Search Results (34,980)

Miniaturized pressure sensors fabricated via micro-electro-mechanical systems (MEMSs) technology are ubiquitous in modern applications. However, the massively produced MEMS pressure sensors, prior to being practically used, need to be calibrated one by one to eliminate or minimize nonlinearity and zero drift. This paper presents a systematic design for the testing and calibration process of MEMS-based absolute pressure sensors. Firstly, a numerical analysis is carried out using finite element method (FEM) simulation, which verifies the accuracy of the temperature control of the physical calibration system. The simulation results reveal a slight non-uniformity of temperature distribution, which is then taken into consideration in the calibration algorithm. Secondly, deploying a home-made calibration system, the MEMS pressure sensors are tested automatically and rapidly. The experimental results show that each batch, which consists of nine sensors, can be calibrated in 80 min. The linearity and temperature coefficient (TC) of the pressure sensors are reduced from 46.5% full-scale (FS) and −1.35 × 10⁻⁴ V·K⁻¹ to 1.5% FS and −8.8 × 10⁻⁷ V·K⁻¹. Full article

This study presents an analytical model to reduce the impact of wave-induced forces on a vertical seawall by introducing a floating elastic plate (EP) located at a specific distance from two bottom-standing porous structures (BSPs). The hydrodynamic interaction with the EP is described using thin plate theory, while the fluid flow through the porous medium is described by the model developed by Sollit and Cross. The resulting boundary value problem is addressed through linear potential theory combined with the eigenfunction expansion method (EEM), and model validation is achieved through consistency checks with recognized results from the literature. A comprehensive parametric analysis is performed to evaluate the influence of key system parameters such as the porosity and frictional coefficient of the BSPs, their height and width, the flexural rigidity of the EP, and the spacing between the EP and BSPs on vital hydrodynamic coefficients, including the wave force on the seawall, free surface elevation, wave reflection coefficient, and energy dissipation coefficient. The results indicate that higher frictional coefficients and higher BSP heights significantly enhance wave energy dissipation and reduce reflection, in accordance with the principle of energy conservation. Oscillatory trends observed with respect to wavenumbers in the reflection and dissipation coefficients highlight resonant interactions between the structures. Moreover, compared with a single BSP, the double BSP arrangement is more effective in minimizing the wave force on the seawall and free surface elevation in the region between the EP and the wall, even when the total volume of porous material remains unchanged. The inter-structural gap is found to play a crucial role in optimizing resonance conditions and supporting the formation of a tranquility zone. Overall, the proposed configuration demonstrates significant potential for coastal protection, offering a practical and effective solution for reducing wave loads on marine infrastructure. Full article

Background/Objectives: The management of immature teeth with wide apical foramina presents significant challenges in endodontic treatment due to difficulties in achieving a hermetic seal. The aim of this study was to evaluate void formation in apical plugs created using three calcium silicate-based materials—Biodentine, NuSmile NeoPUTTY, and Well-Root PT—applied with the help of manual, ultrasonic, or rotary file condensation (XP-endo Shaper) in 3D-printed immature teeth. Methods: Micro-computed tomography analysis was used to assess the internal, external, and total void percentage of material volume. The statistical analysis was performed using two-way ANOVA and the post hoc Bonferroni test. Statistical significance was set at p < 0.05. Results: The materials and techniques used individually do not significantly influence the formation of internal voids, but their combination does (F(4, 99) = 2.717, p = 0.034). Both factors and their interaction are significant for external voids (F(4, 99) = 4.169, p = 0.004), and all have a notable effect on total void percentages (F(4, 99) = 3.456, p = 0.012). No significant differences were observed in internal voids across the groups (p > 0.05), ranging from 0.635% to 1.078%. External voids varied significantly, with Well-Root PT and ultrasonic condensation showing the highest values with a significant difference (p < 0.05), while NeoPUTTY and Biodentine with XP-endo Shaper exhibited the lowest. Total voids remained below 4%, with no significant differences among manual condensation groups. Neither material type nor application technique consistently influenced void formation, except for Well-Root PT with ultrasonic condensation. Conclusions: These findings suggest that modern bioceramic materials and application techniques produce comparable, low-void apical plugs, with XP-endo Shaper showing promise for minimizing external voids. The interaction between material and application technique plays a crucial role during the creation of apical plugs. Full article

