Search Results (41)

Background/Objectives: A marked anteroposterior gradient of nasal fossa pneumatisation over the posterior maxillary alveolar base has been documented at the second premolar level, yet whether this gradient extends to the second upper molar (M2)—the primary site for posterior implant rehabilitation—remains uncharacterised. We aimed to quantify this gradient by classifying pneumatisation patterns above the maxillary alveolar base at M2 (Type 1: pure antral; Type 2: antral with palatine recess; Type 3: Big Nose pattern with combined antral and nasal involvement), assess bilateral symmetry and sex distribution, and compare findings with published second premolar data. Methods: A retrospective study was conducted on 165 cone-beam computed tomography scans (330 sides) from a Romanian population. Patterns were classified as Type 1 (pure antral), Type 2 (antral with palatine recess), or Type 3 (Big Nose pattern). Bilateral symmetry was assessed using Cohen’s kappa, and sex differences using Fisher’s exact test. Results: Type 1 was observed in 93.3% of sides, Type 2 in 4.2%, and Type 3 in 2.4%. Bilateral symmetry was 98.8% (kappa = 0.904), with all Type 3 cases occurring bilaterally. No significant sex difference was found (p = 0.363), although Type 3 showed a non-significant male predominance (OR = 4.55; p = 0.305). The Big Nose pattern was 6.8-fold less prevalent at M2 than at the second premolar level. Conclusions: A 6.8-fold reduction in Big Nose prevalence from the second premolar (16.2%) to M2 (2.4%) confirms a pronounced anteroposterior gradient in nasal fossa involvement over the posterior maxillary alveolar base—the central finding of this study. At M2, the maxillary sinus dominates exclusively in 97.6% of sides, rendering standard sinus floor elevation highly predictable. The invariable bilaterality of the Big Nose pattern at M2 supports contralaterally symmetrical surgical planning. These findings provide a gradient-based clinical framework: nasal-floor-aware augmentation planning is essential anteriorly (premolar region), whereas standard sinus augmentation protocols are reliably applicable at M2. Full article

Body area networks (BANs) require secure intra-body communication, yet sensor nodes are too resource-constrained for conventional public-key cryptography, and pre-shared key schemes conflict with plug-and-play clinical workflows. This paper introduces PhysioKey, a TinyML-based key agreement framework that derives symmetric session keys from physiological signals without pre-shared secrets or trusted third parties. A lightweight 1D-CNN (6320 parameters, INT8-quantized, 31.2 KB flash) extracts embeddings from ECG and PPG windows on ARM Cortex-M4 class devices, which are reconciled through fuzzy commitment with BCH error-correcting codes. Patient-level 5-fold cross-validation on PTB-XL (500 patients, dual-ECG) achieves EER of $7.8\%\pm 0.8\%$ with ROC AUC $0.978\pm 0.004$; on BIDMC (53 patients, ECG + PPG), a dual-encoder architecture reduces cross-modal EER to $30.6\%\pm 1.2\%$. Since standalone PhysioKey yields only 7–24 effective key bits, the recommended deployment mode is a hybrid PhysioKey + ECDH protocol providing 128-bit security while PhysioKey adds physical on-body authentication; standalone operation suits energy-constrained scenarios with its $27\times$ advantage over ECDH. HKDF-SHA-256 post-processing yields session keys passing all six NIST SP 800-22 tests (≥96% at the 1024-bit level). Full article

This paper presents a compact output-stage current-limiting architecture intended for reliable overcurrent protection in CMOS analog and mixed-signal circuits. In modern integrated systems, the output stages of blocks such as operational amplifiers, drivers, buffers, and reference circuits may be exposed to overload conditions, low-impedance loads, or short circuits that can lead to excessive power dissipation and device degradation. The proposed architecture employs scaled replicas of the output transistors together with local negative feedback to sense the delivered load current and independently limit both sinking and sourcing currents. The circuit is demonstrated by integration into a two-stage folded-cascode operational amplifier with a class-AB output stage and evaluated through circuit-level simulations in 130 nm CMOS technology. The results confirm a well-defined current limit across the supply and temperature corners that are relevant to high-reliability applications, spanning 2 V and 5 V supplies and a temperature range from −55 °C to 175 °C. The proposed current-limiting scheme constrains both pull-down and pull-up currents to approximately 9–12 mA across the investigated operating domain. Monte Carlo analysis further shows bounded dispersion and symmetric single-mode distributions, indicating predictable operation under device mismatch. These results demonstrate that the proposed architecture provides a compact and scalable solution for deterministic current limiting in reliability-critical CMOS systems. Full article

