Search Results (3,793)

Polyphenol-Rich Sugarcane Extract (PRSE), derived from Saccharum officinarum, demonstrates significant neuroprotective effects against amyloid-beta (Aβ_1–42)-induced deficits associated with Alzheimer’s disease (AD). This study utilized transgenic C. elegans expressing Aβ_1–42 to investigate PRSE’s impact on lifespan, sensory behavior, learning, memory, and amyloid fibril accumulation. Supplementation with 5 mg/mL of PRSE extended the mean lifespan of Aβ_1–42 worms by 11% (17.78 ± 0.36 days) and reduced amyloid fibril levels by 34% in aged worms compared to untreated worms. PRSE also improved sensory behavior, with a 27% increase in naïve chemotaxis at day 8. Memory deficits were mitigated, with PRSE-treated worms showing 21% and 30% reductions in short-term associative memory loss after 1 h intervals on days 8 and 12, respectively. These improvements can be associated with the polyphenolic compounds in PRSE, which aid in reducing amyloid aggregation. The findings highlight PRSE’s potential as a dietary supplement to address AD-related symptoms and pathologies. Further studies are needed to understand its mechanisms and confirm its effectiveness in mammals, supporting its potential use as a natural preventative supplement for Alzheimer’s and related neurodegenerative diseases. Full article

The annual inflation rate in Sri Lanka accelerated to record levels in recent years, especially after the COVID-19 pandemic. Though the inflation rate had declined to pre-pandemic levels by mid-2024, it is of great importance to identify the factors that caused hyperinflation during the COVID-19 pandemic. The objective of this study is to investigate the drivers of inflation in Sri Lanka using a structural vector autoregressive model and a multiple regression model. The study assesses both the global drivers and the domestic drivers of inflation. The study uses monthly data on the inflation rate, global oil price, exchange rate, policy rate, the global supply chain pressure index, and unemployment rate, covering the period from January 2020 to August 2024, focusing on the period of rapid increase in the inflation rate in Sri Lanka. The empirical results of the study provide evidence to conclude that the inflation rate in Sri Lanka during the 2020–2024 period was mainly driven by the growth rates in money supply, exchange rates, and global supply chain disruptions. The results also show that the volatility of the Sri Lanka inflation rate is mostly explained by the money supply and exchange rate movements in the long run. Full article

The increasing frequency and severity of disasters in urban areas demand sustainable, smart disaster management strategies to leverage technological advancements. This study provides a comprehensive review of mobile apps for disaster awareness available in the Google Play Store, with a particular emphasis on addressing flood disaster readiness and response. Mobile apps have become indispensable tools for disseminating immediate notifications, facilitating emergency communication, and coordinating response activities. A total of 77 mobile apps in the Google Play Store were identified and evaluated using a systematic search. The evaluation criteria included user ratings, download counts, and key crisis management functionalities such as real-time alerts, emergency contact directories, preparedness checklists, and user reporting capabilities. The findings emphasised the following: (a) the importance of integrating cutting-edge technologies, i.e., AI and IoT, to enhance functionality, accuracy, and capacity in mobile applications; (b) the use of crowdsourcing as a valuable mechanism for enriching inclusive and responsible data; (c) enabling timely updates and fostering community engagement; and (d) establishing agency engagements, gamified elements, and real-time reciprocal communication tools, i.e., push-to-talk features to ensure the long-term sustainability of mobile apps. By incorporating these insights, disaster management apps can significantly enhance community resilience and improve the effectiveness of responding to natural disasters in this digital age. Full article

Myeloid leukaemia (ML) is a cancer that occurs by the accumulation of abnormally multiplied myeloid cells in bone marrow, peripheral blood, and other related tissue. MST3 is a gene of the GCK family that has a role in apoptosis, along with other cellular functions like cellular differentiation, cell cycle, metabolism, and others. Objectives: The objectives of this study were to count RBCs and WBCs, study MST3 expression in ML and control samples, and perform an in silico correlation study on the KRAS and NRAS genes. Methods: The counting of RBCs and WBCs was carried out using a hemacytometer, the expression of MST3 was studied using RT-PCR, and a correlation study was carried out using GEPIA. Results: RBC and WBC levels in ML differed from the control levels, and the expression of MST3 was found to be upregulated in ML in comparison to controls, with a 2.90–8.65-fold change, with a significant p-value > 0.05. A positive correlation in expression was also found between MST3 and KRAS and NRAS genes, with a significant r value correlation. Conclusions: From this study, it could be deduced that MST3 might have a role in ML pathogenesis, but further research is needed to study its role in the progression of the disease. Full article

