Search Results (18)

Drawing on Karl Marx’s ecological concepts of the “metabolic rift” and the “emancipation of senses”, this paper explores an alternative ecocinema that integrates the ecological with the social and the economic. Early Hollywood films, such as Sunrise: A Song of Two Humans (1927) and The Good Earth (1937), represent the metabolic rift in human relationships as a byproduct of the metabolic rift with nature created in the process of urbanization; hence, they can be regarded as precursors to an alternative ecocinema, which I refer to as “metabolic cinema”. The Story of the Golden Bell (Jinling Zhuan), a comedy film produced during the Chinese Great Leap Forward in 1958, offers an intriguing case for socialist metabolic cinema as a multisensory medianature that participates in and facilitates the metabolic process between humans and nature, as well as the social metabolism among humans, despite the period’s notorious ecological record. The film not only consciously moves away from the visual-centric model associated with capitalist consumerism by using the aural to rectify the once-aberrant visual but also demonstrates how romantic love, as one of the human senses, must be emancipated along with other senses through denouncing utilitarianism and commercialism and, subsequently, returning to need-based labor as the universal condition for the metabolic interaction between humans and nature. Full article

This study focused on one of the formulas for assessing social metabolism, specifically derived from individual variables. The formula was utilized as a framework for analyzing agricultural activities and combatting food vulnerability in urban communities. Bandung, the capital city of West Java in Indonesia, has implemented an urban agricultural program called Buruan SAE, using a policy formulation oriented towards food self-sufficiency for low-income citizens. This program utilized a policy formulation that involved using empty residential land owned by low-income citizens, distributing food to surrounding residents indiscriminately, and working towards anticipating nutritional vulnerability (stunting). However, the implementation had the opposite effect and pushed urban agriculture into becoming stagnant and undeveloped. This study aims to use individual rift theory as the analytic axiom to discuss the stagnation in the implementation of policy. The analysis was performed using a social monitoring method to form policy instruments that analyze Buruan SAE’s stagnation in Bandung City. Full article

The aim of this article is to show that what seems natural today has a long social and environmental history, associated with the way in which territory has been socially produced. Socioenvironmental change is not natural, but instead is a political ecological project, and in this case, a colonial project deeply connected with the form that capitalism took in Southern Chile from the 16th century. This paper aims to connect three things: the colonial encomienda system as a primitive accumulation based on the capture of people and land to produce profit, the metabolic rift produced by colonial territorial relationships, and the emergence of a new nature which, dialectically, destroyed and created the conditions for the Indigenous uprisings, and the Mapuche resistance that continues today. The case of the fort in Mariquina Valley is used to illustrate the interlinkages between historical geography and landscape archaeology, to make the colonial production of nature visible, to understand how the Spanish fortress supported the production of the new colonial nature and the dispossession and transformation of the Indigenous territories. Full article

The Paleozoic volcano-sedimentary rocks within the structural basement of the horst-and-graben system of the Catalan Coastal Ranges (CCR) are composed of black shale, volcaniclastic sediments, lava flows, sills and lithocrystalloclastic tuffs. Paleozoic sediments are depleted in high-field strength elements (HFSE) such as Nb, Ta, Zr, Hf and Ti, suggesting their accumulation within the Andean-type active continental margin environment. Volcanic rocks within the Paleozoic CCR sequence belong to shoshonitic and high-K volcanic series and are enriched in Cs, Rb and Ba and depleted in HFSE, which is consistent with their derivation from metasomatized (possibly through deep recycling of pelagic sediments) subduction-related mantle source. The presence of sills (sill-sediment complex) suggests that Paleozoic basement of the CCR was formed within the rifted active continental margin or an arc-back-arc basin system akin to the modern Western Pacific subduction configuration. This complex volcanic terroir hosts world-class wines of the Priorat DOQ region. The presence of framboidal pyrite and magnetite, siderite, sphalerite xenotime, (La–Ce–Nd)-monazite, zircon and baddeleyite, as well as cuprite, tenorite and cupriferous and native silver in volcanic-derived black shale (and consequently in the world-famous “llicorella” soil overlying it) may have had dramatic effects on wine quality and sensory characteristics. These mineral features, together with strong enrichment of Priorat shale in Au, Ag and, to a lesser extent, Pt could have pronounced effects on (1) rates and specific types of chemical reactions; (2) plant metabolism; (3) response to nutrient components and (4) determination of grape flavor. Volcanic wine terroirs, such as the Priorat DOQ region, are special geologic environments for wine growth, capable of producing unique wine aromatic and gustatory characteristics. Full article

