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16 pages, 3340 KiB  
Article
Stripe-Patterned Al/PDMS Triboelectric Nanogenerator for a High-Sensitive Pressure Sensor and a Novel Two-Digit Switch with Surface-Edge Enhanced Charge Transfer Behavior
by Chung-Yu Yu, Chia-Chun Hsu, Chin-An Ku and Chen-Kuei Chung
Nanomaterials 2025, 15(10), 760; https://doi.org/10.3390/nano15100760 - 19 May 2025
Viewed by 112
Abstract
A triboelectric nanogenerator (TENG) holds significant potential as a self-powered pressure sensor due to its ability to convert mechanical energy into electrical energy. The output voltage of a TENG is directly correlated with the applied pressure, making it highly suitable for pressure sensing [...] Read more.
A triboelectric nanogenerator (TENG) holds significant potential as a self-powered pressure sensor due to its ability to convert mechanical energy into electrical energy. The output voltage of a TENG is directly correlated with the applied pressure, making it highly suitable for pressure sensing applications. Among the key factors influencing TENG performance, the microstructure on the surface plays a crucial role. However, the effect of surface microstructure on charge transfer behavior remains relatively underexplored. Here, a stripe-patterned rough TENG (SR-TENG) fabricated by laser ablation and molding is proposed. The stripe-patterned rough surface exhibits excellent deformation properties, allowing for more effective contact area between the tribolayers. Additionally, the localized surface-edge enhanced electric field at the stripe boundaries improves surface charge transfer, thereby enhancing overall output performance. The SR-TENG achieved an open-circuit voltage of 97 V, a short-circuit current of 59.6 μA, an instantaneous power of 3.55 mW, and a power density of 1.54 W/m2. As an energy harvester, the SR-TENG successfully powered 150 LEDs. A linear relationship between applied pressure and output voltage was established with a coefficient of determination R2 = 0.94, demonstrating a high sensitivity of 14.14 V/kPa. For practical application, a novel self-powered two-digit pressure switch was developed based on the SR-TENG. This system enables the control of two different LEDs using a single TENG device, triggered by applying a light or hard press. Full article
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32 pages, 1497 KiB  
Review
Redefining Quantum Dot Synthesis with Additive-Manufactured Microfluidics—A Review
by Faisal bin Nasser Sarbaland, Masashi Kobayashi, Daiki Tanaka, Risa Fujita and Masahiro Furuya
J 2025, 8(2), 18; https://doi.org/10.3390/j8020018 - 18 May 2025
Viewed by 112
Abstract
Quantum dots with sizes between 1 and 100 nm possess unique optical and electronic properties, making them valuable in energy, bioimaging, and optoelectronics fields. While traditional synthesis methods offer control over QD properties, they face challenges in scalability and reproducibility. Integrating microfluidics addresses [...] Read more.
Quantum dots with sizes between 1 and 100 nm possess unique optical and electronic properties, making them valuable in energy, bioimaging, and optoelectronics fields. While traditional synthesis methods offer control over QD properties, they face challenges in scalability and reproducibility. Integrating microfluidics addresses these issues, providing precise control and high-throughput capabilities. This review highlights the transition from PDMS-based devices to additive-manufactured microfluidics, emphasizing their ability to overcome limitations in traditional methods. These advancements smooth the way for scalable, cost-effective, and sustainable QD production with enhanced application potential. Full article
(This article belongs to the Section Chemistry & Material Sciences)
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17 pages, 5706 KiB  
Article
Flexible Piezoresistive Sensor Based on CNT/PVA Composite with Wide Linear Detection Range for Human Motion Monitoring
by Lijun Chen, Yucheng Huang, Honglong Ning, Yuxiang Liu, Huacheng Tang, Rui Zhou, Shaojie Jin, Jiahao Zheng, Rihui Yao and Junbiao Peng
Polymers 2025, 17(10), 1378; https://doi.org/10.3390/polym17101378 - 17 May 2025
Viewed by 157
Abstract
In recent years, flexible pressure sensors have attracted significant attention due to their extensive application prospects in wearable devices, healthcare monitoring, and other fields. Herein, we propose a flexible piezoresistive sensor with a broad detection range, utilizing a CNT/PVA composite as the pressure-sensitive [...] Read more.
