Search Results (272)

(1) Background: Recent decades have seen growing interest in neuroplasticity and the activity-dependent mechanisms that allow Brain Networks to adapt functionally. Among the various stimuli, physical exercise has emerged as a key modulator of brain plasticity. This narrative review aims to synthesize evidence on the structural and functional effects of physical exercise on the brain in healthy individuals aged 18–80 years. Exercise modalities were categorized into Cardiovascular, Strength, and Mixed Training. Each was further classified by intensity (Light-to-Moderate vs. Vigorous) and duration (Short- vs. Long-Term). A total of 25 interventions were analyzed to evaluate how these variables influence Brain Networks. Findings indicate that exercise type, intensity, and duration collectively modulate neuroplastic responses. Notably, physical training induces structural and functional changes in major Brain Networks, including the Default Mode Network, Salience Network, Central Executive Network, Visuospatial Network, Sensorimotor Network, and Language and Auditory Networks. These results underscore the potential of physical exercise as an effective non-pharmacological strategy to enhance brain health and plasticity across the adult lifespan. This narrative review aims to highlight the effects of physical exercise in changing the brain either functionally or structurally. Moreover, the most relevant exercise training modalities that may improve/change neural networks in healthy populations (18–80 years) were discussed. (2) Methods: Three different types of exercise were considered: (i) Cardiovascular, (ii) Strength, and (iii) Mixed Exercise. For each of them, two levels of intensity (Light-to-Moderate and Vigorous) and two durations (Short-Term and Long-Term Effects) were included. By analyzing 25 interventions, indications about the effects on the brain considering the three factors (type of exercises, intensities, and durations) were provided. (3) Results: The findings suggest that the type of exercises, intensities, and durations could to lead neural modification over time. Specifically, exercise intervention contributes to both structural and functional changes in brain regions located in key Brain Networks, including the Default Mode Network, Salience Network, Central Executive Network, Visuospatial Network, Sensorimotor Network, and Language and Auditory Networks. (4) Conclusions: In conclusion, the evidence presented herein underscores the beneficial effects of physical exercise on the structural and functional integrity of the brain, highlighting its importance as a non-pharmacological intervention to improve brain plasticity. Full article

“The whole day movement matters to health.” has become an important topic while the associations between executive function and different movement behaviors (i.e., physical activity (PA), sedentary behavior (SB) and sleep) are traditionally examined in isolation. This study aimed to examine the combined associations of movement behaviors (i.e., moderate-to-vigorous PA [MVPA], light PA, screen-based SB, non-screen-based SB, and sleep) with executive function (i.e., working memory, inhibition, and overall executive function) among college students. A total of 366 college students (60.1% female; mean age = 22.59 ± 3.54) were recruited. Validated questionnaires were used to assess light PA, MVPA, screen-based and non-screen-based SB, sleep, and executive function. All the movement behaviors including screen-based SB (β = 0.13), sleep (β = −0.12), and MVPA (β = −0.16) were significant predictors on working memory (R² = 0.09). Only BMI (β = 0.14) was found to be a significant contributor to inhibition (R² = 0.05). The overweight/obese group had significantly higher scores (meaning lower functioning) in inhibition compared to peers with healthy weights (d = 0.24). These findings suggest healthy movement behaviors (i.e., engage in MVPA, reduce screen-based SB, sufficient sleep) and weight management are beneficial for executive function during young adulthood. Full article

Background: Virtual reality (VR) technology has emerged as a promising tool for promoting physical activity through immersive gaming experiences. This study aimed to compare the physiological responses and perceived exertion during VR gaming using two different locomotion interfaces: omnidirectional treadmill and traditional controllers. Methods: Twenty-one university students (7 women, 14 men; age 23.5 ± 1.4 years) participated in a crossover study comparing physical activity intensity during VR gaming using traditional controllers versus an omnidirectional treadmill (Virtuix Omni). Participants played VRZ Torment for 15 min in each condition, separated by 30 min washout periods. Physiological responses were measured using indirect calorimetry (Cortex METAMAX® 3B), heart rate monitoring (Polar V800), and subjective ratings of perceived exertion (RPE). Exercise intensity was classified according to established guidelines, and user satisfaction was assessed using a 10-point scale. Results: Omnidirectional treadmill locomotion resulted in significantly higher physiological responses and perceived exertion across all measured variables compared to controller-based movement: heart rate (76.7 ± 11.7% vs. 51.7 ± 9.5% HRmax, p < 0.001), metabolic equivalents (7.3 ± 1.7 vs. 2.1 ± 0.3 METs, p < 0.001), and RPE (14.4 ± 2.9 vs. 9.3 ± 1.5, p < 0.001). Treadmill gaming achieved vigorous-intensity exercise, while controller gaming remained at light intensity. User satisfaction was significantly higher with treadmill locomotion (8.5 ± 1.3 vs. 5.0 ± 2.3, p < 0.001). Strong correlations were observed between physiological measures only during high-intensity treadmill exercise. Conclusions: Omnidirectional treadmill VR gaming achieves vigorous-intensity physical activity sufficient to meet health recommendations, while traditional controller gaming provides only light-intensity exercise. These findings support the potential of locomotion-enhanced VR systems for health promotion. Full article

