Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (12,393)

Search Parameters:
Keywords = metabolic health

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
16 pages, 2267 KiB  
Article
Placenta-Derived Mesenchymal Stem Cells (pMSCs) Reverse Diabetes-Associated Endothelial Complications in a Preclinical Animal Model
by Yasser Basmaeil, Ahmed Bakillah, Abdullah Mohammed Al Subayyil, Haya Nasser Bin Kulayb, Maha Abdullah AlRodayyan, Abeer Al Otaibi, Sindiyan Al Shaikh Mubarak, Hassan S. Alamri, Altaf A. Kondkar, Jahangir Iqbal and Tanvir Khatlani
Int. J. Mol. Sci. 2025, 26(16), 8057; https://doi.org/10.3390/ijms26168057 (registering DOI) - 20 Aug 2025
Abstract
Diabetes is increasingly recognized as a chronic inflammatory disease marked by systemic metabolic disturbances, with endothelial dysfunction playing a central role in its complications. Hyperglycemia, a hallmark of diabetes, drives endothelial damage by inducing excessive reactive oxygen species (ROS) production, particularly hydrogen peroxide [...] Read more.
Diabetes is increasingly recognized as a chronic inflammatory disease marked by systemic metabolic disturbances, with endothelial dysfunction playing a central role in its complications. Hyperglycemia, a hallmark of diabetes, drives endothelial damage by inducing excessive reactive oxygen species (ROS) production, particularly hydrogen peroxide (H2O2). This oxidative stress impairs endothelial cells, which are vital for vascular health, leading to severe complications such as diabetic nephropathy, retinopathy, and coronary artery disease—major causes of morbidity and mortality in diabetic patients. Recent studies have highlighted the therapeutic potential of placenta-derived mesenchymal stem cells (pMSCs), in mitigating these complications. pMSCs exhibit anti-inflammatory, antioxidant, and tissue-repair properties, showing promise in reversing endothelial damage in laboratory settings. To explore their efficacy in a more physiologically relevant context, we used a streptozotocin (STZ)-induced diabetic mouse model, which mimics type 1 diabetes by destroying pancreatic beta cells and causing hyperglycemia. pMSCs were administered via intra-peritoneal injections, and their effects on endothelial injury and tissue damage were assessed. Metabolic tests, including glucose tolerance tests (GTTs) and insulin tolerance tests (ITTs) revealed that pMSCs did not restore metabolic homeostasis or improve glucose regulation. However, histopathological kidney, heart, and eye tissue analyses demonstrated significant protective effects. pMSCs preserved glomerular structure in the kidneys, protected cardiac blood vessels, and maintained retinal integrity, suggesting their potential to address diabetes-related tissue injuries. Although these findings underscore the therapeutic potential of pMSCs for diabetic complications, further research is needed to optimize dosing, elucidate molecular mechanisms, and evaluate long-term safety and efficacy. Combining pMSCs with other therapies may enhance their benefits, paving the way for future clinical applications. Full article
Show Figures

