Search Results (19,466)

Myokines are secreted by muscle and play crucial roles in muscle repair and regeneration and also impact diverse physiological effects through crosstalk with other metabolic organs. However, aging is associated with a progressive decline in muscle mass, which in turn leads to reduced myokine secretion. This decline may contribute to the development of sarcopenia, leading to an increased risk of metabolic disorders such as type 2 diabetes. Accordingly, interest in identifying novel myokines and elucidating their biological functions is increasing. In this study, we explored the function of biglycan (BGN), a novel myokine, in aging-related metabolic tissues. BGN levels decreased in the muscle tissue and plasma of older adults and aged mice, whereas exercise intervention restored BGN expression in aged mice. BGN counteracted the expression of atrophy-related genes involved in muscle degradation and mitigated muscle mass loss by regulating AKT/mTOR signaling pathway. Notably, BGN decreased the expression of the senescence marker p21 and senescence-associated secretory phenotype (SASP)-related genes in hepatocytes. Additionally, BGN attenuated senescence-induced lipid accumulation and ROS generation. Our results suggest that BGN has beneficial effects against muscle atrophy and hepatocellular senescence, indicating its potential as a protective factor for age-related diseases. Full article

Background: This study examined the effects of high-intensity interval training with change of direction (HIITcod) and small-sided games (SSGs) on components of physical fitness in school-aged children. The aim was to provide practical insights for optimizing exercise interventions in constrained indoor environments. Methods: A randomized controlled trial was conducted during regular physical education (PE) classes in a school’s indoor sports hall. Fifty healthy boys (mean ± SD = 12.6 ± 0.6 years) were randomly assigned to a HIITcod group (n = 25) or an SSG group (n = 25). The intervention lasted eight weeks and consisted of structured training sessions designed to progressively increase intensity and training load in a child-friendly and safe environment. Individual maximal heart rate (HRmax) was determined using the 20 m shuttle run test prior to the intervention. Heart rate monitors were worn throughout all sessions to ensure exercise intensity consistently exceeded 75% of HRmax, with real-time monitoring used to adjust effort when necessary. Physical fitness outcomes, including the shuttle run test (SRT), handgrip strength (HG), 20 m sprint, standing broad jump (SBJ), Illinois agility test, and T-test, were assessed pre- and post-intervention. Results: Both groups demonstrated significant improvements over time in the SRT, SBJ, Illinois agility test, and T-test (p < 0.05). No significant group × time interactions were detected (all p > 0.05). Handgrip strength increased significantly in the HIITcod group (35.03 ± 7.19 kg to 36.80 ± 6.68 kg, p = 0.001, d = 0.25) and showed a non-significant trend in the SSG group (38.28 ± 9.09 kg to 39.23 ± 9.12 kg, p = 0.056). No significant changes were observed in 20 m sprint performance. Conclusions: Based on the study results, both HIITcod and SSGs were associated with improvements in multiple components of physical fitness in school-aged boys. These findings suggest that both training modalities may be viable options for implementation during physical education classes, particularly in limited indoor settings. The observed positive changes in fitness could indicate their potential to positively impact children’s fitness in a structured and engaging manner. Full article

Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease linked to type 2 diabetes (T2D), obesity, and dyslipidaemia, which are all parts of the metabolic syndrome. In 2024, for non-cirrhotic MASH with mild to advanced fibrosis, resmetirom, a selective thyroid hormone receptor-β agonist, became the first FDA-approved treatment for this condition. By increasing β-oxidation and lipid metabolism, it minimises systemic thyroid or cardiac effects while reducing hepatic fat, inflammation, and fibrosis. Resmetirom is being developed for use in combination with lifestyle interventions, such as diet and exercise, to maximize patient benefit. Nevertheless, the lack of congruence between clinical trial populations and real-world payer criteria underscores access obstacles that necessitate policy reform. The successful delivery of screening programs depends on the education of providers from various disciplines and the establishment of uniform screening standards. Future studies should investigate the clinical application of resmetirom in combination with agents that may provide additional benefits, such as GLP-1 receptor agonists, SGLT2 inhibitors, and statins. These results are significant in light of recent long-term safety monitoring of these agents, particularly regarding the thyroid axis. Ensuring equitable uptake will be crucial, as it involves defining fair access through payer endpoints, conducting cost-effectiveness analysis, and considering patient-reported outcomes. Resmetirom represents a breakthrough in MASH management, offering potential metabolic benefits in conjunction with comprehensive clinical and lifestyle approaches. Full article