Background: With China’s rapidly aging population, frailty has become a growing concern among older adults. Physical activity (PA) is known to mitigate frailty-related decline, yet few studies have examined these associations longitudinally. Methods: Using five waves (2011–2020) of CHARLS data, we analyzed Chinese adults aged 60+ to assess the association between frailty—measured by a frailty index (FI)—and PA across various types (light, moderate, vigorous, total, and leisure). A generalized linear mixed-effects model was used, adjusting for demographic, socioeconomic, and health-related factors. Results: All PA types were significantly associated with lower odds of concurrent frailty, including light (OR = 0.37), moderate (OR = 0.37), vigorous (OR = 0.40), total (OR = 0.23), and leisure PA (OR = 0.56). Lagged PA also predicted reduced frailty risk over time, except for light PA. Conclusion: Regular PA is linked to a lower risk of frailty among older Chinese adults. These findings underscore the importance of sustained PA as a strategy to promote healthy aging and inform public health interventions for this population. Full article

Background/Objectives: This study aimed to determine whether the movement patterns and mental health of university teachers changed after returning to on-site class activities following the COVID-19 lockdown. Specifically, it compared levels of physical activity (PA), sedentary behavior time (SBT), active breaks (ABs), and symptoms of depression, anxiety, and stress among university teachers during online and on-site teaching periods. We also analyzed the association between movement patterns with psychological and anthropometric variables. Methods: University teachers who engaged in online teaching activities because of the COVID-19 restrictions and returned to on-site classes were included. Each teacher wore an accelerometer and answered the Depression Anxiety Stress Scales. The following parameters were assessed: SBT, light (LPA), moderate (MPA), and vigorous (VPA) (min/day); moderate–vigorous PA (MVPA) (min/week); steps/day and ABs/day. Results: Thirty-seven teachers with complete data from both phases were included. Once the on-site teaching activities resumed, LPA (9 min/day), MPA (6 min/day), total PA (20 min/day), MVPA (49 min/week), and steps/day (1100) significantly increased. While SBT showed no changes, ABs/day bouts increased. Depression and stress symptoms improved upon returning to on-site teaching activities. A positive association was identified between SBT and waist circumference (WC). There were negative associations between steps/day and MVPA with body mass index (BMI), steps/day with WC, and LPA with stress symptoms. Conclusions: Upon returning to on-site teaching activities, PA levels, steps/day, and ABs/day bouts all increased, although SBT remained elevated compared with during the lockdown. The teachers’ psychological symptoms improved. PA was associated with better health markers, while SBT was associated with increased WC. Full article

In this paper, cultivable actinobacteria were isolated, cultured, and identified from the heavily algal-bloomed waters of Taihu Lake using 16S rRNA gene sequencing. Among the isolates, a single strain exhibiting vigorous cyanocidal activity against Microcystis aeruginosa FACHB-905 was selected for further investigation. The cyanocidal efficacy and underlying mechanisms of this strain, designated TH05, were assessed through using chlorophyll content, cyanobacterial inhibition rate, and cyanobacterial cell morphology measurements. In addition, oxidative stress responses, expression of key functional genes in FACHB-905, and variations in microcystin concentrations were comprehensively evaluated. Cyanobacterial blooms caused by Microcystis aeruginosa pose serious ecological and public health threats due to the release of microcystins (MCs). In this study, we evaluated the cyanocidal activity and mechanism of a novel actinomycete strain, Streptomyces sp. TH05. Optimization experiments revealed that a light–dark cycle of 12 h/12 h, temperature of 25 °C, and pH 7 significantly enhanced cyanocidal efficacy. Under these conditions, TH05 achieved an 84.31% inhibition rate after seven days of co-cultivation with M. aeruginosa. Scanning electron microscopy revealed two distinct cyanocidal modes: direct physical attachment of TH05 mycelia to cyanobacterial cells, causing cell wall disruption, and indirect membrane damage via extracellular bioactive compounds. Biochemical analyses showed increased levels of malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) during the first five days, peaking at 2.47-, 2.12-, and 1.91-fold higher than control levels, respectively, indicating elevated oxidative stress. Gene expression analysis using elf-p as a reference showed that TH05 modulated key genes associated with photosynthesis (PsaB, PstD1, PstD2, RbcL), DNA repair and stress response (RecA, FtsH), and microcystin biosynthesis (McyA, McyD). All genes were upregulated except for RbcL, which was downregulated. In parallel, microcystin content peaked at 32.25 ng/L on day 1 and decreased to 16.16 ng/L by day 9, which was significantly lower than that of the control group on day 9 (29.03 ng/L). These findings suggest that strain TH05 exhibits potent and multifaceted cyanocidal activity, underscoring its potential for application in the biological control of cyanobacterial blooms. Full article