Figure 1

21 pages, 2677 KiB  
Article
A Novel Weizmannia coagulans Strain WC412 with Superior Environmental Resilience Improves Growth Performance of Mice by Regulating the Intestinal Microbiota
by Xue Xiao, Hao Huang, Wendi Yu, Jun Liu, Yuanliang Hu, Xiang Yu and Xicai Zhang
Animals 2025, 15(16), 2446; https://doi.org/10.3390/ani15162446 - 20 Aug 2025
Abstract
The growing demand for sustainable and antibiotic-free animal production has intensified interest in probiotics as functional feed additives. In this study, novel strains of Weizmannia coagulans (WC412 and WC413) were isolated from pickle water—a previously unexplored source for probiotic screening. These isolates, along [...] Read more.
The growing demand for sustainable and antibiotic-free animal production has intensified interest in probiotics as functional feed additives. In this study, novel strains of Weizmannia coagulans (WC412 and WC413) were isolated from pickle water—a previously unexplored source for probiotic screening. These isolates, along with three reference strains (W. coagulans S8, S15, and S17), were evaluated for their tolerance to heat, acid, and bile salts. Strain WC412 exhibited superior environmental resilience, as validated by principal component analysis (PCA) for comprehensive stress-tolerance assessment, and was selected for further investigations. A murine model was employed to assess the physiological and microbiological impacts of WC412 supplementation at varying doses. Medium-dose (1 × 107 CFU·mL−1) administration significantly improved body weight gain by 13% (p < 0.05), modulated serum lipid profiles, and increased antioxidant enzyme activity and IgG/IL-2 levels (p < 0.05). Notably, WC412 uniquely enriched beneficial genera (e.g., Fructilactobacillus and Limosilactobacillus) and promoted metabolic pathways linked to short-chain fatty acid production, as revealed by 16S rDNA sequencing and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. These findings highlight WC412 as a robust probiotic candidate for enhancing animal growth performance and gut health through novel microbiota-mediated mechanisms. Full article
(This article belongs to the Section Animal Nutrition)
15 pages, 764 KiB  
Article
Essential Elements (Fe, Cu, Mn, Zn) in Meconium, and Newborn Length and Weight, in Relation to Maternal Lifestyle and Diet
by Bianka Mimica, Ajka Pribisalic, Zlatka Knezovic and Davorka Sutlovic
Nutrients 2025, 17(16), 2700; https://doi.org/10.3390/nu17162700 - 20 Aug 2025
Abstract
Background/Objectives: Fetal exposure to essential metals, such as iron (Fe), zinc (Zn), copper (Cu), and manganese (Mn), is influenced by maternal nutrition and lifestyle during pregnancy, potentially impacting newborn health. This study aimed to quantify concentrations of these metals in meconium and evaluate [...] Read more.
Background/Objectives: Fetal exposure to essential metals, such as iron (Fe), zinc (Zn), copper (Cu), and manganese (Mn), is influenced by maternal nutrition and lifestyle during pregnancy, potentially impacting newborn health. This study aimed to quantify concentrations of these metals in meconium and evaluate their associations, together with newborn length and weight, in relation to maternal dietary and lifestyle factors. Methods: This cross-sectional study included 152 mother–infant pairs recruited from various regions of Split-Dalmatia County, Croatia. Meconium samples were collected within 24 h after birth and analyzed for Fe, Zn, Cu, and Mn concentrations. Maternal characteristics, dietary intake, supplement use, and lifestyle factors were collected via structured questionnaires and supplemented by hospital records. Associations among maternal factors, meconium metal concentrations, and newborn birth weight and length were assessed using non-parametric statistical methods. Results: Meconium concentrations of Fe, Zn, Cu, and Mn showed substantial interindividual variability, with a strong positive correlation between Fe and Cu. Higher maternal pre-pregnancy BMI was linked to lower meconium Fe, while BMI at delivery was associated with Zn. Dietary patterns influenced metal levels: higher fruit intake was linked to increased Cu, greater vegetable intake with lower Fe, and moderate tea consumption with higher Zn. No significant associations were found with maternal smoking, residence, or supplement use. Maternal meat consumption and higher pre-pregnancy BMI were both associated with higher newborn birth weight and length. Conclusions: Maternal BMI and specific dietary patterns during pregnancy significantly influence essential metal concentrations in newborn meconium and are associated with newborn size, highlighting the importance of balanced maternal nutrition and healthy metabolic status during pregnancy. Full article
(This article belongs to the Special Issue Diet, Maternal Nutrition and Reproductive Health)
Show Figures