This study aimed to evaluate the penetration and bonding performance of three restorative materials—high-viscosity glass ionomer cement (Riva Self Cure HV), resin-modified glass ionomer cement (Riva Light Cure) and a bioactive resin (Activa BioActive Restorative™)—in the healthy and carious dentine of permanent molars. Forty extracted human molars with sound or decayed dentine were restored following standardised protocols and subsequently divided into slices. So, twenty-four samples were used for each group (sound and carious dentine) for interface analysis using confocal laser scanning microscopy, field emission scanning electron microscopy and energy dispersive X-ray spectroscopy, and another eight simples were used for each group (sound and carious dentine) for Vickers microhardness testing. Results showed that both glass ionomer cements achieved consistent chemical bonding in healthy dentine and demonstrated better interfacial adaptation compared to carious dentine, where partially demineralised areas showed weaker bonding. The bioactive resin exhibited good adhesion in sound dentine due to the adhesive system but showed poorer interaction in decayed dentine with signs of interfacial separation. Elemental analysis revealed similar compositions among materials, with no significant differences in material concentrations among the ionomers, while there were significant differences with the other materials. On the other hand, some variations were observed in the sulphur, fluoride and strontium content depending on dentine condition. Microhardness values were higher in healthy dentine than in carious dentine for all materials (p < 0.001), except the high-viscosity glass ionomer, which maintained stable hardness in both substrates (36.33 ± 6.23 VHN vs. 34.56 ± 4.31 VHN; p = 0.605). These findings highlight the relevance of material selection and dentine condition in minimally invasive restorative dentistry. Full article

Improving sowing quality is crucial for ensuring wheat emergence and healthy growth. To address issues of poor wheat sowing quality, such as uneven sowing depth and inadequate soil coverage, in the Yangtze River Delta region of China, this study systematically analyzed the effects of the implement’s structural and operational parameters on sowing quality. Based on this analysis, a double-shaft rotary tillage and double-press seeder was designed. Protrusions on the grooving press roller are used to form seed furrows, rotary tiller blades cover the seeds with soil, and the rear press roller compacts the soil. DEM-MBD (discrete element method–multibody dynamics) coupled simulations, combined with single-factor and central composite design (CCD) experiments, were conducted with seeding depth as the evaluation index and four experimental factors: the protrusion height on the press grooving roller, forward speed, seed mass in the seed box, and straw mulching amount. The optimal protrusion height was 29 mm. The effects of rotary tiller blade working depth, rotational speed, and forward speed on soil-covering mass and its coefficient of variation were evaluated through discrete element method (DEM) simulations. The optimal working depth and rotational speed were found to be 55 mm and 350 r·min⁻¹, respectively, based on single-factor and Box–Behnken Design experiments. Field experiments based on optimized parameters showed results consistent with the simulations. The qualified rate of seeding depth decreased as forward speed increased. The optimal forward speed was 4.5 km·h⁻¹, at which the average seeding depth was 25.7 mm, the qualified seeding depth rate was 90%, the soil-covering mass within a 50 cm² area was 143.2 g, and the coefficient of variation was 13.21%, meeting the requirements for wheat sowing operations. Full article

The environmental challenges posed by global warming have significantly increased the global pursuit of renewable and clean energy sources. Among these, solar energy stands out due to its abundance, renewability, low environmental impact, and favorable long-term economic viability. However, its intermittent nature and dependence on weather conditions hinder consistent and efficient utilization. To address these limitations, nanoparticle-enhanced phase change materials (NPCMs) have emerged as a promising solution for enhancing thermal energy storage in solar thermal systems. NPCMs incorporate superior-performance nanoparticles within traditional phase change material matrices, resulting in improved thermal conductivity, energy storage density, and phase change efficiency. This review systematically examines the recent advances in NPCMs for solar energy applications, covering their classification, structural characteristics, advantages, and limitations. It also explores in-depth analytical approaches, including mechanism-oriented analysis, simulation-based modelling, and algorithm-driven optimization, that explain the behavior of NPCMs at micro and macro scales. Furthermore, the techno-economic implications of NPCM integration are evaluated, with particular attention to cost-benefit analysis, policy incentives, and market growth potential, which collectively support broader adoption. Overall, the findings highlight NPCMs as a frontier in materials innovation and enabling technology for achieving low-carbon, environmentally responsible energy solutions, contributing significantly to global sustainable development goals. Full article