G-quadruplex (G4) DNAzymes, guanine-rich sequences that fold into four-stranded structures and bind hemin to mimic peroxidase activity, are widely used in biosensing. Split G4 DNAzymes offer conditional activation upon target recognition, enabling high specificity and modularity. However, achieving low OFF-state leakage remains a major challenge. Here, we systematically characterized four representative G4 scaffolds, C-myc, Bcl2, PS5.M, and C-kit, under standardized ABTS/H₂O₂ conditions to assess their kinetic properties and suitability for split designs. C-myc exhibited the highest sustained activity and near-linear concentration dependence, making it ideal for quantitative sensing, while Bcl2 showed durable catalysis suited for extended read windows. C-kit produced rapid bursts with early plateaus, favoring binary outputs, and PS5.M initiated quickly but inactivated rapidly, suggesting potential application of systems requiring fast response. Split-mode analysis revealed that symmetric 2:2 partitions often retained significant activity, whereas asymmetric 3:1 splits reduced but did not eliminate leakage. Among the four G4 DNAzymes, PS5.M demonstrated the most promising OFF-state suppression. Design strategies to minimize leakage including non-classical splits, loop/flank edits, and template-assisted assembly could be used to optimize biosensor functionalities. These findings identify essential factors critical for designing robust split DNAzyme biosensors, advancing applications in diagnostics and molecular logic gates. Full article

The confined concrete box steel arch support—composed of box steel and core concrete with a geometrically symmetric double-chamber cross-section—is an innovative solution for effective deformation control in soft rock tunnels. To address the longstanding challenge of balancing accuracy and efficiency in numerical simulations of such supports, this study proposes an improved simulation method. Specifically, a compression-bending yield criterion for the steel–concrete composite structure was derived based on the plane section assumption and full-section plasticity criterion. This criterion was then embedded into a pile element via Fish programming to develop an improved pile element, enabling accurate simulation of the bending moment–axial force coupling effect. Verification results demonstrate that the derived yield criterion precisely captures the axial force–bending moment coupling behavior of the confined concrete box section. Numerical simulation data exhibit excellent consistency with the theoretical m-n curve, with the maximum deviation in yield axial force and bending moment not exceeding 10%. Compared with the solid element model, the improved pile element model shows differences of less than 6%, 13%, and 21% in key indicators of surrounding rock stress, deformation, and plastic zone, respectively—meeting engineering accuracy requirements. Notably, the mesh count of the improved model is only 5.5% of that of the solid element model, achieving over a 40-fold increase in computational efficiency. Furthermore, this study identifies section type and section size as the dominant parameters governing surrounding rock stability, providing valuable insights for the design and numerical simulation optimization of soft-rock tunnel support systems. Full article

We have demonstrated the fabrication of laminate composites with functional features to demonstrate energy storage capabilities. The present study investigates the surface modification of carbon fibers by coating dual materials of reduced graphene oxide (rGO) and cellulose-based activated carbon to enhance their energy storage capacitance for the development of structural supercapacitors. The dual coating on carbon fibers enabled a near 210-fold improvement in surface area, surpassing that of pristine carbon fibers. This formed a highly porous graphene network with activated carbon, resulting in a well-connected fiber–graphene-activated carbon network on carbon fibers. The electrochemical supercapacitor, fabricated from surface-functionalized carbon fibers, provides the best performance, with a specific capacitance of 172 F g⁻¹ in an aqueous electrolyte. Furthermore, the symmetrical structural supercapacitor (SSSC) device delivered a specific capacitance of 227 mF g⁻¹ across a wide potential window of 6 V. The electrochemical stability of the SSSC device was validated by a high capacitance retention of 97.3% over 10,000 cycles. Additionally, the study showcased the practical application of this technology by successfully illuminating an LED using the proof-of-concept SSSC device with G-aC/CF electrodes. Overall, the findings of this study highlight the potential of carbon fiber composites as a promising hybrid material, offering both structural integrity and a functional performance suitable for aerospace and automobile applications. Full article

Skin aging is mainly caused by external factors like sunlight, which triggers oxidative stress and chronic inflammation. Natural halogenated flavonoids have demonstrated anti-inflammatory properties. Inspired by the macroalgae-derived bromophenol BDDE, we investigated the anti-inflammatory potential of structure-related chalcones (1–7). Chalcones 1 and 7 showed the least cytotoxicity in keratinocyte and macrophage cells. Chalcones 1, 2, 4, and 5 exhibited the most significant anti-inflammatory effects in murine macrophages after lipopolysaccharide stimulation, with chalcone 1 having the lowest IC₅₀ value (≈0.58 μM). A SNAP assay confirmed that chalcones do not exert their effects through direct NO scavenging. Symmetrical bromine atoms and 3,4-dimethoxy groups on both aromatic rings improved the anti-inflammatory activity, indicating a relevant structure–activity relationship. Chalcones 1 and 2 were selected for study to clarify their mechanisms of action. At a concentration of 7.5 μM, chalcone 2 demonstrated a rapid and effective inhibitory action on the protein levels of inducible nitric oxide synthase (iNOS), while chalcone 1 exhibited a gradual inhibitory action. Moreover, chalcone 1 effectively activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway with around a 3.5-fold increase at the end of 24 h at 7.5 μM, highlighting its potential as a modulator of oxidative stress responses. These findings place chalcone 1 as a promising candidate for skincare products targeting inflammation and skin aging. Full article

