Oxidative Stress and NRF2 in Health and Disease—2nd Edition

Dear Colleagues,

I am delighted to announce that the Special Issue “Oxidative Stress and NRF2 in Health and Disease” is continuing with its 2nd edition, following the success of its 1st edition, which featured numerous excellent papers. These papers are freely accessible at: https://www.mdpi.com/journal/antioxidants/special_issues/H7968G1761.

Oxidative stress (OS) has long been considered a cause of various noncommunicable diseases. The term refers to the increased formation of reactive oxygen species (ROS) and other byproducts that can react with cellular macromolecules such as proteins, DNA, and lipids to impair cellular function. Earlier research opinions assumed that OS only leads to various pathologies and referred to it as a harmful process that should be abolished. However, further research revealed that OS byproducts, such as hydrogen peroxide, are also important for redox signaling. Depending on the cue, cells use their signaling abilities, which include turning certain protein targets on and off, to provide signal transduction that regulates their own functions or the functions of neighboring cells. The extent of OS is closely intertwined with metabolic switches and antioxidant machinery. While some ROS, such as hydrogen peroxide, are essential for normal physiology, their increase leads to pathology. The NRF2 pathway is the main pathway activated as a response to OS. The NRF2 pathway is the major signaling pathway activated in response to OS. The transcription factor NRF2 (nuclear factor, erythroid 2 like 2) is mainly regulated by Kelch-like ECH-associated protein 1 (KEAP1), although its regulation/activation is more complex. NRF2 regulates the expression of more than 250 genes, not only antioxidant enzymes but also others involved in autophagy, metabolism, detoxification, protein turnover, etc. Its mode of action is not always beneficial to humans and is not fully understood.

We invite researchers in this field and participants of the COST Action CA20121 and the Bench to Bedside Transition for Pharmacological regulation of NRF2 in non-communicable diseases (BenBedPhar) to submit their latest research to this Special Issue. Potential topics include, but are not limited to, deciphering the role of oxidative stress and NRF2 in physiology and pathology, their linkage to other signaling pathways, the “omics” approach to identify specific targets and key molecules, potential therapeutic strategies, etc.

Dr. Lidija Milković
Guest Editor

Manuscript Submission Information

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• oxidative stress
• redox signaling
• NRF2 and its regulation
• redox-modifying therapeutic approach
• omics approach
• physiology
• non-communicable diseases
• metabolism
• aging