Search Results (26,686)

This study presents an analytical model to reduce the impact of wave-induced forces on a vertical seawall by introducing a floating elastic plate (EP) located at a specific distance from two bottom-standing porous structures (BSPs). The hydrodynamic interaction with the EP is described using thin plate theory, while the fluid flow through the porous medium is described by the model developed by Sollit and Cross. The resulting boundary value problem is addressed through linear potential theory combined with the eigenfunction expansion method (EEM), and model validation is achieved through consistency checks with recognized results from the literature. A comprehensive parametric analysis is performed to evaluate the influence of key system parameters such as the porosity and frictional coefficient of the BSPs, their height and width, the flexural rigidity of the EP, and the spacing between the EP and BSPs on vital hydrodynamic coefficients, including the wave force on the seawall, free surface elevation, wave reflection coefficient, and energy dissipation coefficient. The results indicate that higher frictional coefficients and higher BSP heights significantly enhance wave energy dissipation and reduce reflection, in accordance with the principle of energy conservation. Oscillatory trends observed with respect to wavenumbers in the reflection and dissipation coefficients highlight resonant interactions between the structures. Moreover, compared with a single BSP, the double BSP arrangement is more effective in minimizing the wave force on the seawall and free surface elevation in the region between the EP and the wall, even when the total volume of porous material remains unchanged. The inter-structural gap is found to play a crucial role in optimizing resonance conditions and supporting the formation of a tranquility zone. Overall, the proposed configuration demonstrates significant potential for coastal protection, offering a practical and effective solution for reducing wave loads on marine infrastructure. Full article

Monocrystalline silicon is an excellent semiconductor material for integrated circuits. Its surface quality has an enormous effect on its service life. The surfaces are formed by ultra-precision machining using nano-grinding, one of the technologies that can achieve surface roughness at the nano- or sub-nano-scale. Therefore, subsurface damage of monocrystalline silicon in nano-grinding was studied by establishing a molecular dynamics simulation model, and the impact of machining parameters on the force–thermal behavior was analyzed. The results reveal that the mechanism of subsurface damage is mainly structural phase transformation and amorphization. In nano-grinding of monocrystalline silicon, the tangential grinding force has a relatively major role in material removal. With increasing grinding depth and grinding speed, the grinding heat rises, and a certain degree of high temperature strengthens the toughness of the material, improving the subsurface quality of monocrystalline silicon. Therefore, subsurface damage in monocrystalline silicon can be controlled by reducing the grinding depth and increasing the grinding speed. Full article

Background/Objectives: Adapalene is a synthetic retinoid used as a treatment for acne vulgaris. In this study, we attempted to evaluate the dermal pharmacokinetics of adapalene utilizing experimental and in silico tools. Methods: We utilized three over the counter (OTC) adapalene gels to evaluate local dermal pharmacokinetics. A data-driven, robust, mechanistic dermal physiologically based pharmacokinetic (PBPK) model was developed by integrating the physicochemical properties of adapalene, the formulation attributes of the gels, and the biophysical aspects of dermal absorption. The dermal PBPK model was validated against experimental data using in vitro release studies and in vitro permeation studies with human cadaver skin. A clinical study was performed to evaluate the effects of adapalene from the three gel formulations. The impact of adapalene delivery from three gels on the stratum corneum (SC) thickness, pilosebaceous unit area, keratinocyte number, and epidermal thickness was captured using a non-invasive technique, line-field confocal optical coherence tomography (LC–OCT). These responses were evaluated using an Emax model. Results: The dermal PBPK model has successfully predicted adapalene penetration profiles across different gel formulations. The model accuracy, in predicting drug release and permeation characteristics, was confirmed using the experimental data. Clinical evaluation revealed formulation-dependent differences in adapalene’s effects on measured skin parameters, with distinct pharmacodynamic profiles observed for each gel formulation. Conclusions: The overall study gave us a detailed insight into potential effects of formulation on the dermal pharmacokinetics and pharmacodynamics of adapalene using three marketed gels. Full article

