Search Results (1,345)

Single-molecule detection (SMD) has reformed analytical science by enabling the direct observation of individual molecular events, thus overcoming the limitations of ensemble-averaged measurements. This review presents a comprehensive analysis of the principles, devices, and emerging materials that have shaped the current landscape of SMD. We explore a wide range of sensing mechanisms, including surface plasmon resonance, mechanochemical transduction, transistor-based sensing, optical microfiber platforms, fluorescence-based techniques, Raman scattering, and recognition tunneling, which offer distinct advantages in terms of label-free operation, ultrasensitivity, and real-time responsiveness. Each technique is critically examined through representative case studies, revealing how innovations in device architecture and signal amplification strategies have collectively pushed the detection limits into the femtomolar to attomolar range. Beyond the sensing principles, this review highlights the transformative role of advanced nanomaterials such as graphene, carbon nanotubes, quantum dots, MnO₂ nanosheets, upconversion nanocrystals, and magnetic nanoparticles. These materials enable new transduction pathways and augment the signal strength, specificity, and integration into compact and wearable biosensing platforms. We also detail the multifaceted applications of SMD across biomedical diagnostics, environmental monitoring, food safety, neuroscience, materials science, and quantum technologies, underscoring its relevance to global health, safety, and sustainability. Despite significant progress, the field faces several critical challenges, including signal reproducibility, biocompatibility, fabrication scalability, and data interpretation complexity. To address these barriers, we propose future research directions involving multimodal transduction, AI-assisted signal analytics, surface passivation techniques, and modular system design for field-deployable diagnostics. By providing a cross-disciplinary synthesis of device physics, materials science, and real-world applications, this review offers a comprehensive roadmap for the next generation of SMD technologies, poised to impact both fundamental research and translational healthcare. Full article

Plasmonic metasurfaces that convert hydrogen-induced dielectric changes into optical signals hold promise for next-generation hydrogen sensors. Here, we employ simulations and theoretical analysis to systematically assess single-layer, bilayer, and trilayer nanodisk arrays comprising magnesium, palladium, and noble metals. Although monolithic Mg nanodisks show strong optical contrast after hydrogenation, the corresponding surface plasmon resonance disappears completely, preventing quantitative spectral tracking. In contrast, bilayer heterostructures, particularly those combining Mg and Au, achieve a resonance red-shift of Δλ = 62 nm, a narrowed full width at half maximum (FWHM) of 207 nm, and a figure of merit (FoM) of 0.30. Notably, the FoM is boosted by up to 15-fold when tuning both material choice and stacking sequence (from Mg-Ag to Au-Mg), underscoring the critical role of interface engineering. Trilayer “sandwich” architectures further amplify performance, achieving a max 10-fold and 13-fold enhancement in Δλ and FoM, respectively, relative to its bilayer counterpart. Particularly, the trilayer Mg-Au-Mg reaches Δλ = 120 nm and FoM = 0.41, outperforming most previous plasmonic hydrogen sensors. These enhancements arise from maximized electric-field overlap with dynamically changing dielectric regions at noble-metal–hydride interfaces, as confirmed by first-order perturbation theory. These results indicate that multilayer designs combining Mg and noble metals can simultaneously maximize hydrogen-induced spectral shifts and signal quality, providing a practical pathway toward high-performance all-optical hydrogen sensors. Full article

