Search Results (7,463)

Chemical sensors have undergone transformative advances in recent years, driven by the convergence of nanomaterials, advanced fabrication strategies, and state-of-the-art characterization methods. This review emphasizes recent developments, with particular attention to progress achieved over the past decade, and highlights the role of the United States as a major driver of global innovation in the field. Nanomaterials such as graphene derivatives, MXenes, carbon nanotubes, metal–organic frameworks (MOFs), and hybrid composites have enabled unprecedented analytical performance. Representative studies report detection limits down to the parts-per-billion (ppb) and even parts-per-trillion (ppt) level, with linear ranges typically spanning 10–500 ppb for volatile organic compounds (VOCs) and 0.1–100 μM for biomolecules. Response and recovery times are often below 10–30 seconds, while reproducibility frequently exceeds 90% across multiple sensing cycles. Stability has been demonstrated in platforms capable of continuous operation for weeks to months without significant drift. In parallel, additive manufacturing, device miniaturization, and flexible electronics have facilitated the integration of sensors into wearable, stretchable, and implantable platforms, extending their applications in healthcare diagnostics, environmental monitoring, food safety, and industrial process control. Advanced characterization techniques, including in situ Raman spectroscopy, X-ray Photoelectron Spectroscopy (XPS, Atomic Force Microscopy (AFM) , and high-resolution electron microscopy, have elucidated interfacial charge-transfer mechanisms, guiding rational material design and improved selectivity. Despite these achievements, challenges remain in terms of scalability, reproducibility of nanomaterial synthesis, long-term stability, and regulatory validation. Data privacy and cybersecurity also emerge as critical issues for IoT-integrated sensing networks. Looking forward, promising future directions include the integration of artificial intelligence and machine learning for real-time data interpretation, the development of biodegradable and eco-friendly materials, and the convergence of multidisciplinary approaches to ensure robust, sustainable, and socially responsible sensing platforms. Overall, nanomaterial-enabled chemical sensors are poised to become indispensable tools for advancing public health, environmental sustainability, and industrial innovation, offering a pathway toward intelligent and adaptive sensing systems. Full article

The intensifying freshwater crisis underscores the critical need for all-weather, low-energy atmospheric water harvesting technologies. Inspired by the scale-like protrusions and interconnected channels of Tillandsia leaves that enable efficient water capture and release, a polyvinyl alcohol-based foam featuring a three-dimensional porous structure is fabricated using the supercritical carbon dioxide foaming technology. Compared to the traditional freeze-drying method, this approach significantly reduces preparation energy consumption and shortens the production cycle. Lithium chloride integration endows the foam with exceptional moisture absorption capacity, reaching 300% of its weight. Leveraging graphene’s outstanding photothermal conversion properties, the foam achieves a photothermal dehydration rate of 80.7% within 80 min under 1 Sun irradiation, demonstrating a rapid water release capacity. Furthermore, the polyvinyl alcohol-based foam exhibits no performance degradation after 60 cycles, indicating remarkable stability. This technology provides a scalable, low-cost, and all-climate-applicable solution for water-scarce regions. Full article

Background/Objectives: Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, with a poor prognosis and limited therapeutic options. This study aimed to repurpose methylstat, a selective histone demethylase inhibitor, as a novel anti-glioma agent. We characterized its anti-proliferative efficacy, elucidated mechanisms of cell cycle regulation, and evaluated its blood–brain barrier (BBB) permeability potential. Methods: Compounds with transcriptional profiles enriched for cell cycle arrest and tumor-suppressive pathways were identified via Connectivity Map (CMAP) analysis. Methylstat was selected based on its high connectivity score and favorable physicochemical properties. In vitro assays were performed to evaluate its effects on cell viability, proliferation, cell cycle progression, and expression of related molecular markers in U251 and HOG glioma cell lines. Molecular docking and 200 ns molecular dynamics (MD) simulations were performed to evaluate the binding mode and stability of the Methylstat–JMJD2A complex. An in vitro BBB model was established to assess the ability of Methylstat to cross the BBB. Results: Methylstat significantly inhibited glioma cell proliferation in a dose-dependent manner without inducing apoptosis. It caused G1-phase arrest in U251 cells and G2-phase arrest in HOG cells. Mechanistically, methylstat downregulated cyclins and cyclin-dependent kinases via the p53/p21 pathway. Additionally, methylstat reduced the expression of JMJD2A and its downstream targets, including PDK1, AKT, and mTOR. Molecular docking studies and 200 ns MD simulations confirmed the stable binding of methylstat to the catalytic pocket of JMJD2A, effectively inhibiting its enzymatic activity. HPLC analysis confirmed that methylstat could penetrate the in vitro BBB model to varying extents. Conclusions: Methylstat is a promising small-molecule agent that effectively suppresses glioma cell growth by modulating key cell cycle regulators. Its ability to cross the BBB highlights its potential as a novel therapeutic strategy for GBM and other brain tumors. Full article