The performance of lettuce, pepper, and chili pepper, and the biological soil quality, in a ground-mounted PV system under cultivation conditions typical of the Mediterranean environment of the Puglia region were evaluated. Microclimatic parameters, plant growth and yield response, soil quality assessed using the QBS-ar index, and land equivalent ratio (LER) were determined in three different cultivation areas: a cultivation area outside the photovoltaic plant but immediately adjacent to it (‘Control’); the inter-row area closest to the row of panels exposed to sunlight (‘Area close PV structure’); the inter-row area distant from the row of panels (‘Area distant PV structure’). Cumulated solar radiation, in particular during the summer growing cycles, was only slightly affected in the Area distant PV structure (1616 and 2130 MJ m⁻² for pepper and chili pepper, respectively, in the control area, in comparison to 1630 and 2044 MJ m⁻², in the Area distant PV structure), while it was strongly reduced in the Area close PV structure (883 and 1091 MJ m⁻² for pepper and chili pepper, respectively). In general, a reduction in air temperature and wind speed, as well as an increase in relative air humidity, was observed under PV conditions. On average, the evapotranspirative demand was reduced in the PV growing conditions compared to open field, with a more relevant effect in the sub-zone close to the photovoltaic structures, where cumulative ET0 was 28% and 34% lower than the Control in the pepper and chili pepper growing cycle, respectively. Lettuce growth was impaired by PV cultivation conditions, with an average reduction of 15% in plant height and 37% in marketable yield per plant, with no significant differences between the two sub-zones in the PV system. For pepper, the best growing conditions were observed in open field control compared to PV, but with differences related to the PV sub-zone. The plants grown in the Area distant PV structure were more negatively affected by the modified growing conditions, showing the lowest shoot and fruit fresh weight, the latter reduced by 51% compared to the Control; intermediate values were observed for these parameters in the Area close PV structure, with a less severe tendency to yield reduction. For chili pepper, both shoot and fruit fresh weight were lower in PV conditions, regardless of the sub-zone, with a reduction of 82% in yield per plant compared to the Control. However, despite the yield reductions, the LER was improved (1.60 and 1.40 in case of a lettuce + pepper or lettuce + chili pepper annual cropping program, respectively), highlighting a more efficient use of land, without negative or even ameliorative impacts on biological soil quality and biodiversity in terms of QBS-ar and microarthropods taxa abundance. Knowledge of the response of different crops under cultivation conditions typical of specific environments is necessary to define optimal cropping programs aimed at maximizing resource-use efficiency and land use. Full article

Free water surface constructed wetlands can be effective systems for contaminant removal, but their performance is sensitive to interactions among flow dynamics, vegetation, and bed topography. This study presents a numerical investigation into how heterogeneous bed topographies influence hydraulic and contaminant transport behavior in a rectangular wetland. Topographies were generated using a correlated pseudo-random pattern generator, and flow and solute transport were simulated with a two-dimensional, depth-averaged model. Residence time distributions and contaminant removal efficiencies were analyzed as functions of the variance and correlation length of the bed elevation. Results indicate that increasing the variability of bed elevation leads to greater dispersion in residence times, reducing hydraulic efficiency. Moreover, as the variability of bed elevation increases, so does the spread in hydraulic performance among wetlands with the same statistical topographic parameters, indicating a growing sensitivity of flow behavior to the specific spatial configurations of bed features. Larger spatial correlation lengths were found to reduce the residence time variance, as shorter correlation lengths promoted complex flow structures with lateral dead zones and internal islands. Contaminant removal efficiency, evaluated under the assumption of uniform vegetation, was influenced by bed topography, with variations becoming more pronounced under conditions of lower vegetation density. The results underscore the significant impact of bed topography on hydraulic behavior and contaminant removal performance, highlighting the importance of careful topographic design to ensure high wetland efficiency. Full article

Choosing the most sustainable and ecologically stable soil tillage techniques requires dependence on long-term field trials, which are essential for successful interventions and evidence-based decision-making. This research evaluated several factors, including soil biological activity (CO₂ emission), soil chemical properties (pH (KCl), soil organic matter (SOM)), plant growth physiological indicators (Leaf Area Index (LAI), Soil and Plant Analysis Development (SPAD)), crop yield, and grain quality (Zeleny index, protein %, oil %, and gluten % content), under six soil cultivation methods that represent varying degrees of soil disturbance in a long-term (23 years) tillage experiment. Conventional tillage (ploughing (P)) and conservational tillage techniques (loosening (L), deep cultivation (DC), shallow cultivation (SC), disking (D), and no-till (NT)) were examined for three years (2022, 2023, and 2024) in a winter barley–soybean–winter wheat cropping system. Results indicate that tillage intensity has a differential influence on soil biological parameters, with minor variations in SPAD values across treatments. The findings show significant variations in CO₂ emissions, LAI values, and grain quality in certain years, likely due to the influence of P and L tillage treatments. The novelty of this study lies in determining that, although the short-term effects of soil tillage on crop physiological parameters and grain yield may be minimal under fluctuating climatic conditions, long-term tillage practices significantly influence existing disparities, underscoring the necessity for site-specific and climate-resilient tillage strategies in sustainable crop production. Full article

