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22 pages, 2691 KB  
Article
A Short-Term Load Forecasting Method for Typical High Energy-Consuming Industrial Parks Based on Multimodal Decomposition and Hybrid Neural Networks
by Jingyu Li, Yu Shi, Na Zhang and Yuanyu Chen
Appl. Sci. 2025, 15(17), 9578; https://doi.org/10.3390/app15179578 - 30 Aug 2025
Viewed by 272
Abstract
High energy-consuming industrial parks are characterized by high base-load-to-peak-valley ratios, overlapping production cycles, and megawatt-scale step changes, which significantly complicate short-term load forecasting. To tackle these challenges, this study proposes a novel forecasting framework that combines hierarchical multimodal decomposition with a hybrid deep [...] Read more.
High energy-consuming industrial parks are characterized by high base-load-to-peak-valley ratios, overlapping production cycles, and megawatt-scale step changes, which significantly complicate short-term load forecasting. To tackle these challenges, this study proposes a novel forecasting framework that combines hierarchical multimodal decomposition with a hybrid deep learning architecture. First, Maximal Information Coefficient (MIC) analysis is applied to identify key input features and eliminate redundancy. The load series is then decomposed in two stages: seasonal-trend decomposition uses the Loess (STL) isolates trend and seasonal components, while variational mode decomposition (VMD) further disaggregates the residual into multi-scale modes. This hierarchical approach enhances signal clarity and preserves temporal structure. A parallel neural architecture is subsequently developed, integrating an Informer network to model long-term trends and a bidirectional gated recurrent unit (BiGRU) to capture short-term fluctuations. Case studies based on real-world load data from a typical industrial park in northeastern China demonstrate that the proposed model achieves significantly improved forecasting accuracy and robustness compared to benchmark methods. These results provide strong technical support for fine-grained load prediction and intelligent dispatch in high energy-consuming industrial scenarios. Full article
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20 pages, 1786 KB  
Article
Characteristics of Domestic Hot Water Consumption Profiles in Multi-Family Buildings for Energy Modeling Purposes
by Agnieszka Chmielewska
Energies 2025, 18(17), 4578; https://doi.org/10.3390/en18174578 - 29 Aug 2025
Viewed by 283
Abstract
This paper presents a domestic hot water (DHW) consumption model for multi-family residential buildings that captures demand variability across monthly, daily, and hourly timescales. The model enables both the disaggregation of annual consumption for dynamic simulations and the generation of synthetic yet realistic [...] Read more.
This paper presents a domestic hot water (DHW) consumption model for multi-family residential buildings that captures demand variability across monthly, daily, and hourly timescales. The model enables both the disaggregation of annual consumption for dynamic simulations and the generation of synthetic yet realistic DHW load profiles when detailed measurements are unavailable. It is developed from a dataset of 42 buildings containing 1376 apartments. The analysis identifies seasonal, weekly, and hourly usage patterns, reflecting the influence of apartment layout, building size, and user behavior under Polish climatic and cultural conditions. The proposed model reproduces seasonal deviations of up to 23%, with average daily demand falling to 77% of the annual mean in August and rising above the yearly average during winter months. It also captures weekly variability, with weekend consumption exceeding weekday levels by more than 16%. On working days, the hourly profile exhibits a clear dual-peak structure, with approximately 18% of daily demand occurring in the morning and up to 45% in the evening, whereas weekends show a flatter distribution without pronounced peaks. These results provide a robust basis for more accurate demand representation in energy modeling, system design, and optimization under local conditions. Full article
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11 pages, 751 KB  
Article
In Vitro Antimicrobial and Antibiofilm Efficacy of an Aminochalcone-Loaded Hydrogel Against Candida spp.
by Emmanuely de Oliveira Chaves dos Santos, Pedro Luiz Rosalen, Joice Graciani, Josy Goldoni Lazarini, Maria Ligia Rodrigues Macedo, Diego Romário-Silva, Mayara Aparecida Rocha Garcia, Suzana Gonçalves Carvalho, Paola da Mata Siqueira Mesut, Ana Claudia Castelã Nascimento Prates, Luis Octávio Regasini, Marlus Chorilli, Rafael Leonardo Xediek Consani and Janaina de Cássia Orlandi Sardi
Future Pharmacol. 2025, 5(3), 47; https://doi.org/10.3390/futurepharmacol5030047 - 28 Aug 2025
Viewed by 240
Abstract
Background: Prosthetic candidiasis remains a significant clinical challenge, particularly due to the ability of Candida species to form resilient biofilms on dental prostheses, which limits the efficacy of conventional antifungal treatments. In this context, developing strategies to prevent or reduce biofilm formation is [...] Read more.