TiO₂ photocatalysts exhibit great potential in solar fuel production and environmental remediation, yet their practical applications are often hindered by high electron-hole recombination rates. This study presents a novel strategy for fabricating hollow anatase TiO₂-modified ZnS heterostructures (TiO₂/ZnS) via a simple hydrothermal method. The heterostructure effectively combines the high electron mobility of ZnS, which facilitates rapid photogenerated electron transfer, with the high specific surface area of hollow TiO_2, which enhances pollutant adsorption. As a result, TiO₂/ZnS demonstrates superior tetracycline degradation efficiency due to optimized charge separation and improved accessibility to reactive sites, compared to pristine TiO₂ and ZnS. Furthermore, the enhanced photocatalytic activity is attributed to efficient charge separation facilitated by Type-II heterojunctions between ZnS and anatase TiO₂. Cycling tests reveal that TiO₂/ZnS retains over 94% of its activity after 5 cycles. This work offers a versatile approach for stabilizing metal oxides through heterostructure engineering, with significant implications for scalable environmental catalysis. Full article

All-solid-state lithium batteries (ASSLBs) employing Li-rich layered oxide (LLO) cathodes are regarded as promising next-generation energy storage systems owing to their outstanding energy density and intrinsic safety. Polymer-in-salt solid electrolytes (PISSEs) offer advantages such as high room-temperature ionic conductivity, enhanced Li anode interfacial compatibility, and low processing costs; however, their practical deployment is hindered by poor oxidative stability especially under high-voltage conditions. In this study, we report the rational design of a bilayer electrolyte architecture featuring an in situ solidified LiClO₄-doped succinonitrile (LiClO₄–SN) plastic–crystal interlayer between a Li_1.2Mn_0.6Ni_0.2O₂ (LMNO) cathode and a poly (vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP)-based PISSE. This PISSE/SN–LiClO₄ configuration exhibits a wide electrochemical stability window up to 4.7 V vs. Li⁺/Li and delivers a high ionic conductivity of 5.68 × 10⁻⁴ S cm⁻¹ at 25 °C. The solidified LiClO₄-SN layer serves as an effective physical barrier, shielding the PVDF-HFP matrix from direct interfacial contact with LMNO and thereby suppressing its oxidative decomposition at elevated potentials. As a result, the bilayer polymer-based cells with the LMNO cathode demonstrate an initial discharge capacity of ∼206 mAh g⁻¹ at 0.05 C and exhibit good cycling stability with 85.7% capacity retention after 100 cycles at 0.5 C under a high cut-off voltage of 4.6 V. This work not only provides a promising strategy to enhance the compatibility of PVDF-HFP-based electrolytes with high-voltage cathodes through the facile in situ solidification of plastic interlayers but also promotes the application of LMNO cathode material in high-energy ASSLBs. Full article

This paper presents a thermal study of a lithium-ion traction battery with different cooling configurations during simulated city driving and high-power charging. Four liquid cooling configurations—single or triple plates with straight or U-shaped tubes—were evaluated using finite element models in the Q-Bat Toolbox for MATLAB. Simulations were conducted using the Worldwide Harmonized Light Vehicles Test Cycle (WLTC) and a high-current charging profile based on the CHAdeMO standard (up to 400 A). The results indicate that while cooling is not strictly necessary under typical driving conditions, it significantly improves thermal stability and reduces peak temperatures. The best configuration reduced peak cell temperatures by 1.96% during driving and by 16% during fast charging. The cooling system also minimized temperature gradients within the battery, reducing the risk of degradation. Box-plot analysis confirmed that an efficient cooling system stabilizes the temperature distribution and smooths out extreme values. The results highlight the importance of thermal management for extending battery life and ensuring safe operation, particularly during fast charging conditions. Full article