Accurate postharvest quality evaluation of soybeans is essential for preserving product value and meeting industry standards. Traditional inspection methods are often inconsistent, labor-intensive, and unsuitable for high-throughput operations. This study presents a non-destructive soybean classification approach using a simplified reflectance-mode hyperspectral imaging system equipped with a single light source, eliminating the complexity and maintenance demands of dual-light configurations used in prior studies. A spectral–spatial data fusion strategy was developed to classify harvested soybeans into four categories: normal, split, diseased, and foreign materials such as stems and pods. The dataset consisted of 1140 soybean samples distributed across these four categories, with spectral reflectance features and spatial texture attributes extracted from each sample. These features were combined to form a unified feature representation for use in classification. Among multiple machine learning classifiers evaluated, Linear Discriminant Analysis (LDA) achieved the highest performance, with approximately 99% accuracy, 99.05% precision, 99.03% recall and 99.03% F1-score. When evaluated independently, spectral features alone resulted in 98.93% accuracy, while spatial features achieved 78.81%, highlighting the benefit of the fusion strategy. Overall, this study demonstrates that a single-illumination HSI system, combined with spectral–spatial fusion and machine learning, offers a practical and potentially scalable approach for non-destructive soybean quality evaluation, with applicability in automated industrial processing environments. Full article

Background/Objectives: Swallowing disorder(s), or oropharyngeal dysphagia (OPD), are very common in children with cerebral palsy (CP) and pose a significant risk to their health. Behavioural interventions are frequently recommended when targeting OPD in children with CP; however, their efficacy has yet to be determined. This systematic review aimed to synthesise the current evidence for behavioural interventions in the treatment of OPD in children with CP. Methods: A comprehensive search in six databases in October 2024 sought studies that (1) included participants aged 0–18 years with a diagnosis of CP and OPD; (2) utilised and described a behavioural intervention for OPD; and (3) used a randomised controlled trial (RCT) experimental design. Three reviewers independently extracted the data, and results were tabulated. The Revised Cochrane Risk of Bias (ROB-2) tool was used to determine the methodological quality of eligible articles. Results: From an initial yield of 2083 papers, 99 full-text studies were screened for eligibility. Seven RCTs involving 329 participants aged 9.5 months (SD = 2.03) to 10.6 yrs were included. CP description varied. Most studies used a combination of behavioural interventions to treat OPD (n = 6), and oral sensorimotor treatment was the most frequently utilised treatment (n = 4). Positive outcomes were reported in all (n = 7); however, there was high risk of bias in five studies. Conclusions: The use of behavioural interventions to treat OPD in children with CP continues to be supported by low-level evidence. Rigorously designed RCTs with larger samples of children with CP and OPD are needed to evaluate the true effects of behavioural interventions across the developmental phase of childhood. Importantly, consistency in describing and reporting baseline analysis of swallowing and OPD; together with treatment-component data, is a priority in future research. Full article

Objectives: To assess the correlation and agreement of uterocervical angle (UCA) measurements obtained via transabdominal (TAUS), transperineal (TPUS), and transvaginal ultrasound (TVUS) between 16 and 24 weeks of gestation. Methods: In this prospective cross-sectional study, 136 pregnant women underwent UCA and cervical length (CL) assessments using TVUS, TAUS, and TPUS. All measurements were performed by a single experienced operator with an empty bladder. Correlation was assessed using Pearson analysis, while consistency and agreement were evaluated with intraclass correlation coefficient (ICC) and Bland–Altman plots. Results: Mean UCA values differed significantly between modalities (p < 0.001). Moderate correlation (r = 0.547) and consistency (ICC = 0.545) were found between TAUS and TVUS. The Bland–Altman analysis showed a systematic bias of –8° between TAUS and TVUS, with wide limits of agreement (–64° to +32.6°). TPUS showed a higher correlation with TVUS (r = 0.686), but poor consistency (ICC = 0.052), with broader limits of agreement (–32° to +49.2°). Conclusions: Although both TAUS and TPUS showed significant correlation with TVUS for UCA measurement, only TAUS demonstrated moderate consistency, suggesting that it should be used cautiously in clinical practice. TPUS demonstrated considerable variability in individual assessments and does not seem appropriate as a replacement for TVUS. Further studies are needed to validate these findings and improve measurement reliability. Full article

A class of retinal dystrophies known as retinitis pigmentosa (RP) is caused by the loss of photoreceptor cells. RP can be genetically transmitted as an autosomal dominant, autosomal recessive, or X-linked trait. About one-third of genes implicated in retinal degeneration encode for proteins whose functional dysregulation affects the “connecting cilium” in photoreceptors, altering its structure and function. Here we report on a 33-year-old woman who was referred for clinical genetic testing following a previous diagnosis of degenerative retinopathy, which was not informative. She was enrolled in a research program dedicated to undiagnosed retinal disorders, where a whole genome sequencing approach was employed to understand the underlying genetic basis. The genomic analysis documented the occurrence of compound heterozygosity for two functionally relevant missense variants in BAIAP3, which encodes a protein with a well-documented role in SNARE-mediated trafficking and ciliogenesis. Confocal microscopy analysis showed elongated cilia in patient-derived and BAIAP3-depleted fibroblasts compared to control cells. Real-time PCR analyses showed a consistent significant reduction of GLI1 mRNA levels in patient-derived and BAIAP3-depleted cells, both in basal conditions and after treatment with Smoothened agonist, SAG, indicating Sonic hedgehog signaling dysregulation. Collectively, these data suggest that biallelic loss-of-function variants of BAIAP3 may cause photoreceptor degeneration and underlie isolated RP. Full article

