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23 pages, 3751 KB  
Article
DAF-Aided ISAC Spatial Scattering Modulation for Multi-Hop V2V Networks
by Yajun Fan, Jiaqi Wu, Yabo Guo, Jing Yang, Le Zhao, Wencai Yan, Shangjun Yang, Haihua Ma and Chunhua Zhu
Sensors 2025, 25(19), 6189; https://doi.org/10.3390/s25196189 (registering DOI) - 6 Oct 2025
Abstract
Integrated sensing and communication (ISAC) has emerged as a transformative technology for intelligent transportation systems. Index modulation (IM), recognized for its high robustness and energy efficiency (EE), has been successfully incorporated into ISAC systems. However, most existing IM-based ISAC schemes overlook the spatial [...] Read more.
Integrated sensing and communication (ISAC) has emerged as a transformative technology for intelligent transportation systems. Index modulation (IM), recognized for its high robustness and energy efficiency (EE), has been successfully incorporated into ISAC systems. However, most existing IM-based ISAC schemes overlook the spatial multiplexing potential of millimeter-wave channels and remain confined to single-hop vehicle-to-vehicle (V2V) setups, failing to address the challenges of energy consumption and noise accumulation in real-world multi-hop V2V networks with complex road topologies. To bridge this gap, we propose a spatial scattering modulation-based ISAC (ISAC-SSM) scheme and introduce it to multi-hop V2V networks. The proposed scheme leverages the sensed positioning information to select maximum signal-to-noise ratio relay vehicles and employs a detect-amplify-and-forward (DAF) protocol to mitigate noise propagation, while utilizing sensed angle data for Doppler compensation to enhance communication reliability. At each hop, the transmitter modulates index bits on the angular-domain spatial directions of scattering clusters, achieving higher EE. We initially derive a closed-form bit error rate expression and Chernoff upper bound for the proposed DAF ISAC-SSM under multi-hop V2V networks. Both theoretical analyses and Monte Carlo simulations have been made and demonstrate the superiority of DAF ISAC-SSM over existing alternatives in terms of EE and error performance. Specifically, in a two-hop network with 12 scattering clusters, compared with DAF ISAC-conventional spatial multiplexing, DAF ISAC-maximum beamforming, and DAF ISAC-random beamforming, the proposed DAF ISAC-SSM scheme can achieve a coding gain of 1.5 dB, 2 dB, and 4 dB, respectively. Moreover, it shows robust performance with less than a 1.5 dB error degradation under 0.018 Doppler shifts, thereby verifying its superiority in practical vehicular environments. Full article
32 pages, 5868 KB  
Review
A Review of Robotic Interfaces for Post-Stroke Upper-Limb Rehabilitation: Assistance Types, Actuation Methods, and Control Mechanisms
by André Gonçalves, Manuel F. Silva, Hélio Mendonça and Cláudia D. Rocha
Robotics 2025, 14(10), 141; https://doi.org/10.3390/robotics14100141 (registering DOI) - 6 Oct 2025
Abstract
Stroke is a leading cause of long-term disability worldwide, with survivors often facing significant challenges in regaining upper-limb functionality. In response, robotic rehabilitation systems have emerged as promising tools to enhance post-stroke recovery by delivering precise, adaptable, and patient-specific therapy. This paper presents [...] Read more.