This paper extends the concept of the total graph $T_{\mathsf{\Gamma }}\left(R\right)$ associated with a commutative ring to the three-fold Cartesian product $R={\mathbb{Z}}_n\times {\mathbb{Z}}_m\times {\mathbb{Z}}_p$, where $n,m,p>1$. We present complete and self-contained proofs for a wide range of graph-theoretic properties of $T_{\mathsf{\Gamma }}\left(R\right)$, including connectivity, diameter, regularity conditions, clique and independence numbers, and exact criteria for Hamiltonicity and Eulericity. We also derive improved lower bounds for the genus and characterize the automorphism group in both general and symmetric cases. Each result is illustrated through concrete numerical examples for clarity. Beyond theoretical contributions, we discuss potential applications in cryptographic key-exchange systems, fault-tolerant network architectures, and algebraic code design. This work generalizes and deepens prior studies on two-factor total graphs, and establishes a foundational framework for future exploration of higher-dimensional total graphs over finite commutative rings. Full article

This study investigates the unsteady aerodynamic mechanisms underlying the efficient flight of birds and proposes a biomimetic flapping-wing aircraft design utilizing a double-crank double-rocker mechanism. Building upon a detailed analysis of avian flight dynamics, a two-stage foldable flapping mechanism was developed, integrating an optimized double-crank double-rocker structure with a secondary linkage system. This design enables synchronized wing flapping and spanwise folding, significantly enhancing aerodynamic efficiency and dynamic performance. The system’s planar symmetric layout and high-ratio reduction gear configuration ensure movement synchronicity and stability while reducing mechanical wear and energy consumption. Through precise modeling, the motion trajectories of the inner and outer wing segments were derived, providing a robust mathematical foundation for motion control and optimization. Computational simulations based on trajectory equations successfully demonstrated the characteristic figure-eight wingtip motion. Using 3D simulations and CFD analysis, key parameters—including initial angle of attack, aspect ratio, flapping frequency, and flapping speed—were optimized. The results indicate that optimal aerodynamic performance is achieved at an initial angle of attack of 9°, an aspect ratio of 5.1, and a flapping frequency and speed of 4–5 Hz and 4–5 m/s, respectively. These findings underscore the potential of biomimetic flapping-wing aircraft in applications such as UAVs and military technology, providing a solid theoretical foundation for future advancements in this field. Full article

Mitochondrial carriers transport organic acids, amino acids, nucleotides and cofactors across the mitochondrial inner membrane. These transporters consist of a three-fold symmetric bundle of six transmembrane α-helices that encircle a pore with a central substrate binding site, whose alternating access is controlled by a cytoplasmic and a matrix gate (C- and M-gates). The C- and M-gates close by forming two different salt-bridge networks involving the conserved motifs [YF][DE]XX[KR] on the even-numbered and PX[DE]XX[KR] on the odd-numbered transmembrane α-helices, respectively. We have investigated the effects on transport of mutating the C-gate charged residues of the yeast NAD⁺ transporter Ndt1p and performed molecular docking with NAD⁺ and other substrates into structural models of Ndt1p. Double-cysteine substitutions and swapping the positions of the C-gate charged-pair residues showed that all of them contribute to the high transport rate of wild-type Ndt1p, although no single salt bridge is essential for activity. The in silico docking results strongly suggest that both the C-gate motif mutations and our previously reported M-gate mutations affect gate closing, whereas those of the M-gate also affect substrate binding, which is further supported by molecular dynamics. In particular, NAD⁺ most likely interferes with the cation-π interaction between R303-W198, which has been proposed to exist in the Ndt1p M-gate in the place of one of the salt bridges. These findings contribute to understanding the roles of the charged C- and M-gate residues in the transport mechanism of Ndt1p. Full article