Rift valley fever virus (RVFV) is the causative agent of a viral zoonosis that causes a significant clinical burden in domestic and wild ruminants. Major outbreaks of the virus occur in livestock, and contaminated animal products or arthropod vectors can transmit the virus to humans. The viral RNA-dependent RNA polymerase (RdRp; L protein) of the RVFV is responsible for viral replication and is thus an appealing drug target because no effective and specific vaccine against this virus is available. The current study reported the structural elucidation of the RVFV-L protein by in-depth homology modeling since no crystal structure is available yet. The inhibitory binding modes of known potent L protein inhibitors were analyzed. Based on the results, further molecular docking-based virtual screening of Selleckchem Nucleoside Analogue Library (156 compounds) was performed to find potential new inhibitors against the RVFV L protein. ADME (Absorption, Distribution, Metabolism, and Excretion) and toxicity analysis of these compounds was also performed. Besides, the binding mechanism and stability of identified compounds were confirmed by a 50 ns molecular dynamic (MD) simulation followed by MM/PBSA binding free energy calculations. Homology modeling determined a stable multi-domain structure of L protein. An analysis of known L protein inhibitors, including Monensin, Mycophenolic acid, and Ribavirin, provide insights into the binding mechanism and reveals key residues of the L protein binding pocket. The screening results revealed that the top three compounds, A-317491, Khasianine, and VER155008, exhibited a high affinity at the L protein binding pocket. ADME analysis revealed good pharmacodynamics and pharmacokinetic profiles of these compounds. Furthermore, MD simulation and binding free energy analysis endorsed the binding stability of potential compounds with L protein. In a nutshell, the present study determined potential compounds that may aid in the rational design of novel inhibitors of the RVFV L protein as anti-RVFV drugs. Full article

In recent years, the transition to sustainability at a food systems’ scale has drawn major attention both from the scientific and political arenas. Agroecology has become central to such discussions, while impressive efforts have been made to conceptualize the agroecology scaling process. It has thus become necessary to apply the concept of agroecology transitions to the scale of food systems and in different “real-world” contexts. Scaling local agroecology experiences of production, distribution, and consumption, which are often disconnected and/or disorganized, also reveals emergent research gaps. A critical review was performed in order to establish a transdisciplinary dialogue between both political agroecology and the literature on sustainable food systems. The objective was to build insights into how to advance towards Agroecology-based Local Agri-food Systems (ALAS). Our review unveils emergent questions such as: how to overcome the metabolic rift related to segregated activities along the food chain, how to feed cities sustainably, and how they should relate to the surrounding territories, which social subjects should drive such transitions, and which governance arrangements would be needed. The paper argues in favor of the re-construction of food metabolisms, territorial flows, plural subjects and (bottom-up) governance assemblages, placing life at the center of the food system and going beyond the rural–urban divide. Full article

Value chain is identified as the generator of the metabolic rift between nature and society. However, the sustainable value chain can mitigate and reverse this rift. In this paper, firstly, a review of the main digital enablers of Industry 4.0 and the current state of cognitive manufacturing is carried out. Secondly, Cyber-Physical Systems are conceived from the holonic paradigm, as an organizational enabler for the whole of enablers. Thirdly, the bijective relationship between holonic paradigm and container-based technology is analyzed. This technology allows mapping the physical and virtual holon as an intelligent agent embodied at the edge, fog and cloud level, with physical and virtual part. Finally, the proposed holonic system based on the cyber-physical holon is developed through multi-agent systems based on container technology. The proposed system allows to model the metabolism of manufacturing systems, from a cell manufacturing to whole value chain, in order to develop, evolve and improve the sustainable value chain. Full article