Stroke is a leading cause of long-term disability worldwide, with survivors often facing significant challenges in regaining upper-limb functionality. In response, robotic rehabilitation systems have emerged as promising tools to enhance post-stroke recovery by delivering precise, adaptable, and patient-specific therapy. This paper presents a review of robotic interfaces developed specifically for upper-limb rehabilitation. It analyses existing exoskeleton- and end-effector-based systems, with respect to three core design pillars: assistance types, control philosophies, and actuation methods. The review highlights that most solutions favor electrically actuated exoskeletons, which use impedance- or electromyography-driven control, with active assistance being the predominant rehabilitation mode. Resistance-providing systems remain underutilized. Furthermore, no hybrid approaches featuring the combination of robotic manipulators with actuated interfaces were found. This paper also identifies a recent trend towards lightweight, modular, and portable solutions and discusses the challenges in bridging research prototypes with clinical adoption. By focusing exclusively on upper-limb applications, this work provides a targeted reference for researchers and engineers developing next-generation rehabilitation technologies. Full article
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14 pages, 314 KB  
Article
Effects of Challenge Initiative’s Community Health Volunteers (CHVs) on Public Sector Service Provision of Family Planning Services in Urban Sindh, Pakistan
by Junaid-ur-Rehman Siddiqui, Mansoor Ahmed Veesar, Kashif Manzoor, Irum Imran, Amir Saeed, Faisal Mahar, Saqib Ali Shaikh, Zafar Ali Dehraj, Aaliya Habib, Ghazunfer Abbas, Syed Azizur Rab and Victor Igharo
Int. J. Environ. Res. Public Health 2025, 22(10), 1528; https://doi.org/10.3390/ijerph22101528 - 5 Oct 2025
Abstract
To counter the high unmet need for family planning in urban areas of Sindh province, Pakistan, Greenstar Social Marketing began implementation of The Challenge Initiative (TCI) in collaboration with the government departments of Population Welfare and Health in eight urban districts of Sindh [...] Read more.
To counter the high unmet need for family planning in urban areas of Sindh province, Pakistan, Greenstar Social Marketing began implementation of The Challenge Initiative (TCI) in collaboration with the government departments of Population Welfare and Health in eight urban districts of Sindh province. This study aimed to assess the effectiveness of TCI’s Community Health Volunteers (CHVs) on public sector service provision of family planning services in eight urban districts of Sindh province, Pakistan. The Contraceptive Logistics Management Information System (cLMIS) and District Health Information System 2 (DHIS2) were used to obtain monthly contraceptive data from June 2022 to December 2024. CHVs began implementation at different time points in each district, starting from January 2023 to October 2023, when CHVs became operational in all eight districts. Descriptive statistics and two-sample t-tests were used for data analysis. CHVs significantly improved family planning service provision, particularly for short- and long-acting methods at the facility level, with greater change observed in Department of Health facilities. This study provides preliminary evidence of the effectiveness of CHVs in increasing public sector service provision of contraceptives, particularly for Department of Health facilities. CHVs bridge the gap between the community and the facility, particularly in areas uncovered by the government’s existing mobilization staff. Full article
(This article belongs to the Section Health Care Sciences)
18 pages, 1278 KB  
Article
MixModel: A Hybrid TimesNet–Informer Architecture with 11-Dimensional Time Features for Enhanced Traffic Flow Forecasting
by Chun-Chi Ting, Kuan-Ting Wu, Hui-Ting Christine Lin and Shinfeng Lin
Mathematics 2025, 13(19), 3191; https://doi.org/10.3390/math13193191 (registering DOI) - 5 Oct 2025
Abstract
The growing demand for reliable long-term traffic forecasting has become increasingly critical in the development of intelligent transportation systems (ITS). However, capturing both strong periodic patterns and long-range temporal dependencies presents a significant challenge, and existing approaches often fail to balance these factors [...] Read more.