To address the critical challenges in pyrometallurgical recycling processes—such as poor feedstock adaptability, high energy consumption during roasting conversion, and the low added value of rare earth products—this study systematically investigated the mechanism and process optimization of ammonium bifluoride (NH₄HF₂) roasting for the recovery of neodymium–iron–boron (NdFeB) waste. Thermodynamic analysis confirmed the feasibility of the conversion reaction between NH₄HF₂ and the rare earth components in NdFeB waste. Single-factor experiments were conducted to examine the effects of roasting temperature, reaction time, and NH₄HF₂ dosage on rare earth recovery. The optimal conditions were a roasting temperature of 600 °C, a reaction time of 120 min, and a NH₄HF₂ dosage of 75 wt%, achieving a rare earth recovery rate of 98.81%. Furthermore, the response surface methodology (RSM) was employed to establish a quantitative model correlating process parameters with recovery efficiency. Variance analysis demonstrated that the model was highly significant (F = 136.94, p < 0.0001), with excellent agreement between actual and predicted values (R² = 0.9944). Factor contribution analysis revealed that NH₄HF₂ dosage had the most pronounced impact on rare earth fluorination, followed by roasting temperature and reaction time. Under optimized conditions, the purified rare earth fluoride obtained after acid leaching reached a purity of 99.43%, providing high-quality raw material for producing high-value-added rare earth products. Full article

Porosity and permeability are critical parameters in petroleum exploration and development. The relationship between pore structure and permeability in near-source reservoirs is more closely correlated than in other types of reservoirs. This study investigates the pore structure and formation processes of low-permeability sandstone reservoirs in the Wenchang Formation, Huizhou Depression, Pearl River Mouth Basin (Northern South China Sea). We collected ten core samples of low-permeability sandstone reservoirs at various depths from the key well (A). Multiple analytical techniques were employed, including mercury intrusion capillary pressure (MICP), constant velocity mercury injection (CMI), Wood’s metal impregnation (WM), scanning electron microscopy (SEM), X-ray diffraction (XRD), and quantitative evaluation of minerals via scanning electron microscopy (QEMSCAN). Pore-throat types were classified using fractal theory, followed by analyzing the physical and structural characteristics of interconnected pore-throat reservoir systems. This study examined the impact of various pore types on the physical properties of reservoirs, providing a comprehensive classification and characterization of pore structures in low-permeability sandstone reservoirs. Our findings provide significant insights and recommendations for future developmental initiatives in this region. Full article

A perforated aquaculture vessel represents an environmentally sustainable approach to fish farming, leveraging seawater circulation to optimize water quality and enhance fish health and growth. The perforations on the side of the fish tank significantly influence its hydrodynamic characteristics. This study investigated the influence of pore parameters on the perforated fishing tank with various pore designs, such as the asymmetric distribution of the opening in depth, windward, and leeward directions. A numerical study was conducted using STAR-CCM+ to analyze the perforated tank under beam wave conditions. This study aimed to analyze the effects of pore location, opening ratio, and asymmetric distribution on the hydrodynamic performance and flow characteristics within aquaculture tanks. The results demonstrated that an asymmetric pore distribution on the windward and leeward sides of the vessel had a notable impact on the roll motion and the flow velocity in the vicinity of the pores. The findings also indicated that the effects of pore distribution were more significant than those of opening ratio, especially regarding asymmetry. The results revealed that higher flow velocities occurred under a smaller opening ratio. Modifying pore structure parameters on the windward and leeward sides can alter the local flow field. Full article