The use of copper and its alloys in architecture, especially in arid regions, is growing, driven by visual appeal, functional advantages, and sustainability. Changes in visual and colorimetric appearances and patina formation were evaluated for architectural Cu metal, brass (CuZn15), bronze (CuSn4), and a golden alloy (CuZn5Al5). Coupons were exposed over 4 years in Dubai, United Arab Emirates, at a test site located 2 km from the seashore under unsheltered conditions, and at various surface inclinations. Comparative exposures were conducted in Brest, France, at sites of increasing distance from the seashore. Visual appearance was assessed by colorimetry and optical imaging; patina cross-sections were characterized by means of scanning electron microscopy and elemental analysis (SEM/EDS), and crystalline phase identification was conducted by means of x-ray diffraction (XRD). All Dubai surfaces developed red-yellowish, heterogeneous patinas with embedded sand and dust, reducing lightness and visual appeal. Inclination had minor effect, although some extent of spallation occurred on downward-facing CuSn4. Even the corrosion-resistant CuZn5Al5 alloy lost its golden hue due to the incorporation of sand and dust into the patina. In Brest, appearance depended on the distance from the seashore, with green-blue patinas near the sea and red-yellowish farther inland, similar to Dubai. Cleaning may restore some luster, but the desert exposure generally reduced the long-term aesthetic performance of all materials. Full article

This study reports on the preparation and comprehensive characterisation of new brominated hydrogen-bonded liquid crystalline (HBLC) materials. Two distinct series of supramolecular complexes were prepared by hydrogen-bond formation between 3-bromo-4-pentyloxybenzoic acid as the proton donor and non-fluorinated and fluorinated azopyridines with variable terminal chains as proton acceptors. The successful formation of a hydrogen bond was confirmed by FTIR spectroscopy. The impact of alkyl chain length and fluorination on the mesomorphic properties of the HBLCs was systematically investigated. The molecular self-assembly was thoroughly examined using polarised optical microscopy (POM) and differential scanning calorimetry (DSC), revealing the presence of smectic C (SmC), smectic A (SmA), and nematic (N) phases, with thermal stability being highly dependent on the molecular architecture. Notably, the introduction of fluorine atoms significantly influenced the phase transition temperatures and the overall mesophase range. Using bromine as a lateral substituent induces the formation of SmC phases in these HBLCs, a feature absent in their non-brominated analogues. Further structural insights were obtained through X-ray diffraction (XRD) investigations, confirming the nature of the observed LC phases. Additionally, the photo-responsive characteristics of these HBLCs were explored via UV-Vis spectroscopy, demonstrating their ability to undergo reversible photoisomerisation upon light irradiation. These findings underscore the critical role of precise molecular design in tailoring the properties of HBLCs for potential applications such as optical storage devices. Full article

Background: To report a deep learning-based algorithm for automated segmentation of geographic atrophy (GA) among patients with age-related macular degeneration (AMD). Methods: Validation of a deep learning algorithm was performed using optical coherence tomography (OCT) images from patients in routine clinical care diagnosed with GA, with and without concurrent nAMD. For model construction, a 3D U-Net architecture was used with the output modified to generate a 2D mask. Accuracy of the model was assessed relative to the manual labeling of GA with the Dice similarity coefficient (DSC) and correlation r² scores. Results: The OCT data set included 367 scans from the Spectralis (Heidelberg, Germany) from 55 eyes in 33 subjects; 267 (73%) scans had concurrent nAMD. In parallel, 348 scans were collected using the Cirrus (Zeiss), from 348 eyes in 326 subjects; 101 (29%) scans had concurrent nAMD. For Spectralis data, the mean DSC score was 0.83 and r² was 0.91. For Cirrus data, the mean DSC score was 0.82 and r² was 0.88. Conclusions: The reported deep learning algorithm demonstrated strong agreement with manual grading of GA secondary to AMD on the OCT data set from routine clinical practice. The model performed well across two OCT devices as well as amongst patients with GA with concurrent nAMD, suggesting applicability in the clinical space. Full article