The growing demand for reliable long-term traffic forecasting has become increasingly critical in the development of intelligent transportation systems (ITS). However, capturing both strong periodic patterns and long-range temporal dependencies presents a significant challenge, and existing approaches often fail to balance these factors effectively, resulting in unstable or suboptimal predictions. To address this issue, we propose MixModel , a novel hybrid framework that integrates TimesNet and Informer to leverage their complementary strengths. Specifically, the TimesNet branch extracts periodic variations through frequency-domain decomposition and multi-scale convolution, while the Informer branch employs ProbSparse attention to efficiently capture long-range dependencies across extended horizons. By unifying these capabilities, MixModel achieves enhanced forecasting accuracy, robustness, and stability compared with state-of-the-art baselines. Extensive experiments on real-world highway datasets demonstrate the effectiveness of our model, highlighting its potential for advancing large-scale urban traffic management and planning. To the best of our knowledge, MixModel is the first hybrid framework that explicitly bridges frequency-domain periodic modeling and efficient long-range dependency learning for long-term traffic forecasting, establishing a new benchmark for future research in Intelligent Transportation Systems. Full article
25 pages, 440 KB  
Article
An Exhaustive Analysis of the OR-Product of Soft Sets: A Symmetry Perspective
by Keziban Orbay, Metin Orbay and Aslıhan Sezgin
Symmetry 2025, 17(10), 1661; https://doi.org/10.3390/sym17101661 - 5 Oct 2025
Abstract
This paper provides a theoretical investigation of the OR-product (∨-product) in soft set theory, an operation of central importance for handling uncertainty in decision-making. A comprehensive algebraic analysis is carried out with respect to various types of subsets and equalities, with particular emphasis [...] Read more.
This paper provides a theoretical investigation of the OR-product (∨-product) in soft set theory, an operation of central importance for handling uncertainty in decision-making. A comprehensive algebraic analysis is carried out with respect to various types of subsets and equalities, with particular emphasis on M-subset and M-equality, which represent the strictest forms of subsethood and equality. This framework reveals intrinsic algebraic symmetries, particularly in commutativity, associativity, and idempotency, which enrich the structural understanding of soft set theory. In addition, certain missing results on OR-products in the literature are completed, and our findings are systematically compared with existing ones, ensuring a more rigorous theoretical framework. A central contribution of this study is the demonstration that the collection of all soft sets over a universe, equipped with a restricted/extended intersection and the OR-product, forms a commutative hemiring with identity under soft L-equality. This structural result situates the OR-product within one of the most fundamental algebraic frameworks, connecting soft set theory with broader areas of algebra. To illustrate its practical relevance, the int-uni decision-making method on the OR-product is applied to a pilot recruitment case, showing how theoretical insights can support fair and transparent multi-criteria decision-making under uncertainty. From an applied perspective, these findings embody a form of symmetry in decision-making, ensuring fairness and balanced evaluation among multiple decision-makers. By bridging abstract algebraic development with concrete decision-making applications, the results affirm the dual significance of the OR-product—strengthening the theoretical framework of soft set theory while also providing a viable methodology for applied decision-making contexts. Full article
(This article belongs to the Topic Fuzzy Sets Theory and Its Applications)
22 pages, 4315 KB  
Article
Automated Identification, Warning, and Visualization of Vortex-Induced Vibration
by Min He, Peng Liang, Xing-Shun Lu, Yu-Hao Pan and Di Zhang
Sensors 2025, 25(19), 6169; https://doi.org/10.3390/s25196169 (registering DOI) - 5 Oct 2025
Abstract
Vortex-induced vibration (VIV) is a kind of abnormal vibration which needs to be automatically identified and warned in real time to guarantee the operational safety of a bridge. However, the existing VIV identification methods only focus on identification and have limitations in visualizing [...] Read more.