Against the backdrop of the growing popularity of blockchain technology, this study investigates blockchain adoption strategies for the fresh food supply chain (FFSC) under a carbon cap-and-trade (CAT) policy. Taking a two-echelon supply chain consisting of a supplier and a retailer as an example, we designed four blockchain adoption modes based on the supplier’s strategy (adopt or not) and the retailer’s strategy (adopt or not). Combining influencing factors such as consumers’ low-carbon preference, consumers’ freshness preference, and carbon trading price (CTP), we established four game-theoretic models. Using backward induction, we derived the equilibrium strategies for the supplier and retailer under different modes and analyzed the impact of key factors on these equilibrium strategies. The analysis yielded four key findings: (1) BB mode (both adopt blockchain) is the optimal adoption strategy for both FFSC parties when carbon prices are high, and consumers exhibit strong dual preferences. It most effectively mitigates the negative price impact of rising carbon prices by synergistically enhancing emission reduction efforts and freshness preservation efforts, thereby increasing overall profits and achieving a Pareto improvement in the benefits for both parties. (2) Consumers’ low-carbon preference and freshness preference exhibit an interaction effect. These two preferences mutually reinforce each other’s incentive effect on FFSC efforts (emission reduction/freshness preservation). Blockchain’s information transparency makes these efforts more perceptible to consumers, forming a synergistic “emission reduction-freshness preservation” cycle that further drives sales and profit growth. (3) The adoption of blockchain by either the supplier or the retailer significantly lowers the cost threshold for the other party to adopt blockchain, thereby increasing their willingness to adopt. (4) CAT and consumer preferences jointly influence the adoption strategies of suppliers and retailers. Additionally, the adoption strategies of FFSC participants are also affected by the other party’s blockchain adoption status. Drawing on the above conclusions, this study provides actionable guidance for suppliers and retailers in selecting optimal blockchain adoption strategies. Full article

Proxy data-based reconstructions provide an essential basis for understanding comprehensive precipitation variability at multiple time scales. This study compared the variation characteristics of reconstructed precipitation data across different regions in the U.S. and the differences at decadal/multidecadal scales. The reconstruction showed that multiple scales of precipitation variability existed in each region and both multidecadal and decadal variability varied over time and across region. There was weaker multidecadal variability in the latter half of the 18th century and during the mid-19th century to mid-20th century east of the Rocky Mountains (RM); however, multidecadal variability appears to have increased since the 20th century in most regions. Decadal variability was weaker west of the RM except in the Southwest U.S. in the latter half of the 18th century. While decadal variability became stronger in the early 20th century, it shifted from a stronger phase to a weaker phase east of the RM. Then, we compared the spatiotemporal differences between the reconstructed Palmer Drought Severity Index (PDSI) and reconstructed precipitation in this study. The reconstructed annual precipitation mostly remains consistent with the existing PDSI dataset, but there are inconsistencies in the severe dry/wet intensities in some regions. Multiscale analysis of regional precipitation data holds great importance for understanding the relationship between precipitation in different regions and the climate system, while also providing a scientific theoretical basis for precipitation prediction. Full article

During the roasting, leaching, and electrodeposition of zinc ores, lead–silver residues are produced. These residues contain valuable metals (Pb, Zn, and Ag) and toxic metals (Cd and As). In this study, a pyrometallurgical process is proposed for treating Pb-Ag residues, consisting of drying, roasting, and reduction steps to recover valuable metals, such as silver in a metallic Pb phase, while converting the waste into an environmentally friendly slag. First, the Pb-Ag residue is dried at 100 °C, then roasted at 700 °C, and finally reduced at a high temperature, with Na₂CO₃ as a flux and CaSi as a reducing agent, rather than carbon-based reducing agents (carbon or carbon monoxide), to minimize greenhouse gas production. The effects of the reduction temperature and the mass of the reducing agent were investigated on a laboratory scale. The metallic phase and slag obtained in the reduction step were characterized by their chemical composition and mineralogy via chemical analysis, X-ray diffraction, and SEM-EDS. The results showed that silver and lead formed a metallic phase, and that silver content decreased from 1700 ppm in the Pb-Ag residue to 32 ppm in the final slag at 1300 °C. The Pb-Ag residue and final slag were leached with an aqueous acetic acid solution to evaluate their chemical stability. Full article