Background/Objectives: This study examined the effects of 2 weeks of betaine versus placebo supplementation (3 g/d) on 60 km cycling performance, gut permeability, and shifts in plasma metabolites. Methods: Participants included 21 male and female non-elite cyclists. A randomized, placebo-controlled, double-blind, crossover design was used with two 2-week supplementation periods and a 2-week washout period. Supplementation periods were followed by a 60 km cycling time trial. Six blood samples were collected before and after supplementation (overnight fasted state), and at 0 h, 1.5 h, 3 h, and 24 h post-exercise. Five-hour urine samples were collected pre-supplementation and post-60 km cycling after ingesting a sugar solution containing lactulose 5 g, ¹³C mannitol 100 mg, and ¹²C mannitol 1.9 g in 450 mL water. Other outcome measures included plasma intestinal fatty acid binding protein-1 (I-FABP), muscle damage biomarkers (serum creatine kinase, myoglobin), serum cortisol, complete blood cell counts, and shifts in plasma metabolites using untargeted metabolomics. Results: The time to complete the 60 km cycling bout differed significantly between the betaine and placebo trials (mean ± SE, 112.8 ± 2.3, 114.2 ± 2.6 min, respectively, (−1.41 ± 0.7 min) (effect size = 0.475, p = 0.042). No trial differences were found for I-FABP (interaction effect, p = 0.076), L:¹³CM (p = 0.559), the neutrophil/lymphocyte ratio (p = 0.171), serum cortisol (p = 0.982), serum myoglobin (p = 0.942), or serum creatine kinase (p = 0.694). Untargeted metabolomics showed that 214 metabolites exhibited significant trial treatment effects and 130 significant trial x time interaction effects. Betaine versus placebo supplementation was linked to significant increases in plasma betaine, dimethylglycine (DMG), sarcosine, methionine, S-adenosylhomocysteine (SAH), alpha-ketoglutaramate, and 5′methylthioadensone (MTA), and decreases in plasma carnitine and numerous acylcarnitines. Conclusions: Betaine supplementation modestly improved 60 km cycling performance but had no effect on gut permeability. The metabolomics data supported a strong influence of 2-week intake of betaine on the one-carbon metabolism pathway during the 24 h recovery period. Full article

Background: Exercise has been widely recognized as an effective non-pharmacological intervention method for maintaining the mental health and sleep quality of the elderly. However, existing studies rarely distinguish the types of exercise based on cultural attributes, and this is even more so for the situation of elderly women. This oversight limits the accuracy of exercise recommendations for this population. Hence, this study aimed to compare the differential effects of three types of exercise—Oriental exercise, general exercise, and sedentary leisure exercise (SLE)—on physiological indicators and mental health in elderly women and to examine the associations between physiological indicators, sleep quality, and mental health. Methods: A total of 386 participants were included in the study, comprising 252 individuals in the Oriental exercise group (mean ± SD: 67.83 ± 5.36), 110 individuals in the general exercise group (mean ± SD: 67.19 ± 4.47), and 24 individuals in the SLE group (mean ± SD: 67.38 ± 4.75). Psychological tests (Pittsburgh Sleep Quality Index (PSQI), the Satisfaction with Life Scale (SWLS), the Subjective Well-being Scale (SWB), the Geriatric Depression Scale (GDS), the Geriatric Anxiety Scale-20 (GAI-20), and the Exercise Motivation Scale (SMS)) and physiological measurements (such as body weight and pulmonary capacity) were conducted. ANOVA was performed to compare the effects of the three types of exercise on physiological and psychological outcomes, and correlation analyses were conducted to evaluate the associations between different types of exercise and mental health indicators, physiological indicators, and sleep quality. Results: Primary Objective: One-way ANOVA showed significant group differences in key outcomes. Bonferroni post hoc tests confirmed the following: Oriental exercise > general exercise in SWB (p = 0.032); general exercise > SLE in sleep quality (PSQI, p = 0.028) and lower body weight (p = 0.019); Oriental exercise > general exercise in vital capacity (p < 0.001). Secondary Objective: Pearson correlations revealed the following: PSQI negatively correlated with life satisfaction (SWLS: p = 0.035) and positively with GDS (p = 0.021); SWB positively correlated with SWLS (p < 0.001) and negatively with GDS (p = 0.002). Conclusions: Different exercise modalities have distinct benefits for elderly women. Oriental exercise improved vital capacity and well-being, while general exercise reduced body weight and enhanced sleep quality compared with sedentary leisure activity. Tailored exercise programs may effectively promote both physical and mental health in this population. Full article

