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Keywords = optoelectronic feedback

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12 pages, 2752 KB  
Article
Frequency-Stable Low-Threshold SBS-OEO for Precision Temperature Sensing in Electromagnetically Harsh Environments
by Yichao Teng, Mingyuan Yang, Li Han, Jixuan Wang and Guanbo Liu
Sensors 2025, 25(19), 6166; https://doi.org/10.3390/s25196166 - 5 Oct 2025
Viewed by 287
Abstract
In this research, precision temperature sensing for electromagnetically harsh environments was achieved utilizing a low-threshold frequency-stable optoelectronic oscillator (OEO) leveraging stimulated Brillouin scattering (SBS). The sensing mechanism relied on the temperature-dependent frequency shift in the SBS-induced notch filter. By embedding this filter in [...] Read more.
In this research, precision temperature sensing for electromagnetically harsh environments was achieved utilizing a low-threshold frequency-stable optoelectronic oscillator (OEO) leveraging stimulated Brillouin scattering (SBS). The sensing mechanism relied on the temperature-dependent frequency shift in the SBS-induced notch filter. By embedding this filter in the OEO feedback loop, the oscillator’s output frequency was locked to the difference between the optical carrier frequency and the SBS notch center frequency. The temperature variations were translated into microwave frequency shifts through OEO oscillation, which was quantified with heterodyne detection. To suppress environmental perturbations, a Faraday rotation mirror (FRM) was integrated at the fiber end, creating a dual-pass SBS interaction that simultaneously enhanced the vibration immunity and reduced the SBS power threshold by 2.7 dB. The experimental results demonstrated a sensitivity of 1.0609 MHz/°C (R2 = 0.999) and a long-term stability of ±0.004 °C. This innovative scheme demonstrated significant advantages over conventional SBS-OEO temperature sensing approaches, particularly in terms of threshold reduction and environmental stability enhancement. Full article
(This article belongs to the Section Sensors Development)
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14 pages, 14034 KB  
Article
Study on the Dynamic Characteristics of DM-DFBL Self-Delayed Feedback with an Optoelectronic Oscillation Loop
by Nian Xie, Guangfu Bai, Yuanfen Li, Gang Kuang, Shu Xu, Daokai Huang, Xiaonan Wei, Qingzhe Wu and Weichao Huang
Photonics 2025, 12(5), 479; https://doi.org/10.3390/photonics12050479 - 13 May 2025
Viewed by 454
Abstract
Nonlinear dynamical states generated by self-delayed feedback based on fiber structures have broad applications. However, fiber-based optoelectronic feedback or pure optical feedback systems exhibit long delays, and the coupling mechanisms between these two loops differ significantly from those in short-delay systems. A systematic [...] Read more.
Nonlinear dynamical states generated by self-delayed feedback based on fiber structures have broad applications. However, fiber-based optoelectronic feedback or pure optical feedback systems exhibit long delays, and the coupling mechanisms between these two loops differ significantly from those in short-delay systems. A systematic investigation of feedback coupling mechanisms under long-delay conditions is of great significance for optimizing such systems. In this paper, the nonlinear dynamic state generated by directly modulated distributed feedback semiconductor laser (DM-DFBL) self-delayed feedback with an optoelectronic oscillation loop is studied. Both numerical and experimental results show that the DM-DFBL’s dynamical states vary with changes in optical and electrical feedback intensities. In the self-delayed feedback, the DM-DFBL exhibits an evolutionary path from a chaos (CO) state to a period-one (P1) state and finally becomes a steady state with the decrease of optical feedback intensity. In the optoelectronic oscillation loop, the DM-DFBL generates a microwave frequency comb (MFC), a full-frequency oscillation, and a P1 state. Additionally, the dynamic state of the DM-DFBL can be disturbed, and the stability of the P1 state and the QP state can be enhanced when the optoelectronic oscillation loop is introduced. These conclusions contribute to the precise control of dynamic evolution. Full article
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18 pages, 3038 KB  
Article
Design of a Low-Noise Subthreshold CMOS Inverter-Based Amplifier with Resistive Feedback
by Landon Schmucker, Payman Zarkesh-Ha, Luke Emmert, Wolfgang Rudolph and Vitaly Gruzdev
Electronics 2025, 14(5), 902; https://doi.org/10.3390/electronics14050902 - 25 Feb 2025
Viewed by 2331
Abstract
The recent trend in analog design to replace typical analog circuits with digital implementations has led to the use of resistive feedback to pull a CMOS inverter into the switching threshold region to achieve gain, which is ideal for analog operations. Here, we [...] Read more.