Vortex-induced vibration (VIV) is a kind of abnormal vibration which needs to be automatically identified and warned in real time to guarantee the operational safety of a bridge. However, the existing VIV identification methods only focus on identification and have limitations in visualizing identification results, which causes difficulty for bridge governors in other fields to quickly confirm the identification results. This paper proposes an automatic VIV identification, warning, and visualization method. First, a recurrence plot is introduced to analyze the signal to extract the characteristics of the vibration signal in a time domain. Then, a feature index defined as recurrence cycle smoothness is proposed to quantify the stability of the vibration signal, based on which the VIV can be automatically identified. An automatic VIV identification and multi-level warning process is finally established based on the severity of the vibration amplitude. The proposed method is validated through a suspension bridge with serious VIVs. The result indicates that the proposed method can automatically identify the VIV correctly without any manual intervention and can visualize the identification results using a graph, providing a good tool to quickly confirm the VIV identification results. The multi-level warning can successfully warn the serious VIV and provide possible early warning for large amplitude VIV. Full article
(This article belongs to the Section Intelligent Sensors)
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53 pages, 7641 KB  
Article
The Italian Actuarial Climate Index: A National Implementation Within the Emerging European Framework
by Barbara Rogo, José Garrido and Stefano Demartis
Risks 2025, 13(10), 192; https://doi.org/10.3390/risks13100192 - 3 Oct 2025
Abstract
This paper presents the development of a high-resolution composite index to monitor and quantify climate-related risks across Italy. The country’s complex climatic variability, extensive coastline, and low insurance penetration highlight the urgent need for robust, locally calibrated tools to bridge the climate protection [...] Read more.
This paper presents the development of a high-resolution composite index to monitor and quantify climate-related risks across Italy. The country’s complex climatic variability, extensive coastline, and low insurance penetration highlight the urgent need for robust, locally calibrated tools to bridge the climate protection gap. Building on the methodological framework of existing actuarial climate indices, previously adapted for France and the Iberian Peninsula, the index integrates six standardised indicators capturing warm and cool temperature extremes, heavy precipitation intensity, dry spell duration, high wind frequency, and sea level change. It leverages hourly ERA5-Land reanalysis data and monthly sea level observations from tide gauges. Results show a clear upward trend in climate anomalies, with regional and seasonal differentiation. Among all components, sea level is most strongly correlated with the composite index, underscoring Italy’s vulnerability to marine-related risks. Comparative analysis with European indices confirms both the robustness and specificity of the Italian exposure profile, reinforcing the need for tailored risk metrics. The index can support innovative risk transfer mechanisms, including climate-related insurance, regulatory stress testing, and resilience planning. Combining scientific rigour with operational relevance, it offers a consistent, transparent, and policy-relevant tool for managing climate risk in Italy and contributing to harmonised European frameworks. Full article
(This article belongs to the Special Issue Climate Change and Financial Risks)
29 pages, 2319 KB  
Article
Research on the Development of a Building Model Management System Integrating MQTT Sensing
by Ziang Wang, Han Xiao, Changsheng Guan, Liming Zhou and Daiguang Fu
Sensors 2025, 25(19), 6069; https://doi.org/10.3390/s25196069 - 2 Oct 2025
Abstract
Existing building management systems face critical limitations in real-time data integration, primarily relying on static models that lack dynamic updates from IoT sensors. To address this gap, this study proposes a novel system integrating MQTT over WebSocket with Three.js visualization, enabling real-time sensor-data [...] Read more.
Existing building management systems face critical limitations in real-time data integration, primarily relying on static models that lack dynamic updates from IoT sensors. To address this gap, this study proposes a novel system integrating MQTT over WebSocket with Three.js visualization, enabling real-time sensor-data binding to Building Information Models (BIM). The architecture leverages MQTT’s lightweight publish-subscribe protocol for efficient communication and employs a TCP-based retransmission mechanism to ensure 99.5% data reliability in unstable networks. A dynamic topic-matching algorithm is introduced to automate sensor-BIM associations, reducing manual configuration time by 60%. The system’s frontend, powered by Three.js, achieves browser-based 3D visualization with sub-second updates (280–550 ms latency), while the backend utilizes SpringBoot for scalable service orchestration. Experimental evaluations across diverse environments—including high-rise offices, industrial plants, and residential complexes—demonstrate the system’s robustness: Real-time monitoring: Fire alarms triggered within 2.1 s (22% faster than legacy systems). Network resilience: 98.2% availability under 30% packet loss. User efficiency: 4.6/5 satisfaction score from facility managers. This work advances intelligent building management by bridging IoT data with interactive 3D models, offering a scalable solution for emergency response, energy optimization, and predictive maintenance in smart cities. Full article
(This article belongs to the Section Intelligent Sensors)
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20 pages, 16092 KB  
Article
Spatial Accessibility in the Urban Environment of a Medium-Sized City: A Case Study of Public Amenities in Odense, Denmark
by Irma Kveladze
Urban Sci. 2025, 9(10), 407; https://doi.org/10.3390/urbansci9100407 - 2 Oct 2025
Abstract
Spatial accessibility is a key principle in urban studies, shaping how people reach amenities and services across cities. While most research concentrates on large metropolitan areas and central urban services, small and medium-sized cities and their main amenities remain less studied. To bridge [...] Read more.