Accurate mapping of marine aquaculture areas is critical for environmental management and sustainable development for marine ecosystem protection and sustainable resource utilization. However, remote sensing imagery based on single-sensor modalities has inherent limitations when extracting aquaculture zones in complex marine environments. To address this challenge, we constructed a multi-modal dataset from five Chinese coastal regions using cloud detection methods and developed Multi-modal Spatial–Frequency Adaptive Fusion Network (MSAFNet) for optical-radar data fusion. MSAFNet employs a dual-path architecture utilizing a Multi-scale Dual-path Feature Module (MDFM) that combines CNN and Transformer capabilities to extract multi-scale features. Additionally, it implements a Dynamic Frequency Domain Adaptive Fusion Module (DFAFM) to achieve deep integration of multi-modal features in both spatial and frequency domains, effectively leveraging the complementary advantages of different sensor data. Results demonstrate that MSAFNet achieves 76.93% mean intersection over union (mIoU), 86.96% mean F1 score (mF1), and 93.26% mean Kappa coefficient (mKappa) in extracting floating raft aquaculture (FRA) and cage aquaculture (CA), significantly outperforming existing methods. Applied to China’s coastal waters, the model generated 2020 nearshore aquaculture distribution maps, demonstrating its generalization capability and practical value in complex marine environments. This approach provides reliable technical support for marine resource management and ecological monitoring. Full article

With the continuous growth in the demand for safety assurance in major projects and monitoring in extreme environments, sensor technology is facing challenges in harsh working conditions such as high temperatures, high pressures, and complex liquid media. This article focuses on typical complex environments such as underground and marine environments, systematically reviewing the basic principles, performance characteristics and the latest application progress of mechanical, optical and acoustic sensors in complex environments, and deeply analyzing their applicable boundaries and technical bottlenecks. The transmission mechanism of sensor data and the system architecture of the engineering monitoring and early warning platform were further explored, and their key roles in real-time perception and intelligent decision-making were evaluated. Finally, the core challenges and development opportunities currently faced by complex environmental sensing systems are summarized, and the future development directions, such as multi-parameter fusion, autonomous perception and edge intelligence, are prospected. This paper aims to provide a systematic theoretical basis and engineering practice reference for the design of sensors and the construction of monitoring systems in extreme environments. Full article

During UAV aerial photography tasks, influenced by flight altitude and imaging mechanisms, the target in images often exhibits characteristics such as small size, complex backgrounds, and small inter-class differences. Under single optical modality, the weak and less discriminative feature representation of targets in drone-captured images makes them easily overwhelmed by complex background noise, leading to low detection accuracy, high missed-detection and false-detection rates in current object detection networks. Moreover, such methods struggle to meet all-weather and all-scenario application requirements. To address these issues, this paper proposes DVIF-Net, a visible-infrared fusion network for small-target detection in UAV aerial images, which leverages the complementary characteristics of visible and infrared images to enhance detection capability in complex environments. Firstly, a dual-branch feature extraction structure is designed based on YOLO architecture to separately extract features from visible and infrared images. Secondly, a P4-level cross-modal fusion strategy is proposed to effectively integrate features from both modalities while reducing computational complexity. Meanwhile, we design a novel dual context-guided fusion module to capture complementary features through channel attention of visible and infrared images during fusion and enhance interaction between modalities via element-wise multiplication. Finally, an edge information enhancement module based on cross stage partial structure is developed to improve sensitivity to small-target edges. Experimental results on two cross-modal datasets, DroneVehicle and VEDAI, demonstrate that DVIF-Net achieves detection accuracies of 85.8% and 62%, respectively. Compared with YOLOv10n, it has improved by 21.7% and 10.5% in visible modality, and by 7.4% and 30.5% in infrared modality, while maintaining a model parameter count of only 2.49 M. Furthermore, compared with 15 other algorithms, the proposed DVIF-Net attains SOTA performance. These results indicate that the method significantly enhances the detection capability for small targets in UAV aerial images, offering a high-precision and lightweight solution for real-time applications in complex aerial scenarios. Full article