Figure 1

15 pages, 616 KiB  
Article
The Dynamic Interplay of Lifestyle, Dietary Factors, and Cardiometabolic Risk in Hypertension: A Cross-Sectional Investigation Among Saudi Adults
by Mohammad A. Jareebi
Diagnostics 2025, 15(16), 2097; https://doi.org/10.3390/diagnostics15162097 - 20 Aug 2025
Abstract
Background/Objectives: Hypertension is a growing public health concern in Saudi Arabia, driven by rapid socioeconomic changes. This study investigated the interplay between habitual, behavioral, and dietary risk factors associated with hypertension among Saudi adults. Methods: A cross-sectional survey was conducted among [...] Read more.
Background/Objectives: Hypertension is a growing public health concern in Saudi Arabia, driven by rapid socioeconomic changes. This study investigated the interplay between habitual, behavioral, and dietary risk factors associated with hypertension among Saudi adults. Methods: A cross-sectional survey was conducted among 3312 Saudi adults using multistage stratified random sampling. The data were collected via validated questionnaires assessing sociodemographic, anthropometric indicators, lifestyle behaviors, dietary patterns, and medical history. Hypertension status was determined through self-reported diagnosis. Bivariate analyses and multiple logistic regression identified independent predictors (p < 0.05). Results: Hypertension prevalence was 13% (mean age: 34 ± 15 years; 50% male). The strongest predictors were age (OR = 1.08/year; 95% CI: 1.07–1.10; p < 0.001), increased body mass index (OR = 1.03; 95% CI: 1.01–1.06; p = 0.011), smoking (OR = 1.55; 95% CI: 1.04–2.29; p = 0.030), and family history of hypertension (OR = 7.71; 95% CI: 5.61–10.75; p < 0.001). Participants with diabetes mellitus had 89% higher odds of hypertension (OR = 1.89; 95% CI: 1.42–2.51; p < 0.001), and those with dyslipidemia had more than double the odds (OR = 2.45; 95% CI: 1.38–4.22; p = 0.002). Protective factors included higher income (≥15,000 SAR; OR = 0.54; 95% CI: 0.36–0.81; p = 0.003) and regular whole grain consumption (OR = 0.60; 95% CI: 0.46–0.77; p < 0.001). Conclusions: Hypertension risk in Saudi adults is shaped by age, obesity, smoking, comorbid metabolic conditions (diabetes and dyslipidemia), and genetic pre-disposition. In contrast, higher income and whole grain intake may offer protection. These findings underscore the need for comprehensive prevention strategies that address both lifestyle and cardiometabolic comorbidities, in alignment with Saudi Vision 2030 health priorities. Full article
(This article belongs to the Special Issue Hypertension: Diagnosis and Management)
22 pages, 1706 KiB  
Review
Integrating Precision Medicine and Digital Health in Personalized Weight Management: The Central Role of Nutrition
by Xiaoguang Liu, Miaomiao Xu, Huiguo Wang and Lin Zhu
Nutrients 2025, 17(16), 2695; https://doi.org/10.3390/nu17162695 - 20 Aug 2025
Abstract
Obesity is a global health challenge marked by substantial inter-individual differences in responses to dietary and lifestyle interventions. Traditional weight loss strategies often overlook critical biological variations in genetics, metabolic profiles, and gut microbiota composition, contributing to poor adherence and variable outcomes. Our [...] Read more.
Obesity is a global health challenge marked by substantial inter-individual differences in responses to dietary and lifestyle interventions. Traditional weight loss strategies often overlook critical biological variations in genetics, metabolic profiles, and gut microbiota composition, contributing to poor adherence and variable outcomes. Our primary aim is to identify key biological and behavioral effectors relevant to precision medicine for weight control, with a particular focus on nutrition, while also discussing their current and potential integration into digital health platforms. Thus, this review aligns more closely with the identification of influential factors within precision medicine (e.g., genetic, metabolic, and microbiome factors) but also explores how these factors are currently integrated into digital health tools. We synthesize recent advances in nutrigenomics, nutritional metabolomics, and microbiome-informed nutrition, highlighting how tailored dietary strategies—such as high-protein, low-glycemic, polyphenol-enriched, and fiber-based diets—can be aligned with specific genetic variants (e.g., FTO and MC4R), metabolic phenotypes (e.g., insulin resistance), and gut microbiota profiles (e.g., Akkermansia muciniphila abundance, SCFA production). In parallel, digital health tools—including mobile health applications, wearable devices, and AI-supported platforms—enhance self-monitoring, adherence, and dynamic feedback in real-world settings. Mechanistic pathways such as gut–brain axis regulation, microbial fermentation, gene–diet interactions, and anti-inflammatory responses are explored to explain inter-individual differences in dietary outcomes. However, challenges such as cost, accessibility, and patient motivation remain and should be addressed to ensure the effective implementation of these integrated strategies in real-world settings. Collectively, these insights underscore the pivotal role of precision nutrition as a cornerstone for personalized, scalable, and sustainable obesity interventions. Full article
(This article belongs to the Section Nutrition and Public Health)
Show Figures