In 2020, Bill C92, or an Act Respecting First Nations, Inuit and Metis Children, Youth and Families, came into force in Canada. The Act historically recognized and affirmed Indigenous jurisdiction over child and family services and established national minimal standards for service delivery. In 2024, the Supreme Court of Canada upheld the constitutionality of the Act in an appeal from a Quebec Court of Appeal reference case. The Court stressed all parts of the Act must be viewed as “integrated parts of a unified whole” and required the braiding together of Indigenous laws, state laws and international laws into a “single strong rope.” The Act’s aspirations remain in tension with ongoing challenges in implementation. This article outlines the main provisions of the Act. It then examines the law-making efforts and accomplishments of Indigenous governments exercising jurisdiction using the Act, along with some of the hopes and obstacles encountered through this work. Next, it considers some of the emerging jurisprudence interpreting the Act, and some of the implications this case law has on whether the stated purposes of the Act are being achieved. It concludes by highlighting the ongoing uncertainty and hopes for realizing the full potential and aspirations of the Act. Full article

Hypertension in adolescence causes early vascular injury manifesting as endothelial dysfunction (ED), which signifies elevated cardiovascular risk. This review synthesizes recent insights (2020–2025) into ED’s mechanisms and detection in hypertensive youth. We highlight how reduced nitric oxide bioavailability, oxidative stress, inflammation, and hormonal changes in puberty contribute to ED and consequent vascular remodeling. Non-invasive diagnostic tools (e.g., flow-mediated dilation, peripheral arterial tonometry) reveal that even asymptomatic hypertensive adolescents have measurable ED linked to arterial stiffness and cardiac changes. Encouragingly, ED in youth appears reversible: exercise and dietary interventions improve endothelial function, and pharmacotherapy (ACE inhibitors, ARBs) can restore endothelial health beyond blood pressure control. Early identification of ED in hypertensive adolescents is therefore critical—it not only refines risk stratification (e.g., unmasking high-risk “white-coat” hypertension) but also presents an opportunity to initiate lifestyle modifications and therapy to preserve vascular function. Full article

Background: Physical exercise can improve certain musculoskeletal conditions, but adherence remains low due to intimidating environments, limited government support, and financial constraints faced by many individuals. Home-based exercise is a potential strategy to treat that population. Objective: Discuss the main home-based resistance exercise protocols that have been studied and implemented for six highly prevalent musculoskeletal disorders. Methods: A narrative literature review was conducted, using the PubMed database to search for six highly prevalent musculoskeletal conditions: shoulder impingement syndrome (SIS), nonspecific low back pain (NSLBP), greater trochanteric pain syndrome (GTPS), knee osteoarthritis (OA), patellofemoral pain syndrome (PFPS), and Achilles tendinopathy (AT). The strategy included the listed pathologies and the keywords “physical exercise” or “physiotherapy”. Clinical trials, reviews, and retrospective studies from the last 30 years published in English, Portuguese, or Spanish were included. Only studies with sufficient details on the training protocols used and outcome measures were included in the analysis. Results: In SIS, exercise protocols have been more effective in the long term than in the short term. In PFPS and GTPS, strengthening the quadriceps and hip muscles helps reduce pain and improve function. For NSLBP, exercises like Pilates and core training demonstrate pain relief. In knee osteoarthritis, physical exercise improves pain, function, and quality of life both immediately and over time. Eccentric training promotes type I collagen formation in the tendons of patients with Achilles tendinopathy. Conclusions: Home-based resistance exercises studied and implemented in this review offer several general health benefits, including pain reduction, improved functionality, increased muscle strength, and enhanced motor control. Full article

