article formulates and analyzes a discrete-time Human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type I (HTLV-I) coinfection model with latent reservoirs. We consider that the HTLV-I infect the CD$4^{+}$T cells, while HIV-1 has two classes of target cells—CD$4^{+}$T cells and macrophages. The discrete-time model is obtained by discretizing the original continuous-time by the non-standard finite difference (NSFD) approach. We establish that NSFD maintains the positivity and boundedness of the model’s solutions. We derived four threshold parameters that determine the existence and stability of the four equilibria of the model. The Lyapunov method is used to examine the global stability of all equilibria. The analytical findings are supported via numerical simulation. The impact of latent reservoirs on the HIV-1 and HTLV-I co-dynamics is discussed. We show that incorporating the latent reservoirs into the HIV-1 and HTLV-I coinfection model will reduce the basic HIV-1 single-infection and HTLV-I single-infection reproductive numbers. We establish that neglecting the latent reservoirs will lead to overestimation of the required HIV-1 antiviral drugs. Moreover, we show that lengthening of the latent phase can suppress the progression of viral coinfection. This may draw the attention of scientists and pharmaceutical companies to create new treatments that prolong the latency period. Full article

Infection with human immunodeficiency virus type 1 (HIV-1) or human T-lymphotropic virus type I (HTLV-I) or both can lead to mortality. CD4⁺T cells are the target for both HTLV-I and HIV-1. In addition, HIV-1 can infect macrophages. CD4⁺T cells and macrophages play important roles in the immune system response. This article develops and analyzes a discrete-time HTLV-I and HIV-1 co-infection model. The model depicts the within-host interaction of six compartments: uninfected CD4⁺T cells, HIV-1-infected CD4⁺T cells, uninfected macrophages, HIV-1-infected macrophages, free HIV-1 particles and HTLV-I-infected CD4⁺T cells. The discrete-time model is obtained by discretizing the continuous-time model via the nonstandard finite difference (NSFD) approach. We show that NSFD preserves the positivity and boundedness of the model’s solutions. We deduce four threshold parameters that control the existence and stability of the four equilibria of the model. The Lyapunov method is used to examine the global stability of all equilibria. The analytical findings are supported via numerical simulation. The model can be useful when one seeks to design optimal treatment schedules using optimal control theory. Full article

In this paper, the Black–Scholes equation is solved using a new technique. This scheme is derived by combining the Laplace transform method and the nonstandard finite difference (NSFD) strategy. The qualitative properties of the method are discussed, and it is shown that the new method is positive, stable, and consistent when low volatility is assumed. The efficiency of the new method is demonstrated by a numerical example. Full article

In this article, the transmission dynamical model of the deadly infectious disease named Ebola is investigated. This disease identified in the Democratic Republic of Congo (DRC) and Sudan (now South Sudan) and was identified in 1976. The novelty of the model under discussion is the inclusion of advection and diffusion in each compartmental equation. The addition of these two terms makes the model more general. Similar to a simple population dynamic system, the prescribed model also has two equilibrium points and an important threshold, known as the basic reproductive number. The current work comprises the existence and uniqueness of the solution, the numerical analysis of the model, and finally, the graphical simulations. In the section on the existence and uniqueness of the solutions, the optimal existence is assessed in a closed and convex subset of function space. For the numerical study, a nonstandard finite difference (NSFD) scheme is adopted to approximate the solution of the continuous mathematical model. The main reason for the adoption of this technique is delineated in the form of the positivity of the state variables, which is necessary for any population model. The positivity of the applied scheme is verified by the concept of M-matrices. Since the numerical method gives a discrete system of difference equations corresponding to a continuous system, some other relevant properties are also needed to describe it. In this respect, the consistency and stability of the designed technique are corroborated by using Taylor’s series expansion and Von Neumann’s stability criteria, respectively. To authenticate the proposed NSFD method, two other illustrious techniques are applied for the sake of comparison. In the end, numerical simulations are also performed that show the efficiency of the prescribed technique, while the existing techniques fail to do so. Full article