Cold stress severely limits legume productivity, threatening global food security, particularly in climate-vulnerable regions. This review synthesizes advances in understanding and enhancing cold tolerance in key legumes (chickpea, soybean, lentil, and cowpea), addressing three core questions: (1) molecular/physiological foundations of cold tolerance; (2) how emerging technologies accelerate stress dissection and breeding; and (3) integration strategies and deployment challenges. Legume cold tolerance involves conserved pathways (e.g., ICE-CBF-COR, Inducer of CBF Expression, C-repeat Binding Factor, Cold-Responsive genes) and species-specific mechanisms like soybean’s GmTCF1a-mediated pathway. Multi-omics have identified critical genes (e.g., CaDREB1E in chickpea, NFR5 in pea) underlying adaptive traits (membrane stabilization, osmolyte accumulation) that reduce yield losses by 30–50% in tolerant genotypes. Technologically, AI and high-throughput phenotyping achieve >95% accuracy in early cold detection (3–7 days pre-symptoms) via hyperspectral/thermal imaging; deep learning (e.g., CNN-LSTM hybrids) improves trait prediction by 23% over linear models. Genomic selection cuts breeding cycles by 30–50% (to 3–5 years) using GEBVs (Genomic estimated breeding values) from hundreds of thousands of SNPs (Single-nucleotide polymorphisms). Advanced sensors (LIG-based, LoRaWAN) enable real-time monitoring (±0.1 °C precision, <30 s response), supporting precision irrigation that saves 15–40% water while maintaining yields. Key barriers include multi-omics data standardization and cost constraints in resource-limited regions. Integrating molecular insights with AI-driven phenomics and multi-omics is revolutionizing cold-tolerance breeding, accelerating climate-resilient variety development, and offering a blueprint for sustainable agricultural adaptation. Full article

The Qinghai-Tibet Plateau (QTP) is uniquely characterized by widespread permafrost and desertification due to its distinctive natural environment and geographic setting. The current lack of understanding regarding the mechanisms by which the number of freeze-thaw cycles (N) exacerbates soil erosion poses a significant challenge to accurately assessing regional erosion dynamics. Here, we simulate realistic freeze-thaw conditions using an optimized cryogenic simulator and systematically quantify changes in soil physical properties, surface microstructure, and frost heave deformation. Research shows that as the number of freeze-thaw cycles rises, the surface soil moisture content decreases by 54.3%. Total porosity and bulk density display opposite trends. These changes in soil properties are mainly driven by frost heave forces disrupting soil cohesion. In particular, repeated water-ice phase transitions lead to continuous accumulation of axial frost heave stress, which rearranges soil particles. This significantly raises surface porosity with a growth rate as high as 60.3% and greatly reduces the soil’s resistance to external erosion. At the same time, the aggregate size distribution shifts toward finer particles, accompanied by a continued decrease in the mean weight diameter (MWD), which declines by approximately 8%. Notably, this degradation persists even when external loading partially suppresses frost heave. Therefore, the progressive physical degradation induced by frost heave-manifested through as moisture loss, porosity changes, aggregate breakdown, and compromised stability even under load-establishes the core mechanistic pathway through which freeze-thaw cycles intensify erosion in QTP soils. Full article

As internal combustion engine (ICE) systems are increasingly exposed to severe thermal and oxidative environments, the oxidation resistance and structural integrity of exhaust valve materials have become critical for maintaining long-term engine reliability and efficiency. This study presents a comparative evaluation of the cyclic oxidation behavior of two candidate valve steels, 1.4718 (ferritic stainless steel) and 1.4871 (austenitic stainless steel), under service-temperature conditions. The specimens were exposed to repeated oxidation at 550 °C, 650 °C and 750 °C for 25 cycles in ambient air. The surface and cross-sectional morphologies of the oxide layers were analyzed using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) to investigate oxide scale composition, thickness, and growth characteristics. The oxidation behavior of both alloys proceeded in two distinct stages: an initial phase marked by accelerated oxidation, followed by a slower, more stable growth period. The extent of oxidation intensified with increasing temperature. The 1.4718 alloy developed relatively porous but compositionally stable oxide layers consisting primarily of Fe- and Cr-based spinels such as FeCr₂O₄ and Cr₂SiO₄. In contrast, the 1.4871 alloy formed a dense, adherent, dual-layered oxide scale composed of an outer Mn₂O₃-rich layer and an inner Cr₂O₃-rich layer, attributable to its high Mn and Cr content. The results underscore the critical influence of elemental composition, particularly Cr, Mn and Si, on oxide scale stability and spallation resistance, demonstrating the superior cyclic oxidation resistance of the 1.4871 alloy and its potential suitability for exhaust valve applications in thermally aggressive environments. Full article