Background: Prosthetic candidiasis remains a significant clinical challenge, particularly due to the ability of Candida species to form resilient biofilms on dental prostheses, which limits the efficacy of conventional antifungal treatments. In this context, developing strategies to prevent or reduce biofilm formation is essential. Objectives This study investigates the antifungal and antibiofilm potential of a hydrogel formulation incorporating aminochalcone AM-35 as a candidate for the prevention and treatment of prosthetic candidiasis. Methods: To achieve this, experiments were conducted to determine the minimum inhibitory concentration (MIC) of aminochalcone AM-35 against Candida albicans and Candida tropicalis strains. AM-35 was incorporated into a hydrogel, which was subsequently tested on biofilms formed by these yeast species, both individually and in combination. The experimental disks were sterilized and incubated with C. albicans, C. tropicalis, and a mixture of both strains for 120 h to allow biofilm maturation. After contamination, the samples were divided into four experimental groups: Group 1: Hydrogel; Group 2: Hydrogel+AM-35; Group 3: Sodium hypochlorite (positive control); and Group 4: No treatment. The samples were then subjected to a sonication process to disaggregate the cells, which were then cultured on plates for colony-forming unit (CFU/mL) counts. The hydrogel’s toxicity was evaluated in vivo using the Galleria mellonella model. Results: The hydrogel formulation demonstrated significant antimicrobial activity, with an MIC of 7.8 μg/mL for C. albicans and 3.9 μg/mL for C. tropicalis. Treatment with the hydrogel at a concentration of 39 μg/mL resulted in a significant reduction in the formation and viability of mixed-species biofilms (p < 0.05). Additionally, the results indicated robust activity against C. albicans and C. tropicalis without presenting toxicity in the Galleria mellonella model. In conclusion, the hydrogel formulation exhibited effective antibiofilm activity, significantly reducing the microbial load. Conclusions: These findings open new possibilities for the development of alternative treatments for prosthetic candidiasis. The research suggests that the use of chalcone-based compounds may represent a promising approach in combating fungal infections in dentistry. Full article
(This article belongs to the Special Issue Feature Papers in Future Pharmacology 2025)
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17 pages, 1292 KB  
Article
An Instrumental High-Frequency Smart Meter with Embedded Energy Disaggregation
by Dimitrios Kolosov, Matthew Robinson, Pascal A. Schirmer and Iosif Mporas
Sensors 2025, 25(17), 5280; https://doi.org/10.3390/s25175280 - 25 Aug 2025
Viewed by 667
Abstract
Most available smart meters sample at low rates and transmit the acquired measurements to a cloud server for further processing. This article presents a prototype smart meter operating at a high sampling frequency (15 kHz) and performing energy disaggregation locally, thus negating the [...] Read more.