Figure 1

23 pages, 867 KiB  
Review
Sex Differences in Vitamin Metabolism and Their Role in Oxidative Stress Regulation and Cardiometabolic Health
by Joanna Wróblewska, Anna Długosz, Marcin Wróblewski, Jarosław Nuszkiewicz, Weronika Wróblewska and Alina Woźniak
Nutrients 2025, 17(16), 2697; https://doi.org/10.3390/nu17162697 - 20 Aug 2025
Abstract
Vitamins A, D, E, K, B2, B12, and C play a key role in regulating metabolism and oxidative stress, significantly impacting cardiometabolic health. This review uniquely integrates mechanistic and epidemiological data to examine sex-specific differences in the bioavailability, metabolism, and physiological effects of [...] Read more.
Vitamins A, D, E, K, B2, B12, and C play a key role in regulating metabolism and oxidative stress, significantly impacting cardiometabolic health. This review uniquely integrates mechanistic and epidemiological data to examine sex-specific differences in the bioavailability, metabolism, and physiological effects of these vitamins. By linking hormonal and genetic factors with oxidative stress modulation, lipid metabolism, and endothelial function, we outline how individualized vitamin intake strategies may help prevent cardiovascular and metabolic disorders. The paper also identifies natural dietary sources and optimal intake recommendations for each vitamin, emphasizing the importance of tailoring supplementation to sex-related needs. This sex-focused perspective provides a basis for developing personalized nutrition approaches to optimize cardiometabolic outcomes. Full article
15 pages, 1583 KiB  
Brief Report
Oral Health Status and Parental Awareness in Children with X-Linked Hypophosphatemic Rickets: A Case-Control Study
by Victoria Zlateva, Krasimir Hristov, Zdravka Todorova and Ralitsa Bogovska-Gigova
Reports 2025, 8(3), 151; https://doi.org/10.3390/reports8030151 - 20 Aug 2025
Abstract
X-linked hypophosphatemic rickets (XLH) is a rare genetic disorder with a frequency of 1:20,000, caused by mutations in the PHEX gene, resulting in impaired phosphate metabolism and bone mineralization. There is an association between hypophosphatemia and dental issues, though this link is not [...] Read more.
X-linked hypophosphatemic rickets (XLH) is a rare genetic disorder with a frequency of 1:20,000, caused by mutations in the PHEX gene, resulting in impaired phosphate metabolism and bone mineralization. There is an association between hypophosphatemia and dental issues, though this link is not definitively established. This study aims to evaluate the dental status, including oral hygiene, caries prevalence, and malocclusions, as well as parental awareness of dental complications, in children with XLH in Bulgaria, particularly those receiving or about to begin burosumab treatment, and to compare their oral health status with that of healthy children. Eleven children with XLH (seven girls, four boys, aged 2.5–17 years), nine receiving burosumab, were assessed and compared with eleven age- and gender-matched healthy children (seven girls, four boys, aged 2.5–17 years) without XLH or systemic conditions affecting dental health. Parental awareness of dental implications was assessed via a questionnaire, revealing no awareness of potential complications. Oral hygiene, measured using the Oral Hygiene Index-Simplified (OHI-s), was poor in 66.67% of children, with an average of 6.45 ± 5.80 carious lesions per child, and was highest in the 11–16 age group. Malocclusions were observed in 63.64% of children, and spontaneous endodontic infections occurred in 18.18%. Compared with healthy children, patients with XLH had significantly worse oral hygiene (p = 0.013) and a higher caries prevalence (p = 0.001). Children with XLH exhibit poor oral hygiene, a high caries burden, and frequent malocclusions, compounded by a lack of parental awareness of dental risks. These findings underscore the need for targeted dental interventions and education in XLH management, including the integration of routine dental assessments and structured parental education programs into existing clinical protocols to improve oral health outcomes. Full article
(This article belongs to the Special Issue Oral Disorders in the Pediatric Population)
Show Figures