Lithium-ion batteries (LIBs) have become the dominant energy storage technology due to their versatility and superior performance across diverse applications. Silicon (Si) stands out as a particularly promising high-capacity anode material for next-generation LIBs, offering a theoretical capacity nearly ten times greater than conventional graphite anodes. However, its practical implementation faces a critical challenge: the material undergoes a ~300% volume expansion during lithiation/delithiation, which causes severe mechanical stress, electrode pulverization, and rapid capacity decay. In addressing these limitations, advanced polymer binders serve as essential components for preserving the structural integrity of Si-based anodes. Notably, self-healing polymeric binders have emerged as a groundbreaking solution, capable of autonomously repairing cycle-induced damage and significantly enhancing electrode durability. The evaluation of self-healing performance is generally based on mechanical characterization methods while morphological observations by scanning electron microscopy provide direct evidence of crack closure; for electrochemically active materials, electrochemical techniques including GCD, EIS, and CV are employed to monitor recovery of functionality. In this study, a novel self-healing copolymer (PHX-23) was synthesized for Si anodes using a combination of octadecyl acrylate (ODA), methacrylic acid (MA), 2-hydroxyethyl methacrylate (HEMA), and polyethylene glycol methyl ether methacrylate (PEGMA). The copolymer was thoroughly characterized using NMR, FTIR, TGA, SEM, and EDX to confirm its chemical structure, thermal stability, and morphology. Electrochemical evaluation revealed that the PHX-23 binder markedly improves cycling stability, sustaining a reversible capacity of 427 mAh g⁻¹ after 1000 cycles at 1C. During long-term cycling, the Coulombic efficiency of the PHX-23 polymer is 99.7%, and similar functional binders in the literature have shown similar results at lower C-rates. Comparative analysis with conventional binders (e.g., PVDF and CMC/SBR) demonstrated PHX-23’s exceptional performance, exhibiting higher capacity retention and improved rate capability. These results position PHX-23 as a transformative binder for silicon anodes in next-generation lithium-ion batteries. Full article

Fractured rock masses in cold regions are subject to long-term seasonal freeze–thaw cycles. To investigate the fatigue damage characteristics of sandstone with different fracture inclinations under freeze–thaw cycling conditions, samples containing fractures of varying inclinations were prepared using sandstone from Altay, Xinjiang. After vacuum saturation and freeze–thaw cycling treatment (−30 °C to 30 °C), uniaxial cyclic loading tests were conducted to analyze strain, elastic modulus, Poisson’s ratio, and damage variables. The results showed that under cyclic loading, the strain of the sandstone exhibited a “stepwise accumulation” characteristic, with peak and residual strain increasing with the progression of the cycle. Among them, the specimen with a fracture angle of 45° exhibited the fastest strain increase before failure. The peak elastic modulus showed a “continuous decrease within each stage and an initial increase followed by a decrease between stages,” while the residual elastic modulus continued to decrease, with both experiencing a sudden, sharp drop at the end of the cycle. The peak Poisson’s ratio decreases with the number of cycles in the early stage, then transitions to logarithmic growth in the later stage, rapidly increases near failure, and finally, the residual Poisson’s ratio in the final cycle exceeds the peak Poisson’s ratio; the evolution of damage variables exhibits an S-shaped three-stage characteristic, with the initial stage showing an irreversible deformation growth rate exceeding 10% due to compaction. In the middle stage, it grows steadily due to microcrack propagation, and in the final stage, it approaches 1. Samples with steep inclination angles exhibit earlier damage initiation and faster growth rates. The study reveals that crack inclination angle influences the evolution rhythm by regulating the proportion of compaction and shear damage, providing a theoretical basis for assessing the engineering stability of fractured rocks in cold regions. Full article

This study investigates the short-run and long-run dynamics of the financial cycle in South Africa, focusing on its macroeconomic drivers and their asymmetric effects across different phases. It addresses the persistent challenge in emerging market economies of balancing financial development and stability amidst volatile conditions. Using monthly data from 2000 to 2024, the research employs a quantile autoregressive distributed lag (QARDL) model to capture the heterogeneity and persistence of macro-financial linkages across the financial cycle’s distribution. The use of the QARDL model in this study allows for capturing asymmetric and quantile-specific relationships that traditional linear models might overlook. Findings reveal that monetary policy, and the housing sector are key drivers of long-term financial development in South Africa, showing positive effects. Conversely, exchange rate movements, inflation, money supply, and macroprudential policy dampen financial development. Short-term financial booms are associated with GDP growth, credit, share, and housing prices. Money supply and inflation are more closely linked to burst phases. These results underscore the importance of policy coordination, particularly between monetary and macroprudential authorities, to balance promoting financial development and ensuring stability in emerging markets. This study contributes to the empirical literature and offers practical insights for policymakers. Full article