The field of bio-nanotechnology has seen significant advancements in recent years, particularly in the synthesis and application of bio-nanoparticles (BNPs). This review focuses on the green synthesis of BNPs using biological entities such as plants, bacteria, fungi, and algae. The utilization of these organisms for nanoparticle synthesis offers an eco-friendly and sustainable alternative to conventional chemical and physical methods, which often involve toxic reagents and high energy consumption. Phytochemicals present in plant extracts, unique metabolic pathways, and biomolecules in bacteria and fungi, and the rich biochemical composition of algae facilitate the production of nanoparticles with diverse shapes and sizes. This review further explores the wide-ranging applications of BNPs in various fields like therapeutics, fuel cells, energy generation, and wastewater treatment. In therapeutics, BNPs have shown efficacy in antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. In the energy sector, BNPs are being integrated into fuel cells and other energy generation systems like bio-diesel to improve efficiency and sustainability. Their catalytic properties and large surface area enhance the performance of these devices. Wastewater treatment is another critical area where BNPs are employed for the removal of heavy metals, organic pollutants, and microbial contaminants, offering a cost-effective and environmentally friendly solution to water purification. This comprehensive review highlights the potential of bio-nanoparticles synthesized through green methods. It highlights the need for further research to optimize synthesis processes, understand mechanisms of action, and expand the scope of their applications. BNPs can be utilized to address advantages and some of the pressing challenges in medicine, energy, and environmental sustainability, paving the way for innovative and sustainable technological advancements in future prospects. Full article

Frequent ambiguities in contract terms often lead to costly legal disputes and project delays in the construction industry. Large Language Models (LLMs) offer a promising solution, enhancing accuracy and reducing misinterpretations. As studies pointed out, many professionals use LLMs, such as ChatGPT, to assist with their professional tasks at a minor level, such as information retrieval from the Internet and content editing. With access to a construction regulation database, LLMs can automate contract interpretation. However, the lack of Artificial Intelligence tools tailored to industry regulations hinders their adoption in the construction sector. This research addresses the gap by developing and deploying a publicly available specialised chatbot using the ChatGPT language model. The development process includes architectural design, data preparation, vector embeddings, and model integration. The study uses qualitative and quantitative methodologies to evaluate the chatbot’s role in resolving contract-related issues through standardised tests. The specialised chatbot, trained on construction-specific legal information, achieved an average score of 88%, significantly outperforming ChatGPT’s 36%. The integration of a domain-specific language model promises to revolutionise construction practices through increased precision, efficiency, and innovation. These findings demonstrate the potential of optimised language models to transform construction practices. Full article

The integration of Industry 4.0 technologies, Circular Economy (CE) principles, and Green Human Resource Management (GHRM) offers transformative potential to address global sustainability challenges. Industry 4.0, characterized by advanced digital technologies like IoT, Additive Manufacturing (AM), and Big Data Analytics (BDAA), enhances operational efficiency, resource optimization, and waste minimization. Concurrently, CE redefines economic models through resource conservation, lifecycle extension, and reduced environmental impact, supported by frameworks like ReSOLVE. GHRM aligns human resource practices with sustainability objectives, fostering Green behaviors and embedding environmental considerations into organizational culture. Despite the individual benefits of these frameworks, their combined application remains underexplored, with limited research on their systemic integration. This study addresses this gap by examining the synergies between Industry 4.0 technologies, CE principles, and GHRM strategies, identifying opportunities and challenges in their implementation. A theoretical model is proposed, emphasizing systemic innovation, resource efficiency, and collaborative value chains as key enablers of sustainable development. The model highlights the necessity of aligning technological advancements with human-centric approaches to overcome behavioral, organizational, and infrastructural barriers in transitioning toward sustainability. The findings offer practical insights for policymakers and industry leaders, outlining strategies for integrating Industry 4.0 with CE and GHRM to drive sustainability transitions. By synthesizing technological, environmental, and human resource dimensions, this research contributes both theoretically and practically, positioning organizations to enhance sustainability while maintaining competitiveness in evolving economic landscapes. Full article

This study examines the main determinants influencing the commitment of tourism village managers and business stakeholders to implement digital transformation. It will test the impact of perceived benefits, attitudes towards change, consumer behavior change, and the technological context on the intentions and commitments of tourism village managers and enterprises in Bogor Regency, Indonesia. The Causal Step multiple linear regression analysis examined 146 respondents selected through saturated sampling. The findings indicated that attitudes towards change, consumer behavior change, and the technological context significantly influenced the commitment to implement a digital transformation, mediated by the intention to implement digital transformation. The intention to implement digital transformation became a perfect part of the technological context of the commitment to implement digital transformation. It became a partial mediator of the influence of digital attitudes towards change and consumer behavior change on the commitment to implement transformation. Perceived benefits only directly affected the commitment to implement digital transformation. This research has at least two novelties, conceptual and contextual novelties. Conceptual novelty is studied in digital transformation, focusing on tourism villages. The contextual novelty is that the findings offer a more thorough understanding of the conditions and stages of technological transformation embraced by stakeholders and managers of tourism villages. Full article