In recent years, flexible pressure sensors have attracted significant attention due to their extensive application prospects in wearable devices, healthcare monitoring, and other fields. Herein, we propose a flexible piezoresistive sensor with a broad detection range, utilizing a CNT/PVA composite as the pressure-sensitive layer. The effect of the CNT-to-PVA ratio on sensing performance was systematically investigated, revealing that the sensor’s sensitivity initially increases and then decreases with rising CNT content. When the weight percentage of CNTs reaches 11.24 wt%, the sensing film exhibits optimal piezoresistive properties. A resistance model of the composite conductive material was established to elucidate the sensing mechanism associated with CNT content in detail. Furthermore, hill-like microstructures were fabricated on a PDMS substrate using sandpaper as a template to further enhance overall performance. The sensor demonstrates a sensitivity of 0.1377 kPa−1 (<90 kPa), a sensing range of up to 400 kPa, a response time of 160 ms, and maintains excellent stability after 2000 folding cycles. It can accurately detect human joint flexion and muscle activity. This work is expected to provide a feasible solution for flexible electronic devices applied in human motion monitoring and analysis, particularly offering competitive advantages in applications involving wide-range pressure detection. Full article
(This article belongs to the Special Issue Development of Applications of Polymer-Based Sensors and Actuators)
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11 pages, 689 KiB  
Article
Simultaneous Determination of Quercetin and Trans-Resveratrol in Winemaking Waste by Solid Phase Microextraction Coupled to High-Performance Liquid Chromatography with Fluorescence and Ultraviolet Detection
by Antonella Maria Aresta, Giovanna Mancini, Nicoletta De Vietro and Carlo Zambonin
Analytica 2025, 6(2), 19; https://doi.org/10.3390/analytica6020019 - 17 May 2025
Viewed by 88
Abstract
A solid phase microextraction (SPME) method coupled with liquid chromatography (LC) and fluorescence/ultraviolet-diode array detection was developed for the simultaneous determination of quercetin and trans-resveratrol. The chromatographic, detection, and SPME extraction/desorption conditions were systematically optimized. The performance of four commercial SPME fibers—polyacrylate (PA), [...] Read more.
A solid phase microextraction (SPME) method coupled with liquid chromatography (LC) and fluorescence/ultraviolet-diode array detection was developed for the simultaneous determination of quercetin and trans-resveratrol. The chromatographic, detection, and SPME extraction/desorption conditions were systematically optimized. The performance of four commercial SPME fibers—polyacrylate (PA), polyethylene glycol (PEG), polydimethylsiloxane (PDMS), and polydimethylsiloxane-divinylbenzene (PDMS-DVB)—was evaluated and compared with a homemade polydopamine (PDA)-coated fiber. While all of the fibers successfully extracted the target analytes, their efficiencies varied significantly. The PA, PEG, and PDA fibers demonstrated superior performance, exhibiting wide linearity ranges (0.03–1 µg/mL (PA and PEG) and 0.06–1 µg/mL (PDA) for quercetin, 0.01–1 µg/mL for trans-resveratrol); high sensitivity (LODs of 0.01 µg/mL (PA and PEG) and 0.02 µg/mL (PDA) for quercetin, 0.003 µg/mL for trans-resveratrol); and excellent precision. Among these, the polyacrylate coating delivered the best analytical performance and was selected for further application. The optimized method was applied to analyze winemaking by-products (seeds, skins, and stalks) using SPME on ethanol-macerated extracts subjected to brief ultrasonication. Quercetin and trans-resveratrol were quantified in pomace extracts at concentrations of 104.3 ± 8.2 µg/g and 38.5 ± 4.1 µg/g, respectively. Recovery experiments confirmed the method’s accuracy, with recoveries of 99.1 ± 7.4% for quercetin and 98.5 ± 9.8% for trans-resveratrol. This study establishes a reliable, sensitive, and efficient approach for the determination of these bioactive compounds in complex matrices, with potential applications in the food and pharmaceutical industries. Full article
(This article belongs to the Special Issue Green Analytical Techniques and Their Applications)
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17 pages, 630 KiB  
Article
Acute Respiratory and Influenza Viruses Circulating in Kazakhstan During 2018–2024
by Tatyana Glebova, Nailya Klivleyeva, Assem Baimukhametova, Galina Lukmanova, Nurbol Saktaganov, Nuray Ongarbayeva, Baiken Baimakhanova, Gulmira Kassymova, Madisha Sagatova, Almagul Rachimbayeva, Nazgul Zhanuzakova, Tatyana Naidenova, Nigina Rakhmonova and Richard Webby
Pathogens 2025, 14(5), 493; https://doi.org/10.3390/pathogens14050493 - 16 May 2025
Viewed by 79
Abstract
Respiratory tract infections cause serious morbidity and mortality and are a major public health problem. The objective of our study was detection of the prevalence of viral respiratory diseases in the territory of Kazakhstan during the epidemic period of 2018–2024. The presence of [...] Read more.