Nuclear factor erythroid 2-related factor 2 (NRF2) serves as a master transcriptional regulator of cellular antioxidant responses through orchestration of cytoprotective gene expression, establishing its significance as a therapeutic target in cerebral pathophysiology. Classical electrophilic NRF2 activators, despite potent activation potential, exhibit paradoxically reduced therapeutic efficacy relative to single antioxidants, attributable to concurrent oxidative stress generation, glutathione depletion, mitochondrial impairment, and systemic toxicity. Although emerging non-electrophilic pharmacological activators offer therapeutic potential, their utility remains limited by bioavailability and suboptimal potency, underscoring the imperative for innovative therapeutic strategies to harness this cytoprotective pathway. Non-pharmacological interventions, including neuromodulation, physical exercise, and lifestyle modifications, activate NRF2 through non-canonical, non-electrophilic pathways involving protein–protein interaction inhibition, KEAP1 degradation, post-translational and transcriptional modulation, and protein stabilization, though mechanistic characterization remains incomplete. Such interventions utilize multi-mechanistic approaches that synergistically integrate multiple non-electrophilic NRF2 pathways or judiciously combine electrophilic and non-electrophilic mechanisms while mitigating electrophile-induced toxicity. This strategy confers neuroprotective effects without the contraindications characteristic of classical electrophilic activators. This review comprehensively examines the mechanistic underpinnings of non-pharmacological NRF2 modulation, highlighting non-electrophilic activation pathways that bypass the limitations inherent to electrophilic activators. The evidence presented herein positions non-pharmacological interventions as viable therapeutic approaches for achieving non-electrophilic NRF2 activation in the treatment of cerebrovascular and neurodegenerative pathologies. Full article

Background: Psychological distress is one of the leading causes of ill health in the United Arab Emirates (UAE). Nursing students often report higher levels of stress than the general population. Identifying the determinants of mental distress is essential to raise awareness and enable universities to implement preventive interventions. Aim: To examine the relationship between physical activity and psychological distress among nursing students at RAK Medical and Health Sciences University. Methods: A descriptive cross-sectional design was employed. A total of 187 students completed a three-part survey: (I) sociodemographic characteristics, (II) the International Physical Activity Questionnaire-Short Form (IPAQ-SF), and (III) the Depression Anxiety Stress Scale-21 (DASS-21). Results: Among participants, 28.3% were inactive, 36.9% engaged in moderate activity, and 34.8% engaged in vigorous activity. Significant associations were observed between physical activity and gender (χ² = 9.64, p < 0.001), nationality (χ² = 8.09, p = 0.01), anxiety (FET = 99.34, p < 0.001), and stress levels (χ² = 12.41, p = 0.05). Regression analysis showed that gender, nationality, anxiety, and stress significantly predicted physical activity levels (F(3,183) = 62.47, p < 0.001), explaining 51% of the variance (R² = 0.506, adjusted R² = 0.498). Conclusion: Physical activity among nursing students was significantly associated with gender, nationality, anxiety, and stress. Programs that promote physical activity may help reduce psychological distress and improve students’ health and well-being. Failure to address high levels of stress and anxiety may increase the risk of burnout in future professional practice. Full article