Most available smart meters sample at low rates and transmit the acquired measurements to a cloud server for further processing. This article presents a prototype smart meter operating at a high sampling frequency (15 kHz) and performing energy disaggregation locally, thus negating the need to transmit the acquired high-frequency measurements. The prototype’s architecture comprises a custom signal conditioning circuit and an embedded board that performs energy disaggregation using a deep learning model. The influence of the sampling frequency on the model’s accuracy and the edge device power consumption, throughput, and latency across different hardware platforms is evaluated. The architecture embeds NILM inference into the meter hardware while maintaining a compact and energy-efficient design. The presented smart meter is benchmarked across six embedded platforms, evaluating model accuracy, latency, power usage, and throughput. Furthermore, three novel hardware-aware performance metrics are introduced to quantify NILM efficiency per unit cost, throughput, and energy, offering a reproducible framework for future NILM-enabled edge meter designs. Full article
(This article belongs to the Section Electronic Sensors)
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29 pages, 1531 KB  
Article
Dynamic Tariff Adjustment for Electric Vehicle Charging in Renewable-Rich Smart Grids: A Multi-Factor Optimization Approach to Load Balancing and Cost Efficiency
by Dawei Wang, Xi Chen, Xiulan Liu, Yongda Li, Zhengguo Piao and Haoxuan Li
Energies 2025, 18(16), 4283; https://doi.org/10.3390/en18164283 - 12 Aug 2025
Viewed by 561
Abstract
The widespread deployment of electric vehicles (EVs) has introduced substantial challenges to electricity pricing, grid stability, and renewable energy integration. This paper proposes a real-time pricing optimization framework for large-scale EV charging networks incorporating renewable intermittency, demand elasticity, and infrastructure constraints within a [...] Read more.
The widespread deployment of electric vehicles (EVs) has introduced substantial challenges to electricity pricing, grid stability, and renewable energy integration. This paper proposes a real-time pricing optimization framework for large-scale EV charging networks incorporating renewable intermittency, demand elasticity, and infrastructure constraints within a high-dimensional optimization model. The core objective is to dynamically determine spatiotemporal electricity prices that simultaneously reduce system peak load, improve renewable energy utilization, and minimize user charging costs. A rigorous mathematical formulation is developed integrating over 40 system-level constraints, including power balance, transmission capacity, renewable curtailment, carbon targets, voltage regulation, demand-side flexibility, social participation, and cyber resilience. Real-time electricity prices are treated as dynamic decision variables influenced by charging station utilization, elasticity response curves, and the marginal cost of renewable and grid-supplied electricity. The problem is solved over 96 time intervals using a hybrid solution approach, with benchmark comparisons against mixed-integer programming (MILP) and deep reinforcement learning (DRL)-based baselines. A comprehensive case study is conducted on a 500-station EV charging network serving 10,000 vehicles integrated with a modified IEEE 118-bus grid model and 800 MW of variable renewable energy. Historical charging data with ±12% stochastic demand variation and real-world solar and wind profiles are used to simulate realistic operational conditions. Results demonstrate that the proposed framework achieves a 23.4% average peak load reduction per station, a 17.9% improvement in renewable energy utilization, and user cost savings of up to 30% compared to baseline flat-rate pricing. Utilization imbalances across the network are reduced, with congestion mitigation observed at over 90% of high-traffic stations. The real-time pricing model successfully aligns low-price windows with high-renewable periods and off-peak hours, achieving time-synchronized load shifting and system-wide flexibility. Visual analytics including high-resolution 3D surface plots and disaggregated bar charts reveal structured patterns in demand–price interactions, confirming the model’s ability to generate smooth, non-disruptive pricing trajectories. The results underscore the viability of advanced optimization-based pricing strategies for scalable, clean, and responsive EV charging infrastructure management in renewable-rich grid environments. Full article
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25 pages, 2100 KB  
Article
Flexible Demand Side Management in Smart Cities: Integrating Diverse User Profiles and Multiple Objectives
by Nuno Souza e Silva and Paulo Ferrão
Energies 2025, 18(15), 4107; https://doi.org/10.3390/en18154107 - 2 Aug 2025
Viewed by 356
Abstract
Demand Side Management (DSM) plays a crucial role in modern energy systems, enabling more efficient use of energy resources and contributing to the sustainability of the power grid. This study examines DSM strategies within a multi-environment context encompassing residential, commercial, and industrial sectors, [...] Read more.