Respiratory tract infections cause serious morbidity and mortality and are a major public health problem. The objective of our study was detection of the prevalence of viral respiratory diseases in the territory of Kazakhstan during the epidemic period of 2018–2024. The presence of respiratory viruses in nasopharyngeal swabs was analyzed using real-time polymerase chain reaction. The level of specific antibodies in the blood serum was determined by hemagglutination inhibition assay and enzyme-linked immunosorbent assay. In rtRT-PCR, patients were diagnosed with non-influenza viral respiratory tract infections as well as influenza viruses A(H1N1), A(H3N2), and B. Antibodies were detected against A(H1N1)pdm09, influenza A(H3N2), and influenza B viruses and with simultaneous detection of both viruses. The circulation of influenza A(H3N2) viruses belonging to the 3C.2a1b.2a.2a.3a.1 clade was confirmed by whole-genome sequencing. According to the results, in the period 2018–2024, the spread of influenza A and B viruses and non-influenza respiratory tract infections was observed. The data of this study confirm the role of known causative agents of epidemic infection and indicate the need to continue monitoring their spread in Kazakhstan, which may add to the general quality of the health system. Full article
(This article belongs to the Section Viral Pathogens)
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15 pages, 4639 KiB  
Article
Simulation of the Thermodynamic Properties and Hydrophobicity of Polydimethylsiloxane Modified by Grafting Nano-SiO2 with Different Silane Coupling Agents
by Yuzhang Xie, Weiju Dai, Jingyi Yan, Zuhao Wang and Chao Tang
Materials 2025, 18(10), 2323; https://doi.org/10.3390/ma18102323 - 16 May 2025
Viewed by 69
Abstract
Polydimethylsiloxane (PDMS) with good hydrophobicity and nano-SiO2 with excellent thermal stability and mechanical properties are used as a composite coating for cellulose insulating paper in oil-immersed transformers, which effectively reduces the moisture generated by the thermal aging process, thus prolonging each transformer’s [...] Read more.
Polydimethylsiloxane (PDMS) with good hydrophobicity and nano-SiO2 with excellent thermal stability and mechanical properties are used as a composite coating for cellulose insulating paper in oil-immersed transformers, which effectively reduces the moisture generated by the thermal aging process, thus prolonging each transformer’s service life. This study employed molecular dynamics simulations to investigate the effects of surface-modified nano-SiO2 with different silane coupling agents (KH570 and KH151) on the thermodynamic properties and hydrophobicity of PDMS. Four groups of anhydrous models were constructed, namely, PDMS, P-SiO2, P-570, and P-151, as well as four corresponding groups of water-containing models: PDMS/H2O, P-SiO2/H2O, P-570/H2O, and P-151/H2O. The results demonstrate that incorporating silane-coupled nano-SiO2 into PDMS enhances mechanical properties, FFV, CED, MSD, diffusion coefficient, interaction energy, and hydrogen bond count, with KH570-grafted composites exhibiting optimal thermomechanical performance and hydrophobicity. At a temperature of 343 K, KH570 modification increased the bulk modulus and CED by 26.5% and 31.0%, respectively, while reducing the water molecular diffusion coefficient by 24.7% compared to that of unmodified PDMS/SiO2 composites. The extended KH570 chains occupy additional free volume, forming a larger steric hindrance layer, restricting molecular chain mobility, suppressing hydrogen bond formation, and establishing a low energy surface. Full article
(This article belongs to the Section Advanced Composites)
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17 pages, 8321 KiB  
Article
Flexible Piezoresistive Sensor with High Stability Based on GO@PDMS-PU Porous Structure
by Qingfang Zhang, Yi Li, Xingyu Wang, Xiaoyu Zhang, Shuyi Liu, Hengyi Yuan, Xiaodong Yang, Da Li, Zeping Jin, Yujian Zhang, Yutong Liu and Zhengmai Bian
Symmetry 2025, 17(5), 773; https://doi.org/10.3390/sym17050773 - 16 May 2025
Viewed by 41
Abstract
In recent years, flexible piezoresistive sensors based on polydimethylsiloxane (PDMS) matrix materials have developed rapidly, showing broad application prospects in fields such as human motion monitoring, electronic skin, and intelligent robotics. However, achieving a balance between structural durability and fabrication simplicity remains challenging. [...] Read more.