Diabetic cardiomyopathy (DCM) is a serious complication of type 2 diabetes mellitus (T2DM), characterized by cardiac dysfunction, inflammation, and fibrosis. In this study, a T2DM mouse model was established by administering a high-fat diet (60% fat) in combination with streptozotocin injection in male C57BL/6J mice. The mice subsequently underwent an eight-week exercise intervention consisting of swimming training, resistance training, or high-intensity interval training (HIIT). The results showed that all three forms of exercise improved cardiac function and attenuated myocardial hypertrophy in DCM mice. Exercise training further downregulated the expression of pro-inflammatory cytokines, including interleukin-6, tumor necrosis factor-α, nuclear factor κB, and monocyte chemoattractant protein-1, and mitigated myocardial fibrosis by suppressing fibronectin, α-SMA, collagen type I alpha 1 chain, collagen type III alpha 1 chain, and the TGF-β1/Smad signaling pathway. Moreover, exercise inhibited the expression of PANoptosis-related genes and proteins in cardiomyocytes of DCM mice. Notably, HIIT produced the most pronounced improvements across these pathological markers. In addition, all three exercise modalities effectively suppressed the aberrant activation of the cGAS–STING signaling pathway in the myocardium. In conclusion, exercise training exerts beneficial effects against DCM by improving cardiac function and reducing inflammation, PANoptosis, and fibrosis, and HIIT emerged as the most effective strategy. Full article

Background: Physical activity is essential for public health, yet disparities in access to exercise opportunities and institutional support remain significant across European regions. Objectives: This study examines how locally available physical activity options and support from local authorities relate to exercise participation, life expectancy, and healthy life years within the European Union. Methods: Using artificial neural networks and cluster analysis, the research identifies patterns across EU countries and explores associations between exercise behaviors and public health outcomes. Results: The MLP analysis showed that moderate regular physical activity had the most decisive influence on predicting healthy life years (100%), followed by regular activity (44.7%). In comparison, inactivity had a notable negative impact (40.5%). Life expectancy was most closely associated with the model’s strongest predictive pathway (weight = 2.395). Access to physical activity opportunities (100%) and the presence of supportive community providers (90.8%) were the most influential factors in encouraging active lifestyles. Conclusions: Populations with greater access and engagement in physical activity tend to enjoy longer life expectancies and more years of good health. While the study’s observational nature limits causal interpretations, the findings highlight the potential of community-level strategies and infrastructural investment to foster active lifestyles and enhance population health across varied local contexts. Full article

Background: Creatine supplementation is widely used to enhance exercise performance, mainly resistance training adaptations, yet its differential effects on upper- and lower-body strength and muscular power remain unclear across populations. Objective: This systematic review and meta-analysis aimed to quantify the effects of creatine supplementation in studies that included different exercise modalities or no exercise on upper- and lower-body muscular strength and power in adults. Methods: A comprehensive search of PubMed, Scopus, and Web of Science was conducted through 21 September 2024 to identify randomized controlled trials evaluating the effects of creatine supplementation on strength (bench/chest press, leg press, and handgrip) and power (upper and lower body). Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated using random-effects modeling. Subgroup analyses examined the influence of age, sex, training status, dose, duration, and training frequency. Results: A total of 69 studies with 1937 participants were included for analysis. Creatine plus resistance training produced small but statistically significant improvements in bench and chest press strength [WMD = 1.43 kg, p = 0.002], squat strength [WMD = 5.64 kg, p = 0.001], vertical jump [WMD = 1.48 cm, p = 0.01], and Wingate peak power [WMD = 47.81 Watts, p = 0.004] when compared to the placebo. Additionally, creatine supplementation combined with exercise training revealed no significant differences in handgrip strength [WMD = 4.26 kg, p = 0.10] and leg press strength [WMD = 3.129 kg, p = 0.11], when compared with the placebo. Furthermore, subgroup analysis based on age revealed significant increases in bench and chest press [WMD = 1.81 kg, p = 0.002], leg press [WMD = 8.30 kg, p = 0.004], and squat strength [WMD = 6.46 kg, p = 0.001] for younger adults but not for older adults. Subgroup analyses by sex revealed significant increases in leg press strength [WMD = 9.79 kg, p = 0.001], squat strength [WMD = 6.43 kg, p = 0.001], vertical jump [WMD = 1.52 cm, p = 0.04], and Wingate peak power [WMD = 55.31 Watts, p = 0.001] in males, but this was not observed in females. Conclusions: This meta-analysis indicates that creatine supplementation, especially when combined with resistance training, significantly improves strength in key compound lifts such as the bench or chest press and squat, as well as muscular power, but effects are not uniform across all measures. Benefits were most consistent in younger adults and males, while older adults and females showed smaller or non-significant changes in several outcomes. No overall improvement was observed for handgrip strength or leg press strength, suggesting that the ergogenic effects may be more pronounced in certain multi-joint compound exercises like the squat and bench press. Although the leg press is also a multi-joint exercise, results for this measure were mixed in our analysis, which may reflect differences in study design, participant characteristics, or variability in testing protocols. The sensitivity of strength tests to detect changes appears to vary, with smaller or more isolated measures showing less responsiveness. More well-powered trials in underrepresented groups, particularly women and older adults, are needed to clarify population-specific responses. Full article