Exotic invasive plant species can cause biodiversity loss by outcompeting and replacing native species. Herbicides are commonly used to control invasive plants owing to their low cost and high efficiency. However, herbicide use can have unintended effects on co-occurring native plant species by altering the competitive balance. We studied how herbicide application modifies the competition between an invasive and a native species. We examined the effects of applying glyphosate on the mortality, photosynthetic capacity, and growth of Solidago canadensis, an aggressive invasive species, and Imperata cylindrica, a native species that commonly co-occurs with S. canadensis. We also studied how applying glyphosate affected the competition between these species. Various glyphosate concentrations were applied to the two species grown either together or separately. The mortality rate increased while the photosynthetic capacity and growth decreased with increasing glyphosate concentration. Increasing the glyphosate concentration more negatively affected the parameters of I. cylindrica than those of S. canadensis. Plant growth, especially that of I. cylindrica, was more restricted by intraspecific competition than by interspecific competition as the glyphosate concentration increased. Furthermore, the relative competitive potential of the native species decreased with increasing glyphosate concentration. S. canadensis is more tolerant of glyphosate, which enhances its competitive advantage and hinders the proliferation, reintroduction, and success of native plant species. Future studies should focus on developing techniques to mitigate the negative impacts of invasive plant species, for example, via optimizing methods of spraying herbicides. Full article

Lead-free A₂ZrX₆ “defect” perovskites hold significant potential for many optoelectronic applications due to their stability and tunable properties. Extending a previous work, we present a first-principles density functional theory (DFT) study, utilizing PBE and HSE06 functionals, to systematically investigate the impact of A-site cation and X-site halogen substitutions on the structural and electronic properties of these materials. We varied the A-site cation, considering ammonium, methylammonium, dimethylammonium, trimethylammonium, and phosphonium, and the X-site halogen, trying Cl, Br, and I. Our calculations reveal that both these substitutions significantly affect the band gap and the lattice parameters. Increasing A-site cation size generally enlarges the unit cell, while halogen electronegativity directly correlates with the band gap, yielding the lowest values for iodine-containing systems. We predict a broad range of band gaps (from ~4.79 eV for (PH₄)₂ZrCl₆ down to ~2.11 eV for MA₂ZrI₆ using HSE06). The (PH₄)₂ZrX₆ compounds maintain cubic crystal symmetry, unlike the triclinic of the ammonium-derived systems. Finally, our calculations show that the MA cation yields the smallest band gap among the ones studied, a result that is attributed to its size and the charges of the hydrogen atoms attached to nitrogen. Thus, our findings offer crucial theoretical insights into A₂ZrX₆ structure–property relationships, demonstrating how A-site cation and halogen tuning enables control over electronic and structural characteristics, thus guiding future experimental efforts for tailored lead-free perovskite design. Full article

This manuscript introduces a river segmentation method and explores the impact of human interventions through a long-term study of total nitrogen, total phosphorus, chemical oxygen demand, and biochemical oxygen demand. An indicator linking parameter concentrations to the river’s flow rate was used to assess the development of the examined parameters. The analysis spanned from 2011 to 2022, considering both seasonal and yearly variations. Normal probability plots served as statistical tools to evaluate whether the data followed normal distributions and identify outliers. The proposed segmentation divided the Bahlui River into four segments, each defined by anthropogenic stressors. It was found that, due to human activity, each river segment could be viewed as an “independent” river. This supports the idea that river segments can be analyzed separately as distinct components. The proposed segmentation approach represents an alternative approach in river water quality research, moving from traditional continuous system models to fragmented system analysis, which better reflects the reality of heavily modified river systems. The study’s findings are important for understanding how anthropogenic modifications affect river ecosystem functioning in the long term. Full article