Demand Side Management (DSM) plays a crucial role in modern energy systems, enabling more efficient use of energy resources and contributing to the sustainability of the power grid. This study examines DSM strategies within a multi-environment context encompassing residential, commercial, and industrial sectors, with a focus on diverse appliance types that exhibit distinct operational characteristics and user preferences. Initially, a single-objective optimization approach using Genetic Algorithms (GAs) is employed to minimize the total energy cost under a real Time-of-Use (ToU) pricing scheme. This heuristic method allows for the effective scheduling of appliance operations while factoring in their unique characteristics such as power consumption, usage duration, and user-defined operational flexibility. This study extends the optimization problem to a multi-objective framework that incorporates the minimization of CO2 emissions under a real annual energy mix while also accounting for user discomfort. The Non-dominated Sorting Genetic Algorithm II (NSGA-II) is utilized for this purpose, providing a Pareto-optimal set of solutions that balances these competing objectives. The inclusion of multiple objectives ensures a comprehensive assessment of DSM strategies, aiming to reduce environmental impact and enhance user satisfaction. Additionally, this study monitors the Peak-to-Average Ratio (PAR) to evaluate the impact of DSM strategies on load balancing and grid stability. It also analyzes the impact of considering different periods of the year with the associated ToU hourly schedule and CO2 emissions hourly profile. A key innovation of this research is the integration of detailed, category-specific metrics that enable the disaggregation of costs, emissions, and user discomfort across residential, commercial, and industrial appliances. This granularity enables stakeholders to implement tailored strategies that align with specific operational goals and regulatory compliance. Also, the emphasis on a user discomfort indicator allows us to explore the flexibility available in such DSM mechanisms. The results demonstrate the effectiveness of the proposed multi-objective optimization approach in achieving significant cost savings that may reach 20% for industrial applications, while the order of magnitude of the trade-offs involved in terms of emissions reduction, improvement in discomfort, and PAR reduction is quantified for different frameworks. The outcomes not only underscore the efficacy of applying advanced optimization frameworks to real-world problems but also point to pathways for future research in smart energy management. This comprehensive analysis highlights the potential of advanced DSM techniques to enhance the sustainability and resilience of energy systems while also offering valuable policy implications. Full article
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20 pages, 2792 KB  
Article
Capturing High-Frequency Harmonic Signatures for NILM: Building a Dataset for Load Disaggregation
by Farid Dinar, Sébastien Paris and Éric Busvelle
Sensors 2025, 25(15), 4601; https://doi.org/10.3390/s25154601 - 25 Jul 2025
Viewed by 447
Abstract
Advanced Non-Intrusive Load Monitoring (NILM) research is important to help reduce energy consumption. Very-low-frequency approaches have traditionally faced challenges in separating appliance uses due to low discriminative information. The richer signatures available in high-frequency electrical data include many harmonic orders that have the [...] Read more.
Advanced Non-Intrusive Load Monitoring (NILM) research is important to help reduce energy consumption. Very-low-frequency approaches have traditionally faced challenges in separating appliance uses due to low discriminative information. The richer signatures available in high-frequency electrical data include many harmonic orders that have the potential to advance disaggregation. This has been explored to some extent, but not comprehensively due to a lack of an appropriate public dataset. This paper presents the development of a cost-effective energy monitoring system scalable for multiple entries while producing detailed measurements. We will detail our approach to creating a NILM dataset comprising both aggregate loads and individual appliance measurements, all while ensuring that the dataset is reproducible and accessible. Ultimately, the dataset can be used to validate NILM, and we show through the use of machine learning techniques that high-frequency features improve disaggregation accuracy when compared with traditional methods. This work addresses a critical gap in NILM research by detailing the design and implementation of a data acquisition system capable of generating rich and structured datasets that support precise energy consumption analysis and prepare the essential materials for advanced, real-time energy disaggregation and smart energy management applications. Full article
(This article belongs to the Section Intelligent Sensors)
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11 pages, 215 KB  
Article
Appliance-Specific Noise-Aware Hyperparameter Tuning for Enhancing Non-Intrusive Load Monitoring Systems
by João Góis and Lucas Pereira
Energies 2025, 18(14), 3847; https://doi.org/10.3390/en18143847 - 19 Jul 2025
Viewed by 233
Abstract
Load disaggregation has emerged as an effective tool for enabling smarter energy management in residential and commercial buildings. By providing appliance-level energy consumption estimation from aggregate data, it supports energy efficiency initiatives, demand-side management, and user awareness. However, several challenges remain in improving [...] Read more.