In the ever-advancing field of nanotechnology and nanoscience, luminescent carbon dots, or carbon quantum dots, have emerged as one of the most up-and-coming carbon-based nanomaterials in recent years due to their diverse physicochemical properties, which include low toxicity, ease of synthesis, superior photostability, excellent water solubility, high specific surface areas with ease of surface functionalization, and unique electronic and optical properties. They exhibit two-photon absorption and unique tunable fluorescence emission across a wide range of wavelengths, which can be precisely controlled by surface modifications and particle size. These characteristics have led to their widespread usage in a variety of applications, including optical/fluorescent sensing, electrochemical sensing, and energy-related fields, such as light-emitting diodes, photovoltaic supercapacitors, bioimaging, drug delivery, and antimicrobial research. Recently, focus has shifted to the green synthesis of carbon dots, with significant success achieved in this area, opening a plethora of opportunities in both basic and applied sciences. This review is a comprehensive study of milestones achieved in the area of green carbon dots. This review starts with the historical background of luminescent materials and how carbon dots/carbon quantum dots have been emerging as the stars among all luminescent nanomaterials. The challenges of conventional synthesis methods for nanoparticles are also discussed, with a detailed review of the various green synthesis processes reported to date. This section provides insights into widely accepted formation mechanisms and their influence on the shapes and sizes of CDs. In the next section, various physical properties of CDs are discussed, highlighting characteristics such as high quantum yield, photoluminescence stability, and chemical inertness, which make them exceptional nanomaterials. Last but not least, various CD-related challenges and future prospects are highlighted. Overall, this review provides details of recent developments in the area of green CDs. Full article

Background: Hyponatraemia is a rare but potentially life-threatening complication of terlipressin therapy. Case history: In the current case, a 39-year-old female with decompensated liver cirrhosis (Child-Pugh C) and acute variceal bleeding experienced a precipitous decline in serum sodium—from 136 mmol/L to 115 mmol/L—within 48 h of initiating terlipressin therapy. This was accompanied by marked fluid retention, reduced urine output, and symptoms of confusion and agitation. Laboratory tests confirmed dilutional hyponatraemia, characterized by urinary sodium <20 mmol/L and urine osmolality <100 mOsm/kg, indicating excessive free water reabsorption. Outcomes: The prompt discontinuation of terlipressin, fluid restriction and the cautious administration of hypertonic sodium chloride solution (2.7% NaCl) achieved a gradual normalization of sodium levels and resolution of symptoms. Fluid balance monitoring revealed a marked diuretic response following terlipressin cessation. This case aligns with existing reports, emphasizing the dual vasopressin receptor activity of terlipressin and its capacity to induce hyponatraemia, particularly in cirrhotic patients with preserved renal function and higher baseline sodium levels. Conclusions: This case and a literature review underscored the critical need for early fluid balance monitoring to detect retention. This case highlights the importance of individualized risk assessment, multidisciplinary management, and vigilant sodium correction to avoid complications. Practical recommendations are outlined to aid clinicians in the recognition and management of terlipressin-induced hyponatraemia. Full article

Background: Increased expression of MET and hepatocyte growth factor (HGF)-related molecules has been positively correlated with poor prognosis in renal cell carcinoma (RCC). In the current study, the expression and phosphorylation of MET in metastatic RCC (mRCC) are determined by immunohistochemistry, and the therapeutic effect of MET and HGF activation-targeting agents for RCC cell lines is analyzed. Methods: Immunohistochemistry was performed for 76 formalin-fixed paraffin-embedded specimens (primary tumor: 32, metastatic site: 44). The therapeutic effect of capmatinib (MET-I) and SRI-31215 (inhibitor of HGF-activating proteases: HGFA-I) was determined based on the inhibition of MET phosphorylation, cell proliferation, and cell migration in 786-O and caki-1 cell lines. Results: Increased expression and phosphorylation of MET were observed in both primary tumor and metastatic sites; however, phosphorylation was significantly upregulated in metastatic sites (p = 0.0001). In an assay of RCC cell lines, the strongest inhibition of MET phosphorylation, cell proliferation, and migration was confirmed with the combined used of MET-I and HGFA-I. Conclusions: Phosphorylation of MET was significantly upregulated in metastasis, which suggested the importance of downregulation in the treatment of mRCC. Our findings suggest that dual inhibition of MET and HGF activation may offer a promising strategy for mRCC treatment, warranting further clinical validation. Full article