Chemical Looping Combustion (CLC) technology has emerged as a promising approach for carbon capture owing to its CO₂ separation capability, which addresses the pressing challenge of global climate change. Although iron-based oxygen carriers offer economic advantages owing to their abundance and low cost, their limited cyclic stability restricts their industrial deployment. This study focused on optimizing the performance of iron-based oxygen carriers through composite modification with Al₂O₃ and TiO₂. Using Cantera (2.5.0) software and the minimum Gibbs free energy principle, conversion rates and product distributions of Fe₂O₃, Fe₂O₃/Al₂O₃, and Fe₂O₃/TiO₂ were systematically analyzed under varying temperatures (800–950 °C), oxygen carrier-to-fuel molar ratios (O/C = 1–15), and pressures (0.1–1.0 MPa). The optimal conditions were identified as 900 °C, O/C = 8, and 0.1 MPa. After 50 simulation cycles, Fe₂O₃/Al₂O₃ and Fe₂O₃/TiO₂ achieved average total reaction counts of 503 and 543, respectively, substantially exceeding 296 cycles for Fe₂O₃. The results indicated that Al₂O₃ and TiO₂ improved cyclic stability via physical support and structural regulation mechanisms, thereby offering a practical carrier composite modification strategy. This study provides a theoretical basis for the development of high-performance oxygen carriers and supports the industrial application of CLC technology for efficient carbon capture and emission mitigation. Full article

Bacteriophages (phages) play a pivotal role in shaping microbial communities and driving bacterial evolution. Among the diverse mechanisms governing phage–host interactions, the Arbitrium (ARM) communication system represents a recently discovered paradigm in phage decision-making between the lytic and lysogenic cycles. Initially identified in Bacillus-infecting phages, the ARM system employs a quorum-sensing-like peptide signaling mechanism to modulate infection dynamics and optimize population-level survival strategies. Recent studies have elucidated the structural and functional basis of ARM regulation, highlighting its potential applications in antimicrobial therapy, microbiome engineering, and synthetic biology. The significance of ARM systems lies in their ability to regulate bacterial population stability and influence the evolutionary trajectories of microbial ecosystems. Despite being a relatively recent discovery, ARM systems have garnered considerable attention due to their role in decoding phage population dynamics at the molecular level and their promising biotechnological applications. This review synthesizes current advancements in understanding ARM systems, including their molecular mechanisms, ecological implications, and translational potential. By integrating recent findings, we provide a comprehensive framework to guide future research on phage–host communication and its potential for innovative therapeutic strategies. Full article

Skin cancer remains a significant global health challenge, with rising incidence and associated mortality in late-stage and drug-resistant cases. This underscores a continuing need for more effective novel therapeutic options that can be utilized for efficient management of skin cancers. A promising approach involves exploiting novel targets, which are dysregulated in skin cancer, either alone or in combination with existing therapeutics. Among these, polo-like kinases (PLKs), a family of serine/threonine kinases, has emerged as promising candidates due to their essential role in cell cycle and maintaining genomic stability, key hallmarks of cancer. Within this family, polo-like kinase 4 (PLK4) stands out as a structurally distinct member and the master regulator of centriole duplication, ensuring this process occurs only once per cell division. Dysregulation of PLK4 can disrupt genomic integrity, contributing to tumorigenesis, thus making it a promising target for cancer management. Notably, PLK4 is frequently overexpressed in several cancers, including skin cancer, and its precise role in skin cancer is an area of current investigation. Further, several small-molecule PLK4 inhibitors such as centrinone, YLZ-F5, CFI-400945, and RP-1664 have demonstrated efficacy in targeting PLK4. Among these, CFI-400945 has advanced to clinical trials, where it has shown modest anti-cancer activity. In this review, we provide a comprehensive overview of the known functions of PLK4 in skin cancer. Additionally, we discuss potential mechanistic insights into PLK4′s involvement in skin cancer progression by extrapolating evidence from studies in other cancer types including colorectal cancer, thyroid cancer, lymphomas, leukemia, etc., while identifying gaps for future research. Full article