Load disaggregation has emerged as an effective tool for enabling smarter energy management in residential and commercial buildings. By providing appliance-level energy consumption estimation from aggregate data, it supports energy efficiency initiatives, demand-side management, and user awareness. However, several challenges remain in improving the accuracy of energy disaggregation methods. For instance, the amount of noise in energy consumption datasets can heavily impact the accuracy of disaggregation algorithms, especially for low-power consumption appliances. While disaggregation performance depends on hyperparameter tuning, the influence of data characteristics, such as noise, on hyperparameter selection remains underexplored. This work investigates the hypothesis that appliance-specific noise information can guide the selection of algorithm hyperparameters, like the input sequence length, to maximize disaggregation accuracy. The appliance-to-noise ratio metric is used to quantify the noise level relative to each appliance’s energy consumption. Then, the selection of the input sequence length hyperparameter is investigated for each case by inspecting disaggregation performance. The results indicate that the noise metric provides valuable guidance for selecting the input sequence length, particularly for user-dependent appliances with more unpredictable usage patterns, such as washing machines and electric kettles. Full article
(This article belongs to the Topic Water and Energy Monitoring and Their Nexus)
32 pages, 2985 KB  
Article
The Design, Creation, Implementation, and Study of a New Dataset Suitable for Non-Intrusive Load Monitoring
by Carlos Rodriguez-Navarro, Francisco Portillo, Francisco G. Montoya and Alfredo Alcayde
Appl. Sci. 2025, 15(13), 7200; https://doi.org/10.3390/app15137200 - 26 Jun 2025
Viewed by 583
Abstract
The increasing need for efficient energy consumption monitoring, driven by economic and environmental concerns, has made Non-Intrusive Load Monitoring (NILM) a cost-effective alternative to traditional measurement methods. Despite its progress since the 1980s, NILM still lacks standardized benchmarks, limiting objective performance comparisons. This [...] Read more.
The increasing need for efficient energy consumption monitoring, driven by economic and environmental concerns, has made Non-Intrusive Load Monitoring (NILM) a cost-effective alternative to traditional measurement methods. Despite its progress since the 1980s, NILM still lacks standardized benchmarks, limiting objective performance comparisons. This study introduces several key contributions: (1) the development of five new converters with 13-digit timestamp support and harmonic inclusion, improving the data collection accuracy by up to 25%; (2) the implementation of an advanced disaggregation software, achieving a 10–15% increase in the F1-score for certain appliances; (3) a detailed analysis of harmonics’ impact on NILM, reducing the Mean Normalized Error in Assigned Power by up to 40%; and (4) the design of open-source measurement hardware to enhance reproducibility. This study also evaluates open hardware platforms and compares five common household appliances using NILM Toolkit metrics. Results demonstrate that open hardware and software foster reproducibility and accelerate innovation in NILM. The proposed approach contributes to a standardized and scalable NILM framework, facilitating real-world applications in energy management and smart grid optimization. Full article
(This article belongs to the Section Electrical, Electronics and Communications Engineering)
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28 pages, 3797 KB  
Article
Evaluation of Traditional and Data-Driven Algorithms for Energy Disaggregation Under Sampling and Filtering Conditions
by Carlos Rodriguez-Navarro, Francisco Portillo, Isabel Robalo and Alfredo Alcayde
Inventions 2025, 10(3), 43; https://doi.org/10.3390/inventions10030043 - 13 Jun 2025
Cited by 1 | Viewed by 477
Abstract
Non-intrusive load monitoring (NILM) enables the disaggregation of appliance-level energy consumption from aggregate electrical signals, offering a scalable solution for improving efficiency. This study compared the performance of traditional NILM algorithms (Mean, CO, Hart85, FHMM) and deep neural network-based approaches (DAE, RNN, Seq2Point, [...] Read more.