In recent years, flexible piezoresistive sensors based on polydimethylsiloxane (PDMS) matrix materials have developed rapidly, showing broad application prospects in fields such as human motion monitoring, electronic skin, and intelligent robotics. However, achieving a balance between structural durability and fabrication simplicity remains challenging. Traditional methods for preparing PDMS flexible substrates with high porosity and high stability often require complex, costly processes. Breaking through the constraints of conventional material systems, this study innovatively combines the high elasticity of polydimethylsiloxane (PDMS) with the stochastically distributed porous topology of a sponge-derived biotemplate through biomimetic templating replication technology, fabricating a heterogeneous composite system with an architecturally asymmetric spatial network. After 5000 loading cycles, uncoated samples experienced a thickness reduction of 7.0 mm, while PDMS-coated samples showed minimal thickness changes (2.0–3.0 mm), positively correlated with curing agent content (5:1 to 20:1). The 5:1 ratio sample demonstrated exceptional mechanical stability. As evidenced, the PDMS film-encapsulated architecturally asymmetric spatial network demonstrates superior stress dissipation efficacy, effectively mitigating stress concentration phenomena inherent to symmetric configurations that induce matrix fracture, thereby achieving optimal mechanical stability. Compared to the pre-test resistance distribution of 10–248 Ω, after 5000 cyclic loading cycles, the uncoated samples exhibited a narrowed resistance range of 10–50 Ω, while PDMS-coated samples maintained a broader resistance range (10–240 Ω) as the curing agent ratio increased (from 20:1 to 5:1), demonstrating that increasing the curing agent ratio helps maintain conductive network stability. The 5:1 ratio sample displayed the lowest resistance variation rate attenuation—only 3% after 5000 cycles (vs. 80% for uncoated samples)—and consistently minimal attenuation at all stages, validating superior electrical stability. Under 0–6 kPa pressure, the 5:1 ratio device maintained a linear sensitivity of 0.157 kPa−1, outperforming some existing works. Human motion monitoring experiments further confirmed its reliable signal output. Furthermore, the architecturally asymmetric spatial network of the device enables superior conformability to complex curvilinear geometries, leveraging its structural anisotropy to achieve seamless interfacial adaptation. By synergistically optimizing material composition and structural design, this study provides a novel technical method for developing highly durable flexible electronic devices. Full article
(This article belongs to the Section Engineering and Materials)
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17 pages, 5329 KiB  
Article
Stepped Confocal Microlens Array Fabricated by Femtosecond Laser
by Jinchi Wu, Hao Wu, Zheli Lin and Honghao Zhang
Photonics 2025, 12(5), 494; https://doi.org/10.3390/photonics12050494 - 16 May 2025
Viewed by 33
Abstract
Multi-focal microlens arrays provide notable advantages over mono-focal counterparts, such as multi-scale imaging capabilities and optical aberration correction. However, existing multi-focal microlens arrays fabricated on continuous surfaces are incapable of achieving confocal imaging. As a result, multiple focus adjustments are required to acquire [...] Read more.
Multi-focal microlens arrays provide notable advantages over mono-focal counterparts, such as multi-scale imaging capabilities and optical aberration correction. However, existing multi-focal microlens arrays fabricated on continuous surfaces are incapable of achieving confocal imaging. As a result, multiple focus adjustments are required to acquire comprehensive image data, thereby complicating system design and increasing operational duration. To overcome this limitation, a stepped confocal surface microlens array is proposed, capable of simultaneously capturing images with multiple depths of field, various field-of-view scales, and different resolutions—without the need for additional focus adjustments. A combination of femtosecond laser processing and chemical etching was employed to fabricate microlenses with varying curvatures on a stepped fused silica substrate, which was subsequently used as a mold. The final stepped confocal microlens array was replicated via polydimethylsiloxane (PDMS) molding. Preliminary experimental analyses were carried out to determine the relationship between processing parameters and the resulting focal lengths. By precisely controlling these parameters, the fabricated stepped confocal microlens array successfully enabled confocal imaging, allowing for the simultaneous acquisition of diverse image data. This microlens array shows great potential in advancing lightweight, integrated, and highly stable optical systems for applications in optical sensing, spatial positioning, and machine vision. Full article
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14 pages, 5738 KiB  
Article
Fluoro-Silicon-Modified Polythiourethane Copolymer for Marine Antifouling Coatings
by Songbo Xie, Xiufen Liao, Yanye Fan, Jiacheng Li, Qiumei Jiang, Yihua Zheng, Zhimin Huang and Shella Li
Coatings 2025, 15(5), 588; https://doi.org/10.3390/coatings15050588 - 15 May 2025
Viewed by 126
Abstract
Traditional marine antifouling coatings function through releasing toxic antifouling agents, causing serious harm to marine ecosystems. To address this challenge, an eco-friendly fluoro-silicon-modified polythiourethane (FSi-PTU) coating has been prepared via a polymerization reaction with dihydroxy propyl silicone oil (HO-PDMS-OH), 1H,1H,2H,2H-perfluorohexanol (FTOH), hexamethylene diisocyanate [...] Read more.