As the world is technologically advancing, the integration of FSO communication in non-terrestrial platforms is transforming the landscape of global connectivity. By enabling high-data-rate inter-satellite links, secure UAV–ground channels, and efficient HAPS backhaul, FSO technology is paving the way for sustainable 6G non-terrestrial networks. However, the stringent requirement for precise line-of-sight (LoS) alignment between the optical transmitter and receivers poses a hindrance in practical deployment. As non-terrestrial missions require continuous movement across the mission area, the platform is subject to vibrations, dynamic motion, and environmental disturbances. This makes maintaining the LoS between the transceivers difficult. While fine-pointing mechanisms such as fast steering mirrors and adaptive optics are effective for microradian angular corrections, they rely heavily on an initial coarse alignment to maintain the LoS. Coarse pointing modules or gimbals serve as the primary mechanical interface for steering and stabilizing the optical beam over wide angular ranges. This survey presents a comprehensive analysis of coarse pointing and gimbal modules that are being used in FSO communication systems for non-terrestrial platforms. The paper classifies gimbal architectures based on actuation type, degrees of freedom, and stabilization strategies. Key design trade-offs are examined, including angular precision, mechanical inertia, bandwidth, and power consumption, which directly impact system responsiveness and tracking accuracy. This paper also highlights emerging trends such as AI-driven pointing prediction and lightweight gimbal design for SWap-constrained platforms. The final part of the paper discusses open challenges and research directions in developing scalable and resilient coarse pointing systems for aerial FSO networks. Full article

Micro-expression recognition (MER) aims to detect brief and subtle facial movements that reveal suppressed emotions, discerning authentic emotional responses in scenarios such as visitor experience analysis in museum settings. However, it remains a highly challenging task due to the fleeting duration, low intensity, and limited availability of annotated data. Most existing approaches rely solely on either appearance or motion cues, thereby restricting their ability to capture expressive information fully. To overcome these limitations, we propose a lightweight multi-modal fusion network, termed M³ENet, which integrates both motion and appearance cues through early-stage feature fusion. Specifically, our model extracts horizontal, vertical, and strain-based optical flow between the onset and apex frames, alongside RGB images from the onset, apex, and offset frames. These inputs are processed by two modality-specific subnetworks, whose features are fused to exploit complementary information for robust classification. To improve generalization in low data regimes, we employ targeted data augmentation and adopt focal loss to mitigate class imbalance. Extensive experiments on five benchmark datasets, including CASME I, CASME II, CAS(ME)², SAMM, and MMEW, demonstrate that M³ENet achieves state-of-the-art performance with high efficiency. Ablation studies and Grad-CAM visualizations further confirm the effectiveness and interpretability of the proposed architecture. Full article

This paper presents a comprehensive comparative analysis of high-voltage, high-frequency pulse generation techniques for Pockels cell drivers. These drivers are critical in electro-optic systems for laser modulation, where nanosecond-scale voltage pulses with amplitudes of several kilovolts are required. The study reviews key design challenges, with particular emphasis on thermal management strategies, including air, liquid, solid-state, and phase-change cooling methods. Different high-voltage, high-frequency pulse generation architectures including vacuum tubes, voltage multipliers, Marx generators, Blumlein structures, pulse-forming networks, Tesla transformers, switching-mode power supplies, solid-state switches, and high-voltage operational amplifiers are systematically evaluated with respect to cost, complexity, stability, and their suitability for driving capacitive loads. The analysis highlights hybrid approaches that integrate solid-state switching with modular multipliers or pulse-forming circuits as offering the best balance of efficiency, compactness, and reliability. The findings provide practical guidelines for developing next-generation high-performance Pockels cell drivers optimized for advanced optical and laser applications. Full article

This work extends our previous research on spectral clustering for mitigating nonlinear phase noise in optical communication systems by presenting the first complete FPGA implementation of the algorithm, including on-chip eigenvector computation with parallelization strategies. The implementation addresses the computational complexity challenges of spectral clustering through a heterogeneous CPU/FPGA co-design approach that partitions algorithmic stages between ARM processors and the FPGA fabric. While the achieved processing speeds of approximately 36 symbols per second do not yet meet the requirements for commercial optical transceivers, our hardware prototype demonstrates the feasibility and practical challenges of deploying advanced clustering algorithms on real-time hardware architectures. We detail the parallel Jacobi method for eigenvector computation, the Greedy K-means++ initialization strategy, and the comprehensive hardware mapping of all clustering stages. The system processes streaming m-QAM data through a windowed architecture and integrates a demapper to ensure label consistency, demonstrating improved bit error rate performance compared to K-means under severe phase noise conditions of −90 dBc/Hz at a 1 MHz offset. This implementation offers valuable insights into memory bandwidth limitations and resource utilization trade-offs, underscoring the crucial role of FPGAs as a bridge between algorithm development and high-speed optical system deployment. Full article