Background/Objectives: While complete loss-of-function (LoF) SPINK1 variants in the simple heterozygous state cause chronic pancreatitis, biallelic complete LoF variants result in a rare pediatric disorder termed severe infantile isolated exocrine pancreatic insufficiency (SIIEPI). To date, only two individuals with a null SPINK1 genotype have been reported—one homozygous for a whole-gene deletion and the other for an Alu insertion in the 3′ untranslated region. Here, we report the genetic basis of a third SIIEPI case, presenting in early infancy with severe exocrine pancreatic insufficiency and diffuse pancreatic lipomatosis. Methods: Targeted next-generation sequencing (NGS) was used to analyze the entire coding region and exon–intron boundaries of the SPINK1 gene. Copy number variant (CNV) analysis was performed with SeqNext, based on normalized amplicon coverage. Results: The proband harbored compound heterozygous complete LoF SPINK1 variants. One was the known NM_001379610.1:c.180_181del (p.(Cys61PhefsTer2)), inherited from the father. The second, initially detected as an exon 2 deletion and confirmed by quantitative fluorescent multiplex PCR (QFM-PCR), was further characterized by long-range PCR as a complex rearrangement comprising a 1185 bp deletion removing exon 2, a 118 bp templated insertion followed by a non-templated nucleotide, and an 8 bp deletion. The mutational signature is consistent with serial replication slippage or template switching involving translesion synthesis. This maternally inherited variant has not been previously reported. Conclusions: This study expands the mutational spectrum of SPINK1-related SIIEPI and suggests that this distinct pediatric disorder may be under recognized in clinical practice. Full article

Background: Creatine supplementation is widely used to enhance exercise performance, mainly resistance training adaptations, yet its differential effects on upper- and lower-body strength and muscular power remain unclear across populations. Objective: This systematic review and meta-analysis aimed to quantify the effects of creatine supplementation in studies that included different exercise modalities or no exercise on upper- and lower-body muscular strength and power in adults. Methods: A comprehensive search of PubMed, Scopus, and Web of Science was conducted through 21 September 2024 to identify randomized controlled trials evaluating the effects of creatine supplementation on strength (bench/chest press, leg press, and handgrip) and power (upper and lower body). Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated using random-effects modeling. Subgroup analyses examined the influence of age, sex, training status, dose, duration, and training frequency. Results: A total of 69 studies with 1937 participants were included for analysis. Creatine plus resistance training produced small but statistically significant improvements in bench and chest press strength [WMD = 1.43 kg, p = 0.002], squat strength [WMD = 5.64 kg, p = 0.001], vertical jump [WMD = 1.48 cm, p = 0.01], and Wingate peak power [WMD = 47.81 Watts, p = 0.004] when compared to the placebo. Additionally, creatine supplementation combined with exercise training revealed no significant differences in handgrip strength [WMD = 4.26 kg, p = 0.10] and leg press strength [WMD = 3.129 kg, p = 0.11], when compared with the placebo. Furthermore, subgroup analysis based on age revealed significant increases in bench and chest press [WMD = 1.81 kg, p = 0.002], leg press [WMD = 8.30 kg, p = 0.004], and squat strength [WMD = 6.46 kg, p = 0.001] for younger adults but not for older adults. Subgroup analyses by sex revealed significant increases in leg press strength [WMD = 9.79 kg, p = 0.001], squat strength [WMD = 6.43 kg, p = 0.001], vertical jump [WMD = 1.52 cm, p = 0.04], and Wingate peak power [WMD = 55.31 Watts, p = 0.001] in males, but this was not observed in females. Conclusions: This meta-analysis indicates that creatine supplementation, especially when combined with resistance training, significantly improves strength in key compound lifts such as the bench or chest press and squat, as well as muscular power, but effects are not uniform across all measures. Benefits were most consistent in younger adults and males, while older adults and females showed smaller or non-significant changes in several outcomes. No overall improvement was observed for handgrip strength or leg press strength, suggesting that the ergogenic effects may be more pronounced in certain multi-joint compound exercises like the squat and bench press. Although the leg press is also a multi-joint exercise, results for this measure were mixed in our analysis, which may reflect differences in study design, participant characteristics, or variability in testing protocols. The sensitivity of strength tests to detect changes appears to vary, with smaller or more isolated measures showing less responsiveness. More well-powered trials in underrepresented groups, particularly women and older adults, are needed to clarify population-specific responses. Full article