Spatial accessibility is a key principle in urban studies, shaping how people reach amenities and services across cities. While most research concentrates on large metropolitan areas and central urban services, small and medium-sized cities and their main amenities remain less studied. To bridge this gap, this study explores spatial accessibility to public amenities in relation to population density in Odense, a medium-sized city known for its compact layout and robust infrastructure supporting walking, cycling, and public transport. Despite Odense’s proactive planning and multimodal transport network, marked accessibility inequalities still exist, especially in peripheral neighbourhoods. This research uses a data-driven approach combining network-based travel time analysis with grid-cell-based spatial visualisation. Additionally, a multi-criteria accessibility scoring framework is introduced, including indicators such as amenity density, diversity of services, temporal thresholds for walking and cycling, and population distribution. The results show an uneven accessibility landscape, with significant gaps in outer districts, highlighting the limitations of uniform planning thresholds. By applying spatial analytical principles, the study uncovers embedded socio-spatial inequalities in everyday urban access. These insights offer practical guidance for planners and policymakers, underscoring the importance of context-sensitive multimodal infrastructure and decentralised service provision to support sustainable urban growth. Full article
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23 pages, 3872 KB  
Article
Research on the Design Method of Laminated Glass Bridge Deck for Vehicle Applications
by Baojun Zhao, Jiang Xing, Gao Cheng and Jufeng Su
Buildings 2025, 15(19), 3541; https://doi.org/10.3390/buildings15193541 - 1 Oct 2025
Abstract
Owing to the light-transmitting, energy-saving, and load-bearing properties of glass, laminated glass has gradually been adopted as vehicle lane surfaces in scenarios such as multi-storey commercial complexes, glass walkways roads, and underground parking lots. However, currently, a mature design system for vehicle-borne glass [...] Read more.
Owing to the light-transmitting, energy-saving, and load-bearing properties of glass, laminated glass has gradually been adopted as vehicle lane surfaces in scenarios such as multi-storey commercial complexes, glass walkways roads, and underground parking lots. However, currently, a mature design system for vehicle-borne glass bridge decks is still lacking, and the existing design system for pedestrian glass bridge decks cannot be directly applied to vehicle-borne scenarios. Combining domestic and international specifications and research, this study focused on material selection, structural configuration, and structural calculation of vehicle-borne glass bridge decks, proposed a targeted design method, and verified it with engineering examples. The key conclusions are as follows: (1) Laminated glass for bridge decks should preferably use homogenized tempered glass with SGP as the interlayer material; the number of glass layers should be controlled between 3 and 5, the aspect ratio of glass panels should be maintained between 1 and 2, the thickness of a single glass panel should not be less than 8 mm, and the interlayer thickness should be between 0.76 mm and 2.28 mm. (2) This study proposes design loads, load combination methods, calculation models, design criteria, and the equivalent thickness calculation method for vehicle-borne glass bridge decks; meanwhile, it incorporates the adverse working condition of single-layer glass breakage into design considerations. (3) The design method shows good agreement with numerical simulation results: both PVB and SGP-laminated glass can meet the load-bearing capacity requirements, but SGP-laminated glass has a larger safety redundancy under the same thickness; after single-layer glass breakage, the bridge deck still has sufficient load-bearing capacity; the calculation results of the design method are slightly more conservative than the finite element calculation results, but the calculation of stress and deflection for SGP-laminated glass is relatively accurate. (4) Future research will further deepen the study on the impact of the long-term performance of laminated glass on the full-life-cycle of vehicle-borne glass bridge decks and improve this design method. Full article
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20 pages, 10152 KB  
Article
In Vivo Comparison of Resin-Modified and Pure Calcium-Silicate Cements for Direct Pulp Capping
by Fatma Fenesha, Aonjittra Phanrungsuwan, Brian L. Foster, Anibal Diogenes and Sarah B. Peters
Appl. Sci. 2025, 15(19), 10639; https://doi.org/10.3390/app151910639 - 1 Oct 2025
Abstract
Introduction: Direct pulp capping (DPC) aims to preserve the vitality of the dental pulp by placing a protective biocompatible material over the exposed pulp tissue to facilitate healing. There are several calcium-silicate materials that have been designed to promote mineralization and the regulation [...] Read more.