Humanity’s present social–ecological metabolic configuration is not sustainable, and the need for a radical transformation of society to address its metabolic rifts with the rest of nature is increasingly apparent. The work of French Marxist Henri Lefebvre, one of the few thinkers to recognize the significance of Karl Marx’s theory of metabolic rift prior to its rediscovery at the end of the twentieth century, offers valuable insight into contemporary issues of sustainability. His concepts of the urban revolution, autogestion, the critique of everyday life, and total (or metabolic) revolution all relate directly to the key concerns of sustainability. Lefebvre’s work embodies a vision of radical social–ecological transformation aimed at sustainable human development, in which the human metabolic interchange with the rest of nature is to be placed under substantively rational and cooperative control by all its members, enriching everyday life. Other critical aspects of Lefebvre’s work, such as his famous concept of the production of space, his temporal rhythmanalysis, and his notion of the right to the city, all point to the existence of an open-ended research program directed at the core issues of sustainability in the twenty-first century. Full article

Pyrethroid resistance in major malaria vectors such as Anopheles funestus threatens malaria control efforts in Africa. Cytochrome P450-mediated metabolic resistance is best understood for CYP6P9 genes in southern Africa in An. funestus. However, we do not know if this resistance mechanism is spreading across Africa and how it relates to broader patterns of gene flow across the continent. Nucleotide diversity of the CYP6P9a gene and the diversity pattern of five gene fragments spanning a region of 120 kb around the CYP6P9a gene were surveyed in mosquitoes from southern, eastern and central Africa. These analyses revealed that a Cyp6P9a resistance-associated allele has swept through southern and eastern Africa and is now fixed in these regions. A similar diversity profile was observed when analysing genomic regions located 34 kb upstream to 86 kb downstream of the CYP6P9a locus, concordant with a selective sweep throughout the rp1 locus. We identify reduced gene flow between southern/eastern Africa and central Africa, which we hypothesise is due to the Great Rift Valley. These potential barriers to gene flow are likely to prevent or slow the spread of CYP6P9-based resistance mechanism to other parts of Africa and would to be considered in future vector control interventions such as gene drive. Full article

With the frequent outbreaks of emerging infectious diseases in recent years, an effective broad-spectrum antiviral drug is becoming an urgent need for global public health. Cholesterol-25-hydroxylase (CH25H) and its enzymatic products 25-hydroxycholesterol (25HC), a well-known oxysterol that regulates lipid metabolism, have been reported to play multiple functions in modulating cholesterol homeostasis, inflammation, and immune responses. CH25H and 25HC were recently identified as exerting broadly antiviral activities, including upon a variety of highly pathogenic viruses such as human immunodeficiency virus (HIV), Ebola virus (EBOV), Nipah virus (NiV), Rift Valley fever virus (RVFV), and Zika virus (ZIKV). The underlying mechanisms for its antiviral activities are being extensively investigated but have not yet been fully clarified. In this study, we summarized the current findings on how CH25H and 25HC play multiple roles to modulate cholesterol metabolism, inflammation, immunity, and antiviral infections. Overall, 25HC should be further studied as a potential therapeutic agent to control emerging infectious diseases in the future. Full article

The purpose of this paper is to conceptualize a circular business model based on an Eco-Holonic Architecture, through the integration of circular economy and holonic principles. A conceptual model is developed to manage the complexity of integrating circular economy principles, digital transformation, and tools and frameworks for sustainability into business models. The proposed architecture is multilevel and multiscale in order to achieve the instantiation of the sustainable value chain in any territory. The architecture promotes the incorporation of circular economy and holonic principles into new circular business models. This integrated perspective of business model can support the design and upgrade of the manufacturing companies in their respective industrial sectors. The conceptual model proposed is based on activity theory that considers the interactions between technical and social systems and allows the mitigation of the metabolic rift that exists between natural and social metabolism. This study contributes to the existing literature on circular economy, circular business models and activity theory by considering holonic paradigm concerns, which have not been explored yet. This research also offers a unique holonic architecture of circular business model by considering different levels, relationships, dynamism and contextualization (territory) aspects. Full article