Introduction: Women’s futsal demands strength, agility, speed, and endurance, involving sprints, dribbling, and rapid directional changes. In this context, the hamstring/quadriceps (H/Q) strength ratio and bilateral muscle asymmetries are recognized as risk factors for lower limb injuries and may also impact athletic performance. Objective: This study aimed to analyze power output in two inertial flywheel resistance exercises and identify muscle imbalances in the lower limbs of female university futsal players. Methods: Twelve athletes (22.9 ± 2.3 years; 163 ± 6.8 cm; 60.9 ± 9.9 kg; 22.8 ± 3.1 kg/m²; ≥9 years of experience) participated in the study. They performed 2 sets of 8 unilateral knee flexion and extension repetitions per limb, following a warm-up of 20 bodyweight squats. Power output was assessed using a multi-joint isoinertial device (Physical Solutions, SP, Brazil). Data were analyzed using mean and standard deviation, with significance set at α = 0.05. Results: Eccentric power was significantly higher in both exercises and limbs (EJPD = 0.003; EJPE = 0.006; FJPD < 0.001; FJPE < 0.001). An imbalance in the H/Q ratio was observed: concentric right = 50.38% ± 14.67; left = 42.46% ± 9.24; eccentric right = 56.71% ± 15.56; left = 58.38% ± 21.06. The right limb showed a greater concentric imbalance (p = 0.016). Conclusions: Eccentric power was higher in both exercises without inter-limb differences. An H/Q imbalance was detected, with greater asymmetry in the right leg for concentric power. Coaches are encouraged to prioritize eccentric training to address these imbalances. Full article

Affective responses to physical exercise vary according to sensory impressions and can influence motor performance. To assess affective states in exercise contexts, scales such as the Felt Arousal Scale and the Feeling Scale are commonly used. Although widely applied, their psychometric properties have not yet been tested in older adults, which limits their use in this population. This test–retest study aimed to test the reliability of these scales in older adults of both sexes. The sample consisted of 80 volunteers (67 women) engaged in either resistance training (n = 37) or functional training (n = 43), with a mean age of 70 ± 9 years. Data collection occurred on two separate days, with a minimum interval of 15 days. The following instruments were applied: (a) Felt Arousal Scale and Feeling Scale at pre-, during (minutes 20 to 25), and post-training; (b) Borg Scale during and after training; and c) Mini-Mental State Examination during the first visit. The results showed strong to very strong correlations for both scales (Feeling Scale: ρ = 0.936 during, ρ = 0.840 post; Felt Arousal Scale: r = 0.967 during, r = 0.887 post), as well as good internal consistency (Feeling Scale: α = 0.887; Felt Arousal Scale: α = 0.860) and excellent temporal stability (Feeling Scale: ICC = 0.925; Felt Arousal Scale: ICC = 0.869). It is concluded that both instruments are reliable for measuring affect and arousal in older adults who engage in physical exercise. Full article