The recent trend in analog design to replace typical analog circuits with digital implementations has led to the use of resistive feedback to pull a CMOS inverter into the switching threshold region to achieve gain, which is ideal for analog operations. Here, we report a three-transistor (3T) CMOS resistive-feedback inverter-based amplifier capable of achieving high gain paralleled with reduced noise, low power consumption, and enhanced stability. Unlike conventional resistive-feedback inverter-based amplifiers, the transistors are operated in the subthreshold region, which allows for a lower supply voltage and current, leading to lower power consumption. Subthreshold conduction also reduces typical amplifier noise sources. This design provides a novel approach to resistive feedback in the inverter amplifier, allowing for a large gain while occupying minimal layout area. The reported amplifier design facilitates unique capabilities, e.g., detection of ultra-low (fC) charges or sub-pA currents for newly emerging PHz electronic and optoelectronic devices driven by few-cycle laser pulses. As proof of concept, the specifications of the proposed amplifier are successfully measured and verified by multiple test chips designed and fabricated in TSMC’s 180 nm CMOS process. The fabricated amplifier operates at a 1.35 V power supply with a measured voltage gain of 53.61 dB (or 480 V/V), a bandwidth of 94 kHz, and an equivalent input voltage noise of 6.4 nV/Hz, consuming only 13.5 µW. Full article
(This article belongs to the Section Circuit and Signal Processing)
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10 pages, 3762 KB  
Article
All-Optical Single-Longitudinal-Mode Forward Brillouin Microwave Oscillator with an Unbalanced Fiber Mach–Zehnder Interferometer
by Xinyue Fang, Wenjun He, Wen Wang, Yi Liu, Yajun You, Qing Yan, Yafei Hou, Zepeng Wu, Lei Yu, Songquan Yan, Mingxing Li, Jian He and Xiujian Chou
Micromachines 2025, 16(2), 209; https://doi.org/10.3390/mi16020209 - 12 Feb 2025
Viewed by 916
Abstract
An all-optical single-longitudinal-mode (SLM) forward Brillouin microwave oscillator (FB-MO) with an unbalanced Fiber Mach–Zehnder interferometer (UF-MZI) for microwave photonics (MWP) generation is proposed and experimentally investigated. UF-MZI consists of an optical coupler (OC), a polarization controller (PC), and two asymmetric length arms with [...] Read more.
An all-optical single-longitudinal-mode (SLM) forward Brillouin microwave oscillator (FB-MO) with an unbalanced Fiber Mach–Zehnder interferometer (UF-MZI) for microwave photonics (MWP) generation is proposed and experimentally investigated. UF-MZI consists of an optical coupler (OC), a polarization controller (PC), and two asymmetric length arms with 5 km and 500 m single-mode fibers (SMFs), which implements two unbalanced length feedback rings that are connected to one another. One long-length ring with a forward Brillouin gain cooperates with the other short-length ring to maintain a spectral Vernier effect and improve the effective free spectral range (FSR). By contrast with traditional optoelectronic oscillators (OEOs), this design does not require any photoelectric conversion devices and additional modulation, avoids external electromagnetic interference, and side-mode suppression and linewidth are favorable. Experimental results reveal that the 3-dB linewidth of the all-optical SLM FB-MO with UF-MZI is about 140 Hz. The acoustic-mode and side-mode suppression ratios are 26 dB and 31 dB. Within 60 min of the stability experiment, the power and frequency stability fluctuation were ±1 dB and ±100 Hz. Thanks to its long main ring cavity length, our all-optical SLM FB-MO with UF-MZI maintains good phase-noise performance. The measurement shows that a phase noise as low as −120 dBc/Hz at an offset frequency of 100 kHz is achieved. This SLM MWP generation technology holds great potential for applications in radar monitoring and wireless communication systems. Full article
(This article belongs to the Special Issue Fiber-Optic Technologies for Communication and Sensing)
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19 pages, 5615 KB  
Article
An Approach to Reduce Tuning Sensitivity in the PIC-Based Optoelectronic Oscillator by Controlling the Phase Shift in Its Feedback Loop
by Vladislav Ivanov, Ivan Stepanov, Grigory Voronkov, Ruslan Kutluyarov and Elizaveta Grakhova
Micromachines 2025, 16(1), 32; https://doi.org/10.3390/mi16010032 - 28 Dec 2024
Cited by 1 | Viewed by 1392
Abstract
Radio photonic technologies have emerged as a promising solution for addressing microwave frequency synthesis challenges in current and future communication and sensing systems. One particularly effective approach is the optoelectronic oscillator (OEO), a simple and cost-effective electro-optical system. The OEO can generate microwave [...] Read more.