Introduction: Direct pulp capping (DPC) aims to preserve the vitality of the dental pulp by placing a protective biocompatible material over the exposed pulp tissue to facilitate healing. There are several calcium-silicate materials that have been designed to promote mineralization and the regulation of inflammation. These have strong potential for the repair and regeneration of dental pulp. Among them, Biodentine (BD) and EndoSequence RRM Putty (ES) have been found to promote in vitro and in vivo mineralization while minimizing some of the limitations of the first-generation calcium-silicate-based materials. Theracal-LC (TLC), a light-cured, resin-modified calcium-silicate material, is a newer product with potential to improve the clinical outcomes of DPC, but existing studies have reported conflicting findings regarding its biocompatibility and ability to support pulpal healing in direct contact with the pulp. A comprehensive assessment of the biocompatibility and pulpal protection provided by these three capping materials has not yet been performed. Aim: We aimed to quantify the inflammatory response, dentin bridge formation, and material adaptation following DPC using three calcium-silicate materials: ES, BD, and TLC. Materials and Methods: DPC was performed on the maxillary first molar of C57BL/6 female mice. Maxilla were collected and processed at 1 and 21 days post-DPC. The early inflammatory response was measured 24 h post-procedure using confocal imaging of anti-Lys6G6C, which indicates the extent of neutrophil and monocyte infiltration. Reparative mineralized bridge formation was assessed at 21 days post-procedure using high-resolution micro-computed tomography (micro-CT) and histology. Lastly, the homogeneity of the capping materials was evaluated by quantifying voids in calcium-silicate restorations using micro-CT. Results: DPC using TLC induced less infiltration of Lys6G6C+ cells at 24 h than BD or ES. BD promoted higher volumes of tertiary dentin than TLC, but TLC and ES showed no significant differences in volume. No differences were observed in material adaptation and void spaces among the three capping materials. Conclusions: All three materials under investigation supported pulp healing and maintained marginal integrity. However, TLC induced a lower inflammatory response on day 1 and induced similar levels of tertiary dentin to ES. These observations challenge the common perception that resin-based capping materials are not suitable for direct pulp capping. Our findings underscore the need to balance biological responses with physical properties when selecting pulp capping materials to improve long-term clinical success. Full article
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90 pages, 29362 KB  
Review
AI for Wildfire Management: From Prediction to Detection, Simulation, and Impact Analysis—Bridging Lab Metrics and Real-World Validation
by Nicolas Caron, Hassan N. Noura, Lise Nakache, Christophe Guyeux and Benjamin Aynes
AI 2025, 6(10), 253; https://doi.org/10.3390/ai6100253 - 1 Oct 2025
Abstract
Artificial intelligence (AI) offers several opportunities in wildfire management, particularly for improving short- and long-term fire occurrence forecasting, spread modeling, and decision-making. When properly adapted beyond research into real-world settings, AI can significantly reduce risks to human life, as well as ecological and [...] Read more.