Chile has gone through more than four decades of neoliberalism, inaugurated by the civil–military dictatorship (1973–1990). One of the central aspects of the current model is the neoliberal exploitation of natural commons such as land, water and minerals. In some territories, such as the central-north province of Petorca, the accelerated extractivism of this period has disrupted the reproduction of life cycles, leading to disruptive influences in the form of "socio-metabolic fractures". In this article we highlight aspects of this process as it relates to rural community water management. Based on literature and media analysis we first describe the case of Petorca from a political, ecological point of view. We then use the concept of institutional bricolage (ad hoc construction) to analyze qualitative interviews, allowing us to establish a more in-depth insight into the organizational structures of Petorca. Although we point to the weakening of community organization, we highlight in this article how, in a scenario of profound dispossession, as is taking place in the province of Petorca, ongoing experiences of community organization continue to emerge and challenge the impacts of the socio-metabolic rift. Thereby we shed light upon the often less visible structures of power and the processes of meaning and legitimacy within these social innovations. Full article

The circular economy (CE) is widely known as a way to implement and achieve sustainability, mainly due to its contribution towards the separation of biological and technical nutrients under cyclic industrial metabolism. The incorporation of the principles of the CE in the links of the value chain of the various sectors of the economy strives to ensure circularity, safety, and efficiency. The framework proposed is aligned with the goals of the 2030 Agenda for Sustainable Development regarding the orientation towards the mitigation and regeneration of the metabolic rift by considering a double perspective. Firstly, it strives to conceptualize the CE as a paradigm of sustainability. Its principles are established, and its techniques and tools are organized into two frameworks oriented towards causes (cradle to cradle) and effects (life cycle assessment), and these are structured under the three pillars of sustainability, for their projection within the proposed framework. Secondly, a framework is established to facilitate the implementation of the CE with the use of standards, which constitute the requirements, tools, and indicators to control each life cycle phase, and of key enabling technologies (KETs) that add circular value 4.0 to the socio-ecological transition. Full article

This article will explore how degrowth imaginaries inform the representation of social reproduction and environmental collapse in Jenni Fagan’s The Sunlight Pilgrims (2016) and John Burnside’s Havergey (2017). It will argue that the two novels deploy the trope of the end of times to frame the unravelling of the world-ecology that binds capital and nature together in the Capitalocene, according to Jason Moore. They suggest that this is what makes possible, and necessary, a re-organisation of social reproduction and of the patterns of energy consumption or generation with which this is entangled. The first part of this article will examine the metabolic rift with which The Sunlight Pilgrims and Havergey are concerned, while the second part will delineate the ways in which degrowth imaginaries frame the representation of reorganised forms of social (re-)production. Drawing on disability studies and situating The Sunlight Pilgrims and Havergey within the disciplinary framework of Scottish literature, I will continue to consider how Burnside’s and Fagan’s novels feature narratives of disability and the nation. These may come across as marginal to the plot but function as the foci through which the politics of the degrowth communities represented come to the fore. Full article

The vague, yet undoubtedly desirable, notion of sustainability has been discussed and debated by many natural and social scientists. We argue that mainstream conceptions of sustainability, and the related concept of sustainable development, are mired in a “pre-analytic vision” that naturalizes capitalist social relations, closes off important questions regarding economic growth, and thus limits the potential for an integrative socio-ecological analysis. Theoretical and empirical research within environmental sociology provides key insights to overcome the aforementioned problems, whereby the social, historical, and environmental relationships associated with the tendencies and qualities of the dominant economic system are analyzed. We highlight how several environmental sociology perspectives—such as human ecology, the treadmill of production, and metabolic analysis—can serve as the basis for a more integrative socio-ecological conception and can help advance the field of sustainability science. Full article