Background/Objectives: Immune checkpoint inhibitors targeting the PD-1/PD-L1 axis have become a standard in the treatment of all stages of non-small lung cancer. Beyond tumor-intrinsic biomarkers like PD-L1 expression, evidence points to the role of patient-related factors, such as body mass index, sarcopenia, and cachexia. These body composition parameters may reflect metabolic reserve or even immune competence and could help stratify outcomes in patients treated with PD-1 and PD-L1. This systematic review aims to evaluate the impact of body composition—specifically BMI, pretreatment weight loss, sarcopenia, and cachexia—on clinical outcomes such as progression-free and overall survival in NSCLC patients treated with immune checkpoint inhibitors. Methods: A systematic literature search was conducted across multiple databases including PubMed, Google Scholar, and Science Direct. We included full-text original research articles (1 January 2020–1 May 2025) reporting clinical outcomes of NSCLC patients treated with PD-1 or PD-L1 inhibitors, in relation to body composition factors (BMI, pretreatment weight loss, sarcopenia, cachexia). Eligible studies involved adults (>18 years) and included observational cohorts or controlled trials; animal or in vitro studies were excluded. Data extraction and risk of bias assessments were performed independently by two reviewers, with discrepancies being resolved through a third one. Results: From 12,358 records identified, 21 studies met the inclusion criteria. Most were retrospective cohorts assessing the impact of pre-treatment weight loss, cachexia, and sarcopenia on ICI outcomes in NSCLC. These factors consistently predicted poorer survival and response, while BMI alone showed limited prognostic value. Considerable heterogeneity in body composition definitions and outcome reporting was observed. Conclusions: Body composition—particularly weight loss, cachexia, and sarcopenia—significantly impacts survival and response in NSCLC patients treated with ICIs. These factors reflect immune–metabolic dysfunction that may impair treatment efficacy. BMI alone is insufficient; routine assessment of muscle mass and cachexia could improve risk stratification. Full article

A comprehensive overview is provided on factors and processes influencing the final quality of a cup of coffee, with an emphasis on the brewing method’s central role. Coffee quality assessment, both at the bean and cup level, combines objective parameters (color, moisture, bean defects, density) with a notable degree of subjectivity, as consumer sensory perception is ultimately decisive. The brewing technique is described as a critical determinant of the final chemical, physical, and sensory attributes. Key parameters such as aroma profile, pH, titratable acidity, total and filtered solids, lipid and fatty acid content, viscosity, foam (crema), and colorimetric indices are detailed as essential metrics in coffee quality evaluation. Roasting creates most of coffee’s key aroma compounds. The brewing method further shapes the extraction of both volatile and other bioactive compounds like caffeine, chlorogenic acids, and lipids. Brewing methods significantly affect acidity, “body,” and crema stability, while water quality, temperature, and pressure are shown to impact extraction results and sensory properties. Attention is paid to how methods such as Espresso, filter, French press, and cold brew yield distinct physicochemical and sensory profiles in the cup. Overall, the review highlights the multifaceted nature of coffee cup quality and the interplay between raw material, processing, and preparation, ultimately shaping the coffee sensory experience and market value. Full article

One characteristic of tumor cells is the increased anaerobic metabolism through glycolysis leading to an acidic environment of the tumor. This acidity is linked to tumor progression, invasion and metastasis, besides stimulated survival pathways in the malignant cells. The aim of our analysis is to investigate the role of systemic acid–base parameters such as the pH, bicarbonate, baseexcess and lactate in lung cancer patients. Furthermore, alterations in electrolytes and hemoglobin were investigated regarding their impact on overall survival. Data of 937 non-small-cell lung cancer (NSCLC) patients, who underwent anatomic video-assisted thoracoscopic surgery (VATS) resection, was collected in a prospectively maintained database and analyzed. To minimize confounding effects and due to the retrospective study design, we decided to use data from the first arterial blood gas analysis during surgery and the most recent lab results prior to surgery. We found significant correlations between low systemic bicarbonate (<20 mEq/L) and overall survival (p = 0.006). Hyponatremia (<135 mmol/L) correlated with lower 5-year overall survival (p = 0.004) and decreased disease-free survival (p = 0.017). Hypochloremia (<98 mmol/L) was linked to reduced overall survival (p = 0.003) and hypocalcemia (<1.15 mmol/L) with worse disease-free survival (p = 0.015). Hemoglobin under 12 g/dL for women and 13 g/dL for men was associated with poorer outcomes (p < 0.001). Other acid–base parameters such as the pH (p = 0.563), baseexcess (BE) (p = 0.290) and lactate (p = 0.527) did not show significant differences in overall or disease-free (pH: p = 0.130; BE: p = 0.148; lactate: p = 0.418) survival. Systemic bicarbonate, sodium, calcium, chloride and hemoglobin levels were found as prognostic markers and possible therapeutic targets to improve overall survival. Further investigations are necessary to develop therapeutic strategies. Full article