Artificial intelligence (AI) offers several opportunities in wildfire management, particularly for improving short- and long-term fire occurrence forecasting, spread modeling, and decision-making. When properly adapted beyond research into real-world settings, AI can significantly reduce risks to human life, as well as ecological and economic damages. However, despite increasingly sophisticated research, the operational use of AI in wildfire contexts remains limited. In this article, we review the main domains of wildfire management where AI has been applied—susceptibility mapping, prediction, detection, simulation, and impact assessment—and highlight critical limitations that hinder practical adoption. These include challenges with dataset imbalance and accessibility, the inadequacy of commonly used metrics, the choice of prediction formats, and the computational costs of large-scale models, all of which reduce model trustworthiness and applicability. Beyond synthesizing existing work, our survey makes four explicit contributions: (1) we provide a reproducible taxonomy supported by detailed dataset tables, emphasizing both the reliability and shortcomings of frequently used data sources; (2) we propose evaluation guidance tailored to imbalanced and spatial tasks, stressing the importance of using accurate metrics and format; (3) we provide a complete state of the art, highlighting important issues and recommendations to enhance models’ performances and reliability from susceptibility to damage analysis; (4) we introduce a deployment checklist that considers cost, latency, required expertise, and integration with decision-support and optimization systems. By bridging the gap between laboratory-oriented models and real-world validation, our work advances prior reviews and aims to strengthen confidence in AI-driven wildfire management while guiding future research toward operational applicability. Full article
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45 pages, 7020 KB  
Review
Mechanism, Efficacy, and Safety of Natural Antibiotics
by Andrei Teodor Matei and Anita Ioana Visan
Antibiotics 2025, 14(10), 981; https://doi.org/10.3390/antibiotics14100981 - 29 Sep 2025
Abstract
The growing ineffectiveness of common antibiotics against multidrug-resistant pathogens has made antimicrobial resistance (AMR) a serious global health concern. This review emphasizes that natural antibiotics from animals, bacteria, fungi, and plants are worthy alternatives for combating this crisis. Evolutionary pressure has shaped these [...] Read more.
The growing ineffectiveness of common antibiotics against multidrug-resistant pathogens has made antimicrobial resistance (AMR) a serious global health concern. This review emphasizes that natural antibiotics from animals, bacteria, fungi, and plants are worthy alternatives for combating this crisis. Evolutionary pressure has shaped these molecules, leading to antibiotic-resistant bacteria that can withstand single-target synthetic drugs but are vulnerable to multiple attack pathways (e.g., cell wall disruption, protein synthesis inhibition, biofilm interference) from natural compounds. Natural antibiotics are frequently incorporated into treatment strategies or drug-delivery systems for minimizing side effects, reducing doses, and improving their effectiveness. The review discusses recent progress in this field, describing the mechanisms of action of natural antibiotics, their incorporation into several drug-delivery systems, and their ‘omics’-driven discovery to improve production, while expressing the challenges that remain. Extracellular application of these compounds, however, is compromised by their low stability in the extracellular environment; furthermore, formulation advancements, such as nanoparticle encapsulation, have been shown to enhance the bioavailability and activity of these substances. Combining indigenous knowledge and modern scientific advances, natural antibiotics may be developed to fight AMR both as monotherapy and adjuvants in a sustainable way. Leveraging these synergies, alongside the latest advances in research, is key to bridging the antibiotic discovery–resistance gap and may provide a route to clinical translation and global AMR control. The promise of natural antibiotics is clear, but their path to mainstream medicine is fraught with obstacles like reproducibility, standardization, and scalability. It is more realistic to see these substances as powerful complements to existing therapies, not outright replacements. Their true strength is in their ability to interfere with resistance mechanisms and create new possibilities for drug development, positioning them as a vital, though complicated, part of the global effort to combat AMR. Full article
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38 pages, 2502 KB  
Review
A Modular Perspective on the Evolution of Deep Learning: Paradigm Shifts and Contributions to AI
by Yicheng Wei, Yifu Wang and Junzo Watada
Appl. Sci. 2025, 15(19), 10539; https://doi.org/10.3390/app151910539 - 29 Sep 2025
Abstract
The rapid development of deep learning (DL) has demonstrated its modular contributions to artificial intelligence (AI) techniques, such as large language models (LLMs). DL variants have proliferated across domains such as feature extraction, normalization, lightweight architecture design, and module integration, yielding substantial advancements [...] Read more.