Figure 1

28 pages, 1337 KiB  
Review
Recent Advances in Microbial Bioconversion as an Approach to Boost Hydroxytyrosol Recovery from Olive Mill Wastewater
by Irene Maria Zingale, Anna Elisabetta Maccarronello, Claudia Carbone, Cinzia Lucia Randazzo, Teresa Musumeci and Cinzia Caggia
Fermentation 2025, 11(8), 477; https://doi.org/10.3390/fermentation11080477 - 20 Aug 2025
Abstract
Olive mill wastewater (OMWW) is a highly complex matrix derived from olive oil extraction, containing phenolic compounds, lipids, minerals, and organic acids. Hydroxytyrosol (HT), an outstanding antioxidant and health-promoting phenolic compound, has garnered significant interest as a natural preservative and functional ingredient. Enzymatic [...] Read more.
Olive mill wastewater (OMWW) is a highly complex matrix derived from olive oil extraction, containing phenolic compounds, lipids, minerals, and organic acids. Hydroxytyrosol (HT), an outstanding antioxidant and health-promoting phenolic compound, has garnered significant interest as a natural preservative and functional ingredient. Enzymatic hydrolysis, utilizing purified enzymes to cleave glycosidic or ester bonds, and microbial bioconversion, employing whole microorganisms with their intrinsic enzymes and metabolic pathways, are effective biotechnological strategies for fostering the release of HT from its conjugated forms. These approaches offer great potential for the sustainable recovery of HT from OMWW, contributing to the valorization of this environmentally impactful agro-industrial by-product. Processed OMWW can lead to clean-label HT-enriched foods and beverages, capitalizing on by-product valorization and improving food safety and quality. In this review, the most important aspects of the chemistry, technology, and microbiology of OMWW were explored in depth. Recent trends and findings in terms of both enzymatic and microbial bioconversion processes are critically discussed, including spontaneous and driven fermentation, using selected microbial strains. These approaches are presented as economically viable options for obtaining HT-enriched OMWW for applications in the food and nutraceutical sectors. The selected topics aim to provide the reader with a solid background while inspiring and facilitating future research and innovation. Full article
(This article belongs to the Special Issue Microbial Upcycling of Organic Waste to Biofuels and Biochemicals)
Show Figures

Figure 1

19 pages, 1259 KiB  
Article
Planetary Health Diet and Body Mass Distribution in Relation to Kidney Health: Evidence from NHANES 2003–2018
by Guido Gembillo, Luca Soraci, Maria Elsa Gambuzza, Maria Princiotto, Antonino Catalano, Edlin Villalta, Salvatore Silipigni, Giada Ida Greco, Andrea Corsonello and Domenico Santoro
Nutrients 2025, 17(16), 2692; https://doi.org/10.3390/nu17162692 - 20 Aug 2025
Abstract
Background/Objectives: Chronic kidney disease (CKD) and diabetic kidney disease (DKD) are growing public health challenges. While diet and body composition influence metabolic and renal health, their combined role remains underexplored. This study investigates the association between the Planetary Health Diet Index (PHDI), body [...] Read more.
Background/Objectives: Chronic kidney disease (CKD) and diabetic kidney disease (DKD) are growing public health challenges. While diet and body composition influence metabolic and renal health, their combined role remains underexplored. This study investigates the association between the Planetary Health Diet Index (PHDI), body mass distribution, and the prevalence of CKD and DKD in U.S. adults. Methods: We analyzed data from 8093 adults aged ≥40 years from NHANES 2003–2018. PHDI was computed using two 24 h dietary recalls. Body composition was assessed using dual-energy X-ray absorptiometry (DXA), focusing on the android-to-gynoid fat ratio (AGFR) and lean mass ratio (AGLR). Survey-weighted linear and logistic regressions evaluated cross-sectional associations between PHDI score, body composition indices, and prevalence of CKD and DKD. Mediation analyses explored AGLR, AGFR, and body mass index (BMI) as potential mediators of the association between PHDI score and either CKD or DKD. Results: Higher PHDI scores were mildly associated with lower odds of CKD (OR per 10-point increase: 0.91; 95% CI: 0.83–0.99) and DKD (OR: 0.86; 95% CI: 0.76–0.97). Greater PHDI scores correlated with lower BMI, AGFR, and AGLR. Among participants with diabetes, AGLR mediated 17% of the relationship between a 10-point increase in PHDI score and decreased DKD prevalence, suggesting central lean mass distribution as a relevant pathway. No significant mediation was observed for AGFR, BMI, or for CKD. Conclusions: Adherence to PHD is associated with healthier body composition and lower prevalence of CKD and DKD. These findings support the promotion of dietary strategies that enhance metabolic and renal health in middle-aged and older individuals. Full article
Show Figures