Radio photonic technologies have emerged as a promising solution for addressing microwave frequency synthesis challenges in current and future communication and sensing systems. One particularly effective approach is the optoelectronic oscillator (OEO), a simple and cost-effective electro-optical system. The OEO can generate microwave signals with low phase noise and high oscillation frequencies, often outperforming traditional electrical methods. However, a notable disadvantage of the OEO compared to conventional signal generation methods is its significant frequency tuning step. This paper presents a novel approach for continuously controlling the output frequency of an optoelectronic oscillator (OEO) based on integrated photonics. This is achieved by tuning an integrated optical delay line within a feedback loop. The analytical model developed in this study calculates the OEO’s output frequency while accounting for nonlinear errors, enabling the consideration of various control schemes. Specifically, this study examines delay lines based on the Mach–Zehnder interferometer and microring resonators, which can be controlled by either the thermo-optic or electro-optic effect. To evaluate the model, we conducted numerical simulations using Ansys Lumerical software. The OEO that utilized an MRR-based electro-optical delay line demonstrated a tuning sensitivity of 174.5 MHz/V. The calculated frequency tuning sensitivity was as low as 6.98 kHz when utilizing the precision digital-to-analog converter with a minimum output voltage step of 40 μV. The proposed approach to controlling the frequency of the OEO can be implemented using discrete optical components; however, this approach restricts the minimum frequency tuning sensitivity. It provides an additional degree of freedom for frequency tuning within the OEO’s operating range, which is ultimately limited by the amplitude-frequency characteristic of the notch filter. Thus, the proposed approach opens up new opportunities for increasing the accuracy and flexibility in generating microwave signals, which can be significant for various communications and radio engineering applications. Full article
(This article belongs to the Special Issue Silicon Photonics–CMOS Integration and Device Applications)
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12 pages, 6298 KB  
Article
A CMOS Optoelectronic Transimpedance Amplifier Using Concurrent Automatic Gain Control for LiDAR Sensors
by Yeojin Chon, Shinhae Choi and Sung-Min Park
Photonics 2024, 11(10), 974; https://doi.org/10.3390/photonics11100974 - 17 Oct 2024
Cited by 1 | Viewed by 2299
Abstract
This paper presents a novel optoelectronic transimpedance amplifier (OTA) for short-range LiDAR sensors used in 180 nm CMOS technology, which consists of a main transimpedance amplifier (m-TIA) with an on-chip P+/N-well/Deep N-well avalanche photodiode (P+/NW/DNW APD) and a replica [...] Read more.