Sungkai leaves were selected due to their herbal medicine prevalence and documented biological activities. This study explores the immunomodulatory potential of kaempferol isolated from Sungkai (Peronema canescens Jack.) through a combination of in silico and in vitro methods. P. canescens leaves were extracted with ethanol using maceration, followed by fractionation with n-hexane, ethyl acetate, and water using a separatory funnel. Among all the fractions, the ethyl acetate fraction demonstrated the strongest inhibitory effect on IL-6 (Interleukin 6) expression, leading to further separation for the enhanced analysis of its activity. The resulting sub-fractions were purified by vacuum liquid chromatography with n-hexane and ethyl acetate gradient. Sub-fraction E was isolated through preparative thin-layer chromatography to obtain a pure compound identified as kaempferol using UV, FTIR, MS, and NMR analyses. The isolated kaempferol was then evaluated by molecular docking and molecular dynamics simulations, employing MM-PBSA (Molecular Mechanics Poisson–Boltzmann Surface Area) for binding affinity calculations. Kaempferol showed a binding affinity (ΔG) of −5.98 kcal/mol, slightly stronger than TLA (tartaric acid) (−5.90 kcal/mol). Key interactions with amino acid residues, such as Gln175, Arg182, and Arg179, were observed. Additionally, molecular dynamics simulation demonstrated that kaempferol exhibited better stability than TLA between 15 ns and 100 ns. The MM-PBSA analysis showed that kaempferol has strong van der Waals (−17.02 kcal/mol) and electrostatic interactions (−293.16 kcal/mol), with binding free energy (−17.85 kcal/mol) significantly stronger than TLA (−1.00 kcal/mol). This stability, combined with its ability to reduce IL-6 expression in vitro, highlights kaempferol’s immunomodulatory potential. Full article

The objectives of this study are, firstly, to determine the impact of tourism village development on economic, social, cultural, and environmental aspects in supporting the achievement of Sustainable Development Goals (SDGs) and, secondly, to formulate a halal, local culture-based, and sustainable tourism village development model. The research method was qualitative and quantitative. Survey data were collected using questionnaires and interviews. The data were analyzed using a difference test before and after the development of the tourism village. Based on the data analysis, significant differences in economic, social, cultural, and environmental aspects existed before and after the development of the Benteng Ciampea tourism village in Bogor Regency, Indonesia. Many studies have examined the impact of tourism village development on social, economic, cultural, and environmental aspects. However, no comprehensive research has been conducted that is supported by empirical data. Most studies have been conducted partially and not linked to the SDGs. The SDGs issue distinguishes this from previous studies on developing sustainable halal tourism villages. Full article

Microbial-induced carbonate precipitation (MICP) is gaining attention as an eco-friendly and sustainable method for concrete crack repair. However, key challenges related to its large-scale implementation, regulatory approval, and integration into existing construction standards remain underexplored. This review examines recent advances in MICP, emphasizing its role in circular economy practices and sustainable building solutions. Traditional synthetic sealants contribute to environmental pollution and have limited long-term durability, highlighting the need for greener alternatives. Global research trends reveal an increasing focus on self-healing materials, biomineralization, and durability enhancement, alongside emerging innovations such as encapsulation technologies, marine applications, and bio-based composites. Unlike previous reviews, this study integrates bibliometric analysis to systematically assess research trends, identify key collaboration networks, and evaluate regulatory challenges that impact MICP adoption. While MICP offers significant advantages, including self-healing capabilities and compatibility with industrial by-products, barriers related to cost, scalability, and policy integration persist. This review identifies critical thematic clusters which include microbial action, sustainability, and engineering applications. This helps to provide actionable insights for researchers, engineers, and policymakers. By fostering interdisciplinary collaboration, MICP has the potential to become a transformative solution for resilient and environmentally sustainable infrastructure. Full article

Tile delamination on the façades of tall buildings poses significant concerns for public safety worldwide. This study investigates the underlying causes of tile delamination and their linkages with other prevalent façade defects in order to develop a risk assessment for preventing future tile delamination in tall buildings. Drawing on Singapore’s experience, data were gathered from case studies through field inspections and expert interviews. The results have been supported by data findings and past laboratory testing conducted in the Singaporean context. The findings indicate that the main causes of tile delamination in Singapore’s tall buildings are linked to design, workmanship, materials, and environmental conditions. Notably, cracks and water penetration often indicate a high risk of tile delamination, highlighting a strong connection between delamination’s root causes and their frequent occurrence on tile façades. Finally, this study gives recommendations for designers, constructors, and maintenance teams to mitigate and eliminate risks associated with tile delamination, aiming to enhance the safety and durability of building façades. Full article