Figure 1

18 pages, 3970 KiB  
Article
Cassava–Maize Rotation Improves Soil Quality and Microbial Gene Profiles Compared to Continuous Cassava Cropping
by Yanmei Zhu, Yundong Wei and Xingming Qin
Agronomy 2025, 15(8), 1999; https://doi.org/10.3390/agronomy15081999 - 20 Aug 2025
Abstract
Due to limited land resources and traditional farming practices, continuous cassava cropping is common in China. This practice leads to soil degradation, including reduced fertility, imbalanced microbial communities, and lower crop yields. In this study, we investigated the impacts of continuous cassava cropping [...] Read more.
Due to limited land resources and traditional farming practices, continuous cassava cropping is common in China. This practice leads to soil degradation, including reduced fertility, imbalanced microbial communities, and lower crop yields. In this study, we investigated the impacts of continuous cassava cropping (CC) and cassava–maize rotation (RC) systems on soil physicochemical properties, microbial community composition, and functional gene abundance related to carbon and nitrogen cycling. The RC system consists of a five-year rotation cycle: cassava is planted in the first year, followed by two consecutive years of maize, and then, cassava is planted again in the last two years. The soil type is classified as Haplic Acrisols with a clay loam texture in this research. Soil samples from both cropping systems were analyzed for physicochemical properties and enzyme activities, and the results showed significant decreases in soil pH, available nitrogen, available phosphorus, and available potassium in CC. Using metagenomic sequencing, 1,280,928 and 1,224,958 unigenes were identified under RC and CC, respectively, with differences in microbial taxonomic and functional profiles. Bacteria accounted for 89.257% of the soil community in RC, whereas the proportion was 88.72% in CC. The proportions of eukaryota and viruses in RC were 0.031% and 0.006%, respectively; in contrast, their proportions were 0.04% and 0.02% in CC, respectively. Cassava–maize rotation promoted the metabolic activities of soil microbes, leading to a significant enhancement in functional genes related to nitrogen and carbon cycling, such as nasA, nasD, nrtC, coxA, porA, and frdA. This shows that microbial activity and nutrient cycling improved in the crop rotation system. Thus, these findings highlight the importance of crop rotation for maintaining soil health, enhancing microbial functions, and improving sustainable cassava production. This study provides valuable insights into the management of cassava agroecosystems and the mitigation of the adverse effects of continuous cropping. Full article
(This article belongs to the Section Innovative Cropping Systems)
Show Figures

Figure 1

18 pages, 2961 KiB  
Article
Office Posture Detection Using Ceiling-Mounted Ultra-Wideband Radar and Attention-Based Modality Fusion
by Wei Lu, Christopher Bird, Moid Sandhu and David Silvera-Tawil
Sensors 2025, 25(16), 5164; https://doi.org/10.3390/s25165164 - 20 Aug 2025
Abstract
Prolonged sedentary behavior in office environments is a key risk factor for musculoskeletal disorders and metabolic health issues. While workplace stretching interventions can mitigate these risks, effective monitoring solutions are often limited by privacy concerns and constrained sensor placement. This study proposes a [...] Read more.
Prolonged sedentary behavior in office environments is a key risk factor for musculoskeletal disorders and metabolic health issues. While workplace stretching interventions can mitigate these risks, effective monitoring solutions are often limited by privacy concerns and constrained sensor placement. This study proposes a ceiling-mounted ultra-wideband (UWB) radar system for privacy-preserving classification of working and stretching postures in office settings. In this study, data were collected from ten participants in five scenarios: four posture classes (seated working, seated stretching, standing working, standing stretching), and empty environment. Distance and Doppler information extracted from the UWB radar signals was transformed into modality-specific images, which were then used as inputs to two classification models: ConcatFusion, a baseline model that fuses features by concatenation, and AttnFusion, which introduces spatial attention and convolutional feature integration. Both models were evaluated using leave-one-subject-out cross-validation. The AttnFusion model outperformed ConcatFusion, achieving a testing accuracy of 90.6% and a macro F1-score of 90.5%. These findings demonstrate the effectiveness of a ceiling-mounted UWB radar combined with attention-based modality fusion for unobtrusive office posture monitoring. The approach offers a privacy-preserving solution with potential applications in real-time ergonomic assessment and integration into workplace health and safety programs. Full article
(This article belongs to the Special Issue Sensor-Based Human Activity Recognition)
Show Figures