Non-intrusive load monitoring (NILM) enables the disaggregation of appliance-level energy consumption from aggregate electrical signals, offering a scalable solution for improving efficiency. This study compared the performance of traditional NILM algorithms (Mean, CO, Hart85, FHMM) and deep neural network-based approaches (DAE, RNN, Seq2Point, Seq2Seq, WindowGRU) under various experimental conditions. Factors such as sampling rate, harmonic content, and the application of power filters were analyzed. A key aspect of the evaluation was the difference in testing conditions: while traditional algorithms were evaluated under multiple experimental configurations, deep learning models, due to their extremely high computational cost, were analyzed exclusively under a specific configuration consisting of a 1-s sampling rate, with harmonic content present and without applying power filters. The results confirm that no universally superior algorithm exists, and performance varies depending on the type of appliance and signal conditions. Traditional algorithms are faster and more computationally efficient, making them more suitable for scenarios with limited resources or rapid response requirements. However, significantly more computationally expensive deep learning models showed higher average accuracy (MAE, RMSE, NDE) and event detection capability (F1-SCORE) in the specific configuration in which they were evaluated. These models excel in detailed signal reconstruction and handling harmonics without requiring filtering in this configuration. The selection of the optimal NILM algorithm for real-world applications must consider a balance between desired accuracy, load types, electrical signal characteristics, and crucially, the limitations of available computational resources. Full article
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27 pages, 1612 KB  
Article
Employing Quantum Entanglement for Real-Time Coordination of Distributed Electric Vehicle Charging Stations: Advancing Grid Efficiency and Stability
by Dawei Wang, Hanqi Dai, Yuan Jin, Zhuoqun Li, Shanna Luo and Xuebin Li
Energies 2025, 18(11), 2917; https://doi.org/10.3390/en18112917 - 2 Jun 2025
Viewed by 627
Abstract
The widespread deployment of electric vehicles (EVs) has introduced substantial challenges to electricity pricing, grid stability, and renewable energy integration. This paper presents the first real-time quantum-enhanced electricity pricing framework for large-scale EV charging networks, marking a significant departure from existing approaches based [...] Read more.
The widespread deployment of electric vehicles (EVs) has introduced substantial challenges to electricity pricing, grid stability, and renewable energy integration. This paper presents the first real-time quantum-enhanced electricity pricing framework for large-scale EV charging networks, marking a significant departure from existing approaches based on mixed-integer programming (MILP) and deep reinforcement learning (DRL). The proposed framework incorporates renewable intermittency, demand elasticity, and infrastructure constraints within a high-dimensional optimization model. The objective is to dynamically determine spatiotemporal electricity prices that reduce system peak load, improve renewable utilization, and minimize user charging costs. A rigorous mathematical formulation is developed, integrating over 40 system-level constraints, including power balance, transmission limits, renewable curtailment, carbon targets, voltage regulation, demand-side flexibility, social participation, and cyber-resilience. Real-time electricity prices are treated as dynamic decision variables influenced by station utilization, elasticity response curves, and the marginal cost of renewable and grid electricity. The model is solved across 96 time intervals using a quantum-classical hybrid method, with benchmark comparisons against MILP and DRL baselines. A comprehensive case study is conducted on a 500-station EV network serving 10,000 vehicles, coupled with a modified IEEE 118-bus grid and 800 MW of variable renewable energy. Historical charging data with ±12% stochastic demand variation and real-world solar/wind profiles are used to simulate realistic conditions. Results show that the proposed framework achieves a 23.4% average peak load reduction per station, a 17.9% gain in renewable utilization, and up to 30% user cost savings compared to flat-rate pricing. Network congestion is mitigated at over 90% of high-traffic stations. Pricing trajectories align low-price windows with high-renewable periods and off-peak hours, enabling synchronized load shifting and enhanced flexibility. Visual analytics using 3D surface plots and disaggregated bar charts confirm structured demand-price interactions and smooth, stable price evolution. These findings validate the potential of quantum-enhanced optimization for scalable, clean, and adaptive EV charging coordination in renewable-rich grid environments. Full article
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17 pages, 4319 KB  
Article
Hybrid Transformer–Convolutional Neural Network Approach for Non-Intrusive Load Analysis in Industrial Processes
by Gengsheng He, Yu Huang, Ying Zhang, Yuanzhe Zhu, Yuan Leng, Nan Shang, Jincan Zeng and Zengxin Pu
Energies 2025, 18(10), 2464; https://doi.org/10.3390/en18102464 - 11 May 2025
Viewed by 569
Abstract
With global efforts intensifying towards achieving carbon neutrality, accurately monitoring and managing energy consumption in industrial sectors has become critical. Non-Intrusive Load Monitoring (NILM) technology presents a cost-effective solution for industrial energy management by decomposing aggregate power data into individual device-level information without [...] Read more.