Objectives: We aimed to identify clustering patterns of the device-measured physical activity (PA) levels (i.e., light PA and moderate-to-vigorous PA) and sedentary time (ST), screen time, sleep duration, and breakfast consumption of Spanish adolescents and their associations with the mode of commuting to and from schools (i.e., active and passive). Methods: A total of 151 adolescents aged 14.4 ± 0.6 years (53.64% girls) were included in this study. Participants wore an accelerometer device during seven consecutive days to measure PA levels and ST levels. Screen time, sleep duration, breakfast consumption, and the mode of commuting to and from school were self-reported by the participants. A two-step cluster analysis was performed to examine the different lifestyle behavior patterns (defined as data-driven groupings of daily behaviors identified through cluster analysis). Logistic regression models were used to determine the associations among the lifestyle behavior patterns and the mode of commuting to and from school. Results: The main characteristics of the three identified clusters were as follows: (active) high PA levels and low ST (38.4%); (inactive) high sleep duration and daily breakfast consumption, but low PA levels and high ST and screen time (37.2%); and (unhealthy) low PA levels and sleep duration, high ST and screen time, and usually skip breakfast (24.4%). No associations were found between these clusters and the mode of commuting to and from school (all, p > 0.05). Conclusions: Three different lifestyle behavior patterns were identified among Spanish adolescents, but no associations were found between these patterns and their mode of commuting to and from school. Full article

Background/Objectives: Psychological factors play a crucial role in the experience of acute low back pain and may influence functional outcomes. However, the interplay between these factors and levels of physical activity remains poorly understood. Methods: This cross-sectional observational study examined the relationship between psychological variables and functional disability in individuals with acute low back pain, considering different levels of physical activity. Data were collected from 1021 participants through an online platform between 8 June 2022 and 8 April 2023. Standardized instruments were used to assess functional limitations, emotional distress (depression, anxiety, and stress), daily pain catastrophizing, and physical activity levels. A canonical correlation analysis was conducted to explore the multivariate associations between psychological and functional variables. Results: There was a statistically significant association between higher levels of emotional distress and greater functional impairment related to low back pain. This association was observed in both the light-physical-activity group (canonical coefficient = 0.266; p = 0.017), the moderate-physical-activity group (0.237; p = 0.092), and the vigorous-physical-activity group (0.177; p = 0.013). Participants engaging in vigorous physical activity exhibited more favorable psychological profiles and lower functional disability compared to those with lower levels of activity. Conclusions: Regular and vigorous physical activity appears to be a protective factor for mental health and may help reduce functional disability in individuals with acute low back pain. These findings underscore the importance of considering physical activity levels when addressing psychological and functional outcomes in this population. Full article

Background: Knee joint immobilization is common after surgery or injury. Whether remaining physically active during immobilization preserves muscle strength and size has not been studied. Objectives: This observational study examined correlations between muscle strength, size, and physical activity (PA) levels during one week of knee joint immobilization. Methods: Nine healthy adults (five males, four females) immobilized their left knee and ambulated with crutches for one week. Ankle accelerometers monitored compliance and tracked PA. Isometric and concentric isokinetic peak torque at 30°/s and 180°/s and vastus lateralis (VL) cross-sectional area (CSA) were assessed before and after immobilization. Bivariate correlations were used to examine relationships between time spent in sedentary, light, moderate, and vigorous PA, and changes in isometric and concentric isokinetic peak torque, as well as VL CSA. Results: After immobilization, isometric strength declined by 17.1%. Concentric isokinetic peak torque declined by 5.5% at 30°/s and 2.3% at 180°/s. VL CSA declined by 6.7%. There were weak correlations between strength measures and PA levels (r = −0.497–0.574; p = 0.106–0.709). For CSA, an unexpected pattern was found in which greater sedentary time was correlated with decreased atrophy (r = 0.701; p = 0.035), but light (r = −0.673; p = 0.047) and moderate (r = −0.738; p = 0.023) PA levels were correlated with increased atrophy. Vigorous PA had weak correlations with CSA (r = −0.321; p = 0.399). Conclusions: Contrary to our hypothesis, increased PA levels were not correlated with the preservation of strength and were correlated with greater declines in CSA during knee joint immobilization. Full article

