Development of Physiologically Based Pharmacokinetic (PBPK) Modeling
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 2419
Special Issue Editors
Interests: blood-brain barrier; bioequivalence; in vivo predictive dissolution; in vitro-in vivo correlation; PBPK; pharmacokinetics
Interests: PBPK; biowaivers; pharmacokinetics; dissolution; absorption; drug solubility
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Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to this Special Issue: “Development of Physiologically Based Pharmacokinetic (PBPK) Modeling”. PBPK modeling is a mathematical tool which is able to describe the drug concentration in an organism using compartments that correspond to the different tissues and taking into consideration the physiology of this organism to parameterize the model.
This type of model has become useful in drug development since its discovery and early phases, when in vitro data and physicochemical properties could be used to obtain plasma profiles, which would be, later on, validated in vivo, until the clinical development phases, in which simulations can be used to describe drug performance in special populations.
This Special Issue aims to compile the latest research carried out with this tool, in both preclinical and clinical development stages. Original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: early drug development, risk assessment and toxicity assessment, absorption/formulation modeling, and the prediction of drug–disease interactions and drug–drug interactions.
We look forward to receiving your contributions.
Dr. Bárbara Sánchez-Dengra
Prof. Dr. Isabel Gonzalez-Alvarez
Guest Editors
Manuscript Submission Information
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Keywords
- physiologically based pharmacokinetic modeling (PBPK)
- modeling and simulations (M&S)
- pharmacokinetics
- ADME
- pharmacometrics