Traditional marine antifouling coatings function through releasing toxic antifouling agents, causing serious harm to marine ecosystems. To address this challenge, an eco-friendly fluoro-silicon-modified polythiourethane (FSi-PTU) coating has been prepared via a polymerization reaction with dihydroxy propyl silicone oil (HO-PDMS-OH), 1H,1H,2H,2H-perfluorohexanol (FTOH), hexamethylene diisocyanate (HDI), and pentaerythritol tetrakis (3-mercaptopropionate) (PETMP). The FSi-PTU polymer incorporates siloxane segments and fluorinated side chains, which are inhomogeneously distributed on the coating surface and construct a hydrophobic surface. The FSi-PTU coating exhibits good hydrophobicity, strong adhesion (≥2.14 MPa), and improved mechanical properties. The antifouling properties of the FSi-PTU coating have been researched. The results of laboratory tests demonstrate that the FSi-PTU coating exhibits excellent anti-protein adsorption and anti-algal attachment performance. The FSi-PTU-2 coating shows certain antifouling properties in the actual seawater test for three months. The results provide a certain reference value for developing eco-friendly marine antifouling coatings. Full article
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12 pages, 3193 KiB  
Article
High-Efficiency Luminescence of Mn2+-Doped Two-Dimensional Hybrid Metal Halides and X-Ray Detection
by Yue Fan, Yingyun Wang, Yunlong Bai, Bingsuo Zou and Ruosheng Zeng
Nanomaterials 2025, 15(10), 713; https://doi.org/10.3390/nano15100713 - 9 May 2025
Viewed by 200
Abstract
Mn2+ doping in metal halide perovskites enables host-to-dopant energy transfer, creating new emission pathways for optoelectronic applications. However, achieving high-efficiency luminescence in 2D systems remains challenging. We synthesized Mn2+-doped 2D PEA2CdCl4 via the hydrothermal method, characterizing its [...] Read more.
Mn2+ doping in metal halide perovskites enables host-to-dopant energy transfer, creating new emission pathways for optoelectronic applications. However, achieving high-efficiency luminescence in 2D systems remains challenging. We synthesized Mn2+-doped 2D PEA2CdCl4 via the hydrothermal method, characterizing its properties through PL spectroscopy, quantum yield measurements, and DFT calculations. Flexible films were fabricated using PDMS and PMMA matrices. The 15% Mn2+-doped crystal showed orange–red emission with 90.85% PLQY, attributed to efficient host-to-Mn2+ energy transfer and 4T16A1 transition. Prototype LEDs exhibited stable emission, while PDMS films demonstrated flexibility and PMMA films showed excellent X-ray imaging capability. This work demonstrates Mn2+ doping as an effective strategy to enhance luminescence in 2D perovskites, with potential applications in flexible optoelectronics and X-ray scintillators. Full article
(This article belongs to the Special Issue Metal Halide Perovskite Nanocrystals and Thin Films)
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19 pages, 1866 KiB  
Article
Mechanical and Thermal Performance of In-Situ Synthesized PDMS-SiO2 Composite as Electrical Insulating Coatings
by Aldo Cordoba, Rossana Faride Vargas-Coronado, Rodrigo Velázquez-Castillo, Juan Valerio Cauich-Rodríguez and Karen Esquivel
Molecules 2025, 30(10), 2107; https://doi.org/10.3390/molecules30102107 - 9 May 2025
Viewed by 185
Abstract
Polydimethylsiloxane (PDMS) has been extensively employed in electrical insulation applications owing to its excellent thermal stability, hydrophobicity, and dielectric properties. However, its inherent mechanical limitations require structural reinforcement to enhance its performance under more demanding operational conditions. In this study, the mechanical, thermal, [...] Read more.