While a majority of older adults fail to engage in recommended levels of physical activity (PA), lower-income older adults face unique challenges. They are at greater risk for low levels of PA, but little is known about the barriers they face. Objectives: This study aimed to investigate self-reported PA and barriers to PA for older adult residents of subsidized low-income senior housing, comparing barriers for those with lower and higher levels of PA. Methods: Ninety-two older adults (mean age 76.57 (SD = 7.50)) were recruited from low-income senior housing facilities. They completed a demographic questionnaire, the International Physical Activity Questionnaire (IPAQ), which measures MET-minutes/week of engaging in vigorous, moderate, and light PA levels, and the 27-item Inventory of Physical Activity Barriers (IPAB), which measures multifaceted barriers to PA. Results: The most common barrier for all residents was the PA priority. Independent t-tests revealed that the low-active group faced greater barriers than the high-active group in physical health barriers (t = 2.329, p = 0.022), PA priority of (t = 2.836, p = 0.006), environmental barriers (t = 2.072, p = 0.042), and total PA barriers (t = 2.281, p = 0.025). No significant differences were found between the low-active and high-active groups for emotional health barriers, skill barriers, external factor barriers, and social barriers. Conclusions: The low-active older adults were less likely to overcome barriers, such as physical health issues, PA priority, and environmental factors. Further research is necessary to gain a deeper understanding of the characteristics and underlying mechanisms of these barriers and to develop effective strategies for addressing them. However, findings should be interpreted cautiously due to the small and convenient sample and potential bias from self-reported PA measures. Full article

Modifications to daily sedentary behavior (SB) and participation in moderate-to-vigorous physical activity (MVPA) may provide beneficial results in the prevention and management of mental disorders, such as Major Depressive Disorder (MDD). This cross-sectional research investigated the minimum number of follow-up days needed to reliably estimate the time spent in SB and MVPA from accelerometer data in people with MDD. SB and physical activity (PA) were assessed using an accelerometer, and classified as time spent in SB and in different PA intensities (light—LPA, moderate—MPA, vigorous—VPA, MVPA, or total—TPA). The minimum days of use were calculated using Spearman–Brown analyses, considering only variables with an ICC > 0.8 (cut point-considered acceptable). In the results, 98 people with MDD showed no differences between the days of the week, and an ICC > 0.8 for SB, MPA, and MVPA (for 2-3-4-5-6 vs. 7). Thus, Spearman–Brown analyses were performed considering 2 days (minimum days with ICC > 0.8) and 7 days (maximum days of original test with ICC > 0.8). Our results suggest that a minimum of 3 days of accelerometer use is necessary to reliably estimate the time of SB, MPA, and MVPA. This finding has a significant practical application, allowing data collection using a reduced duration of accelerometer wear. The optimization of time needed in this context permits the utilization of accelerometers among a greater number of individuals, possibly affecting the sample size of MDD patients in research and decreasing acquisition costs in this scientific area. Full article

Objectives: The present study seeks to analyze the relationships between the intensity of physical activity, mental hyperactivity and sleep quality. A comparative, descriptive and exploratory study was carried out. Methods: A sample of 1907 university students belonging to the degree of Physiotherapy and Physical Activity and Sport Sciences was used. The International Physical Activity and Mental Hyperactivity Questionnaires were used. The scale used was the Pittsburgh sleep quality index. The proposed model analyzes the relationships of physical activity with mental hyperactivity and various sleep-related factors. Results: The following fit indices were evaluated: Chi-Square = 80.242; Degrees of Freedom = 3; Incremental Fit Index = 0.951, Comparative Fit Index = 0.977; Normed Fit Index = 0.946; Root Mean Square Error of Approximation = 0.071. The values obtained show the good fit of the theoretical model. Statistically significant differences are observed (p < 0.05) in the causal relationship of mental hyperactivity with the personal assessment of sleep as a function of the intensity of physical activity. A greater effect of light (β = 0.671) compared to moderate- (β = 0.428) or vigorous-intensity (β = 0.343) physical activity in personal sleep assessment is evident. Statistically significant differences were also observed in the causal relationship of mental hyperactivity with the time to fall asleep (p < 0.05). Light physical activity (β = 0.479) has a greater causal relationship with time to fall asleep than moderate- (β = 0.302) or vigorous-intensity (β = 0.413) physical activity. Conclusions: Based on the results obtained, it is concluded that the intensity with which physical activity is performed has a modulating effect on sleep quality and mental hyperactivity. Full article