This paper presents a novel optoelectronic transimpedance amplifier (OTA) for short-range LiDAR sensors used in 180 nm CMOS technology, which consists of a main transimpedance amplifier (m-TIA) with an on-chip P+/N-well/Deep N-well avalanche photodiode (P+/NW/DNW APD) and a replica TIA with another on-chip APD, not only to acquire circuit symmetry but to also obtain concurrent automatic gain control (AGC) function within a narrow single pulse-width duration. In particular, for concurrent AGC operations, 3-bit PMOS switches with series resistors are added in parallel with the passive feedback resistor in the m-TIA. Then, the PMOS switches can be turned on or off in accordance with the DC output voltage amplitudes of the replica TIA. The post-layout simulations reveal that the OTA extends the dynamic range up to 74.8 dB (i.e., 1 µApp~5.5 mApp) and achieves a 67 dBΩ transimpedance gain, an 830 MHz bandwidth, a 16 pA/Hz noise current spectral density, a −31 dBm optical sensitivity for a 10−12 bit error rate, and a 6 mW power dissipation from a single 1.8 V supply. The chip occupies a core area of 200 × 120 µm2. Full article
(This article belongs to the Section Optoelectronics and Optical Materials)
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12 pages, 1071 KB  
Article
A Numerical Study of Microwave Frequency Comb Generation in a Semiconductor Laser Subject to Modulated Optical Injection and Optoelectronic Feedback
by Chenpeng Xue, Wei Chen, Beibei Zhu, Zuxing Zhang and Yanhua Hong
Photonics 2024, 11(8), 741; https://doi.org/10.3390/photonics11080741 - 8 Aug 2024
Cited by 2 | Viewed by 1502
Abstract
This study presents a comprehensive numerical investigation on the generation of a microwave frequency comb (MFC) using a semiconductor laser subjected to periodic-modulated optical injection. To enhance performance, optoelectronic feedback is incorporated through a dual-drive Mach–Zehnder modulator. The results show that the first [...] Read more.
This study presents a comprehensive numerical investigation on the generation of a microwave frequency comb (MFC) using a semiconductor laser subjected to periodic-modulated optical injection. To enhance performance, optoelectronic feedback is incorporated through a dual-drive Mach–Zehnder modulator. The results show that the first optoelectronic feedback loop, with a delay time inversely proportional to the modulation frequency, can optimize MFC generation through a mode-locking effect and the second optoelectronic feedback loop with a multiple delay time of the first one can further enhance the performance of the MFC. The comb linewidth appears to decrease with the increase in the second-loop delay time in the power function. These results are consistent with experimental observations reported in the literature. We also explore the impact of the feedback index on comb contrast, the statistical characteristics of the central 128 lines within the MFC, and side peak suppression. The simulation results demonstrate the presence of an optimal feedback index. The study also reveals that linewidth reduction, through increasing the feedback index and delay time, comes at the cost of declining side peak suppression. These findings collectively contribute to a deeper understanding of the factors influencing MFC generation and pave the way for the design and optimization of high-performance MFC systems for various applications. Full article
(This article belongs to the Special Issue New Perspectives in Microwave Photonics)
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11 pages, 2726 KB  
Article
A DFB-SOA Based Optical Vector Network Analyzer for Characterization of Bandpass Optical Devices
by Ye Deng, Hui Gao, Zhixiong Shen, Bin Li and Jinping Zhang
Appl. Sci. 2024, 14(15), 6644; https://doi.org/10.3390/app14156644 - 30 Jul 2024
Viewed by 1154
Abstract
In this paper a novel optical vector network analyzer (OVNA) utilizing a distributed feedback semiconductor optical amplifier (DFB-SOA) is introduced. The proposed OVNA is implemented by converting the transmission response of the optical device under test (ODUT) into the electrical domain. The main [...] Read more.
In this paper a novel optical vector network analyzer (OVNA) utilizing a distributed feedback semiconductor optical amplifier (DFB-SOA) is introduced. The proposed OVNA is implemented by converting the transmission response of the optical device under test (ODUT) into the electrical domain. The main principle of the OVNA is predicated on the optical carrier restoration facilitated by the wavelength-selective amplification attribute of the DFB-SOA. The implemented OVNA effectively determined the transmission spectrum of an optical filter possessing a passband of 9-GHz bandwidth, achieving a commendable resolution of 25 MHz in the measurement process. The dynamic range of the OVNA can be broadened by adjust the driven current under the DFB-SOA. Additionally, the detection range of our system can be expanded through the utilization of broadband optoelectronic devices. Furthermore, the OVNA possesses considerable potential for integration onto a single chip. Full article
(This article belongs to the Special Issue Recent Advances in Microwave Photonics)
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23 pages, 9534 KB  
Article
Adaptive Disturbance Suppression Method for Servo Systems Based on State Equalizer
by Jinzhao Li, Yonggang Li, Xiantao Li, Dapeng Mao and Bao Zhang
Sensors 2024, 24(13), 4418; https://doi.org/10.3390/s24134418 - 8 Jul 2024
Viewed by 1273
Abstract
Disturbances in the aviation environment can compromise the stability of the aviation optoelectronic stabilization platform. Traditional methods, such as the proportional integral adaptive robust (PI + ARC) control algorithm, face a challenge: once high-frequency disturbances are introduced, their effectiveness is constrained by the [...] Read more.