This article introduces a diffractive neural network-enabled spectral object detection approach (DNN-SOD) to efficiently process massive sky-based multidimensional light field data. DNN-SOD combines the novel exploitation of target spectral features with the intrinsic parallelism of optical computing to process multidimensional information efficiently. DNN-SOD detects targets by segmenting the spectral data cube and processing it with the DNN. The DNN maps spectral intensity to the designated area of the detector, then reconstructs spectral curves, and differentiates targets by comparing them with reference spectral signatures. Classification results from individual sub-spectral data cubes are compiled in sequence, enabling accurate target detection. Simulation results indicate that the architecture achieved an accuracy of 91.56% on the MNIST multi-spectral dataset and 84.27% on the infrared target multi-spectral dataset, validating its feasibility for target detection. This architecture represents an innovative outcome at the intersection of remote sensing and optical computing, significantly advancing the dissemination and practical adoption of optical computing in the field. Full article

Fiber-optic sensing systems based on a forward transmission interferometric structure can achieve high sensitivity and a wide frequency response over long distances. However, there are still shortcomings in its ability to position multi-point vibrations and detect low-frequency vibrations, which limits its usefulness. To address these challenges, we study the viability of merging long-range forward-transmission distributed vibration sensing (FTDVS) with high spatial resolution optical frequency-domain reflectometry (OFDR), forming the first reported hybrid distributed sensing method between these two methods. The probe light source is shared between the two sub-systems, which utilizes stable linear optical frequency sweeping facilitated by high-order sideband injection locking. As a result, this is a new approach for the FTDVS method, which conventionally uses fixed-frequency continuous light. The method of nearest neighbor signal replacement (NSR) is proposed to address the issue of discontinuity in phase demodulation under periodic external modulation. The experimental results demonstrate that the hybrid system can determine the position of vibration signals between 0 and 900 Hz within a sensing distance of 21 km. When the sensing distance is extended to 71 km, the FTDVS module can still function adequately for high-frequency vibration signals. This hybrid architecture offers a fresh approach to simultaneously achieving long-distance sensing and wide frequency response, making it suitable for the combined measurement of dynamic (e.g., gas leakage, pipeline excavation warning) and quasi-static (e.g., pipeline displacement) events in long-distance applications. Full article

Accurate semantic segmentation of high-resolution remote sensing imagery is challenged by substantial intra-class variability, inter-class similarity, and the limitations of single-modality data. This paper proposes MMFNet, a novel multimodal fusion network that leverages the Mamba architecture to efficiently capture long-range dependencies for semantic segmentation tasks. MMFNet adopts a dual-encoder design, combining ResNet-18 for local detail extraction and VMamba for global contextual modelling, striking a balance between segmentation accuracy and computational efficiency. A Multimodal Feature Fusion Block (MFFB) is introduced to effectively integrate complementary information from optical imagery and digital surface models (DSMs), thereby enhancing multimodal feature interaction and improving segmentation accuracy. Furthermore, a frequency-aware upsampling module (FreqFusion) is incorporated in the decoder to enhance boundary delineation and recover fine spatial details. Extensive experiments on the ISPRS Vaihingen and Potsdam benchmarks demonstrate that MMFNet achieves mean IoU scores of 83.50% and 86.06%, outperforming eight state-of-the-art methods while maintaining relatively low computational complexity. These results highlight MMFNet’s potential for efficient and accurate multimodal semantic segmentation in remote sensing applications. Full article