With global efforts intensifying towards achieving carbon neutrality, accurately monitoring and managing energy consumption in industrial sectors has become critical. Non-Intrusive Load Monitoring (NILM) technology presents a cost-effective solution for industrial energy management by decomposing aggregate power data into individual device-level information without extensive hardware requirements. However, existing NILM methods primarily tailored for residential applications struggle to capture complex inter-device correlations and production-dependent load dynamics prevalent in industrial environments, such as cement plants. This paper proposes a novel sequence-to-sequence-based non-intrusive load disaggregation method that integrates Convolutional Neural Networks (CNN) and Transformer architectures, specifically addressing the challenges of multi-device load disaggregation in industrial settings. An innovative time–application attention mechanism was integrated to effectively model long-term temporal dependencies and the collaborative operational relationships between industrial devices. Additionally, global constraints—including consistency, smoothness, and sparsity—were introduced into the loss function to ensure power conservation, reduce noise, and achieve precise zero-power predictions for inactive equipment. The proposed method was validated on real-world power consumption data collected from a cement production facility. Experimental results indicate that the proposed method significantly outperforms traditional NILM approaches with average improvements of 4.98%, 3.70%, and 4.38% in terms of accuracy, recall, and F1-score, respectively. These findings underscore its superior robustness in noisy conditions and under device fault conditions, further affirming its applicability and potential for deployment in industrial settings. Full article
(This article belongs to the Special Issue Challenges and Research Trends of Integrated Zero-Carbon Power Plant)
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15 pages, 727 KB  
Article
The Impact of Power Definitions on the Disaggregation of Home Loads for Smart Meter Measurements
by Vitor Fernão Pires, Armando Cordeiro, Tito G. Amaral, João. F. Martins and Ilhami Colak
Appl. Sci. 2025, 15(9), 5004; https://doi.org/10.3390/app15095004 - 30 Apr 2025
Viewed by 370
Abstract
The use of load-monitoring systems in residential homes is fundamental in the context of smart homes and smart grids. Specifically, these systems will allow, for example, the provision of efficient energy management and/or load forecasting for residential homes. To achieve this goal, these [...] Read more.
The use of load-monitoring systems in residential homes is fundamental in the context of smart homes and smart grids. Specifically, these systems will allow, for example, the provision of efficient energy management and/or load forecasting for residential homes. To achieve this goal, these systems can be based on the concept of a smart meter. However, a smart meter provides aggregate power consumption, which makes it extremely complex to identify individual home appliances, even using advanced algorithms. In line with this, this paper proposes to analyze the impact of power definitions on the disaggregation of home appliance loads. Moreover, it will also consider the distortion of the voltage grid, which is usually not addressed in the resolution of this problem. This effect will be verified through an approach that is based on a genetic algorithm. The approach will be tested through the use of several scenarios, in which an aggregation of home appliances is used. Full article
(This article belongs to the Special Issue Smart Energy Systems for Carbon-Neutral Urban Communities)
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21 pages, 4883 KB  
Article
Osteogenic and Antibacterial Response of Levofloxacin-Loaded Mesoporous Nanoparticles Functionalized with N-Acetylcysteine
by Alberto Polo-Montalvo, Natividad Gómez-Cerezo, Mónica Cicuéndez, Blanca González, Isabel Izquierdo-Barba and Daniel Arcos
Pharmaceutics 2025, 17(4), 519; https://doi.org/10.3390/pharmaceutics17040519 - 15 Apr 2025
Viewed by 835
Abstract
Background/Objectives: Bone infection is one of the most prevalent complications in orthopedic surgery. This pathology is mostly due to bacterial pathogens, among which S. aureus stands out. The formation of a bacterial biofilm makes systemic treatment with antibiotics ineffective. Herein we propose [...] Read more.