Disturbances in the aviation environment can compromise the stability of the aviation optoelectronic stabilization platform. Traditional methods, such as the proportional integral adaptive robust (PI + ARC) control algorithm, face a challenge: once high-frequency disturbances are introduced, their effectiveness is constrained by the control system’s bandwidth, preventing further stability enhancement. A state equalizer speed closed-loop control algorithm is proposed, which combines proportional integral adaptive robustness with state equalizer (PI + ARC + State equalizer) control algorithm. This new control structure can suppress high-frequency disturbances caused by mechanical resonance, improve the bandwidth of the control system, and further achieve fast convergence and stability of the PI + ARC algorithm. Experimental results indicate that, in comparison to the control algorithm of PI + ARC, the inclusion of a state equalizer speed closed-loop compensation in the model significantly increases the closed-loop bandwidth by 47.6%, significantly enhances the control system’s resistance to disturbances, and exhibits robustness in the face of variations in the model parameters and feedback sensors of the control object. In summary, integrating a state equalizer speed closed-loop with PI + ARC significantly enhances the suppression of high-frequency disturbances and the performance of control systems. Full article
(This article belongs to the Section Optical Sensors)
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14 pages, 5825 KB  
Article
A Proposal for a Solar Position Sensor System with Multifiber Optical Cable
by Fernanda Oliveira, Gustavo Cruz, Maria Barbosa, Fernando Junior, Ricardo Lima and Luis Gómez-Malagón
Sensors 2024, 24(11), 3269; https://doi.org/10.3390/s24113269 - 21 May 2024
Cited by 5 | Viewed by 1616
Abstract
A solar position sensor is an essential optoelectronic device used to monitor the sun’s position in solar tracking systems. In closed-loop systems, this sensor is responsible for providing feedback signals to the control system, allowing motor adjustments to optimize the angle of incidence [...] Read more.
A solar position sensor is an essential optoelectronic device used to monitor the sun’s position in solar tracking systems. In closed-loop systems, this sensor is responsible for providing feedback signals to the control system, allowing motor adjustments to optimize the angle of incidence and minimize positioning errors. The accuracy required for solar tracking systems varies depending on the specific photovoltaic concentration. In the case of the concentrator photovoltaic (CPV), it is normally essential to track the sun with a position error of less than ±0.6°. To achieve such precision, a proposed sensor configuration composed of low-cost embedded electronics and multifiber optical cable is subjected to characterization through a series of measurements covering range, sensitivity, and resolution. These measurements are performed in controlled indoor environments as well as outdoor conditions. The results obtained exhibit a resolution of 2.6×103 degrees when the sensor is illuminated within its designated field of view of ±0.1°, particularly in external conditions. Considering the performance demonstrated by the proposed solar position sensor, coupled with its straightforward modeling and assembly compared to position sensors documented in the literature, it emerges as a promising candidate for integration into solar tracking systems. Full article
(This article belongs to the Section Optical Sensors)
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17 pages, 1969 KB  
Article
A Machine Learning App for Monitoring Physical Therapy at Home
by Bruno Pereira, Bruno Cunha, Paula Viana, Maria Lopes, Ana S. C. Melo and Andreia S. P. Sousa
Sensors 2024, 24(1), 158; https://doi.org/10.3390/s24010158 - 27 Dec 2023
Cited by 13 | Viewed by 5253
Abstract
Shoulder rehabilitation is a process that requires physical therapy sessions to recover the mobility of the affected limbs. However, these sessions are often limited by the availability and cost of specialized technicians, as well as the patient’s travel to the session locations. This [...] Read more.