The rapid development of deep learning (DL) has demonstrated its modular contributions to artificial intelligence (AI) techniques, such as large language models (LLMs). DL variants have proliferated across domains such as feature extraction, normalization, lightweight architecture design, and module integration, yielding substantial advancements in these subfields. However, the absence of a unified review framework to contextualize DL’s modular evolutions within AI development complicates efforts to pinpoint future research directions. Existing review papers often focus on narrow technical aspects or lack systemic analysis of modular relationships, leaving gaps in our understanding how these innovations collectively drive AI progress. This work bridges this gap by providing a roadmap for researchers to navigate DL’s modular innovations, with a focus on balancing scalability and sustainability amid evolving AI paradigms. To address this, we systematically analyze extensive literature from databases including Web of Science, Scopus, arXiv, ACM Digital Library, IEEE Xplore, SpringerLink, Elsevier, etc., with the aim of (1) summarizing and updating recent developments in DL algorithms, with performance benchmarks on standard dataset; (2) identifying innovation trends in DL from a modular viewpoint; and (3) evaluating how these modular innovations contribute to broader advances in artificial intelligence, with particular attention to scalability and sustainability amid shifting AI paradigms. Full article
(This article belongs to the Special Issue Advances in Deep Learning and Intelligent Computing)
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29 pages, 1730 KB  
Article
Explaining Corporate Ratings Transitions and Defaults Through Machine Learning
by Nazário Augusto de Oliveira and Leonardo Fernando Cruz Basso
Algorithms 2025, 18(10), 608; https://doi.org/10.3390/a18100608 - 28 Sep 2025
Abstract
Credit rating transitions and defaults are critical indicators of corporate creditworthiness, yet their accurate modeling remains a persistent challenge in risk management. Traditional models such as logistic regression (LR) and structural approaches (e.g., Merton’s model) offer transparency but often fail to capture nonlinear [...] Read more.
Credit rating transitions and defaults are critical indicators of corporate creditworthiness, yet their accurate modeling remains a persistent challenge in risk management. Traditional models such as logistic regression (LR) and structural approaches (e.g., Merton’s model) offer transparency but often fail to capture nonlinear relationships, temporal dynamics, and firm heterogeneity. This study proposes a hybrid machine learning (ML) framework to explain and predict corporate rating transitions and defaults, addressing key limitations in existing literature. We benchmark four classification algorithms—LR, Random Forest (RF), Extreme Gradient Boosting (XGBoost), and Support Vector Machines (SVM)—on a structured corporate credit dataset. Our approach integrates segment-specific modeling across rating bands, out-of-time validation to simulate real-world applicability, and SHapley Additive exPlanations (SHAP) values to ensure interpretability. The results demonstrate that ensemble methods, particularly XGBoost and RF, significantly outperform LR and SVM in predictive accuracy and early warning capability. Moreover, SHAP analysis reveals differentiated drivers of rating transitions across credit quality segments, highlighting the importance of tailored monitoring strategies. This research contributes to the literature by bridging predictive performance with interpretability in credit risk modeling and offers practical implications for regulators, rating agencies, and financial institutions seeking robust, transparent, and forward-looking credit assessment tools. Full article
(This article belongs to the Special Issue AI Applications and Modern Industry)
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