Background/Objectives: Bone infection is one of the most prevalent complications in orthopedic surgery. This pathology is mostly due to bacterial pathogens, among which S. aureus stands out. The formation of a bacterial biofilm makes systemic treatment with antibiotics ineffective. Herein we propose a nanosystem composed of mesoporous bioactive glass nanoparticles (MBGN) loaded with levofloxacin and functionalized with N-acetylcysteine (NAC), aiming to offer an alternative to current treatments. These nanoparticles would present antibacterial activity able to disintegrate the biofilm and regenerate the peri-implantar osseous tissue. Methods: MBGN of composition 82.5 SiO2—17.5 CaO have been synthesized, loaded with levofloxacin, and functionalized with NAC (MBGN-L-NAC). The antimicrobial activity against mature S. aureus biofilms and bioactivity of the nanosystem have been evaluated, as well as its biocompatibility and ability to promote murine pre-osteoblastic MC3T3-E1 differentiation. Results: MBGNs exhibited high surface areas and radial mesoporosity, allowing up to 23.1% (% w/w) of levofloxacin loading. NAC was covalently bound keeping the mucolytic thiol group, SH, available. NAC and levofloxacin combination enhances the activity against S. aureus by disrupting mature biofilm integrity. This nanosystem was biocompatible with pre-osteoblasts, enhanced their differentiation towards a mature osteoblast phenotype, and promoted bio-mimetic mineralization under in vitro conditions. MBGN-L-NAC nanoparticles induced greater osteogenic response of osteoprogenitor cells through increased alkaline phosphatase expression, increased mineralization, and stimulation of pre-osteoblast nodule formation. Conclusions: MBGN-L-NAC exhibits a more efficient antibacterial activity due to the biofilm disaggregation exerted by NAC, which also contributes to enhance the osteoinductive properties of MBGNs, providing a potential alternative to conventional strategies for the management of bone infections. Full article
(This article belongs to the Section Nanomedicine and Nanotechnology)
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16 pages, 3545 KB  
Communication
Incubation of Horseradish Peroxidase near 50 Hz AC Equipment Promotes Its Disaggregation and Enzymatic Activity
by Yuri D. Ivanov, Ivan D. Shumov, Andrey F. Kozlov, Alexander N. Ableev, Angelina V. Vinogradova, Ekaterina D. Nevedrova, Oleg N. Afonin, Dmitry D. Zhdanov, Vadim Y. Tatur, Andrei A. Lukyanitsa, Nina D. Ivanova, Evgeniy S. Yushkov, Dmitry V. Enikeev, Vladimir A. Konev and Vadim S. Ziborov
Micromachines 2025, 16(3), 344; https://doi.org/10.3390/mi16030344 - 19 Mar 2025
Viewed by 684
Abstract
Low-frequency electromagnetic fields, induced by alternating current (AC)-based equipment such as transformers, are known to influence the physicochemical properties and function of enzymes, including their catalytic activity. Herein, we have investigated how incubation near a 50 Hz AC autotransformer influences the physicochemical properties [...] Read more.
Low-frequency electromagnetic fields, induced by alternating current (AC)-based equipment such as transformers, are known to influence the physicochemical properties and function of enzymes, including their catalytic activity. Herein, we have investigated how incubation near a 50 Hz AC autotransformer influences the physicochemical properties of horseradish peroxidase (HRP), by atomic force microscopy (AFM) and spectrophotometry. We found that a half-hour-long incubation of the enzyme above the coil of a loaded autotransformer promoted the adsorption of the monomeric form of HRP on mica, enhancing the number of adsorbed enzyme particles by two orders of magnitude in comparison with the control sample. Most interestingly, the incubation of HRP above the switched-off transformer, which was unplugged from the mains power supply, for the same period of time was also found to cause a disaggregation of the enzyme. Notably, an increase in the activity of HRP against ABTS was observed in both cases. We hope that the interesting effects reported will emphasize the importance of consideration of the influence of low-frequency electromagnetic fields on enzymes in the design of laboratory and industrial equipment intended for operation with enzyme systems. The effects revealed in our study indicate the importance of proper shielding of AC-based transformers in order to avoid the undesirable influence of low-frequency electromagnetic fields induced by these transformers on humans. Full article
(This article belongs to the Special Issue Emerging Research on Molecular Sensors)
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