Shoulder rehabilitation is a process that requires physical therapy sessions to recover the mobility of the affected limbs. However, these sessions are often limited by the availability and cost of specialized technicians, as well as the patient’s travel to the session locations. This paper presents a novel smartphone-based approach using a pose estimation algorithm to evaluate the quality of the movements and provide feedback, allowing patients to perform autonomous recovery sessions. This paper reviews the state of the art in wearable devices and camera-based systems for human body detection and rehabilitation support and describes the system developed, which uses MediaPipe to extract the coordinates of 33 key points on the patient’s body and compares them with reference videos made by professional physiotherapists using cosine similarity and dynamic time warping. This paper also presents a clinical study that uses QTM, an optoelectronic system for motion capture, to validate the methods used by the smartphone application. The results show that there are statistically significant differences between the three methods for different exercises, highlighting the importance of selecting an appropriate method for specific exercises. This paper discusses the implications and limitations of the findings and suggests directions for future research. Full article
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13 pages, 5554 KB  
Article
Smartphone-Based Video Analysis for Guiding Shoulder Therapeutic Exercises: Concurrent Validity for Movement Quality Control
by Maria Lopes, Ana S. C. Melo, Bruno Cunha and Andreia S. P. Sousa
Appl. Sci. 2023, 13(22), 12282; https://doi.org/10.3390/app132212282 - 13 Nov 2023
Cited by 4 | Viewed by 1965
Abstract
Neuromuscular re-education through therapeutic exercise has a determinant role in chronic shoulder pain rehabilitation. Smartphones are an interesting strategy to extend the rehabilitation to a home-based scenario as it can increase the attraction and involvement of users by providing feedback. Objective: To analyze [...] Read more.
Neuromuscular re-education through therapeutic exercise has a determinant role in chronic shoulder pain rehabilitation. Smartphones are an interesting strategy to extend the rehabilitation to a home-based scenario as it can increase the attraction and involvement of users by providing feedback. Objective: To analyze the concurrent validity of a smartphone’s application based on 2D video analysis against the gold-standard 3D optoelectronic system for assessing movement quality during upper limb therapeutic exercises. Methods: Fifteen young adults were evaluated while executing two different shoulder exercises with a smartphone’s 2D video and a 3D optoelectronic system simultaneously in two conditions: (1) with the supervision and instructions of a physiotherapist (guided exercise), and (2) without the feedback of the physiotherapist (non-guided exercise). The data obtained during the guided and non-guided exercises were compared to calculate the movement quality index based on the approximation of the non-guided exercise to the guided exercise for the head, trunk, and shoulder’s range of movement. The agreement of the movement quality index assessed with the smartphone application and the optoelectronic system was carried out through Bland–Altman analysis. Results: The Bland–Altman analysis indicates the range of agreement and bias tendency. This tendency demonstrates that the percentage of difference between the two methods increases as the movement quality index decreases. Conclusions: There is agreement between the movement quality evaluated by a gold-standard method and the developed application, although the proposed method appears to have less sensitivity for evaluating movements with lower quality index. Full article
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12 pages, 750 KB  
Article
Optical Bistability and Thermal Mode Hopping in External Cavity Feedback Semiconductor Lasers
by Da Meng, Haiyang Yu, Yejin Zhang and Jianguo Liu
Photonics 2023, 10(9), 1027; https://doi.org/10.3390/photonics10091027 - 8 Sep 2023
Cited by 10 | Viewed by 2530
Abstract
The external cavity feedback semiconductor laser shows obvious optical bistability in practice. That is, at the same operating temperature, different temperature tuning directions will lead to different laser mode outputs. This will lead to optical mode hopping and unstable output wavelength of the [...] Read more.