Figure 1

20 pages, 8469 KiB  
Review
Electrochemical Biosensors for Oilseed Crops: Nanomaterial-Driven Detection and Smart Agriculture
by Youwei Jiang, Kun Wan, Aiting Chen, Nana Tang, Na Liu, Tao Zhang, Qijun Xie and Quanguo He
Foods 2025, 14(16), 2881; https://doi.org/10.3390/foods14162881 - 20 Aug 2025
Abstract
Electrochemical biosensors have emerged as a promising tool for the early detection of diseases in oilseed crops such as rapeseed, soybean, and peanut. These biosensors offer high sensitivity, portability, and cost-effectiveness. Timely diagnosis is critical, as many pathogens exhibit latent infection phases or [...] Read more.
Electrochemical biosensors have emerged as a promising tool for the early detection of diseases in oilseed crops such as rapeseed, soybean, and peanut. These biosensors offer high sensitivity, portability, and cost-effectiveness. Timely diagnosis is critical, as many pathogens exhibit latent infection phases or produce invisible metabolic toxins, leading to substantial yield losses before visible symptoms occur. This review summarises recent advances in the field of nanomaterial-assisted electrochemical sensing for oilseed crop diseases, with a particular focus on sensor mechanisms, interface engineering, and biomolecular recognition strategies. The following innovations are highlighted: nanostructured electrodes, aptamer- and antibody-based probes, and signal amplification techniques. These innovations have enabled the detection of pathogen DNA, enzymes, and toxins at ultra-low concentrations. Notwithstanding these achievements, challenges persist, including signal interference from plant matrices, limitations in device miniaturization, and the absence of standardized detection protocols. Future research should explore the potential of AI-assisted data interpretation, the use of biodegradable sensor materials, and the integration of these technologies with agricultural IoT networks. The aim of this integration is to enable real-time, field-deployable disease surveillance. The integration of laboratory innovations with field applications has been demonstrated to have significant potential in supporting sustainable agriculture and strengthening food security through intelligent crop health monitoring. Full article
Show Figures

Graphical abstract

26 pages, 4388 KiB  
Article
Deciphering Common Genetic Pathways to Antibiotic Resistance in Escherichia coli Using a MEGA-Plate Evolution System
by Nami Morales-Durán, Angel León-Buitimea, Roberto Álvarez Martínez and José Rubén Morones-Ramírez
Antibiotics 2025, 14(8), 841; https://doi.org/10.3390/antibiotics14080841 - 20 Aug 2025
Abstract
Background. Antimicrobial resistance (AMR) poses a significant global health threat, necessitating a deeper understanding of bacterial adaptation mechanisms. Introduction. This study investigates the genotypic and phenotypic evolutionary trajectories of Escherichia coli under meropenem and gentamicin selection, and it benchmarks these findings against florfenicol-evolved [...] Read more.
Background. Antimicrobial resistance (AMR) poses a significant global health threat, necessitating a deeper understanding of bacterial adaptation mechanisms. Introduction. This study investigates the genotypic and phenotypic evolutionary trajectories of Escherichia coli under meropenem and gentamicin selection, and it benchmarks these findings against florfenicol-evolved strains. Methodology. Utilizing a downsized, three-layer acrylic modified “Microbial Evolution and Growth Arena (MEGA-plate) system”—scaled to 40 × 50 cm for sterile handling and uniform 37 °C incubation—we tracked adaptation over 9–13 days, enabling real-time visualization of movement across antibiotic gradients. Results. Meropenem exposure elicited pronounced genetic heterogeneity and morphological remodeling (filamentous and circular forms), characteristic of SOS-mediated division arrest and DNA-damage response. In contrast, gentamicin exposure produced a uniform resistance gene profile and minimal shape changes, suggesting reliance on conserved defenses without major morphological adaptation. Comprehensive genomic analysis revealed a core resistome of 22 chromosomal loci shared across all three antibiotics, highlighting potential cross-resistance and the central roles of baeR, gadX, and marA in coordinating adaptive responses. Gene ontology enrichment underscored the positive regulation of gene expression and intracellular signaling as key themes in resistance evolution. Discussion. Our findings illustrate the multifaceted strategies E. coli employs—combining metabolic flexibility with sophisticated regulatory networks—to withstand diverse antibiotic pressures. This study underscores the utility of the MEGA-plate system in dissecting spatiotemporal AMR dynamics in a controlled yet ecologically relevant context. Conclusions. The divergent responses to meropenem and gentamicin highlight the complexity of resistance development and reinforce the need for integrated, One Health strategies. Targeting shared regulatory hubs may open new avenues for antimicrobial intervention and help preserve the efficacy of existing drugs. Full article
(This article belongs to the Section Mechanism and Evolution of Antibiotic Resistance)
Show Figures