Polydimethylsiloxane (PDMS) has been extensively employed in electrical insulation applications owing to its excellent thermal stability, hydrophobicity, and dielectric properties. However, its inherent mechanical limitations require structural reinforcement to enhance its performance under more demanding operational conditions. In this study, the mechanical, thermal, and surface properties of PDMS-SiO2 nanocomposites synthesized via in situ sol–gel process was systematically investigated. The influence of different SiO2 nanoparticle concentrations (5, 10, and 15 wt%), sol–gel catalyst type (acidic and alkaline), and tetraethyl orthosilicate (TEOS) crosslinking agent ratios (15:1, 10:1, 5:1) was evaluated. Tensile mechanical testing, dynamic mechanical analysis (DMA), and thermogravimetric analysis (TGA) revealed that the incorporation of SiO2 notably improved both the mechanical strength and thermal stability of the composites. The 5-15b and 10-15a composites exhibited the highest tensile stress and viscoelastic modulus among all samples. Furthermore, the composites retained key functional properties, including hydrophobicity, high volumetric electrical resistivity (~1011 Ω·cm), and strong adhesion. These findings confirm the potential of in situ PDMS-SiO2 nanocomposites for use as high-performance insulating coatings in advanced electrical applications. Full article
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16 pages, 1014 KiB  
Article
Characterization of a Novel 2018 Influenza Virus Outbreak on the Yucatan Peninsula, Mexico, in the Summer
by Lumumba Arriaga-Nieto, David Alejandro Cabrera-Gaytán, Alfonso Vallejos-Parás, Porfirio Felipe Hernández-Bautista, Clara Esperanza Santacruz-Tinoco, Julio Elías Alvarado-Yaah, Yu-Mei Anguiano-Hernández, Bernardo Martínez-Miguel, María Erandhí Prieto-Torres, Concepción Grajales-Muñiz, Nancy Sandoval-Gutiérrez and Horacia Celina Velarde-Scull
Microorganisms 2025, 13(5), 1086; https://doi.org/10.3390/microorganisms13051086 - 7 May 2025
Viewed by 140
Abstract
During the 2017–2018 influenza season, there was high influenza activity, with a predominance of influenza A(H1N1)pdm09 circulation in the country. The influenza circulation pattern in the area of the Yucatan Peninsula was different from that of the rest of the country. However, in [...] Read more.
During the 2017–2018 influenza season, there was high influenza activity, with a predominance of influenza A(H1N1)pdm09 circulation in the country. The influenza circulation pattern in the area of the Yucatan Peninsula was different from that of the rest of the country. However, in the summer of 2018, there was a sudden increase in the number of identified cases. A retrospective analysis was performed using data generated by four molecular diagnostic laboratories of the Mexican Social Security Institute. Demographics, influenza positivity, seasonality and case fatality rates were recorded. We used odds ratios to compare outpatients who were confirmed by laboratory tests to be positive with those who were confirmed to be negative. The Kaplan–Meier method and Cox multivariate analysis were used to calculate cumulative risk. There were 4460 cases of ILI/SARI between Yucatan and Quintana Roo, which represented 53.1% of the total number of cases reported. Compared with that in 2009, the epidemic wave in 2018 was shorter and more expansive, with a greater number of reported cases, as well as a greater number of people who required hospitalization. The dominant pattern of A(H1N1)pdm09 influenza activity on the Yucatan Peninsula in the summer of 2018 has not been observed since the influenza pandemic of 2009. Full article
(This article belongs to the Special Issue Pandemics and Infectious Diseases)
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21 pages, 1192 KiB  
Review
Advancing Organ-on-a-Chip Systems: The Role of Scaffold Materials and Coatings in Engineering Cell Microenvironment
by Guido Andrés Ramírez-González, Chiara Consumi-Tubito, Ernesto Vargas-Méndez and Carolina Centeno-Cerdas
Polymers 2025, 17(9), 1263; https://doi.org/10.3390/polym17091263 - 6 May 2025
Viewed by 434
Abstract
For organ-on-a-chip (OoC) engineering, the use of biocompatible coatings and materials is not only recommended but essential. Extracellular matrix (ECM) components are commonly used as coatings due to their effects on cell orientation, protein expression, differentiation, and adhesion. Among the most frequently used [...] Read more.