The external cavity feedback semiconductor laser shows obvious optical bistability in practice. That is, at the same operating temperature, different temperature tuning directions will lead to different laser mode outputs. This will lead to optical mode hopping and unstable output wavelength of the laser. In this work, we measured this phenomenon and explained it through a theoretical model with thermal synchronization considered. Our measured results show obvious bistability and temperature tuning direction dependence. In order to explain this phenomenon, we considered the physical characteristics of each optoelectronic component in the external cavity, and found that the temperature changes of each component were not synchronized over time. After establishing a model that takes into account the thermal asynchrony phenomenon, we have effectively explained this phenomenon. Full article
(This article belongs to the Section Lasers, Light Sources and Sensors)
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19 pages, 6230 KB  
Article
Design and Experimental Validation of a 3D-Printed Embedded-Sensing Continuum Robot for Neurosurgery
by Donatella Dragone, Francesca Federica Donadio, Chiara Mirabelli, Carlo Cosentino, Francesco Amato, Paolo Zaffino, Maria Francesca Spadea, Domenico La Torre and Alessio Merola
Micromachines 2023, 14(9), 1743; https://doi.org/10.3390/mi14091743 - 6 Sep 2023
Cited by 7 | Viewed by 2998
Abstract
A minimally-invasive manipulator characterized by hyper-redundant kinematics and embedded sensing modules is presented in this work. The bending angles (tilt and pan) of the robot tip are controlled through tendon-driven actuation; the transmission of the actuation forces to the tip is based on [...] Read more.
A minimally-invasive manipulator characterized by hyper-redundant kinematics and embedded sensing modules is presented in this work. The bending angles (tilt and pan) of the robot tip are controlled through tendon-driven actuation; the transmission of the actuation forces to the tip is based on a Bowden-cable solution integrating some channels for optical fibers. The viability of the real-time measurement of the feedback control variables, through optoelectronic acquisition, is evaluated for automated bending of the flexible endoscope and trajectory tracking of the tip angles. Indeed, unlike conventional catheters and cannulae adopted in neurosurgery, the proposed robot can extend the actuation and control of snake-like kinematic chains with embedded sensing solutions, enabling real-time measurement, robust and accurate control of curvature, and tip bending of continuum robots for the manipulation of cannulae and microsurgical instruments in neurosurgical procedures. A prototype of the manipulator with a length of 43 mm and a diameter of 5.5 mm has been realized via 3D printing. Moreover, a multiple regression model has been estimated through a novel experimental setup to predict the tip angles from measured outputs of the optoelectronic modules. The sensing and control performance has also been evaluated during tasks involving tip rotations. Full article
(This article belongs to the Special Issue Fundamentals and Applications of Micro-Nanorobotics)
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21 pages, 29126 KB  
Article
AIEE-Active Flavones as a Promising Tool for the Real-Time Tracking of Uptake and Distribution in Live Zebrafish
by Yi Wu, Ying He, Huiqing Luo, Tingting Jin and Feng He
Int. J. Mol. Sci. 2023, 24(12), 10183; https://doi.org/10.3390/ijms241210183 - 15 Jun 2023
Cited by 1 | Viewed by 2113
Abstract
In recent years, aggregation-induced emission enhancement (AIEE) molecules have shown great potential for applications in the fields of bio-detection, imaging, optoelectronic devices, and chemical sensing. Based on our previous studies, we investigated the fluorescence properties of six flavonoids and confirmed that compounds 1 [...] Read more.
In recent years, aggregation-induced emission enhancement (AIEE) molecules have shown great potential for applications in the fields of bio-detection, imaging, optoelectronic devices, and chemical sensing. Based on our previous studies, we investigated the fluorescence properties of six flavonoids and confirmed that compounds 13 have good aggregation-induced emission enhancement (AIEE) properties through a series of spectroscopic experiments. Compounds with AIEE properties have addressed the limitation imposed by the aggregation-caused quenching (ACQ) of classic organic dyes owing to their strong fluorescence emission and high quantum yield. Based on their excellent fluorescence properties, we evaluated their performance in the cell and we found that they could label mitochondria specifically by comparing their Pearson correlation coefficients (R) with Mito Tracker Red and Lyso-Tracker Red. This suggests their future application in mitochondrial imaging. Furthermore, studies of uptake and distribution characterization in 48 hpf zebrafish larvae revealed their potential for monitoring real-time drug behavior. The uptake of compounds by larvae varies significantly across different time cycles (between uptake and utilization in the tissue). This observation has important implications for the development of visualization techniques for pharmacokinetic processes and can enable real-time feedback. More interestingly, according to the data presented, tested compounds aggregated in the liver and intestine of 168 hpf larvae. This finding suggests that they could potentially be used for monitoring and diagnosing liver and intestinal diseases. Full article
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