In the current article, we introduce several new subclasses of m-fold symmetric analytic and bi-univalent functions associated with bounded boundary and bounded radius rotation within the open unit disk $\mathbb{D}.$ Utilizing the Faber polynomial expansion, we derive upper bounds for the coefficients $|b_{mk+1}|$ and establish initial coefficient bounds for $|b_{m+1}|$ and $|b_{2m+1}|.$ Additionally, we explore the Fekete–Szegö inequalities applicable to the functions that fall within these newly defined subclasses. Full article

For the purpose of improving performance and reducing the fabrication difficulty of terahertz traveling wave tubes (TWTs), this paper proposes a novel single-section high-gain slow wave structure (SWS), which is named the symmetrical quasi-synchronous step-transition (SQSST) folded waveguide (FW). The SQSST-FW SWS has an artificially designed quasi-synchronous region (QSR) to suppress self-oscillations for sustaining a high gain in an untruncated circuit. Simultaneously, a symmetrical design can improve the efficiency performance to some extent. A prototype of the SQSST-FW SWS for 650 GHz TWTs is designed based on small-signal analysis and numerical simulation. The simulation results indicate that the maximum saturation gain of the designed 650 GHz SQSST-FW TWT is 39.1 dB in a 34.3 mm slow wave circuit, occurring at the 645 GHz point when a 25.4 kV 15 mA electron beam and a 0.43 mW sinusoidal input signal are applied. In addition, a maximum output power exceeding 4 W is observed at the 648 GHz point using the same beam with an increased input power of around 2.8 mW. Full article

At every point $p$ on a smooth $n$-manifold M there exist $\left(n+1\right)$ skew-symmetric tensor spaces spanning differential $r$-forms $\omega$ with $r=0,1,\cdots ,n$. Because $d\circ d$ is always zero where $d$ is the exterior differential, it follows that every exact $r$-form (i.e., $\omega =d\lambda$ where $\lambda$ is an $\left(r-1\right)$-form) is closed (i.e., $d\omega =0$) but not every closed $r$-form is exact. This implies the existence of a third type of differential $r$-form that is closed but not exact. Such forms are called harmonic forms. Every smooth $n$-manifold has an underlying topological structure. Many different possible topological structures exist. What distinguishes one topological structure from another is the number of holes of various dimensions it possesses. De Rham’s theory of differential forms relates the presence of $r$-dimensional holes in the underlying topology of a smooth $n$-manifold $M$ to the presence of harmonic $r$-form fields on the smooth manifold. A large amount of theory is required to understand de Rham’s theorem. In this paper we summarize the differential geometry that links holes in the underlying topology of a smooth manifold with harmonic fields on the manifold. We explore the application of de Rham’s theory to (i) visual, (ii) mechanical, (iii) electrical and (iv) fluid flow systems. In particular, we consider harmonic flow fields in the intracellular aqueous solution of biological cells and we propose, on mathematical grounds, a possible role of harmonic flow fields in the folding of protein polypeptide chains. Full article

With the worldwide awareness of sustainability, biomass-derived carbon electrode materials for supercapacitors have attracted growing attention. In this research, for the first time, we explored the feasibility of making use of the carbon byproduct from hydrothermal liquefaction (HTL) of microalgae, termed herein as algae-derived carbon (ADC), to prepare sustainable carbon electrode materials for high-performance supercapacitor development. Specifically, we investigated carbon activation with a variety of activating reagents as well as N- and Fe-doping of the obtained ADC with the intention to enhance its electrochemical performance. We characterized the structure of the activated and doped ADCs using scanning electron microscope (SEM), Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and BET surface area and pore analysis, and correlated the ADCs’ structure with their electrochemical performance as evaluated using cyclic voltammetry (CV), galvanostatic charge/discharge (GCD), impedance, and cycle stability through an assembled symmetric two-electrode cell with 1 M H₂SO₄ as electrolyte. It was found that the ADC that is activated using KOH (KOH-ADC) showed the best electrochemical performance, and its specific capacitance was 14.1-fold larger with respect to that of the raw ADC and reached 234.5 F/g in the GCD test at a current density of 0.5 A/g. The KOH-ADC also demonstrated excellent capacitance retention (97% after 10,000 cycles at a high current density of 10 A/g) for stable long-term operations. This research pointed out a promising direction to develop sustainable electrode materials for supercapacitors from the carbon byproduct produced after HTL processing of algae. Full article

The m-fold symmetric in terms of a generalized distribution series has not been considered in the literature. In this study, however, the authors investigated the bi-univalency of m-fold symmetric functions for the generalized distribution of two subclasses of analytic functions. The initial few coefficient bounds $\left|\frac{a_m}{S}\right|$ and $\left|\frac{a_{2m}}{S}\right|$ are obtained for the two subclasses of functions defined and the results serve as a new generalization in this direction. Full article