For organ-on-a-chip (OoC) engineering, the use of biocompatible coatings and materials is not only recommended but essential. Extracellular matrix (ECM) components are commonly used as coatings due to their effects on cell orientation, protein expression, differentiation, and adhesion. Among the most frequently used coatings are collagen, fibronectin, and Matrigel, according to the specific cell type and intended OoC application. Additionally, materials such as polydimethylsiloxane (PDMS), thermoplastics, chitosan, and alginate serve as scaffolding components due to their biomechanical properties and biocompatibility. Here, we discuss some of the most employed coating techniques, including SAMs, dip coating, spin coating, microcontact printing, and 3D bioprinting, each offering advantages and drawbacks. Current challenges comprise enhancing biocompatibility, exploring novel materials, and improving scalability and reproducibility. Full article
(This article belongs to the Special Issue Biocompatible and Biodegradable Polymer Materials)
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12 pages, 5190 KiB  
Article
Flexible Stretchable Strain Sensor Based on LIG/PDMS for Real-Time Health Monitoring of Test Pilots
by Shouqing Li, Zhanghui Wu, Hongyun Fan, Mian Zhong, Xiaoqing Xing, Yongzheng Wang, Huaxiao Yang, Qijian Liu and Deyin Zhang
Sensors 2025, 25(9), 2884; https://doi.org/10.3390/s25092884 - 2 May 2025
Viewed by 315
Abstract
In the rapidly advancing era of intelligent technology, flexible strain sensors are emerging as a key component in wearable electronics. Laser-induced graphene (LIG) stands out as a promising fabrication method due to its rapid processing, environmental sustainability, low cost, and superior physicochemical properties. [...] Read more.
In the rapidly advancing era of intelligent technology, flexible strain sensors are emerging as a key component in wearable electronics. Laser-induced graphene (LIG) stands out as a promising fabrication method due to its rapid processing, environmental sustainability, low cost, and superior physicochemical properties. However, the stretchability and conformability of LIG are often limited by the substrate material, hindering its application in scenarios requiring high deformation. To address this issue, we propose a high-performance flexible and stretchable strain sensor fabricated by generating graphene on a polyimide (PI) substrate using laser induction and subsequently transferred onto a polydimethylsiloxane (PDMS). The resultant sensor demonstrates an ultra-low detection limit (0.1%), a rapid response time (150 ms), a wide strain range (40%), and retains stable performance after 1000 stretching cycles. Notably, this sensor has been successfully applied to the real-time monitoring of civil aviation test pilots during flight for the first time, enabling the accurate detection of physiological signals such as pulse, hand movements, and blink frequency. This study introduces a unique and innovative solution for the real-time health monitoring of civil aviation test pilots, with significant implications for enhancing flight safety. Full article
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9 pages, 2086 KiB  
Article
Metasurface Design for Dual-Mode Sensors Based on Broken Symmetry Structure
by Rundong Yang, Minjing Dai, Yihao Zhao and Xiangfu Wang
Nanomaterials 2025, 15(9), 687; https://doi.org/10.3390/nano15090687 - 30 Apr 2025
Viewed by 205
Abstract
Dual-mode sensors are currently facing difficulties in achieving independent sensing of parameters as well as low sensitivity. In this paper, we propose a dual-mode sensor using the finite element method (FEM) based on a coupled silver–PDMS–gold (SPG) cavity. We coupled a square ring [...] Read more.
Dual-mode sensors are currently facing difficulties in achieving independent sensing of parameters as well as low sensitivity. In this paper, we propose a dual-mode sensor using the finite element method (FEM) based on a coupled silver–PDMS–gold (SPG) cavity. We coupled a square ring resonant cavity with a double-ring resonant cavity structure, thus identifying a unique resonant cavity structure. The square ring resonator is made of silver and a double-ring resonant cavity filled with PDMS. Our proposed SPG cavity can independently achieve temperature and refractive index sensing. The SPG cavity enables us to obtain the highest biosensing sensitivity of about 1030 nm/RIU and the highest temperature sensitivity of about 216 pm/K. In addition, SPG cavities have excellent tolerances for geometric parameters. Our results provide new methodologies for metasurface design for dual-mode sensing. Full article
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