Physical function is likely bidirectionally associated with physical activity (PA), sedentary behavior (SB), and sleep. We examined trajectories of physical function as predictors of these behaviors in community-dwelling adults aged ≥65 y without dementia from the Adult Changes in Thought cohort. Exposures were trajectories of physical performance (short Performance-Based Physical Function [sPPF]) and self-reported activities of daily living (ADL) impairment. Outcomes were device-measured PA and SB and self-reported sleep. We fit linear mixed-effects models to define trajectory slopes and intercepts for each functional measure over the prior 10 years. We used multivariable linear regression to investigate the relationship between trajectory features and outcomes, using bootstrap confidence intervals. Participants (N = 905) were 77.6 (SD = 6.9) years old, 55% female, 91% white, and had a median sPPF score of 9 (IQR = [8, 11]) and median impairment of 1 ADL (IQR = [0, 2]) at the time of activity measurement (baseline). Steeper decreases in sPPF (0.3-unit, 25% of the range) were associated with fewer steps (−1180, 95% CI = [−2853, −185]) and less moderate-to-vigorous PA (−15.7 min/day [−35.6, −2.3]). Steeper increases in ADL impairment were associated with 35.0 min/day (4.3, 65.0) additional sitting time, longer mean sitting bout duration (3.5 min/bout [0.8, 6.2]), fewer steps (−1372 [−2223, −638]), less moderate-to-vigorous PA (−13 min/day [−22.6, −5.0]), and more time-in-bed (25.5 min/day [6.5, 43.5]). No associations were observed with light PA or sleep quality. Worsening physical function is associated with lower PA and higher SB, but not with light-intensity movement or sleep quality, supporting the bidirectional nature of the relationship between physical function and physical behaviors. Full article

Background: Previous research has examined the relationship between physical activity (PA) and sleep quality in young people. However, studies exploring how different intensities of PA relate to light and deep sleep, using objective measurement tools, remain scarce. Therefore, the aim of the present study was to analyze the potential associations between PA intensity and sleep stages and to determine the most effective intensity of PA for positively influencing sleep during adolescence. Methods: The sample consisted of 1072 Spanish pre-adolescents and adolescents (53% girls and 47% boys) aged 13.03 ± 1.79 years. Sleep and intensity of PA were measured using the Xiaomi Mi Band 4 smartband. Sleep was categorized as light or deep, while PA intensity was determined by heart rate (HR) and classified as light (resting to 50% of maximum HR), moderate (50–70% of max HR), and vigorous (70–85% of max HR). Results: Analyses revealed that greater daily time spent in light-intensity PA was associated with less light sleep and more deep sleep. Additionally, vigorous-intensity PA was positively associated with increased deep sleep. No negative associations were observed between moderate-intensity PA and sleep quality. In conclusion, this study suggests that promoting prolonged light-intensity activities (e.g., walking) or short bursts of vigorous activity (e.g., sports participation) may enhance sleep quality during pre-adolescence and adolescence. Full article

Background/Objectives: Master athletes in team sports represent a growing population of individuals who continue to engage in structured training and competition. Among these sports, basketball has primarily been investigated in older athletes; however, age-related effects on training load within the broader master athlete population remain largely unexplored. This study aimed to examine the age-related differences in workloads among master basketball athletes and determine whether game participation can facilitate the achievement of the recommended physical activity level. Methods: A total of 178 male athletes were divided into three age groups (35–45, 46–60, and ≥60 years) and participated in a national tournament. External load metrics, including accumulated acceleration load (AAL), mechanical load (ML), and jump load (JL), were recorded using tri-axial microsensors. Internal load (IL) was assessed via session ratings of perceived exertion (sRPE). Physical activity levels were categorized into light, moderate, and vigorous intensity using accelerometry-derived metabolic equivalents. Results: Significant age-related differences (p < 0.01) were observed in AAL, ML, and JL, with the youngest group showing the highest values. Likewise, the time spent in moderate-to-vigorous physical activity (MVPA) displayed an age-dependent manner and decreased with age. Older athletes spent more time in low-intensity activities and employed energy-conserving strategies, avoiding high-speed and high-impact actions. Despite these variations, sRPE ratings were similar among groups. Conclusions: In conclusion, age is a crucial regulator of training load and physical activity and should be considered by practitioners and coaches who design training and physical activity plans for master basketball athletes. Despite the age-related differences, participation in basketball matches provides a substantial opportunity for increasing daily MVPA. Full article