Graphical abstract

5 pages, 297 KiB  
Proceeding Paper
Patterns of Supplement Consumption and Interaction Risks Among Polymedicated Older Adults: A Descriptive Study
by Maria Deolinda Auxtero and Ana Isabel Fernandes
Med. Sci. Forum 2025, 37(1), 4; https://doi.org/10.3390/msf2025037004 - 19 Aug 2025
Abstract
This study investigates the use of food supplements (FS) among polymedicated elderly individuals and assesses potential FS–drug interaction risks. A total of 98 community-dwelling older adults were surveyed and 18.4% reported FS use. FS were mostly used for musculoskeletal and cognitive support, with [...] Read more.
This study investigates the use of food supplements (FS) among polymedicated elderly individuals and assesses potential FS–drug interaction risks. A total of 98 community-dwelling older adults were surveyed and 18.4% reported FS use. FS were mostly used for musculoskeletal and cognitive support, with 71% having potential metabolic interactions via CYP enzymes or P-glycoprotein. Monthly costs reached €55. The findings reveal a complex interaction landscape and financial burden, underscoring the need for medication reviews and health literacy efforts to ensure safer FS use in older adults. This study aligns with One Health principles by linking clinical, social, and economic aspects of aging. Full article
Show Figures

Figure 1

13 pages, 794 KiB  
Communication
Preparturient Oral Selenitetriglycerides Supplementation Elevates Erythrocyte Glutathione Peroxidase Activity and Modulates Hepatic TNF-α, PPAR-α, and PPAR-δ mRNA in Postparturient Holstein–Friesian Cows
by Katarzyna Żarczyńska, Katarzyna Różańska, Paweł Brym and Dawid Tobolski
Int. J. Mol. Sci. 2025, 26(16), 8018; https://doi.org/10.3390/ijms26168018 - 19 Aug 2025
Abstract
The transition period in dairy cows, spanning late pregnancy and early lactation, is associated with substantial metabolic and immunological challenges, leading to increased oxidative stress and inflammation. Selenium (Se), particularly in organic forms, supports antioxidant defenses, immune function, and metabolic regulation. This study [...] Read more.
The transition period in dairy cows, spanning late pregnancy and early lactation, is associated with substantial metabolic and immunological challenges, leading to increased oxidative stress and inflammation. Selenium (Se), particularly in organic forms, supports antioxidant defenses, immune function, and metabolic regulation. This study investigated the effects of supplementing periparturient Holstein–Friesian cows with orally administered selenitetriglycerides (0.5 mg Se/kg body weight/day starting 12 days before the expected calving date and continuing until parturition) on antioxidant enzyme activity and on the hepatic expression of key inflammatory and metabolic genes. Serum selenium concentrations and erythrocyte glutathione peroxidase (GSH-Px) activity were assessed before and after parturition, and hepatic gene expression levels of tumor necrosis factor alpha (TNF-α), peroxisome proliferator-activated receptor alpha (PPAR-α) and delta (PPAR-δ) were assessed 24 h and 7 days postpartum. Supplemented cows showed significantly elevated serum Se levels and increased GSH-Px activity, reflecting improved antioxidant capacity. Moreover, hepatic expression of TNF-α and PPAR-δ was significantly reduced postpartum in the supplemented group, whereas PPAR-α expression remained stable. These findings indicate that selenitetriglycerides effectively enhance antioxidant defenses, moderate inflammation, and stabilize metabolic pathways during the periparturient phase, potentially reducing postpartum metabolic disorders and improving dairy-cow health. Full article
Show Figures

Figure 1

Back to TopTop